J M Miro

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. pmc Survival outcomes and effect of early vs. deferred cART among HIV-infected patients diagnosed at the time of an AIDS-defining event: a cohort analysis
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    PLoS ONE 6:e26009. 2011
  2. pmc High-dose daptomycin plus fosfomycin is safe and effective in treating methicillin-susceptible and methicillin-resistant Staphylococcus aureus endocarditis
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 56:4511-5. 2012
  3. doi request reprint Outcome of HCV/HIV-coinfected liver transplant recipients: a prospective and multicenter cohort study
    J M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Transplant 12:1866-76. 2012
  4. doi request reprint Infections in solid organ transplantation in special situations: HIV-infection and immigration
    Jose M Miro
    Department of Infectious Diseases, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Enferm Infecc Microbiol Clin 30:76-85. 2012
  5. doi request reprint Simultaneous pancreas-kidney transplantation in HIV-infected patients: a case report and literature review
    J M Miro
    Infectious Diseases Service, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Transplant Proc 42:3887-91. 2010
  6. doi request reprint Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV type 1-infected patients using a nonnucleoside reverse transcriptase inhibitor-based or a boosted protease inhibitor-based antiretroviral regimen: three-year results (The Advanz T
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 26:747-57. 2010
  7. pmc Addition of gentamicin or rifampin does not enhance the effectiveness of daptomycin in treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    J M Miro
    Infectious Diseases Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain
    Antimicrob Agents Chemother 53:4172-7. 2009
  8. doi request reprint Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity
    Jose M Miro
    Infectious Diseases Service, Hospital Clinic, Helios Building, Desk no 26, Villarroel 170, 08036 Barcelona, Spain
    Scand J Infect Dis 40:968-72. 2008
  9. ncbi request reprint [Liver transplantation in patients with HIV infection: a reality in 2004]
    Jose M Miro
    Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Universidad de Barcelona, Barcelona, Spain
    Enferm Infecc Microbiol Clin 22:529-38. 2004
  10. ncbi request reprint [Advances in the diagnosis and treatment of acute human immunodeficiency virus type 1 (HIV-1) infection]
    Jose M Miro
    Servicio de Enfermedades Infecciosas, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Universidad de Barcelona, Spain
    Enferm Infecc Microbiol Clin 22:643-59. 2004

Detail Information

Publications86

  1. pmc Survival outcomes and effect of early vs. deferred cART among HIV-infected patients diagnosed at the time of an AIDS-defining event: a cohort analysis
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    PLoS ONE 6:e26009. 2011
    ..We analyzed clinical progression among persons diagnosed with HIV at the time of an AIDS-defining event, and assessed the impact on outcome of timing of combined antiretroviral treatment (cART)...
  2. pmc High-dose daptomycin plus fosfomycin is safe and effective in treating methicillin-susceptible and methicillin-resistant Staphylococcus aureus endocarditis
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 56:4511-5. 2012
    ..aureus isolates and proved to be synergistic against 11 (79%) strains and bactericidal against 8 (57%) strains. This combination deserves further clinical study...
  3. doi request reprint Outcome of HCV/HIV-coinfected liver transplant recipients: a prospective and multicenter cohort study
    J M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Transplant 12:1866-76. 2012
    ..In conclusion, 5-year survival in HCV/HIV-coinfected liver recipients was lower than in HCV-monoinfected recipients, although an important subset with a favorable prognosis was identified in the former...
  4. doi request reprint Infections in solid organ transplantation in special situations: HIV-infection and immigration
    Jose M Miro
    Department of Infectious Diseases, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Enferm Infecc Microbiol Clin 30:76-85. 2012
    ....
  5. doi request reprint Simultaneous pancreas-kidney transplantation in HIV-infected patients: a case report and literature review
    J M Miro
    Infectious Diseases Service, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Transplant Proc 42:3887-91. 2010
    ....
  6. doi request reprint Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV type 1-infected patients using a nonnucleoside reverse transcriptase inhibitor-based or a boosted protease inhibitor-based antiretroviral regimen: three-year results (The Advanz T
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 26:747-57. 2010
    ..At 1 and 3 years, the immune reconstitution induced by an efavirenz-based regimen in very immunosuppressed patients was at least as potent as that induced by a ritonavir-boosted protease inhibitor-based antiretroviral regimen...
  7. pmc Addition of gentamicin or rifampin does not enhance the effectiveness of daptomycin in treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    J M Miro
    Infectious Diseases Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain
    Antimicrob Agents Chemother 53:4172-7. 2009
    ..In conclusion, the addition of gentamicin or rifampin does not enhance the effectiveness of daptomycin in the treatment of experimental endocarditis due to MRSA...
  8. doi request reprint Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity
    Jose M Miro
    Infectious Diseases Service, Hospital Clinic, Helios Building, Desk no 26, Villarroel 170, 08036 Barcelona, Spain
    Scand J Infect Dis 40:968-72. 2008
    ..The relapse was cured with ampicillin plus ceftriaxone, which was introduced after gentamicin-induced acute renal failure. This double beta-lactam combination showed a bactericidal effect in time-killing curve studies...
  9. ncbi request reprint [Liver transplantation in patients with HIV infection: a reality in 2004]
    Jose M Miro
    Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Universidad de Barcelona, Barcelona, Spain
    Enferm Infecc Microbiol Clin 22:529-38. 2004
    ..There is little experience with pegylated interferon and ribavirin treatment in this population...
  10. ncbi request reprint [Advances in the diagnosis and treatment of acute human immunodeficiency virus type 1 (HIV-1) infection]
    Jose M Miro
    Servicio de Enfermedades Infecciosas, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Universidad de Barcelona, Spain
    Enferm Infecc Microbiol Clin 22:643-59. 2004
    ..However, this is a controversial issue and currently most guidelines recommend treatment only if these patients can be included in clinical trials or if they show lasting or severe clinical manifestations...
  11. ncbi request reprint [GESIDA/GESITRA-SEIMC, PNS and ONT consensus document on solid organ transplant (SOT) in HIV-infected patients in Spain (March, 2005)]
    Jose M Miro
    AIDS Study Group GESIDA of the Spanish Society of Infectious Diseases and Clinical Microbiology SEIMC
    Enferm Infecc Microbiol Clin 23:353-62. 2005
    ..Up to now, experience with pegylated interferon and ribavirin is scarce in this population. The English version of the manuscript is available at http://www.gesidaseimc.com...
  12. ncbi request reprint Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database
    Jose M Miro
    Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 41:507-14. 2005
    ..Staphylococcus aureus native valve infective endocarditis (SA-NVIE) is not completely understood. The objective of this investigation was to describe the characteristics of a large, international cohort of patients with SA-NVIE...
  13. ncbi request reprint Liver transplantation in HIV/hepatitis co-infection
    Jose M Miro
    Infectious Diseases Service, Hospital Clinic IDIBAPS, Villarroel, 08036 Barcelona, Spain
    J HIV Ther 12:24-35. 2007
    ..Finally, this field is evolving continuously and the indications for liver transplantation or the management of HCV co-infection may change in the future as more evidence becomes available...
  14. ncbi request reprint Discontinuation of primary and secondary Toxoplasma gondii prophylaxis is safe in HIV-infected patients after immunological restoration with highly active antiretroviral therapy: results of an open, randomized, multicenter clinical trial
    Jose M Miro
    Institut d Investigacions Biomediques August Pi Sunyer Hospital Clinic, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 43:79-89. 2006
    ..To our knowledge, no randomized trials have evaluated whether prophylaxis against toxoplasmic encephalitis can be safely discontinued after the CD4+ T cell count increases in response to highly active antiretroviral therapy...
  15. pmc Efficacy of telavancin in the treatment of experimental endocarditis due to glycopeptide-intermediate Staphylococcus aureus
    Jose M Miro
    Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 51:2373-7. 2007
    ..All isolates from vegetations remained susceptible to telavancin after therapy. The results suggest that telavancin may be an effective treatment for endocarditis caused by glycopeptide-intermediate S. aureus...
  16. doi request reprint [Clinical management of acute and chronic human immunodeficiency virus infection before starting antiretroviral treatment]
    Jose M Miro
    Servicio de Enfermedades Infecciosas, Hospital Clinico IDIBAPS, Universidad de Barcelona, Barcelona, Spain
    Enferm Infecc Microbiol Clin 29:759-72. 2011
    ..No less important is the psychological support, as these patients must learn to live with a chronic infection, which managed properly can ensure a very good long-term prognosis and quality of life...
  17. ncbi request reprint Comparison of immunologic restoration and virologic response in plasma, tonsillar tissue, and cerebrospinal fluid in HIV-1-infected patients treated with double versus triple antiretroviral therapy in very early stages: The Spanish EARTH-2 Study. Early An
    F Garcia
    Infectious Diseases Unit and Microbiology and Immunology Laboratories, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 25:26-35. 2000
    ..HIV-1-related immune system abnormalities improved but were still defective after 1 year of antiretroviral therapy...
  18. ncbi request reprint Residual low-level viral replication could explain discrepancies between viral load and CD4+ cell response in human immunodeficiency virus-infected patients receiving antiretroviral therapy
    F Garcia
    Infectious Diseases Unit, Hospital Clinic, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 30:392-4. 2000
    ..A low level of HIV-1 replication could explain the lack of immunologic response in patients with apparent virological response...
  19. ncbi request reprint Comparison of twice-daily stavudine plus once- or twice-daily didanosine and nevirapine in early stages of HIV infection: the scan study
    F Garcia
    Infectious Diseases Unit, Institut d Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic, Faculty of Medicine, University of Barcelona, Spain
    AIDS 14:2485-94. 2000
    ..To evaluate the safety and effectiveness of once-daily didanosine and nevirapine plus twice-daily stavudine versus twice-daily administration of all three drugs...
  20. ncbi request reprint Comparison of T-cell subsets' reconstitution after 12 months of highly active antiretroviral therapy initiated during early versus advanced states of HIV disease
    C Tortajada
    Infectious Diseases Unit and Immunology Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 25:296-305. 2000
    ..Control group: 10 healthy HIV-negative individuals. Immunophenotypic markers were evaluated before and after 6-and 12-months' therapy. Functional assays were performed in one subset...
  21. pmc Daptomycin is effective for treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus epidermidis
    C Garcia-de-la-Maria
    Microbiology Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain
    Antimicrob Agents Chemother 54:2781-6. 2010
    ..In conclusion, daptomycin at doses of 6 mg/kg/day or 10 mg/kg/day is more effective than vancomycin for the treatment of experimental endocarditis due to MRSE and GISE...
  22. doi request reprint Relationship between adherence level, type of the antiretroviral regimen, and plasma HIV type 1 RNA viral load: a prospective cohort study
    M Martin
    Pharmacy Department, Hospital Clinic, 08036 Barcelona, Spain
    AIDS Res Hum Retroviruses 24:1263-8. 2008
    ..For patients taking NNRTI- or boosted PI-based regimens with adherence rates of 80%, the failure rate is <10%. These data do not affect the goal of achieving the highest level of adherence possible...
  23. ncbi request reprint Lymphoid tissue viral burden and duration of viral suppression in plasma
    E Martinez
    Unit of Infectious Diseases, Clinical Institute of Infectious Diseases and Immunology IDIBAPS Hospital Clínic Universitari, Barcelona, Spain
    AIDS 15:1477-82. 2001
    ..To assess virological response in lymphoid tissue and its impact on the durability of response in plasma in HIV-1-infected persons who achieved sustained suppression of plasma viraemia with different antiretroviral regimens...
  24. ncbi request reprint Switching from zidovudine to didanosine in patients with symptomatic HIV infection and disease progression. ddI Iberian Study Group
    J M Gatell
    Hospital Clinic, Barcelona, Spain
    J Acquir Immune Defic Syndr Hum Retrovirol 12:249-58. 1996
    ..This effect tended to be greater among individuals with higher CD4 counts (>100/mm3)...
  25. ncbi request reprint Risk of selecting de novo drug-resistance mutations during structured treatment interruptions in patients with chronic HIV infection
    M Arnedo-Valero
    Microbiology Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    Clin Infect Dis 41:883-90. 2005
    ..Structured treatment interruption (STI) may allow viral replication in the presence of decreased plasma drug levels, with risk of selection of resistance mutations...
  26. doi request reprint Hepatotoxicity of nevirapine in virologically suppressed patients according to gender and CD4 cell counts
    E De Lazzari
    Biostatistic Unit, Hospital Clinic, University of Barcelona, Spain
    HIV Med 9:221-6. 2008
    ..It is unclear whether this higher risk also applies to stable virologically suppressed patients starting NcART...
  27. doi request reprint Prevalence and clinical characteristics of HIV type 1-infected patients receiving dialysis in Spain: results of a Spanish survey in 2006: GESIDA 48/05 study
    J C Trullas
    Infectious Diseases Service, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 24:1229-35. 2008
    ..05). The prevalence of HIV infection in Spanish dialysis units in 2006 was 0.54% HCV coinfection was very frequent (61%) and the percentage of patients included on the Spanish RT waiting list was low (12%)...
  28. ncbi request reprint Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality
    Miriam J Alvarez-Martinez
    Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Diagn Microbiol Infect Dis 62:34-43. 2008
    ..03 and P < 0.001, respectively). The prevalence of DHPS mutants in Spain is low and is not associated with a worse outcome. Severe respiratory failure at admission is the strongest predictor of PCP outcome...
  29. doi request reprint Efficacy and safety of outpatient parenteral antibiotic therapy for infective endocarditis: a ten-year prospective study
    Carlos Cervera
    Service of Infectious Diseases, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Enferm Infecc Microbiol Clin 29:587-92. 2011
    ....
  30. ncbi request reprint Influence of human immunodeficiency virus 1 infection and degree of immunosuppression in the clinical characteristics and outcome of infective endocarditis in intravenous drug users
    E Ribera
    Infectious Diseases Service, Hospital Vall d Hebron, Universidad Autonoma de Barcelona, Spain
    Arch Intern Med 158:2043-50. 1998
    ..The impact of HIV infection and the degree of immunosuppression on the clinical characteristics and outcome of infective endocarditis (IE) in intravenous (IV) drug users has not been well characterized...
  31. doi request reprint Optimal timing for initiation of highly active antiretroviral therapy in treatment-naïve human immunodeficiency virus-1-infected individuals presenting with AIDS-defining diseases: the experience of the PISCIS Cohort
    C Manzardo
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Clin Microbiol Infect 19:646-53. 2013
    ..002; hazard ratio 1.83; 95% CI 1.25-2.68). Other independent risk factors for poorer outcome were baseline diagnosis of AIDS-defining lymphoma, age >35 years, and low CD4(+) count (<50 cells/μL)...
  32. ncbi request reprint The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection
    F Garcia
    Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    AIDS 15:F29-40. 2001
    ..We hypothesized that cyclic structured treatment interruptions structured treatment interruptions (STI) could augment HIV-1 specific immune responses in chronic HIV-1 infection, which might help to control HIV-1 replication off therapy...
  33. doi request reprint Acute meningoencephalitis due to human immunodeficiency virus type 1 infection in 13 patients: clinical description and follow-up
    S Villar del Saz
    Hospital Universitari Vall d Hebron, Infectious Diseases Department, Autonomous University of Barcelona, Barcelona, Spain
    J Neurovirol 14:474-9. 2008
    ..Although all patients tend to recover and the necessity of ART is not well established, some data suggest its potential benefit in these patients...
  34. pmc Daptomycin is effective in treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus
    Francesc Marco
    Microbiology Service, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain
    Antimicrob Agents Chemother 52:2538-43. 2008
    ..01). No statistically significant difference between the vancomycin HD and the vancomycin RD for MRSA treatment was noted. These results support the use of daptomycin for the treatment of aortic valve endocarditis caused by GISA and MRSA...
  35. ncbi request reprint Native valve endocarditis due to Candida glabrata treated without valvular replacement: a potential role for caspofungin in the induction and maintenance treatment
    M J Jiménez-Expósito
    Institut d Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 39:e70-3. 2004
    ....
  36. ncbi request reprint Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group
    D Podzamczer
    Infectious Disease Service, Ciutat Sanitaria de Bellvitge, c Feixa Llarga s n L Hospitalet, Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 19:89-95. 2000
    ..Administration of antiretroviral therapy was the only factor associated with a lower incidence of relapse...
  37. ncbi request reprint Influence on survival of p24 antigen levels in patients with AIDS or advanced AIDS related complex treated with zidovudine
    L Zamora
    Infectious Disease Unit, University Hospital, Faculty of Medicine, Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 11:1181-5. 1992
    ....
  38. doi request reprint HIV-1 infected patients older than 50 years. PISCIS cohort study
    G Navarro
    Corporación Sanitaria Parc Taulí, Sabadell, Barcelona, Spain
    J Infect 57:64-71. 2008
    ..The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people...
  39. ncbi request reprint Pulmonary infiltrates in HIV-infected patients in the highly active antiretroviral therapy era in Spain
    N Benito
    Institut Clinic d Infeccions i Immunologia, Hospital Clinic Universitari, Universitat de Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 27:35-43. 2001
    ..To study the incidence, etiology, and outcome of pulmonary infiltrates (PIs) in HIV-infected patients and to evaluate the yield of diagnostic procedures...
  40. ncbi request reprint Influence of environmental temperature on incidence of indinavir-related nephrolithiasis
    E Martinez
    Institut d Investigacions Biomédiques, August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Clin Infect Dis 29:422-5. 1999
    ..However, the risk of nephrolithiasis is higher for a certain subgroup of patients when the environment is hot irrespective of adequate water intake...
  41. ncbi request reprint Efficacy and safety of once-daily combination therapy with didanosine, lamivudine and nevirapine in antiretroviral-naive HIV-infected patients
    Esteban Ribera
    Infectious Diseases Service, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Antivir Ther 10:605-14. 2005
    ..The purpose of this study was to evaluate the efficacy and safety of a once-daily regimen consisting of didanosine (ddI), lamivudine (3TC) and nevirapine (NVP) for adult antiretroviral-naive patients with HIV-1 infection...
  42. ncbi request reprint Long-term results after cardiac surgery in patients infected with the human immunodeficiency virus type-1 (HIV-1)
    Carlos A Mestres
    Department of Cardiovascular Surgery, Hospital Clinico, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Eur J Cardiothorac Surg 23:1007-16; discussion 1016. 2003
    ..Assessment of long-term results of immunodeficiency virus type-1 (HIV-1)-infected patients undergoing cardiac surgery...
  43. ncbi request reprint Brief communication: treatment of Enterococcus faecalis endocarditis with ampicillin plus ceftriaxone
    Joan Gavalda
    Hospital Universitari Vall d Hebron, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Ann Intern Med 146:574-9. 2007
    ..High-level aminoglycoside resistance (HLAR) that precludes bactericidal synergism with penicillins or glycopeptides and nephrotoxicity related to aminoglycoside treatment are major problems in treating Enterococcus faecalis endocarditis...
  44. ncbi request reprint Incidence and causes of death in HIV-infected persons receiving highly active antiretroviral therapy compared with estimates for the general population of similar age and from the same geographical area
    E Martinez
    Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic Universitari, Barcelona, Spain
    HIV Med 8:251-8. 2007
    ....
  45. ncbi request reprint Failure of a short-term prednisone regimen to prevent nevirapine-associated rash: a double-blind placebo-controlled trial: the GESIDA 09/99 study
    H Knobel
    Department of Internal Medicine Infectious Diseases, Hospital del Mar, Barcelona, Spain
    J Acquir Immune Defic Syndr 28:14-8. 2001
    ..The use of prednisone has been controversial in this setting. A double-blind placebo-controlled study was performed to evaluate its efficacy in nevirapine-induced rash prevention...
  46. doi request reprint Pulmonary infections in HIV-infected patients: an update in the 21st century
    N Benito
    Infectious Diseases Unit, Internal Medicine Service, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Eur Respir J 39:730-45. 2012
    ..Achieving an aetiological diagnosis of pulmonary infection in these patients is important due to its prognostic consequences...
  47. doi request reprint Predictors of hepatitis B virus genotype and viraemia in HIV-infected patients with chronic hepatitis B in Europe
    Vincent Soriano
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Antimicrob Chemother 65:548-55. 2010
    ..Information about factors determining HBV genotype distribution and viraemia in HIV/HBV-co-infected patients is scarce...
  48. ncbi request reprint Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infection
    Felipe Garcia
    Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    J Infect Dis 191:1680-5. 2005
    ..This response was associated with changes in HIV-1-specific CD4(+) lymphoproliferative and CD8(+) T cell responses. These changes were not observed in a group of nonimmunized control patients...
  49. pmc Inflammatory responses in blood samples of human immunodeficiency virus-infected patients with pulmonary infections
    Natividad Benito
    Service of Infectious Diseases, Institut Clínic de Infeccions i Inmunologia, Clinic Hospital IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
    Clin Diagn Lab Immunol 11:608-14. 2004
    ..An elevated IL-8 level (>61 pg/ml) at the time of admission was an independent factor associated with higher mortality (odds ratio, 12; 95% confidence interval, 1.2 to 235.5)...
  50. ncbi request reprint Long-term CD4+ T-cell response to highly active antiretroviral therapy according to baseline CD4+ T-cell count
    Felipe Garcia
    Clinic Institute of Infectious Diseases and Immunology, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    J Acquir Immune Defic Syndr 36:702-13. 2004
    ..It seems that the immune recovery slows down after approximately 3 years of HAART and reaches a plateau after 4-5 years of HAART...
  51. ncbi request reprint Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistence
    Llucia Alos
    Department of Pathology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Mod Pathol 18:127-36. 2005
    ..However, these parameters studied in lymphoid tissue are not re-established completely, even after 36 months of highly active antiretroviral therapy...
  52. ncbi request reprint A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/emtricitabine in HIV-1-infected patients with virological suppression
    Esteban Martinez
    Hospital Clinic Institut d Investigaciones Biomediques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain
    J Acquir Immune Defic Syndr 51:290-7. 2009
    ..We compared 48-week efficacy and safety of these combinations as substitutes of nucleosides in patients with virological suppression...
  53. ncbi request reprint A randomized trial comparing the efficacy and tolerability of two HAART strategies at two years in antiretroviral naive patients
    J Mallolas
    Infectious Diseases Service, Hospital Clinic, Barcelona, Spain
    Rev Clin Esp 207:427-32. 2007
    ....
  54. ncbi request reprint Effect of mycophenolate mofetil on immune response and plasma and lymphatic tissue viral load during and after interruption of highly active antiretroviral therapy for patients with chronic HIV infection: a randomized pilot study
    Felipe Garcia
    Infectious Diseases Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    J Acquir Immune Defic Syndr 36:823-30. 2004
    ..005) after 6 months off HAART. We found that combining MMF and HAART delayed VL rebound and improved control of viral replication without HAART but only when inhibition of lymphocyte proliferation was achieved...
  55. doi request reprint [Characteristics of hepatitis and influenza antivirals: update 2009]
    Ester Lopez-Suñé
    Servicio de Farmacia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic Universitari, Barcelona, Espana
    Enferm Infecc Microbiol Clin 28:253.e1-17. 2010
    ..The review of each drug focuses on dosage depending on treatment indication, dosage adjustment in renal or hepatic impairment, main pharmacokinetic features and the most significant adverse effects and drug interactions...
  56. ncbi request reprint Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adults
    Esteban Martinez
    Infectious Diseases Unit, Hospital Clinic, University of Barcelona, Calle Villarroel 170, 08036 Barcelona, Spain
    Lancet 364:65-7. 2004
    ..666, 95% CI 1.246-91.294, p=0.031). These results suggest that the risk of pancreatitis is heightened when didanosine and tenofovir are given together...
  57. ncbi request reprint [Infectious diseases research]
    Jordi Carratala
    Servicio de Enfermedades Infecciosas, Hospital Universitari de Bellvitge IDIBELL, Universitat de Barcelona, L Hospitalet de Llobregat, Barcelona, Espana
    Enferm Infecc Microbiol Clin 26:40-50. 2008
    ..The research activity in Infectious Diseases carried out in our country is a great opportunity for the training of specialists in this area of knowledge...
  58. ncbi request reprint Relevance of HIV-1-specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3
    Montserrat Plana
    Clinic Institute of Infectious Diseases and Immunology, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
    J Acquir Immune Defic Syndr 36:791-9. 2004
    ..To analyze the dynamics of both HIV-1-specific CD4 and CD8 T-cell responses during structured treatment interruptions (STIs) in chronically HIV-1-infected (CHI) patients and to correlate them with the viral set point achieved...
  59. ncbi request reprint HIV-1 upregulates intercellular adhesion molecule-1 gene expression in lymphoid tissue of patients with chronic HIV-1 infection
    Marta Garrido
    Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 46:268-74. 2007
    ..Our main objective was to study ICAM-1 expression in LT from HIV-1-infected persons and to correlate this expression with LT viral load and the immunoarchitecture alteration before and after highly active antiretroviral therapy (HAART)...
  60. ncbi request reprint Immune restoration in HIV-positive, antiretroviral-naive patients after 1 year of zidovudine/lamivudine plus nelfinavir or nevirapine
    Montserrat Plana
    Institut Clinic d Infeccions i Immunologia, Immunology, Infectious Diseases and Microbiology Units, Institut de Investigació Biomèdica Agusti Pi i Suñer, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Antivir Ther 9:197-204. 2004
    ..To evaluate the immunological response in HIV-1-infected, antiretroviral-naive patients receiving highly active antiretroviral therapy regimen of two nucleosides plus a protease inhibitor or a non-nucleoside reverse transcriptase inhibitor...
  61. ncbi request reprint Optimal timing and best antiretroviral regimen in treatment-naive HIV-infected individuals with advanced disease
    Christian Manzardo
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 46:S9-18. 2007
    ....
  62. ncbi request reprint [Specialized home care for infectious disease. Experience from 1995 to 2002]
    Juan Pablo Horcajada
    Servicio de Enfermedades Infecciosas, Hospital Clinic IDIBAPS, Universidad de Barcelona, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Espana
    Enferm Infecc Microbiol Clin 25:429-36. 2007
    ..This study reviews the experience of this service from 1995 to 2002 using prospectively recorded data...
  63. doi request reprint Prevalence of dihydropteroate synthase genotypes before and after the introduction of combined antiretroviral therapy and their influence on the outcome of Pneumocystis pneumonia in HIV-1-infected patients
    Miriam J Alvarez-Martinez
    Hospital Clínic IDIBAPS Institut d Investigació August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Diagn Microbiol Infect Dis 68:60-5. 2010
    ..However, their presence did not worsen prognosis of PcP. The response to TMP-SMX with therapeutic doses was successful in most cases...
  64. ncbi request reprint Streptococcus agalactiae infective endocarditis: analysis of 30 cases and review of the literature, 1962-1998
    A Sambola
    Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, E 08036 Barcelona, Spain
    Clin Infect Dis 34:1576-84. 2002
    ..S. agalactiae is an uncommon cause of endocarditis with a high mortality rate, although the prognosis of native valve endocarditis has improved in recent years, probably because of an increased use of cardiac surgery...
  65. pmc Profound reduction of CD4+ lymphocytes without HIV infection: two cases from the horn of Africa
    J E Ollé-Goig
    Catalan Association for the Control of Tuberculosis in the Third World ACTMON, Barcelona, Spain
    Afr Health Sci 12:331-3. 2012
    ..In poor resource-areas where HIV testing may not be available it is important to bear in mind that severe immunodepression and a clinical presentation compatible with AIDS do not necessary carry the diagnosis of AIDS...
  66. doi request reprint Predicting bacteremic pneumonia in HIV-1-infected patients consulting the ED
    Rafael Perello
    Emergency Department, Hospital Clinic, Barcelona, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer IDIBAPS, University of Barcelona 08036, Spain
    Am J Emerg Med 28:454-9. 2010
    ..Bacteremia has been associated with a higher risk of complications in such patients. We investigated factors associated with bacteremia in HIV-1-infected patients with CAP presenting at the emergency department...
  67. ncbi request reprint Clinical characteristics and outcome of aortic endocarditis with periannular abscess in the International Collaboration on Endocarditis Merged Database
    Ignasi Anguera
    The Corporació Sanitària Parc Taulí, Hospital de Sabadell, University of Barcelona, Barcelona, Spain
    Am J Cardiol 96:976-81. 2005
    ..S. aureus infection is an independent prognostic factor for mortality in patients who have abscess formation...
  68. doi request reprint Efficacy and safety of switching from boosted lopinavir to boosted atazanavir in patients with virological suppression receiving a LPV/r-containing HAART: the ATAZIP study
    Josep Mallolas
    Hospital Clinic Universitari IDIBAPS, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 51:29-36. 2009
    ..To evaluate the efficacy and safety of switching from boosted lopinavir (LPV/r) to boosted atazanavir (ATV/r) in virologically suppressed HIV-1-infected patients versus continuing LPV/r...
  69. ncbi request reprint Effect of thymoglobulin induction on HIV-infected renal transplant recipients: differences between HIV-positive and HIV-negative patients
    Joan C Trullas
    Infectious Diseases Service, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 23:1161-5. 2007
    ..Thymoglobulin was safe in our three HIV-infected renal transplant recipients. Until those data are confirmed in larger studies, close monitoring is recommended during the thymoglobulin-induced CD4(+) T cell lymphocytopenia period...
  70. ncbi request reprint [Antiretroviral therapy of HIV infection: duration and reasons for changing the first therapeutic regimen in 518 patients]
    Laura Gratacòs
    Servicio de Farmacia, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain
    Med Clin (Barc) 126:241-5. 2006
    ..The objectives of this study are to determine the median duration of different therapy combinations in naive patients between 1998-2000 and the main reasons for changing or stopping this first antiretroviral therapy (ARVT)...
  71. ncbi request reprint [Pharmacokinetics and interactions of raltegravir]
    Maria Mercè Placeres Alsina
    Servicio de Farmacia, Hospital Clinic, Barcelona, Espana
    Enferm Infecc Microbiol Clin 26:23-8. 2008
    ..Raltegravir is well tolerated and does not require dose adjustments in patients with severe renal impairment or mild-to-moderate liver impairment. There are no studies in patients with severe liver impairment...
  72. ncbi request reprint Depressive symptoms after initiation of interferon therapy in human immunodeficiency virus-infected patients with chronic hepatitis C
    Montserrat Laguno
    Infectious Diseases Unit, Hospital Clinic Universitari de Barcelona, Barcelona, Spain
    Antivir Ther 9:905-9. 2004
    ..In this study, we evaluated the incidence and management of depressive symptoms during IFN-alpha therapy in HIV-infected patients with CHC...
  73. ncbi request reprint Management of dyslipidaemia in HIV-infected patients receiving antiretroviral therapy
    Esteban Martinez
    Infectious Diseases, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Antivir Ther 9:649-63. 2004
    ..Development of new PIs with more favourable effects on the lipid profile should be of benefit...
  74. ncbi request reprint [Health problems and social vulnerability in immigrants admitted for an infectious disease: a case-control study]
    T Faura
    Escuela Universitaria de Enfermería de la Universidad de Barcelona, C Villaroel 170, 08036 Barcelona, Spain
    Rev Clin Esp 207:234-9. 2007
    ..Health resources needed by immigrants have increased steadily in the last few years. Studying health problems and social vulnerability in immigrants would help to improve the health care quality...
  75. ncbi request reprint Identifying high risk patients for Staphylococcus aureus infections: skin and soft tissue infections
    A Trilla
    Infection Control Program, University of Barcelona, Spain
    J Chemother 7:37-43. 1995
    ..aureus infective endocarditis (IE). The origin of IE in IVDUs is probably the skin. Data from a Collaborative Spanish Study of IVDU infectious complications (including more than 10,000 episodes) are discussed...
  76. doi request reprint Patients at risk of complications of Staphylococcus aureus bloodstream infection
    Ana del Rio
    Infectious Diseases Service, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 48:S246-53. 2009
    ..aureus infection. Nasal carriage is the most important source of S. aureus BSI. Better eradication and control strategies, including nasal decolonization and more-active antibiotics, are needed to combat S. aureus BSIs...
  77. doi request reprint Risk factors and management of Gram-positive bacteraemia
    Carlos Cervera
    Infectious Diseases Service, Hospital Clinic IDIBAPS, University of Barcelona School of Medicine, Barcelona, Spain
    Int J Antimicrob Agents 34:S26-30. 2009
    ..The recently described synergism of ampicillin plus ceftriaxone is a good therapeutic option for Enterococcus faecalis bacteraemia and endocarditis caused by high-level aminoglycoside-resistant strains...
  78. ncbi request reprint Short communication: reversible mitochondrial respiratory chain impairment during symptomatic hyperlactatemia associated with antiretroviral therapy
    Oscar Miro
    Mitochondrial Research Laboratory, Department of Internal Medicine, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain
    AIDS Res Hum Retroviruses 19:1027-32. 2003
    ..Mitochondrial abnormalities had almost disappeared later when the patient became asymptomatic. Our findings support the hypothesis that MRC dysfunction stands at the basis of HAART-related hyperlactatemia...
  79. ncbi request reprint Failure of cetirizine to prevent nevirapine-associated rash: a double-blind placebo-controlled trial for the GESIDA 26/01 Study
    Hernando Knobel
    Department of Internal Medicine, Infectious Diseases, Hospital del Mar, Barcelona, Spain
    J Acquir Immune Defic Syndr 37:1276-81. 2004
    ..The use of antihistamines remains unclear in this setting. A double-blind placebo-controlled study was performed to evaluate the efficacy of cetirizine in the prevention of nevirapine rash...
  80. ncbi request reprint Infective endocarditis and cardiac surgery in intravenous drug abusers and HIV-1 infected patients
    Jose M Miro
    Infectious Diseases Service, Institut Clinic Infeccions i Immunologia, Institut d Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic, University of Barcelona, Barcelona, Spain
    Cardiol Clin 21:167-84, v-vi. 2003
    ..In our experience, in the IE in HIV-infected IVDA group, the 1-year survival is 65% and the 5 and 10-year actuarial survival is 35%. For patients operated on for coronary artery disease, the 5-year survival is 100%...
  81. ncbi request reprint Cryopreserved mitral homograft in the tricuspid position for infective endocarditis: a valve that can be repaired in the long-term (13 years)
    Carlos A Mestres
    Department of Cardiovascular Surgery, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    J Heart Valve Dis 15:389-91. 2006
    ..One year later, transthoracic echocardiography showed no tricuspid regurgitation. The cryopreserved mitral homograft is a potentially repairable valve in the long-term...
  82. ncbi request reprint Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS
    Alex Soriano
    Service of Infectious Diseases and AIDS Unit, Hospital Clinic de Barcelona, Villarroel, 170, 08036, Barcelona, Spain
    Immunogenetics 57:644-54. 2005
    ..Further studies are required to confirm these findings...
  83. ncbi request reprint Preoperative risk stratification in infective endocarditis. Does the EuroSCORE model work? Preliminary results
    Carlos A Mestres
    Hospital Clinico, University of Barcelona, Barcelona, Spain
    Eur J Cardiothorac Surg 32:281-5. 2007
    ..Patients with infective endocarditis (IE) have a particularly high risk of mortality. The aim was to assess the performance of European System for Cardiac Operative Risk Evaluation (EuroSCORE) in IE...
  84. ncbi request reprint [Infections associated with prosthetic heart valves, vascular prostheses, and cardiac pacemakers and defibrillators]
    Benito Almirante
    Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Enferm Infecc Microbiol Clin 26:647-64. 2008
    ..Treatment is complex and requires prolonged antibiotic administration targeting the isolated organisms, and device removal to attain cure...
  85. doi request reprint [Characteristics of antiviral drugs, excluding antiretroviral agents: update 2009]
    Montse Tuset
    Servicio de Farmacia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic Universitari, Barcelona, Espana
    Enferm Infecc Microbiol Clin 28:199.e1-199.e33. 2010
    ....
  86. pmc Health care-associated native valve endocarditis: importance of non-nosocomial acquisition
    Natividad Benito
    Hospital de Santa Creu i Sant Pau, University Autonoma of Barcelona, and Hospital Clínic IDIBAPS, University of Barcelona, Barcelona, Spain
    Ann Intern Med 150:586-94. 2009
    ..The clinical profile and outcome of nosocomial and non-nosocomial health care-associated native valve endocarditis are not well defined...