Silvia Hernandez

Summary

Affiliation: Universitat Pompeu Fabra
Country: Spain

Publications

  1. ncbi request reprint Manual versus laser micro-dissection in molecular biology
    Silvia Hernandez
    Experimental and Health Sciences Department CEXS, Universitat Pompeu Fabra, Barcelona, Spain
    Ultrastruct Pathol 30:221-8. 2006
  2. doi request reprint FGFR3 mutations in prostate cancer: association with low-grade tumors
    Silvia Hernandez
    Department of Health and Experimental Sciences, Universitat Pompeu Fabra, Barcelona, Spain
    Mod Pathol 22:848-56. 2009
  3. ncbi request reprint Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
    Silvia Hernandez
    Universitat Pompeu Fabra, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    J Clin Oncol 24:3664-71. 2006
  4. doi request reprint PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF, KRAS and AKT1 mutations are infrequent events
    Laia Agell
    Department of Pathology, Hospital del Mar Parc de Salut Mar, Barcelona, Spain
    Mod Pathol 24:443-52. 2011
  5. doi request reprint Molecular alterations of EGFR and PTEN in prostate cancer: association with high-grade and advanced-stage carcinomas
    Silvia de Muga
    Department of Health and Experimental Sciences, Universitat Pompeu Fabra, Barcelona, Spain
    Mod Pathol 23:703-12. 2010
  6. doi request reprint KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations
    Laia Agell
    Department of Pathology, Hospital del Mar, Barcelona, Spain
    Mod Pathol 21:1470-8. 2008
  7. ncbi request reprint PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Carrer del Dr Aiguader 80, 08003 Barcelona, Spain
    Cancer Res 66:7401-4. 2006
  8. ncbi request reprint The p53 pathway and outcome among patients with T1G3 bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, and Hospital del Mar, Barcelona, Spain
    Clin Cancer Res 12:6029-36. 2006
  9. doi request reprint CXCR4 mRNA overexpression in high grade prostate tumors: lack of association with TMPRSS2-ERG rearrangement
    Silvia de Muga
    Department of Pathology, Hospital del Mar Parc de Salut Mar IMIM, Barcelona, Spain
    Cancer Biomark 12:21-30. 2012
  10. doi request reprint A 12-gene expression signature is associated with aggressive histological in prostate cancer: SEC14L1 and TCEB1 genes are potential markers of progression
    Laia Agell
    Department of Pathology, Hospital del Mar Mar Health Park, Barcelona, Spain
    Am J Pathol 181:1585-94. 2012

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Manual versus laser micro-dissection in molecular biology
    Silvia Hernandez
    Experimental and Health Sciences Department CEXS, Universitat Pompeu Fabra, Barcelona, Spain
    Ultrastruct Pathol 30:221-8. 2006
    ..In this review, the most important micro-dissection methods are put into perspective, and some requirements and limitations are discussed with regard to sample fixation, staining, dissection and molecular analysis...
  2. doi request reprint FGFR3 mutations in prostate cancer: association with low-grade tumors
    Silvia Hernandez
    Department of Health and Experimental Sciences, Universitat Pompeu Fabra, Barcelona, Spain
    Mod Pathol 22:848-56. 2009
    ..This gene does not seem to be central to the pathogenesis of prostate cancer, but it is significantly associated with a subgroup of low-grade prostate tumors, and with the finding of other tumors, mainly arising in bladder and skin...
  3. ncbi request reprint Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
    Silvia Hernandez
    Universitat Pompeu Fabra, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    J Clin Oncol 24:3664-71. 2006
    ..To determine the frequency and the prognostic value of fibroblast growth factor receptor 3 (FGFR3) mutations in patients with nonmuscle invasive bladder tumors according to tumor stage and grade...
  4. doi request reprint PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF, KRAS and AKT1 mutations are infrequent events
    Laia Agell
    Department of Pathology, Hospital del Mar Parc de Salut Mar, Barcelona, Spain
    Mod Pathol 24:443-52. 2011
    ..PIK3CA, BRAF, KRAS and AKT1 mutations are very infrequent events in prostate tumors. However, PI3K signaling pathway is activated by PIK3CA FISH gain and/or mRNA overexpression, leading to an increased pAKT protein expression...
  5. doi request reprint Molecular alterations of EGFR and PTEN in prostate cancer: association with high-grade and advanced-stage carcinomas
    Silvia de Muga
    Department of Health and Experimental Sciences, Universitat Pompeu Fabra, Barcelona, Spain
    Mod Pathol 23:703-12. 2010
    ..Alterations in the EGFR-PTEN signaling pathway are present in a third of prostate adenocarcinomas, particularly affecting the more advanced cases...
  6. doi request reprint KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations
    Laia Agell
    Department of Pathology, Hospital del Mar, Barcelona, Spain
    Mod Pathol 21:1470-8. 2008
    ..When using FFPE tissues, it is mandatory to perform at least two independent rounds of PCR and sequencing to confirm mutations and exclude Taq polymerase-induced artifacts...
  7. ncbi request reprint PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Carrer del Dr Aiguader 80, 08003 Barcelona, Spain
    Cancer Res 66:7401-4. 2006
    ..PIK3CA may constitute a novel diagnostic and prognostic tool, as well as a therapeutic target, in bladder cancer...
  8. ncbi request reprint The p53 pathway and outcome among patients with T1G3 bladder tumors
    Elena Lopez-Knowles
    Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, and Hospital del Mar, Barcelona, Spain
    Clin Cancer Res 12:6029-36. 2006
    ..The aim was to analyze Tp53 and HDM2 in T1G3 bladder tumors and to determine the prognostic value of their alterations...
  9. doi request reprint CXCR4 mRNA overexpression in high grade prostate tumors: lack of association with TMPRSS2-ERG rearrangement
    Silvia de Muga
    Department of Pathology, Hospital del Mar Parc de Salut Mar IMIM, Barcelona, Spain
    Cancer Biomark 12:21-30. 2012
    ..In conclusion, our results reveal for the first time that CXCR4 overexpression is associated with high Gleason score prostate tumors, but that it is independent of the TMPRSS2-ERG rearrangement...
  10. doi request reprint A 12-gene expression signature is associated with aggressive histological in prostate cancer: SEC14L1 and TCEB1 genes are potential markers of progression
    Laia Agell
    Department of Pathology, Hospital del Mar Mar Health Park, Barcelona, Spain
    Am J Pathol 181:1585-94. 2012
    ..This set of genes may contribute to a better understanding of the molecular basis of prostate cancer. TCEB1 and SELC14L1 are good candidate markers for predicting prognosis and progression of prostate cancer...
  11. ncbi request reprint Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors
    Silvia Hernandez
    Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    J Invest Dermatol 127:1664-6. 2007
    ..1%) EN but it was absent from unaffected skin. In two patients with EN and UC, both lesions were FGFR3 wild type. Our findings indicate that: (1) FGFR3 mutations occur in mosaicism and can cause EN and (2) other genes are involved in EN...
  12. ncbi request reprint FGFR3 and Tp53 mutations in T1G3 transitional bladder carcinomas: independent distribution and lack of association with prognosis
    Silvia Hernandez
    Universitat Pompeu Fabra, Institut Municipal d Investigacio Medica, Hospital del Mar, Barcelona, Spain
    Clin Cancer Res 11:5444-50. 2005
    ..15-13.75), wt/mut 0.67 (0.19-2.31), mut/mut 1.62 (0.27-9.59). These molecular features support the notion that T1G3 tumors are at the crossroads of the two main molecular pathways proposed for bladder cancer development and progression...