R Maldonado

Summary

Affiliation: Universitat Pompeu Fabra
Country: Spain

Publications

  1. doi request reprint Endocannabinoid system and drug addiction: new insights from mutant mice approaches
    Rafael Maldonado
    Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, c Dr Aiguader, 88, 08003 Barcelona, Spain
    Curr Opin Neurobiol 23:480-6. 2013
  2. doi request reprint Comparison of the pharmacokinetics and clinical efficacy of new extended-release formulations of methylphenidate
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, C Dr Aiguader 88, 08003 Barcelona, Spain
    Expert Opin Drug Metab Toxicol 9:1001-14. 2013
  3. pmc Essential role of the N-terminal region of TFII-I in viability and behavior
    Jaume Lucena
    Genetics Unit, de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    BMC Med Genet 11:61. 2010
  4. pmc [The endogenous opioid system and drug addiction]
    R Maldonado
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Espagne
    Ann Pharm Fr 68:3-11. 2010
  5. ncbi request reprint [Endocannabinoid system: new perspectives in the global management of cardiometabolic risk factors]
    Rafael Maldonado
    Departamento de Ciencias Experimentales i de la Salud, Laboratorio de Neurofarmacologia, Universitat Pompeu Fabra, Barcelona, Espana
    Med Clin (Barc) 130:615-22. 2008
  6. ncbi request reprint Involvement of the endocannabinoid system in drug addiction
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
    Trends Neurosci 29:225-32. 2006
  7. ncbi request reprint Participation of the opioid system in cannabinoid-induced antinociception and emotional-like responses
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Departament de Ciènces Experimentals i de la Salut, Universitat Pompeu Fabra, C Doctor Aiguader, s n 08003, Barcelona, Spain
    Eur Neuropsychopharmacol 13:401-10. 2003
  8. ncbi request reprint Mu-opioid receptors are involved in the tolerance to nicotine antinociception
    Lola Galeote
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Neurochem 97:416-23. 2006
  9. doi request reprint Neurochemical basis of cannabis addiction
    R Maldonado
    Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomédica de Barcelona PRBB, Calle Dr Aiguader 88, Barcelona 08003, Spain
    Neuroscience 181:1-17. 2011
  10. ncbi request reprint Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence
    A Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Dr Aiguader, 80, 08003 Barcelona, Spain
    Neuropharmacology 43:857-67. 2002

Research Grants

  1. VULNERABILITY TO NICOTINE ADDICTION
    Rafael Maldonado; Fiscal Year: 2007

Collaborators

Detail Information

Publications93

  1. doi request reprint Endocannabinoid system and drug addiction: new insights from mutant mice approaches
    Rafael Maldonado
    Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, c Dr Aiguader, 88, 08003 Barcelona, Spain
    Curr Opin Neurobiol 23:480-6. 2013
    ..Novel genetic tools will allow determining if the modulation of CB2 cannabinoid receptor activity and 2-arachidonoylglycerol tone can also have an important therapeutic relevance for drug addiction. ..
  2. doi request reprint Comparison of the pharmacokinetics and clinical efficacy of new extended-release formulations of methylphenidate
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, C Dr Aiguader 88, 08003 Barcelona, Spain
    Expert Opin Drug Metab Toxicol 9:1001-14. 2013
    ..Extended-release (ER) formulations have been developed to help overcome the drawbacks associated with immediate-release (IR) preparations...
  3. pmc Essential role of the N-terminal region of TFII-I in viability and behavior
    Jaume Lucena
    Genetics Unit, de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    BMC Med Genet 11:61. 2010
    ..Unfortunately nothing is now about the behavioral characterization of heterozygous mice...
  4. pmc [The endogenous opioid system and drug addiction]
    R Maldonado
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Espagne
    Ann Pharm Fr 68:3-11. 2010
    ..This review is focused on the contribution of each component of the endogenous opioid system in the addictive properties of the different drugs of abuse...
  5. ncbi request reprint [Endocannabinoid system: new perspectives in the global management of cardiometabolic risk factors]
    Rafael Maldonado
    Departamento de Ciencias Experimentales i de la Salud, Laboratorio de Neurofarmacologia, Universitat Pompeu Fabra, Barcelona, Espana
    Med Clin (Barc) 130:615-22. 2008
  6. ncbi request reprint Involvement of the endocannabinoid system in drug addiction
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Carrer Dr Aiguader 80, 08003 Barcelona, Spain
    Trends Neurosci 29:225-32. 2006
    ..In agreement, clinical trials have suggested that the CB(1) cannabinoid antagonist rimonabant can cause smoking cessation. Thus, CB(1) cannabinoid antagonists could represent a new generation of compounds to treat drug addiction...
  7. ncbi request reprint Participation of the opioid system in cannabinoid-induced antinociception and emotional-like responses
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Departament de Ciènces Experimentals i de la Salut, Universitat Pompeu Fabra, C Doctor Aiguader, s n 08003, Barcelona, Spain
    Eur Neuropsychopharmacol 13:401-10. 2003
    ..On the other hand, cannabinoid administration can induce anxiolytic-like responses that are mediated at least in part by an endogenous opioid activity on micro- and delta-opioid receptors...
  8. ncbi request reprint Mu-opioid receptors are involved in the tolerance to nicotine antinociception
    Lola Galeote
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Neurochem 97:416-23. 2006
    ..These results indicate that mu-opioid receptors play an important role in the development of tolerance to nicotine antinociceptive effects...
  9. doi request reprint Neurochemical basis of cannabis addiction
    R Maldonado
    Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomédica de Barcelona PRBB, Calle Dr Aiguader 88, Barcelona 08003, Spain
    Neuroscience 181:1-17. 2011
    ....
  10. ncbi request reprint Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence
    A Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Dr Aiguader, 80, 08003 Barcelona, Spain
    Neuropharmacology 43:857-67. 2002
    ..These results demonstrate that some acute effects and motivational responses elicited by nicotine can be modulated by the endogenous cannabinoid system and support the existence of a physiological interaction between these two systems...
  11. ncbi request reprint Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene
    Fernando Berrendero
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Neurosci 25:1103-12. 2005
    ....
  12. ncbi request reprint Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors
    Sandy Ghozland
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:1146-54. 2002
    ..Thus, an opposing activity of mu- and kappa-opioid receptors in modulating reward pathways forms the basis for the dual euphoric-dysphoric activity of THC...
  13. pmc FAAH deficiency promotes energy storage and enhances the motivation for food
    C Tourino
    Laboratori de Neurofarmacologia, Departament de Ciències de Experimentals i de la Salut Universitat Pompeu Fabra, PRBB, Barcelona, Spain
    Int J Obes (Lond) 34:557-68. 2010
    ..To elucidate the role of FAAH in food intake and energy balance, we have evaluated different metabolic and behavioral responses related to feeding in FAAH-deficient (FAAH(-/-)) mice and their wild-type littermates...
  14. ncbi request reprint Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice
    O Valverde
    Laboratori de Neuropharmacologia, Facultat de Ciencies de la Salut i de la Vida, Universidat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 20:9284-9. 2000
    ..These results indicate that the endogenous enkephalinergic system is involved in the antinociceptive responses of Delta9-tetrahydrocannabinol and participates in the expression of cannabinoid abstinence...
  15. ncbi request reprint Attenuation of nicotine-induced rewarding effects in A2A knockout mice
    Anna Castañé
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Neuropharmacology 51:631-40. 2006
    ..Together, the present results identify A2A adenosine receptors as an important factor that contributes to the rewarding properties of nicotine...
  16. ncbi request reprint CB1 cannabinoid receptor modulates 3,4-methylenedioxymethamphetamine acute responses and reinforcement
    Clara Touriño
    Grup de Recerca de Neurobiologia del Comportament GRNC, Departament de Ciències de Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Biol Psychiatry 63:1030-8. 2008
    ..The endocannabinoid system is involved in the addictive processes induced by different drugs of abuse. However, the role of this system in the pharmacological effects of MDMA has not yet been clarified...
  17. ncbi request reprint Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice
    Fernando Berrendero
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:10935-40. 2002
    ..In summary, the present results show that mu-opioid receptors are involved in the rewarding responses induced by nicotine and participate in its antinociceptive responses and the expression of nicotine physical dependence...
  18. ncbi request reprint Involvement of the opioid system in the effects induced by nicotine on anxiety-like behaviour in mice
    Graciela N Balerio
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Psychopharmacology (Berl) 181:260-9. 2005
    ..Recent studies have revealed the participation of the endogenous opioid system in several behavioural responses induced by nicotine including antinociception, rewarding properties, and physical drug dependence...
  19. doi request reprint Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain
    A S Bura
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Eur J Pain 17:832-43. 2013
    ..The aim of this study was to use an operant self-administration model to reveal the potential interest of a new sigma 1 receptor antagonist, S1RA, in chronic pain that was developed in mice by a partial ligation of the sciatic nerve...
  20. pmc Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes
    S A Bura
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Br J Pharmacol 150:758-65. 2007
    ....
  21. ncbi request reprint Lack of CB1 cannabinoid receptor impairs cocaine self-administration
    Guadalupe Soria
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropsychopharmacology 30:1670-80. 2005
    ..This work clearly demonstrates that CB1 receptors play an important role in the consolidation of cocaine reinforcement, although are not required for its acute effects on mesolimbic dopaminergic transmission...
  22. ncbi request reprint 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice
    Jose Manuel Trigo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Biol Psychiatry 62:669-79. 2007
    ..The aim of the present study was to determine the contribution of the serotonin transporter (SERT) in MDMA self-administration behavior by using knockout (KO) mice deficient in SERT...
  23. pmc Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene
    R Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciences de la Salut I de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Br J Pharmacol 132:1485-92. 2001
    ..The decreased response of delta-agonists in mutant mice suggests that some cooperativity may exist between mu- and delta-opioid receptors in these vas deferens preparations...
  24. pmc Behavioural and biochemical responses to morphine associated with its motivational properties are altered in adenosine A(2A) receptor knockout mice
    A Castañé
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelone Biomedical Research Park, Barcelona, Spain
    Br J Pharmacol 155:757-66. 2008
    ..The aim of the present study was to investigate the specific role of A(2A) adenosine receptors (A(2A)Rs) in the behavioural and neurochemical responses to morphine associated with its motivational properties...
  25. pmc Behavioural and biochemical evidence for interactions between Delta 9-tetrahydrocannabinol and nicotine
    Emmanuel Valjent
    Laboratori de Neurofarmacologia, Facultat de Ciences de la Salut I de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Br J Pharmacol 135:564-78. 2002
    ..The facilitation of THC-induced acute pharmacological and biochemical responses, tolerance and physical dependence by nicotine could play an important role in the development of addictive processes...
  26. doi request reprint Advances in the field of cannabinoid--opioid cross-talk
    Patricia Robledo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Spain
    Addict Biol 13:213-24. 2008
    ..The present review is focused on the latest developments in the cannabinoid-opioid cross-modulation of their behavioural effects and the possible neurobiological substrates involved...
  27. ncbi request reprint Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice
    Anna Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Eur J Neurosci 17:155-9. 2003
    ..Interestingly, the somatic manifestations of THC withdrawal were also significantly attenuated in mutant mice, suggesting that a cooperative action of MOR and DOR is required for the entire expression of THC dependence...
  28. pmc Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior
    Ainhoa Plaza-Zabala
    Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Pompeu Fabra University, 08003 Barcelona, Spain
    J Neurosci 30:2300-10. 2010
    ..Indeed, Hcrt-1 reinstates nicotine-seeking through a mechanism independent of CRF activation whereas CRF mediates the reinstatement induced by stress...
  29. ncbi request reprint Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice
    D M Hutcheson
    , Facultat de Ciences de la Salut I de la Vida, Universitat Pompeu Fabra, Doctor Aiguader, 80, E-08003, Barcelona, Spain
    Eur J Neurosci 13:153-61. 2001
    ..In conclusion, mu-opioid receptors, which are not involved in deltorphin II antinociception, appear to mediate the effects of chronic deltorphin II on rewarding responses, physical dependence and adaptive changes to PKC...
  30. doi request reprint Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice
    S Andreea Bura
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB Barcelona, Spain
    Eur Neuropsychopharmacol 20:369-78. 2010
    ..Our results suggest a modulatory role of the endocannabinoid system on the effects induced by nicotine on metabolic parameters and anxiety-like responses...
  31. ncbi request reprint A reliable model of intravenous MDMA self-administration in naïve mice
    Jose Manuel Trigo
    Universitat Pompeu Fabra, Calle Dr Aiguader, 80, 08003, Barcelona, Spain
    Psychopharmacology (Berl) 184:212-20. 2006
    ..In this sense, the establishment of a reliable model of MDMA self-administration in mice could represent an important approach to study the neuronal substrates associated with MDMA reward by using genetically modified mice...
  32. ncbi request reprint Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol
    Fernando Berrendero
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 163:111-7. 2002
    ..Recent studies have shown that several pharmacological actions induced by cannabinoids, including antinociception and reward, involve the participation of the endogenous opioid system...
  33. ncbi request reprint Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice
    Fernando Berrendero
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 17:315-24. 2003
    ..These results suggest that both receptors participate in the control of emotional behaviour and seem to play an opposite role in the expression of opioid physical dependence...
  34. doi request reprint Involvement of kappa/dynorphin system in the development of tolerance to nicotine-induced antinociception
    Lola Galeote
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, Barcelona, Spain
    J Neurochem 105:1358-68. 2008
    ..In summary, these data indicate that KOP-r is directly involved in the development of tolerance to nicotine antinociception by a mechanism independent from dynorphin and NMDA receptors...
  35. ncbi request reprint The lack of A2A adenosine receptors diminishes the reinforcing efficacy of cocaine
    Guadalupe Soria
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropsychopharmacology 31:978-87. 2006
    ..Our study demonstrates that A2A adenosine receptors play an important role in cocaine addictive properties, and these receptors seem to be required to develop the addictive effects of this drug...
  36. ncbi request reprint Endogenous cannabinoid and opioid systems and their role in nicotine addiction
    Rafael Maldonado
    Laboratori de Neurofarmacologia Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, c Doctor Aiguader 88, 08003 Barcelona, Spain
    Curr Drug Targets 11:440-9. 2010
    ..According to preclinical studies, clinical trials suggest that the manipulation of these systems with cannabinoid or opioid antagonists could be a potential therapeutical strategy for treating nicotine addiction...
  37. ncbi request reprint Effects of nandrolone on acute morphine responses, tolerance and dependence in mice
    Evelyne Celerier
    Laboratori de Neurofarmacologia, Facultat de Ciences de la Salut I de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Pharmacol 465:69-81. 2003
    ..These results indicate that anabolic-androgenic steroid consumption may induce adaptations in neurobiological systems implicated in the development of morphine dependence...
  38. doi request reprint Differential changes in mesolimbic dopamine following contingent and non-contingent MDMA self-administration in mice
    Maria Juliana Orejarena
    Laboratori de Neurofarmacologia, Universitat Pompeu Fabra, PRBB, Calle Dr Aiguader, 88, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 205:457-66. 2009
    ..There is evidence demonstrating changes in dopamine (DA) transmission in the nucleus accumbens (NAc) related to contingent versus non-contingent drug administration...
  39. ncbi request reprint Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice
    Olga Valverde
    Laboratori de Neurofarmacologia, Facultat de Ciences de la Salut I de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropsychopharmacology 29:1122-33. 2004
    ..Our results emphasize the selective role played by neuronal CREB in emotional-like behavior and the somatic expression morphine withdrawal, without participating in the rewarding properties induced by morphine and cocaine...
  40. doi request reprint New operant model of nicotine-seeking behaviour in mice
    Elena Martin-Garcia
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Int J Neuropsychopharmacol 12:343-56. 2009
    ..The validation of this new model of nicotine-seeking behaviour and reinstatement in mice provides an important tool to help clarify the genetic and neurochemical bases of nicotine addiction...
  41. pmc Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization
    L Romero
    ESTEVE, Drug Discovery and Preclinical Development, Barcelona, Spain
    Br J Pharmacol 166:2289-306. 2012
    ....
  42. ncbi request reprint Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration
    J A Garcia-Sevilla
    Laboratori de Neurofarmacologia, Unitat Associada de l Instituto de Neurobiología Ramón y Cajal CSIC, Facultat de Ciencies, Universitat de les Illes Balears, E 07122 Palma de Mallorca, Spain
    Neuropharmacology 46:519-30. 2004
    ..The induction of heterologous receptor adaptations in mu-KO mice may explain this paradoxical effect of morphine...
  43. doi request reprint A reliable method to study cue-, priming-, and stress-induced reinstatement of cocaine self-administration in mice
    Guadalupe Soria
    Laboratorio de Neurofarmacologia, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, C Dr Aiguader 88, Barcelona, Spain
    Psychopharmacology (Berl) 199:593-603. 2008
    ..The design of an appropriate reinstatement model in mice is required in order to use genetically modified animals with the aim of clarifying the mechanisms involved in cocaine relapse...
  44. ncbi request reprint Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain
    Andres Ozaita
    Laboratori de Neurofarmacologia Facultat de Ciencies de la Salut i de la Vida Universitat Pompeu Fabra, Barcelona, Spain
    J Neurochem 102:1105-14. 2007
    ..In addition, THC increased the phosphorylation of glycogen synthase kinase 3 beta. Therefore, activation of the PI3K/Akt/GSK-3 signaling pathway may be related to the in vivo neuroprotective properties attributed to cannabinoids...
  45. pmc Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin
    Jose M Trigo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropharmacology 56:1147-53. 2009
    ..The dissociation between nicotine rewarding properties and physical dependence suggests a differential implication of beta-endorphin in these addictive related responses...
  46. doi request reprint MDMA reinstates cocaine-seeking behaviour in mice
    Jose Manuel Trigo
    Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salud, Universitat Pompeu Fabra, Calle Dr Aiguader 88, 08003 Barcelona, Spain
    Eur Neuropsychopharmacol 19:391-7. 2009
    ..MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse...
  47. ncbi request reprint Behavioural and neurochemical effects of combined MDMA and THC administration in mice
    Patricia Robledo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Psychopharmacology (Berl) 195:255-64. 2007
    ..Cannabis is the most widely consumed drug associated with 3,4-methylenedioxymethamphetamine (MDMA) use...
  48. ncbi request reprint The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors
    Patricia Robledo
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 20:853-8. 2004
    ..These differences could be due to distinct mechanisms controlling dopamine release in the nucleus accumbens and suggest that the effects of MDMA on dopaminergic neurons are independent of micro -opioid receptors...
  49. ncbi request reprint Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice
    Victoria Mendizabal
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropsychopharmacology 31:1957-66. 2006
    ..These results indicate that the activation of the kappa/dynorphin opioid system after WIN 55,212-2 administration could counteract cannabinoid rewarding effects...
  50. ncbi request reprint The role of the cannabinoid system in nicotine addiction
    Anna Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Dr Aiguader, 80 08003 Barcelona, Spain
    Pharmacol Biochem Behav 81:381-6. 2005
    ....
  51. ncbi request reprint Morphine withdrawal is modified in pituitary adenylate cyclase-activating polypeptide type I-receptor-deficient mice
    Miquel Martin
    Laboratory of Neuropharmacology, Faculty of Medicine, University Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Brain Res Mol Brain Res 110:109-18. 2003
    ..These data therefore suggested that most likely disruption of PAC1-mediated signalling in afferents towards the locus coeruleus but not within the intrinsic locus coeruleus system led to the enhancement of somatic withdrawal signs...
  52. ncbi request reprint Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC
    Guadalupe Soria
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 20:2203-13. 2004
    ..Therefore, this study shows, for the first time, a specific involvement of A2A receptors in the addictive-related properties of cannabinoids...
  53. ncbi request reprint Study of cannabinoid dependence in animals
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciences de la Salut I de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Pharmacol Ther 95:153-64. 2002
    ..The mesolimbic dopaminergic system seems to be the substrate for the rewarding properties of cannabinoids...
  54. ncbi request reprint Influence of the anabolic-androgenic steroid nandrolone on cannabinoid dependence
    Evelyne Celerier
    Laboratori of Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Neuropharmacology 50:788-806. 2006
    ..Taken together, our results suggest that chronic nandrolone treatment alters behavioural responses related to cannabinoid addictive properties...
  55. ncbi request reprint Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
    Miquel Martin
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 17:701-8. 2003
    ..Phenotypes of mutant mice were subtle, suggesting a low endogenous opioid tone in the regulation of physiological pain...
  56. ncbi request reprint Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice
    M Martin
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 12:4038-46. 2000
    ..p.) produced rewarding responses in both wild-type and knockout mice. These results demonstrate that CB1 receptors are essential for adaptive responses produced by chronic morphine but not by chronic cocaine treatment...
  57. doi request reprint Prodynorphin gene disruption increases the sensitivity to nicotine self-administration in mice
    Lola Galeote
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Int J Neuropsychopharmacol 12:615-25. 2009
    ..These findings reveal a specific role of endogenous peptides derived from prodynorphin in nicotine self-administration, probably through the modulation of its aversive effects...
  58. doi request reprint MDMA modifies active avoidance learning and recall in mice
    Jose Manuel Trigo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Psychopharmacology (Berl) 197:391-400. 2008
    ..However, the extent of the impairments observed in learning or memory tasks remains unclear...
  59. ncbi request reprint Cannabinoid receptor and WIN 55 212-2-stimulated [35S]-GTPgammaS binding in the brain of mu-, delta- and kappa-opioid receptor knockout mice
    Fernando Berrendero
    Laboratori de Neurofarmacologia, Facultat de Ciències de la Saluti i de la Vida, Univeristat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 18:2197-202. 2003
    ....
  60. doi request reprint Central and peripheral consequences of the chronic blockade of CB1 cannabinoid receptor with rimonabant or taranabant
    Elena Martin-Garcia
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, Barcelona, Spain
    J Neurochem 112:1338-13351. 2010
    ....
  61. ncbi request reprint MDMA attenuates THC withdrawal syndrome in mice
    Clara Touriño
    Grup de Recerca de Neurobiologia del Comportament, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, C Dr Aiguader 80, 08003, Barcelona, Spain
    Psychopharmacology (Berl) 193:75-84. 2007
    ..However, the interaction between MDMA and cannabis in addictive processes such as physical dependence has not been elucidated yet...
  62. ncbi request reprint Cannabinoid addiction: behavioral models and neural correlates
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:3326-31. 2002
    ..Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000; Schlicker and Kathmann, 2001)...
  63. ncbi request reprint Neuropathic pain is enhanced in delta-opioid receptor knockout mice
    Xavier Nadal
    Laboratori de Neurofarmacologia Facultat de Ciencies de la Salut i de la Vida Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 23:830-4. 2006
    ..These results reveal the involvement of DOR in the control of neuropathic pain and suggest a new potential therapeutic use of DOR agonists...
  64. doi request reprint Active and passive MDMA ('ecstasy') intake induces differential transcriptional changes in the mouse brain
    N Fernàndez-Castillo
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Genes Brain Behav 11:38-51. 2012
    ....
  65. doi request reprint Lack of CB1 receptor activity impairs serotonergic negative feedback
    Ester Aso
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, Barcelona, Spain
    J Neurochem 109:935-44. 2009
    ....
  66. pmc GPR3 receptor, a novel actor in the emotional-like responses
    Olga Valverde
    Departament de Ciencies Experimentals i de la Salut, Grup de Recerca de Neurobiologia del Comportament, Universitat Pompeu Fabra, Barcelona, Spain
    PLoS ONE 4:e4704. 2009
    ..GPR3 qualifies as a new player in the modulation of behavioral responses to stress and constitutes a novel promising pharmacological target for treatment of emotional disorders...
  67. doi request reprint The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevention of the nociceptive response by on-site delivery of enkephalins
    David Cabañero
    Anesthesiology Research Unit, Instituto Municipal de Investigaciones Médicas Universitat Autònoma de Barcelona, Barcelona, Spain
    Pain 141:88-96. 2009
    ..The study suggests that down-regulation of DOR contributes to remifentanil and surgery-induced nociception, and that postoperative pain is completely reversed by increasing enkephalin levels in the spinal cord and the periphery...
  68. ncbi request reprint Involvement of CB1 cannabinoid receptors in emotional behaviour
    Miquel Martin
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 159:379-87. 2002
    ..Recently, knockout mice deficient in the CB1 cannabinoid receptor have been generated, and these animals result in an excellent tool to evaluate the neurophysiology of the endogenous cannabinoid system...
  69. ncbi request reprint BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice
    Ester Aso
    Grup de Recerca de Neurobiologia del Comportament GRNC, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, Barcelona, Spain
    J Neurochem 105:565-72. 2008
    ....
  70. doi request reprint Delta-9-tetrahydrocannabinol enhances food reinforcement in a mouse operant conflict test
    Maria Flavia Barbano
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, C Dr Aiguader 88, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 205:475-87. 2009
    ..Cannabinoid compounds are known to regulate feeding behavior by modulating the hedonic and/or the incentive properties of food...
  71. ncbi request reprint Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice
    Graciela N Balerio
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Psychopharmacology (Berl) 184:504-13. 2006
    ..Acute behavioural effects and motivational responses induced by nicotine can be modulated by the endocannabinoid system supporting the existence of a physiological interaction between these two systems...
  72. ncbi request reprint Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a delta-opioid tone inhibits FADD
    M Julia Garcia-Fuster
    Laboratori de Neurofarmacologia, Institut Universitari d Investigacio en Ciencies de la Salut IUNICS, Universitat de les Illes Balears, E 07122 Palma de Mallorca, Spain
    Eur Neuropsychopharmacol 17:366-74. 2007
    ..These data are in line with the acute opposite modulation of Fas and FADD induced by mu- and delta-opiate agonists, and strongly support the notion of an anti-apoptotic delta-opioid tone that restrains Fas signaling...
  73. ncbi request reprint Development and expression of neuropathic pain in CB1 knockout mice
    Anna Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropharmacology 50:111-22. 2006
    ..Taken together, our results indicate that CB1 cannabinoid receptors are not critically implicated in the development of neuropathic pain nor in the anti-allodynic and anti-hyperalgesic effects of gabapentin in this model...
  74. ncbi request reprint Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase
    Evelyne Celerier
    Anesthesiology Research Unit, Instituto Municipal de Investigaciones Médicas, Barcelona, Spain
    Anesthesiology 104:546-55. 2006
    ..The role of the inducible nitric oxide synthase on surgical pain and opioid-induced pronociception also was investigated...
  75. ncbi request reprint Neuropathic pain: some clues for future drug treatments
    J E Banos
    Department of Experimental and Health Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
    Mini Rev Med Chem 3:719-27. 2003
    ..In this review, we will consider the pathophysiology of neuropathic pain to understand the basis of pharmacological treatments that are currently being investigated. Some examples of these drugs will also be considered...
  76. ncbi request reprint Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry
    I Sahún
    Genes and Disease Program, Center for Genomic Regulation CRG, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    Amino Acids 33:677-88. 2007
    ....
  77. pmc Role of different brain structures in the behavioural expression of WIN 55,212-2 withdrawal in mice
    Anna Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Dr Aiguader, 80, 08003 Barcelona, Spain
    Br J Pharmacol 142:1309-17. 2004
    ..The cerebellum and to a lesser extent the hippocampus and the amygdala participate in the behavioural expression of cannabinoid withdrawal...
  78. doi request reprint The endogenous opioid system: a common substrate in drug addiction
    Jose Manuel Trigo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, Barcelona, Spain
    Drug Alcohol Depend 108:183-94. 2010
    ..In this review, we will describe the adaptive changes produced by different drugs of abuse on the EOS, and the current knowledge about the contribution of each component of this neurobiological system to their addictive properties...
  79. doi request reprint Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling
    Emma Puighermanal
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Nat Neurosci 12:1152-8. 2009
    ....
  80. ncbi request reprint Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene
    Evelyne Celerier
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, c Doctor Aiguader 80, E 08003 Barcelona, Spain
    Neuropharmacology 46:264-72. 2004
    ..This study identifies the PKCgamma as a key element that links opioid receptor activation with the recruitment of opposite systems to opioid analgesia involved in a physiological compensatory pain enhancement...
  81. doi request reprint Effects of the endogenous PPAR-alpha agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice
    Ainhoa Plaza-Zabala
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003Barcelona, Spain
    Synapse 64:379-89. 2010
    ..These results suggest that OEA administration can modulate the cognitive deficits induced by MDMA in a DAT-independent manner...
  82. ncbi request reprint The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10
    Patrick Laurent
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire I R I B H M, Universite Libre de Bruxelles, Campus Erasme, Route de Lennik 808, Brussels, Belgium
    Nat Neurosci 8:1735-41. 2005
    ..Altogether, our data identify the PrRP-GPR10 system as a new and potent negative modulator of the opioid system...
  83. ncbi request reprint CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors
    Susana Mato
    Department of Physiology and Pharmacology, University of Cantabria, Cantabria, Spain
    J Neurochem 103:2111-20. 2007
    ....
  84. ncbi request reprint Delta9-tetrahydrocannabinol decreases somatic and motivational manifestations of nicotine withdrawal in mice
    Graciela N Balerio
    Laboratori de Neurofarmacologia Facultat de Ciències de la Salut i de la Vida Universitat Pompeu Fabra C Dr Aiguader, 80 08003 Barcelona, Spain
    Eur J Neurosci 20:2737-48. 2004
    ..In addition, Delta9-THC also ameliorated the aversive motivational consequences of nicotine withdrawal...
  85. ncbi request reprint Age-related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, I 00133 Rome, Italy
    Eur J Neurosci 15:1178-86. 2002
    ....
  86. ncbi request reprint Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice
    Leyre Urigüen
    Servicio de Psiquiatría y Unidad de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain
    Eur J Neurosci 22:2106-10. 2005
    ....
  87. ncbi request reprint Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain
    Olga Pol
    Department of Anesthesiology, Hospital del Mar, IMIM, Universitat Autonoma de Barcelona, Spain
    Neuropharmacology 50:123-32. 2006
    ..These data revealed specific changes induced by neuropathic pain in MOR expression and c-fos levels in the DRG and/or spinal cord that were not modified by the genetic disruption of CB1 cannabinoid receptors...
  88. ncbi request reprint Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory
    Cristina Mazzucchelli
    San Raffaele Research Institute and University, Via Olgettina 58, 20132 Milano, Italy
    Neuron 34:807-20. 2002
    ..Our results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction...
  89. ncbi request reprint Study of the behavioural responses related to the potential addictive properties of MDMA in mice
    Patricia Robledo
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Naunyn Schmiedebergs Arch Pharmacol 369:338-49. 2004
    ..These results reveal the rewarding properties of MDMA in mice, and suggest that chronic MDMA administration does not induce classical manifestations of physical dependence in mice...
  90. ncbi request reprint Spontaneous network activity of cerebellar granule neurons: impairment by in vivo chronic cannabinoid administration
    Sandy Ghozland
    Laboratory of Neuropharmacology, University Pompeu Fabra, Barcelona 08003, Spain
    Eur J Neurosci 16:641-51. 2002
    ..These data provide physiological evidence of the involvement of cerebellar circuits in the adaptive changes occurring during chronic THC exposure and withdrawal...
  91. ncbi request reprint Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
    Mara Dierssen
    Genes and Disease Program, Genomic Regulation Center CRG UPF, Barcelona, Biomedical Research Park, E 08003 Barcelona, Catalonia, Spain
    Neurobiol Dis 24:403-18. 2006
    ..Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety...
  92. pmc Domain interactions on the ntr signal transduction pathway: two-hybrid analysis of mutant and truncated derivatives of histidine kinase NtrB
    Isabel Martinez-Argudo
    Division de Genetica, Universidad de Alicante, Apartado 99, E 03080 Alicante, Spain
    J Bacteriol 184:200-6. 2002
    ....
  93. doi request reprint Place preference test in rodents
    Sylvain Roux
    Porsolt and Partners Pharmacology, Boulogne Billancourt, France
    Curr Protoc Neurosci . 2003
    ..Due to the recent availability of multiple lines of genetically modified mice, this unit includes procedures for testing place preference in both rats and mice...

Research Grants5

  1. VULNERABILITY TO NICOTINE ADDICTION
    Rafael Maldonado; Fiscal Year: 2007
    ..abstract_text> ..