Arcadi Navarro

Summary

Affiliation: Universitat Pompeu Fabra
Country: Spain

Publications

  1. ncbi request reprint Chromosomal speciation and molecular divergence--accelerated evolution in rearranged chromosomes
    Arcadi Navarro
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
    Science 300:321-4. 2003
  2. ncbi request reprint Accumulating postzygotic isolation genes in parapatry: a new twist on chromosomal speciation
    Arcadi Navarro
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
    Evolution 57:447-59. 2003
  3. doi request reprint Interrogating 11 fast-evolving genes for signatures of recent positive selection in worldwide human populations
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Institut de Biologia Evolutiva UPF CSIC, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 26:2285-97. 2009
  4. pmc Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
  5. ncbi request reprint Balancing selection is the main force shaping the evolution of innate immunity genes
    Anna Ferrer-Admetlla
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Unitat de Biologia Evolutiva, Barcelona, Catalonia, Spain
    J Immunol 181:1315-22. 2008
  6. pmc The portability of tagSNPs across populations: a worldwide survey
    Anna Gonzalez-Neira
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Genome Res 16:323-30. 2006
  7. pmc The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements
    Tomas Marques-Bonet
    Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    BMC Genomics 9:384. 2008
  8. pmc On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees
    Tomas Marques-Bonet
    Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Catalonia, Spain
    Genome Biol 8:R230. 2007
  9. pmc Copy number variation analysis in the great apes reveals species-specific patterns of structural variation
    Elodie Gazave
    Institute of Evolutionary Biology UPF CSIC, PRBB, 08003 Barcelona, Spain
    Genome Res 21:1626-39. 2011
  10. doi request reprint SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data
    Carlos Morcillo-Suarez
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    Bioinformatics 24:1643-4. 2008

Detail Information

Publications29

  1. ncbi request reprint Chromosomal speciation and molecular divergence--accelerated evolution in rearranged chromosomes
    Arcadi Navarro
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
    Science 300:321-4. 2003
    ..Also, nucleotide variability is slightly lower in rearranged chromosomes. These patterns of divergence and polymorphism may be, at least in part, the molecular footprint of speciation events in the human and chimpanzee lineages...
  2. ncbi request reprint Accumulating postzygotic isolation genes in parapatry: a new twist on chromosomal speciation
    Arcadi Navarro
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
    Evolution 57:447-59. 2003
    ..The model makes testable qualitative predictions about the genetic signature of speciation...
  3. doi request reprint Interrogating 11 fast-evolving genes for signatures of recent positive selection in worldwide human populations
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Institut de Biologia Evolutiva UPF CSIC, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 26:2285-97. 2009
    ..Based on these data, it therefore appears that adaptation for human-specific and for population-specific traits may have involved different genes...
  4. pmc Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
    ..Within each gene region and population we use r2 between all possible single nucleotide polymorphism (SNP) pairs as a measure of linkage disequilibrium and focus on the proportion of SNP pairs with r2 greater than 0.8...
  5. ncbi request reprint Balancing selection is the main force shaping the evolution of innate immunity genes
    Anna Ferrer-Admetlla
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Unitat de Biologia Evolutiva, Barcelona, Catalonia, Spain
    J Immunol 181:1315-22. 2008
    ..However, we also describe evidence from African populations, which may reflect parallel or long-term selective forces acting in different geographic areas...
  6. pmc The portability of tagSNPs across populations: a worldwide survey
    Anna Gonzalez-Neira
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Genome Res 16:323-30. 2006
    ..This high degree of portability lends promise to the search for disease association in different populations, once tagSNPs are defined in a few reference populations like those analyzed in the HapMap initiative...
  7. pmc The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements
    Tomas Marques-Bonet
    Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    BMC Genomics 9:384. 2008
    ....
  8. pmc On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees
    Tomas Marques-Bonet
    Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Catalonia, Spain
    Genome Biol 8:R230. 2007
    ..To date, however, results are contradictory. Here we revisit this issue by making use of the available human and chimpanzee genome sequence to study the relationship between chromosomal rearrangements and rates of DNA sequence evolution...
  9. pmc Copy number variation analysis in the great apes reveals species-specific patterns of structural variation
    Elodie Gazave
    Institute of Evolutionary Biology UPF CSIC, PRBB, 08003 Barcelona, Spain
    Genome Res 21:1626-39. 2011
    ..Finally, we identified a number of interesting genomic regions that present high-frequency CNVs in all great apes, while containing only very rare or even pathogenic structural variants in humans...
  10. doi request reprint SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data
    Carlos Morcillo-Suarez
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    Bioinformatics 24:1643-4. 2008
    ..Many different quality control and analysis procedures can be performed either by using built-in SNPator algorithms or by calling standard genetic software. AVAILABILITY: Access is granted from the SNPator webpage http://www.snpator.org...
  11. pmc The prion protein gene in humans revisited: lessons from a worldwide resequencing study
    Marta Soldevila
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Genome Res 16:231-9. 2006
    ....
  12. pmc Patterns and rates of intron divergence between humans and chimpanzees
    Elodie Gazave
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Carrer Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain
    Genome Biol 8:R21. 2007
    ..Several studies have investigated levels of evolutionary constraint along introns and across classes of introns of different length and location within genes. However, thus far these studies have yielded contradictory results...
  13. pmc Recent human evolution has shaped geographical differences in susceptibility to disease
    Urko M Marigorta
    Institute of Evolutionary Biology UPF CSIC, PRBB, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain
    BMC Genomics 12:55. 2011
    ..Here, we focus on the world-wide patterns of replicability of published association studies...
  14. pmc Statistical power analysis of neutrality tests under demographic expansions, contractions and bottlenecks with recombination
    Anna Ramírez-Soriano
    Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Genetics 179:555-67. 2008
    ..Nevertheless, they are strongly affected by misestimations of recombination, so they should not be used when recombination levels are unknown. Instead, class I tests, particularly Tajima's D or R2, are recommended...
  15. ncbi request reprint Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example
    Michelle Gardner
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain
    Hum Genet 121:759-62. 2007
    ..In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene...
  16. pmc High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants
    Urko M Marigorta
    Institute of Evolutionary Biology Universitat Pompeu Fabra CSIC, PRBB, Barcelona, Catalonia, Spain
    PLoS Genet 9:e1003566. 2013
    ....
  17. ncbi request reprint Association Cluster Detector: a tool for heuristic detection of significance clusters in whole-genome scans
    Tomas Marques-Bonet
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Bioinformatics 21:ii180-1. 2005
    ....
  18. ncbi request reprint Murine segmental duplications are hot spots for chromosome and gene evolution
    Lluis Armengol
    Genes and Disease Program, Center for Genomic Regulation, Passeig Maritim 37 49, 08003 Barcelona, Catalonia, Spain
    Genomics 86:692-700. 2005
    ....
  19. pmc Similarity in recombination rate estimates highly correlates with genetic differentiation in humans
    Hafid Laayouni
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e17913. 2011
    ..This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans...
  20. ncbi request reprint Chromosomal rearrangements and the genomic distribution of gene-expression divergence in humans and chimpanzees
    Tomas Marques-Bonet
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader, 80 08003 Barcelona, Catalonia, Spain
    Trends Genet 20:524-9. 2004
    ..In addition, our results are consistent with a role for some rearrangements in the original speciation events that separated the human and chimpanzee lineages...
  21. ncbi request reprint Chromosomal rearrangements are associated with higher rates of molecular evolution in mammals
    Tomas Marques-Bonet
    Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
    Gene 353:147-54. 2005
    ..Still, there are other possible causes and further research is needed to properly explore them...
  22. doi request reprint Genome-wide association studies pipeline (GWASpi): a desktop application for genome-wide SNP analysis and management
    Fernando Muñiz-Fernandez
    Institut de Biologia Evolutiva, Universitat Pompeu Fabra, Biomedical Research Park PRBB, Barcelona, Spain
    Bioinformatics 27:1871-2. 2011
    ..AVAILABILITY: Freely available on the web at http://www.gwaspi.org. Implemented in Java, Apache-Derby and NetCDF-3, with all major operating systems supported. CONTACT: gwaspi@upf.edu; arcadi.navarro@upf.edu...
  23. doi request reprint Chromosomal speciation revisited: rearranging theory with pieces of evidence
    Rui Faria
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Trends Ecol Evol 25:660-9. 2010
    ..Finally, we question some previous predictions and suggest new empirical and theoretical approaches to understanding the relevance of rearrangements in the origin of species...
  24. pmc Geographic stratification of linkage disequilibrium: a worldwide population study in a region of chromosome 22
    Anna Gonzalez-Neira
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Hum Genomics 1:399-409. 2004
    ....
  25. pmc HeT-A_pi1, a piRNA target sequence in the Drosophila telomeric retrotransposon HeT-A, is extremely conserved across copies and species
    Natalia Petit
    Departament de Ciències Experimentals i de la Salut DCEXS, Universitat Pompeu Fabra, Barcelona, Spain
    PLoS ONE 7:e37405. 2012
    ..The high conservation of this piRNA target in contrast with the surrounding sequence, suggests an important function of the HeT-A_pi1 sequence in the co-evolution of the HeT-A retrotransposon and the Drosophila genome...
  26. ncbi request reprint Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineage
    Aida M Andres
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Hum Genet 115:377-86. 2004
    ....
  27. pmc Dynamics of a human interparalog gene conversion hotspot
    Elena Bosch
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Genome Res 14:835-44. 2004
    ..Analysis of great ape homologs shows that conversion in this hotspot has a deep evolutionary history...
  28. ncbi request reprint Inversions with classical style and trendy lines
    Arcadi Navarro
    Nat Genet 37:115-6. 2005
  29. ncbi request reprint Frequent appearance of novel protein-coding sequences by frameshift translation
    Kohji Okamura
    The Centre for Applied Genomics, Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Canada ON M5G 1L7
    Genomics 88:690-7. 2006
    ....