Hafid Laayouni

Summary

Affiliation: Universitat Pompeu Fabra
Country: Spain

Publications

  1. pmc The annotation and the usage of scientific databases could be improved with public issue tracker software
    Giovanni Marco Dall'olio
    Institute of Evolutionary Biology, UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Database (Oxford) 2010:baq035. 2010
  2. pmc Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
  3. doi request reprint A genome-wide survey does not show the genetic distinctiveness of Basques
    Hafid Laayouni
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Genet 127:455-8. 2010
  4. pmc A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e24996. 2011
  5. pmc Distribution of events of positive selection and population differentiation in a metabolic pathway: the case of asparagine N-glycosylation
    Giovanni Marco Dall'olio
    IBE, Institut de Biologia Evolutiva UPF CSIC, Parc de Recerca Biomédica de Barcelona PRBB, Dr, Aiguader, 88, 08003, Barcelona, Catalonia, Spain
    BMC Evol Biol 12:98. 2012
  6. pmc Genetic adaptation of the antibacterial human innate immunity network
    Ferran Casals
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    BMC Evol Biol 11:202. 2011
  7. pmc The annotation of the asparagine N-linked glycosylation pathway in the Reactome database
    Giovanni Marco Dall'olio
    Institute of Evolutionary Biology, Carrer Doctor Aiguader 88, Barcelona, Catalonia, Spain
    Glycobiology 21:1395-400. 2011
  8. pmc A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations
    Martin Sikora
    Institut de Biologia Evolutiva UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Eur J Hum Genet 19:84-8. 2011
  9. ncbi request reprint A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Mol Genet 18:3136-44. 2009
  10. pmc 1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans
    Marc Pybus
    Program for Population Genetics, Institute of Evolutionary Biology CSIC Universitat Pompeu Fabra, 08003 Barcelona, Spain, Population Genomics Node, National Institute for Bioinformatics INB, Universitat Pompeu Fabra, 08003 Barcelona, Spain, Institute of Molecular Biology and Biotechnology FORTH, Heraklion, Crete GR 700 13, Greece and Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Nucleic Acids Res 42:D903-9. 2014

Detail Information

Publications19

  1. pmc The annotation and the usage of scientific databases could be improved with public issue tracker software
    Giovanni Marco Dall'olio
    Institute of Evolutionary Biology, UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Database (Oxford) 2010:baq035. 2010
    ..Also, the effort made by the user that reports the error often goes unacknowledged, putting him in a discouraging position...
  2. pmc Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
    ..Within each gene region and population we use r2 between all possible single nucleotide polymorphism (SNP) pairs as a measure of linkage disequilibrium and focus on the proportion of SNP pairs with r2 greater than 0.8...
  3. doi request reprint A genome-wide survey does not show the genetic distinctiveness of Basques
    Hafid Laayouni
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Genet 127:455-8. 2010
    ..Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised...
  4. pmc A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e24996. 2011
    ..To our knowledge, this is the first large-scale genetic study on placental malaria infection to date, opening the door for follow-up studies trying to elucidate the genetic basis of this neglected form of malaria...
  5. pmc Distribution of events of positive selection and population differentiation in a metabolic pathway: the case of asparagine N-glycosylation
    Giovanni Marco Dall'olio
    IBE, Institut de Biologia Evolutiva UPF CSIC, Parc de Recerca Biomédica de Barcelona PRBB, Dr, Aiguader, 88, 08003, Barcelona, Catalonia, Spain
    BMC Evol Biol 12:98. 2012
    ....
  6. pmc Genetic adaptation of the antibacterial human innate immunity network
    Ferran Casals
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    BMC Evol Biol 11:202. 2011
    ..The evolution of the immune system has therefore been influenced by these pressures. Genomic scans have revealed that immune system is one of the functions enriched with genes under adaptive selection...
  7. pmc The annotation of the asparagine N-linked glycosylation pathway in the Reactome database
    Giovanni Marco Dall'olio
    Institute of Evolutionary Biology, Carrer Doctor Aiguader 88, Barcelona, Catalonia, Spain
    Glycobiology 21:1395-400. 2011
    ..Finally, we discuss the status of the annotation of this pathway and point out which steps are worth further investigation or need better experimental validation...
  8. pmc A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations
    Martin Sikora
    Institut de Biologia Evolutiva UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Eur J Hum Genet 19:84-8. 2011
    ..Finally, we find a strong differentiation of the southeastern Bantu population from Mozambique, which suggests an assimilation of a pre-Bantu substrate by Bantu speakers in the region...
  9. ncbi request reprint A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Mol Genet 18:3136-44. 2009
    ..These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection...
  10. pmc 1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans
    Marc Pybus
    Program for Population Genetics, Institute of Evolutionary Biology CSIC Universitat Pompeu Fabra, 08003 Barcelona, Spain, Population Genomics Node, National Institute for Bioinformatics INB, Universitat Pompeu Fabra, 08003 Barcelona, Spain, Institute of Molecular Biology and Biotechnology FORTH, Heraklion, Crete GR 700 13, Greece and Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany
    Nucleic Acids Res 42:D903-9. 2014
    ..We believe that this expandable resource will facilitate the interpretation of signals of selection on different temporal, geographical and genomic scales...
  11. pmc Similarity in recombination rate estimates highly correlates with genetic differentiation in humans
    Hafid Laayouni
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e17913. 2011
    ..This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans...
  12. doi request reprint Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes
    Martino Colombo
    Institute of Evolutionary Biology CSIC Pompeu Fabra University, CEXS UPF PRBB, Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain
    Evolution 68:605-13. 2014
    ..These results demonstrate the importance of considering the dynamical functioning of gene networks when assessing the action of selection on system-level properties. ..
  13. doi request reprint Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations
    Pierre Luisi
    Institute of Evolutionary Biology CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 29:1379-92. 2012
    ..This observation indicates that the impact of positive selection on genes involved in the insulin/TOR pathway is affected by the pathway structure...
  14. pmc A system-level, molecular evolutionary analysis of mammalian phototransduction
    Brandon M Invergo
    Institute of Evolutionary Biology CSIC Universitat Pompeu Fabra, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    BMC Evol Biol 13:52. 2013
    ..We have performed a molecular evolutionary analysis of proteins involved in mammalian phototransduction in order to unravel how the action of natural selection has been distributed throughout the system to evolve such traits...
  15. pmc Human genome variation and the concept of genotype networks
    Giovanni Marco Dall'olio
    Institut de Biologia Evolutiva, CSIC Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    PLoS ONE 9:e99424. 2014
    ....
  16. doi request reprint Molecular evolution and network-level analysis of the N-glycosylation metabolic pathway across primates
    Ludovica Montanucci
    Department of Experimental and Health Sciences, Institute of Evolutionary Biology, Universitat Pompeu Fabra Consejo Superior de Investigaciones Cientificas, Barcelona, Catalonia, Spain
    Mol Biol Evol 28:813-23. 2011
    ..This result confirms that network topology does shape the evolution of the genes and that the connectivity within metabolic pathways and networks plays a major role in constraining evolutionary rates...
  17. doi request reprint A natural history of FUT2 polymorphism in humans
    Anna Ferrer-Admetlla
    Institut de Biologia Evolutiva CSIC UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 26:1993-2003. 2009
    ..Thus, a convergent phenotype composition has been achieved through different mutations with different evolutionary histories...
  18. pmc Great ape genetic diversity and population history
    Javier Prado-Martinez
    Institut de Biologia Evolutiva, CSIC Universitat Pompeu Fabra, PRBB, Doctor Aiguader 88, Barcelona, Catalonia 08003, Spain
    Nature 499:471-5. 2013
    ..This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations. ..
  19. ncbi request reprint The evolutionary history of Drosophila buzzatii. XXXV. Inversion polymorphism and nucleotide variability in different regions of the second chromosome
    Hafid Laayouni
    Grup de Biologia Evolutiva, Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Barcelona, Spain
    Mol Biol Evol 20:931-44. 2003
    ....