Research Topics
Species | Arcadi NavarroSummaryAffiliation: Universitat Pompeu Fabra Country: Spain Publications
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Detail Information
Publications
Chromosomal speciation and molecular divergence--accelerated evolution in rearranged chromosomesArcadi Navarro
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
Science 300:321-4. 2003..Also, nucleotide variability is slightly lower in rearranged chromosomes. These patterns of divergence and polymorphism may be, at least in part, the molecular footprint of speciation events in the human and chimpanzee lineages...- Accumulating postzygotic isolation genes in parapatry: a new twist on chromosomal speciationArcadi Navarro
Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
Evolution 57:447-59. 2003..The model makes testable qualitative predictions about the genetic signature of speciation... 
Interrogating 11 fast-evolving genes for signatures of recent positive selection in worldwide human populationsAndres Moreno-Estrada
Departament de Ciencies Experimentals i de la Salut, Institut de Biologia Evolutiva UPF CSIC, Universitat Pompeu Fabra, Barcelona, Spain
Mol Biol Evol 26:2285-97. 2009..Based on these data, it therefore appears that adaptation for human-specific and for population-specific traits may have involved different genes...
Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LDElena Bosch
Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
BMC Genomics 10:338. 2009..Within each gene region and population we use r2 between all possible single nucleotide polymorphism (SNP) pairs as a measure of linkage disequilibrium and focus on the proportion of SNP pairs with r2 greater than 0.8...- Balancing selection is the main force shaping the evolution of innate immunity genesAnna Ferrer-Admetlla
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Unitat de Biologia Evolutiva, Barcelona, Catalonia, Spain
J Immunol 181:1315-22. 2008..However, we also describe evidence from African populations, which may reflect parallel or long-term selective forces acting in different geographic areas... - The portability of tagSNPs across populations: a worldwide surveyAnna Gonzalez-Neira
Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
Genome Res 16:323-30. 2006..This high degree of portability lends promise to the search for disease association in different populations, once tagSNPs are defined in a few reference populations like those analyzed in the HapMap initiative... - The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangementsTomas Marques-Bonet
Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
BMC Genomics 9:384. 2008.... - On the association between chromosomal rearrangements and genic evolution in humans and chimpanzeesTomas Marques-Bonet
Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Catalonia, Spain
Genome Biol 8:R230. 2007..To date, however, results are contradictory. Here we revisit this issue by making use of the available human and chimpanzee genome sequence to study the relationship between chromosomal rearrangements and rates of DNA sequence evolution... - Copy number variation analysis in the great apes reveals species-specific patterns of structural variationElodie Gazave
Institute of Evolutionary Biology UPF CSIC, PRBB, 08003 Barcelona, Spain
Genome Res 21:1626-39. 2011..Finally, we identified a number of interesting genomic regions that present high-frequency CNVs in all great apes, while containing only very rare or even pathogenic structural variants in humans... - SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP dataCarlos Morcillo-Suarez
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
Bioinformatics 24:1643-4. 2008..Many different quality control and analysis procedures can be performed either by using built-in SNPator algorithms or by calling standard genetic software. AVAILABILITY: Access is granted from the SNPator webpage http://www.snpator.org... - The prion protein gene in humans revisited: lessons from a worldwide resequencing studyMarta Soldevila
Unitat de Biologia Evolutiva, , Universitat Pompeu Fabra, 08003 Barcelona, Spain
Genome Res 16:231-9. 2006.... - Patterns and rates of intron divergence between humans and chimpanzeesElodie Gazave
Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Carrer Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain
Genome Biol 8:R21. 2007..Several studies have investigated levels of evolutionary constraint along introns and across classes of introns of different length and location within genes. However, thus far these studies have yielded contradictory results... - Recent human evolution has shaped geographical differences in susceptibility to diseaseUrko M Marigorta
Institute of Evolutionary Biology UPF CSIC, PRBB, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain
BMC Genomics 12:55. 2011..Here, we focus on the world-wide patterns of replicability of published association studies... - Statistical power analysis of neutrality tests under demographic expansions, contractions and bottlenecks with recombinationAnna Ramírez-Soriano
Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
Genetics 179:555-67. 2008..Nevertheless, they are strongly affected by misestimations of recombination, so they should not be used when recombination levels are unknown. Instead, class I tests, particularly Tajima's D or R2, are recommended... - Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 exampleMichelle Gardner
Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain
Hum Genet 121:759-62. 2007..In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene... - Association Cluster Detector: a tool for heuristic detection of significance clusters in whole-genome scansTomas Marques-Bonet
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
Bioinformatics 21:ii180-1. 2005..AVAILABILITY: The tool can be downloaded from http://www.upf.es/cexs/recerca/bioevo/softanddata.htm.. - Murine segmental duplications are hot spots for chromosome and gene evolutionLluis Armengol
Genes and Disease Program, Center for Genomic Regulation, Passeig Maritim 37 49, 08003 Barcelona, Catalonia, Spain
Genomics 86:692-700. 2005.... - Chromosomal rearrangements and the genomic distribution of gene-expression divergence in humans and chimpanzeesTomas Marques-Bonet
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader, 80 08003 Barcelona, Catalonia, Spain
Trends Genet 20:524-9. 2004..In addition, our results are consistent with a role for some rearrangements in the original speciation events that separated the human and chimpanzee lineages... - Similarity in recombination rate estimates highly correlates with genetic differentiation in humansHafid Laayouni
IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
PLoS ONE 6:e17913. 2011..This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans... - Chromosomal rearrangements are associated with higher rates of molecular evolution in mammalsTomas Marques-Bonet
Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
Gene 353:147-54. 2005..Still, there are other possible causes and further research is needed to properly explore them... - Genome-wide association studies pipeline (GWASpi): a desktop application for genome-wide SNP analysis and managementFernando Muñiz-Fernandez
Institut de Biologia Evolutiva, Universitat Pompeu Fabra, Biomedical Research Park PRBB, Barcelona, Spain
Bioinformatics 27:1871-2. 2011..AVAILABILITY: Freely available on the web at http://www.gwaspi.org. Implemented in Java, Apache-Derby and NetCDF-3, with all major operating systems supported. CONTACT: gwaspi@upf.edu; arcadi.navarro@upf.edu... - Chromosomal speciation revisited: rearranging theory with pieces of evidenceRui Faria
Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
Trends Ecol Evol 25:660-9. 2010..Finally, we question some previous predictions and suggest new empirical and theoretical approaches to understanding the relevance of rearrangements in the origin of species... - Geographic stratification of linkage disequilibrium: a worldwide population study in a region of chromosome 22Anna Gonzalez-Neira
Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
Hum Genomics 1:399-409. 2004.... - HeT-A_pi1, a piRNA target sequence in the Drosophila telomeric retrotransposon HeT-A, is extremely conserved across copies and speciesNatalia Petit
Departament de Ciències Experimentals i de la Salut DCEXS, Universitat Pompeu Fabra, Barcelona, Spain
PLoS ONE 7:e37405. 2012..The high conservation of this piRNA target in contrast with the surrounding sequence, suggests an important function of the HeT-A_pi1 sequence in the co-evolution of the HeT-A retrotransposon and the Drosophila genome... - Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineageAida M Andres
Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
Hum Genet 115:377-86. 2004.... - Dynamics of a human interparalog gene conversion hotspotElena Bosch
Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
Genome Res 14:835-44. 2004..Analysis of great ape homologs shows that conversion in this hotspot has a deep evolutionary history... - Inversions with classical style and trendy linesArcadi Navarro
Nat Genet 37:115-6. 2005 - Frequent appearance of novel protein-coding sequences by frameshift translationKohji Okamura
The Centre for Applied Genomics, Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Canada ON M5G 1L7
Genomics 88:690-7. 2006....