E Herrero

Summary

Affiliation: Universitat de Lleida
Country: Spain

Publications

  1. ncbi request reprint Glutaredoxins and oxidative stress defense in yeast
    Enrique Herrero
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, 25198 Lleida, Spain
    Methods Enzymol 348:136-46. 2002
  2. pmc Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe-2S] clusters
    Sibali Bandyopadhyay
    Department of Chemistry, Centre for Metalloenzyme Studies, University of Georgia, Athens, GA, USA
    EMBO J 27:1122-33. 2008
  3. pmc Evolution based on domain combinations: the case of glutaredoxins
    Rui Alves
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, IRBLLEIDA, Lleida, Spain
    BMC Evol Biol 9:66. 2009
  4. ncbi request reprint Glutaredoxins in fungi
    Enrique Herrero
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008, Lleida, Spain
    Photosynth Res 89:127-40. 2006
  5. ncbi request reprint Evolutionary relationships between Saccharomyces cerevisiae and other fungal species as determined from genome comparisons
    Enrique Herrero
    Departamento de Ciencias Medicas Basicas, Facultad de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    Rev Iberoam Micol 22:217-22. 2005
  6. ncbi request reprint Monothiol glutaredoxins: a common domain for multiple functions
    E Herrero
    Departament de Ciencies Mediques Basiques, IRBLLEIDA, Universitat de Lleida, Montserrat Roig 2, Lleida, Spain
    Cell Mol Life Sci 64:1518-30. 2007
  7. ncbi request reprint Comparative genomics of yeast species: new insights into their biology
    Enrique Herrero
    Department of Basic Medical Sciences, University of Lleida, Faculty of Medicine, 25198 Lleida, Spain
    Int Microbiol 6:183-90. 2003
  8. pmc An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast
    G Belli
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    Nucleic Acids Res 26:942-7. 1998
  9. ncbi request reprint Osmotic stress causes a G1 cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae
    G Belli
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    Mol Microbiol 39:1022-35. 2001
  10. pmc G1 cyclins block the Ime1 pathway to make mitosis and meiosis incompatible in budding yeast
    N Colomina
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Catalunya, Spain
    EMBO J 18:320-9. 1999

Collaborators

  • Fernando Antunes
  • Rui Alves
  • José García-Martínez
  • A Sorribas
  • Alicia Izquierdo
  • Ester Vilaprinyo
  • Joaquin Arino
  • Joaquín Moreno
  • José E Pérez-Ortín
  • Per Sunnerhagen
  • R Luise Krauth-Siegel
  • B Dujon
  • Marcelo A Comini
  • Nicolas Rouhier
  • Gemma Belli
  • Ana Garcera
  • Maria Micaela Molina-Navarro
  • Jordi Tamarit
  • Maria Angeles de la Torre-Ruiz
  • Maria Teresa Rodriguez-Manzaneque
  • G Belli
  • Jordi Torres
  • Joaquim Ros
  • Lina Barreto
  • María Micaela Molina
  • Elisa Cabiscol
  • Celia Casas
  • Sibali Bandyopadhyay
  • Michael Filser
  • José Solla-Gullón
  • E Gari
  • M Aldea
  • Ana C Matias
  • Nuria Pujol-Carrion
  • Lidia Piedrafita
  • Felipe Vilella
  • María Angeles De la Torre
  • Inmaculada Moreno
  • Susana Rodriguez-Navarro
  • Maria M Molina-Navarro
  • Michael K Johnson
  • Antonio Aldaz
  • Filipe Gama
  • Jean Pierre Jacquot
  • Julia Marin-Navarro
  • Laia Castells-Roca
  • N Colomina
  • Paramaconi Rodriguez
  • M T Rodríguez-Manzaneque
  • Jose Manuel Gualberto
  • Ronald Claxton
  • Boi Hanh Huynh
  • Natalie Dirdjaja
  • Sunil G Naik
  • Juan M Feliu
  • Nuno Pedroso
  • José Manuel Nogueira
  • H Susana Marinho
  • Nuno Teodoro
  • Luisa Cyrne
  • Antoni Nogues
  • Kristina Jansson
  • Sergi Maicas
  • Rafael Sentandreu
  • Yolanda Pedreno
  • Eulogio Valentin
  • Genoveva Uber
  • Denis Marchesan
  • Julio Polaina
  • Charles J Di Como
  • Anna Ramne
  • Bertrand Llorente
  • Pedro Echave
  • J Ros
  • E Cabiscol
  • C Gallego
  • L Piedrafita

Detail Information

Publications38

  1. ncbi request reprint Glutaredoxins and oxidative stress defense in yeast
    Enrique Herrero
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, 25198 Lleida, Spain
    Methods Enzymol 348:136-46. 2002
  2. pmc Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe-2S] clusters
    Sibali Bandyopadhyay
    Department of Chemistry, Centre for Metalloenzyme Studies, University of Georgia, Athens, GA, USA
    EMBO J 27:1122-33. 2008
    ..Alternatively, they may function in the storage and/or delivery of preformed Fe-S clusters or in the regulation of the chloroplastic Fe-S cluster assembly machinery...
  3. pmc Evolution based on domain combinations: the case of glutaredoxins
    Rui Alves
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, IRBLLEIDA, Lleida, Spain
    BMC Evol Biol 9:66. 2009
    ..GRXs are responsible for the reduction of protein disulfides or glutathione-protein mixed disulfides and are involved in cellular redox regulation, although their specific roles and targets are often unclear...
  4. ncbi request reprint Glutaredoxins in fungi
    Enrique Herrero
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008, Lleida, Spain
    Photosynth Res 89:127-40. 2006
    ..The function of yeast Grx5 seems to be conserved along the evolutionary scale...
  5. ncbi request reprint Evolutionary relationships between Saccharomyces cerevisiae and other fungal species as determined from genome comparisons
    Enrique Herrero
    Departamento de Ciencias Medicas Basicas, Facultad de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    Rev Iberoam Micol 22:217-22. 2005
    ..This allows diversification of protein functions while saving gene information...
  6. ncbi request reprint Monothiol glutaredoxins: a common domain for multiple functions
    E Herrero
    Departament de Ciencies Mediques Basiques, IRBLLEIDA, Universitat de Lleida, Montserrat Roig 2, Lleida, Spain
    Cell Mol Life Sci 64:1518-30. 2007
    ..Therefore, monothiol glutaredoxins share a common basic structural motif and biochemical mechanism of action, while participating in a diversity of cellular functions as protein redox regulators...
  7. ncbi request reprint Comparative genomics of yeast species: new insights into their biology
    Enrique Herrero
    Department of Basic Medical Sciences, University of Lleida, Faculty of Medicine, 25198 Lleida, Spain
    Int Microbiol 6:183-90. 2003
    ..e., genes not found in other organisms, a fact that can account for the biological characteristics of this pathogenic dimorphic yeast which is able to colonize a large variety of environments...
  8. pmc An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast
    G Belli
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    Nucleic Acids Res 26:942-7. 1998
    ..The dual system here described may be useful for the functional analysis of essential genes whose conditional expression can be tightly controlled by tetracyclines...
  9. ncbi request reprint Osmotic stress causes a G1 cell cycle delay and downregulation of Cln3/Cdc28 activity in Saccharomyces cerevisiae
    G Belli
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    Mol Microbiol 39:1022-35. 2001
    ..Although Hog1 is not required for the observed cell cycle arrest in hyperosmotic conditions, it is necessary to resume the cell cycle at KCl concentrations higher than 0.4 M...
  10. pmc G1 cyclins block the Ime1 pathway to make mitosis and meiosis incompatible in budding yeast
    N Colomina
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Catalunya, Spain
    EMBO J 18:320-9. 1999
    ..The existence of a negative cross-talk mechanism between mitosis and meiosis may help explain why these two developmental options are incompatible in budding yeast...
  11. ncbi request reprint Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin
    Jordi Tamarit
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    J Biol Chem 278:25745-51. 2003
    ..The fact that wild type Grx5 efficiently reduced a glutathiolated protein used as a substrate indicated that Grx5 may act as a thiol reductase inside the mitochondria...
  12. pmc Saccharomyces cerevisiae cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases
    Ana Garcera
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    Biochem J 398:187-96. 2006
    ..Therefore the residues adjacent to the respective active cysteine residues in Gto2 and Grx5 are important determinants for the thiol transferase activity against small disulphide-containing molecules...
  13. ncbi request reprint Saccharomyces cerevisiae glutaredoxin 5-deficient cells subjected to continuous oxidizing conditions are affected in the expression of specific sets of genes
    Gemma Belli
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    J Biol Chem 279:12386-95. 2004
    ..This effect is suppressed by HAP4 overexpression. Inhibition of respiratory metabolism during continuous moderately oxidative conditions could be a protective response by the cell...
  14. pmc Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes
    Maria Teresa Rodriguez-Manzaneque
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Spain
    Mol Biol Cell 13:1109-21. 2002
    ..Hence, Grx5 forms part of the mitochondrial machinery involved in the synthesis and assembly of iron/sulfur centers...
  15. ncbi request reprint Nuclear monothiol glutaredoxins of Saccharomyces cerevisiae can function as mitochondrial glutaredoxins
    María Micaela Molina
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    J Biol Chem 279:51923-30. 2004
    ..We have concluded that dithiol glutaredoxins are functionally divergent from monothiol ones, but the latter can interchange their biological activities when compartment barriers are surpassed...
  16. ncbi request reprint Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast
    Jordi Torres
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, Lleida 25198, Spain
    J Biol Chem 277:43495-504. 2002
    ....
  17. ncbi request reprint Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae
    Nuria Pujol-Carrion
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, Lleida 25198, Spain
    J Cell Sci 119:4554-64. 2006
    ..However, our results also suggest that Grx3 and Grx4 might play additional roles in the oxidative stress response through proteins other than Aft1...
  18. doi request reprint Comprehensive transcriptional analysis of the oxidative response in yeast
    Maria Micaela Molina-Navarro
    Departament de Ciències Mèdiques Bàsiques and IRBLleida, Universitat de Lleida, Montserrat Roig 2, Lleida, Spain
    J Biol Chem 283:17908-18. 2008
    ....
  19. pmc Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae
    M T Rodríguez-Manzaneque
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Spain
    Mol Cell Biol 19:8180-90. 1999
    ..Grx5-deficient mutants are also sensitive to osmotic stress, which indicates a relationship between the two types of stress in yeast cells...
  20. ncbi request reprint Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism. II. Role of glutaredoxin Grx5
    Rui Alves
    Departament de Ciencies Mediques Basiques, Universidad de Lleida, Lleida, Spain
    Proteins 57:481-92. 2004
    ....
  21. ncbi request reprint Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism: I. The role of the protein pair ferredoxin-ferredoxin reductase (Yah1-Arh1)
    Rui Alves
    Departament de Ciencies Mediques Basiques, Universidad de Lleida, Lleida, Spain
    Proteins 56:354-66. 2004
    ..Only when this mode of action of either of the two proteins in FeSC synthesis is considered can previously reported results be reproduced...
  22. pmc A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism
    Lina Barreto
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    Eukaryot Cell 5:1748-59. 2006
    ..This protein is also located at the peroxisomes in S. cerevisiae, where it is involved in transulfuration of cysteine into homocysteine, and requires a conserved cysteine residue for its biological activity...
  23. ncbi request reprint Structure-function analysis of yeast Grx5 monothiol glutaredoxin defines essential amino acids for the function of the protein
    Gemma Belli
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    J Biol Chem 277:37590-6. 2002
    ..Substitution of Phe(50) alters the beta-sheet in the thioredoxin fold structure and inhibits Grx5 function. None of the substitutions tested affect the structure at a significant enough level to reduce protein stability...
  24. ncbi request reprint Sit4 is required for proper modulation of the biological functions mediated by Pkc1 and the cell integrity pathway in Saccharomyces cerevisiae
    Maria Angeles de la Torre-Ruiz
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    J Biol Chem 277:33468-76. 2002
    ..Sit4 affects all known biological functions involving Pkc1, namely Mpk1 activity and cell wall integrity, actin cytoskeleton organization, and ribosomal gene transcription...
  25. ncbi request reprint Prokaryotic and eukaryotic monothiol glutaredoxins are able to perform the functions of Grx5 in the biogenesis of Fe/S clusters in yeast mitochondria
    Maria Micaela Molina-Navarro
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    FEBS Lett 580:2273-80. 2006
    ..The chicken cGRX5 gene was significantly expressed throughout the embryo stages in different tissues. These results underline the functional conservation of Grx5 homologues throughout evolution...
  26. ncbi request reprint Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress
    Felipe Vilella
    Departament de Ciencies Mediques Basiques, Alcalde Rovira Roure 44, Universitat de Lleida, Lleida 25198, Spain
    J Biol Chem 280:9149-59. 2005
    ....
  27. doi request reprint Expression of Candida albicans glutathione transferases is induced inside phagocytes and upon diverse environmental stresses
    Ana Garcera
    Departament de Ciencies Mediques Basiques, IRBLLEIDA, Universitat de Lleida, Lleida, Spain
    FEMS Yeast Res 10:422-31. 2010
    ..Under these conditions, the promoter of GTT14 (GTT1/2 class) also becomes activated. These observations point to the importance of C. albicans GSTs in the defence against phagocytes...
  28. ncbi request reprint Functional analysis of yeast essential genes using a promoter-substitution cassette and the tetracycline-regulatable dual expression system
    G Belli
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Spain
    Yeast 14:1127-38. 1998
    ..Analysis of terminal phenotypes of the promoter-substituted cells in the presence of the antibiotic may facilitate functional analysis of essential orphan genes...
  29. ncbi request reprint Mitochondrial Hsp60, resistance to oxidative stress, and the labile iron pool are closely connected in Saccharomyces cerevisiae
    Elisa Cabiscol
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Spain
    J Biol Chem 277:44531-8. 2002
    ..These results indicate that the role of Hsp60 in oxidative-stress defense is explained by protection of several Fe/S proteins, which prevent the release of iron ions and thereby avert further damage...
  30. pmc Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathway
    Alicia Izquierdo
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    Eukaryot Cell 7:1415-26. 2008
    ..However, the differences in location and expression responses against stresses suggest that their functions are not totally overlapping...
  31. doi request reprint Selenite-induced cell death in Saccharomyces cerevisiae: protective role of glutaredoxins
    Alicia Izquierdo
    Departament de Ciencies Mediques Basiques, IRBLLEIDA, Universitat de Lleida, Montserrat Roig 2, 25008 Lleida, Spain
    Microbiology 156:2608-20. 2010
    ..In the absence of the latter, intracellular protein carbonylation is reduced after prolonged selenite treatment, supporting the supposition that part of the oxidative damage is contributed by apoptotic cells...
  32. doi request reprint Redox control and oxidative stress in yeast cells
    Enrique Herrero
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, Lleida, Spain
    Biochim Biophys Acta 1780:1217-35. 2008
    ..In combination with Gpx3 peroxidase and Ybp1 protein, the activity of Yap1 is itself controlled depending on the redox state of some of its cysteine residues, which determines the nucleocytoplasmic location of the Yap1 molecules...
  33. ncbi request reprint Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6
    Susana Rodriguez-Navarro
    Departamento de Bioquimica y Biologia Molecular, Universitat de Valencia, C Dr Moliner 50, E 46100, Burjassot, Spain
    Yeast 19:1261-76. 2002
    ..Whereas copy 1 is required for conditions in which B(6) is essential for growth, copies 2 and 3 seem more related with B(1) biosynthesis during the exponential phase...
  34. ncbi request reprint Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1
    Michael Filser
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, D 69120 Heidelberg, Germany
    Biol Chem 389:21-32. 2008
    ..This is surprising because even bacterial and plant 1-Cys-glutaredoxins efficiently revert the defects, and may be due to the lack of two basic residues conserved in all but the trypanosomatid proteins...
  35. ncbi request reprint Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2
    Ana C Matias
    Centro de Quimica e Bioquimica, Faculdade de Ciencias da Universidade de Lisboa, 1749 016 Lisboa, Portugal
    Free Radic Biol Med 43:1458-65. 2007
    ..Very-long-chain fatty acids (VLCFA) through interdigitation or by modulating formation of lipid rafts may decrease the overall or localized plasma membrane permeability to H2O2, respectively, thus conferring a higher resistance to H2O2...
  36. ncbi request reprint Characterization of a Candida albicans gene encoding a putative transcriptional factor required for cell wall integrity
    Inmaculada Moreno
    Departamento de Microbiologia y Ecologia, Facultad de Farmacia, Universidad de Valencia, Avda Vicente Andrés Estellés s n Burjassot, 46100, Valencia, Spain
    FEMS Microbiol Lett 226:159-67. 2003
    ..The CaCWT1 gene is more expressed in stationary phase cells than in cells growing exponentially. To our knowledge, this is the first Zn(II) Cys(6) transcriptional factor-encoding gene implicated in the cell wall architecture...
  37. doi request reprint Surface characterization of platinum electrodes
    José Solla-Gullón
    Instituto de Electroquimica, Universidad de Alicante, Apdo 99, E 03080 Alicante, Spain
    Phys Chem Chem Phys 10:1359-73. 2008
    ..The information about the surface-site distribution can also be applied to analyze the voltammetric profile of nanocrystalline platinum electrodes...