Research Topics
Genomes and GenesSpecies | Hafid LaayouniSummaryAffiliation: Universitat Pompeu Fabra Country: Spain Publications
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Detail Information
Publications
Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LDElena Bosch
Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
BMC Genomics 10:338. 2009..Within each gene region and population we use r2 between all possible single nucleotide polymorphism (SNP) pairs as a measure of linkage disequilibrium and focus on the proportion of SNP pairs with r2 greater than 0.8...
A genome-wide survey does not show the genetic distinctiveness of BasquesHafid Laayouni
IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
Hum Genet 127:455-8. 2010..Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised...- A targeted association study of immunity genes and networks suggests novel associations with placental malaria infectionMartin Sikora
Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
PLoS ONE 6:e24996. 2011..To our knowledge, this is the first large-scale genetic study on placental malaria infection to date, opening the door for follow-up studies trying to elucidate the genetic basis of this neglected form of malaria... - Distribution of events of positive selection and population differentiation in a metabolic pathway: the case of asparagine N-glycosylationGiovanni Marco Dall'olio
IBE, Institut de Biologia Evolutiva UPF CSIC, Parc de Recerca Biomédica de Barcelona PRBB, Dr, Aiguader, 88, 08003, Barcelona, Catalonia, Spain
BMC Evol Biol 12:98. 2012.... - Genetic adaptation of the antibacterial human innate immunity networkFerran Casals
Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
BMC Evol Biol 11:202. 2011..The evolution of the immune system has therefore been influenced by these pressures. Genomic scans have revealed that immune system is one of the functions enriched with genes under adaptive selection... - The annotation of the asparagine N-linked glycosylation pathway in the Reactome databaseGiovanni Marco Dall'olio
Institute of Evolutionary Biology, Carrer Doctor Aiguader 88, Barcelona, Catalonia, Spain
Glycobiology 21:1395-400. 2011..Finally, we discuss the status of the annotation of this pathway and point out which steps are worth further investigation or need better experimental validation... - A variant in the gene FUT9 is associated with susceptibility to placental malaria infectionMartin Sikora
Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
Hum Mol Genet 18:3136-44. 2009..These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection... - A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populationsMartin Sikora
Institut de Biologia Evolutiva UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
Eur J Hum Genet 19:84-8. 2011..Finally, we find a strong differentiation of the southeastern Bantu population from Mozambique, which suggests an assimilation of a pre-Bantu substrate by Bantu speakers in the region... - Similarity in recombination rate estimates highly correlates with genetic differentiation in humansHafid Laayouni
IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
PLoS ONE 6:e17913. 2011..This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans... - Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populationsPierre Luisi
Institute of Evolutionary Biology CEXS UPF PRBB, Barcelona, Catalonia, Spain
Mol Biol Evol 29:1379-92. 2012..This observation indicates that the impact of positive selection on genes involved in the insulin/TOR pathway is affected by the pathway structure... - A natural history of FUT2 polymorphism in humansAnna Ferrer-Admetlla
Institut de Biologia Evolutiva CSIC UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
Mol Biol Evol 26:1993-2003. 2009..Thus, a convergent phenotype composition has been achieved through different mutations with different evolutionary histories... - The annotation and the usage of scientific databases could be improved with public issue tracker softwareGiovanni Marco Dall'olio
Institute of Evolutionary Biology, UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
Database (Oxford) 2010:baq035. 2010..Also, the effort made by the user that reports the error often goes unacknowledged, putting him in a discouraging position... - Molecular evolution and network-level analysis of the N-glycosylation metabolic pathway across primatesLudovica Montanucci
Department of Experimental and Health Sciences, Institute of Evolutionary Biology, Universitat Pompeu Fabra Consejo Superior de Investigaciones Cientificas, Barcelona, Catalonia, Spain
Mol Biol Evol 28:813-23. 2011..This result confirms that network topology does shape the evolution of the genes and that the connectivity within metabolic pathways and networks plays a major role in constraining evolutionary rates... 
The evolutionary history of Drosophila buzzatii. XXXV. Inversion polymorphism and nucleotide variability in different regions of the second chromosomeHafid Laayouni
Grup de Biologia Evolutiva, Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Barcelona, Spain
Mol Biol Evol 20:931-44. 2003....