Marta Giralt

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. ncbi Adipose tissue biology and HIV-infection
    Marta Giralt
    Department of Biochemistry and Molecular Biology and Institut de Biomedicina IBUB, University of Barcelona, Barcelona, Catalonia, Spain
    Best Pract Res Clin Endocrinol Metab 25:487-99. 2011
  2. ncbi HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy
    Marta Giralt
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Antivir Ther 11:729-40. 2006
  3. ncbi Lipotoxicity on the basis of metabolic syndrome and lipodystrophy in HIV-1-infected patients under antiretroviral treatment
    Marta Giralt
    Department of Biochemistry and Molecular Biology, Facultat de Biologia, Universitat de Barcelona Avda Diagonal 645 08028 Barcelona, Spain
    Curr Pharm Des 16:3371-8. 2010
  4. ncbi Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue
    Meritxell Rosell
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avinguda Diagonal 643, E 08028 Barcelona, Spain
    Endocrinology 153:1162-73. 2012
  5. ncbi Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta
    M Carmen Carmona
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, E 08028 Barcelona, Catalunya, Spain
    Biochem J 389:47-56. 2005
  6. ncbi Reverse transcriptase inhibitors alter uncoupling protein-1 and mitochondrial biogenesis in brown adipocytes
    M Luísa Rodriguez de la Concepción
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Antivir Ther 10:515-26. 2005
  7. ncbi Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy
    Jordi P Guallar
    Department of Biochemistry and Molecular Biology and Institut de Biomedicina IBUB, University of Barcelona, and CIBER Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Barcelona, Spain
    AIDS 22:575-84. 2008
  8. ncbi Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    Elayne Hondares
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
    Cell Metab 11:206-12. 2010
  9. ncbi Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia
    Gloria Garrabou
    Mitochondrial Research Laboratory, Internal Medicine Department, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona and CIBER de Enfermedades Raras, CIBERER, Barcelona, Spain
    J Acquir Immune Defic Syndr 52:443-51. 2009
  10. ncbi In vivo effects of highly active antiretroviral therapies containing the protease inhibitor nelfinavir on mitochondrially driven apoptosis
    Oscar Miro
    Mitochondrial Research Laboratory, Hospital Clinic, IDIBAPS, Barcelona, Catalonia, Spain
    Antivir Ther 10:945-51. 2005

Collaborators

Detail Information

Publications47

  1. ncbi Adipose tissue biology and HIV-infection
    Marta Giralt
    Department of Biochemistry and Molecular Biology and Institut de Biomedicina IBUB, University of Barcelona, Barcelona, Catalonia, Spain
    Best Pract Res Clin Endocrinol Metab 25:487-99. 2011
    ....
  2. ncbi HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy
    Marta Giralt
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Antivir Ther 11:729-40. 2006
    ....
  3. ncbi Lipotoxicity on the basis of metabolic syndrome and lipodystrophy in HIV-1-infected patients under antiretroviral treatment
    Marta Giralt
    Department of Biochemistry and Molecular Biology, Facultat de Biologia, Universitat de Barcelona Avda Diagonal 645 08028 Barcelona, Spain
    Curr Pharm Des 16:3371-8. 2010
    ..Moreover, pharmacological strategies that reduce lipotoxicity and promote adipose tissue expandability can be expected to ameliorate the overall metabolic abnormalities in HIV-1-infected, antiretroviral-treated patients...
  4. ncbi Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue
    Meritxell Rosell
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avinguda Diagonal 643, E 08028 Barcelona, Spain
    Endocrinology 153:1162-73. 2012
    ....
  5. ncbi Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta
    M Carmen Carmona
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, E 08028 Barcelona, Catalunya, Spain
    Biochem J 389:47-56. 2005
    ..In summary, defective thermoregulation owing to the lack of C/EBPbeta is associated with the reduced capacity to supply fatty acids as fuels to sustain brown fat thermogenesis...
  6. ncbi Reverse transcriptase inhibitors alter uncoupling protein-1 and mitochondrial biogenesis in brown adipocytes
    M Luísa Rodriguez de la Concepción
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Antivir Ther 10:515-26. 2005
    ..The aim of this study was to evaluate the effects of reverse transcriptase inhibitors (RTIs) on primary brown adipocytes differentiated in culture...
  7. ncbi Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy
    Jordi P Guallar
    Department of Biochemistry and Molecular Biology and Institut de Biomedicina IBUB, University of Barcelona, and CIBER Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Barcelona, Spain
    AIDS 22:575-84. 2008
    ..To elucidate the molecular basis of the progressive enlargement of dorso-cervical adipose tissue, the so-called 'buffalo hump', that appears in a sub-set of patients with HIV-1/HAART-associated lipodystrophy...
  8. ncbi Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    Elayne Hondares
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
    Cell Metab 11:206-12. 2010
    ..We propose that the induction of FGF21 production by the liver mediates direct activation of brown fat thermogenesis during the fetal-to-neonatal transition...
  9. ncbi Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia
    Gloria Garrabou
    Mitochondrial Research Laboratory, Internal Medicine Department, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona and CIBER de Enfermedades Raras, CIBERER, Barcelona, Spain
    J Acquir Immune Defic Syndr 52:443-51. 2009
    ....
  10. ncbi In vivo effects of highly active antiretroviral therapies containing the protease inhibitor nelfinavir on mitochondrially driven apoptosis
    Oscar Miro
    Mitochondrial Research Laboratory, Hospital Clinic, IDIBAPS, Barcelona, Catalonia, Spain
    Antivir Ther 10:945-51. 2005
    ....
  11. ncbi Effects of rilpivirine on human adipocyte differentiation, gene expression, and release of adipokines and cytokines
    Julieta Diaz-Delfin
    Department of Biochemistry and Molecular Biology, Institut de Biomedicina, IBUB, University of Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Spain
    Antimicrob Agents Chemother 56:3369-75. 2012
    ..It is concluded that rilpivirine causes an antiadipogenic and proinflammatory response pattern, but only at high concentrations, whereas efavirenz causes similar effects at lower concentrations...
  12. ncbi Reduced levels of serum FGF19 and impaired expression of receptors for endocrine FGFs in adipose tissue from HIV-infected patients
    José M Gallego-Escuredo
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 61:527-34. 2012
    ..To determine the role of fibroblast growth factor (FGF)-19 and FGF21 and the endocrine FGFs receptor system in the metabolic alterations that manifest in HIV-1-infected patients undergoing highly active antiretroviral treatment (HAART)...
  13. ncbi HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes
    Julieta Diaz-Delfin
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Spain
    Antivir Ther 17:529-40. 2012
    ..We have studied the effects of Tat on SGBS adipocytes to gain insight on its role on the development of lipodystrophy...
  14. ncbi Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines
    Julieta Diaz-Delfin
    Department of Biochemistry and Molecular Biology and Institut de Biomedicina IBUB, University of Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Spain
    Antiviral Res 91:112-9. 2011
    ..It is concluded that, in contrast with the profound anti-adipogenic and pro-inflammatory response elicited by efavirenz, nevirapine does not impair adipogenesis...
  15. ncbi Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16
    Elayne Hondares
    Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutricion, Barcelona, Catalonia, Spain
    J Biol Chem 286:43112-22. 2011
    ..Collectively, these results suggest that PPARα acts as a key component of brown fat thermogenesis by coordinately regulating lipid catabolism and thermogenic gene expression via induction of PGC-1α and PRDM16...
  16. ncbi Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients
    Jordi P Guallar
    Department of Biochemistry and Molecular Biology, University of Barcelona and Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
    Antivir Ther 12:853-63. 2007
    ..Nucleoside transporter proteins (NTs) encoded by members of the SLC28 and SLC29 gene families contribute to nucleoside and nucleobase recycling but also modulate extracellular adenosine levels and thus adenosine-regulated metabolic targets...
  17. ncbi Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype
    Albert Giralt
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutricion, 08028 Barcelona, Spain
    J Biol Chem 286:16958-66. 2011
    ..The present results indicate that Pgc-1α controls Sirt3 gene expression and this action is an essential component of the overall mechanisms by which Pgc-1α induces the full acquisition of a brown adipocyte differentiated phenotype...
  18. ncbi PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle
    Elayne Hondares
    Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain
    Biochem Biophys Res Commun 354:1021-7. 2007
    ..These data point to a distinct value of PPARdelta rather than PPARalpha agonists in the improvement of oxidative metabolism in muscle...
  19. ncbi Differential effects of efavirenz and lopinavir/ritonavir on human adipocyte differentiation, gene expression and release of adipokines and pro-inflammatory cytokines
    José M Gallego-Escuredo
    Department of Biochemistry and Molecular Biology and Institut de Biomedicina IBUB, University of Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
    Curr HIV Res 8:545-53. 2010
    ..These findings may have implications for the pathogenesis of HIV-1-associated lipodystrophy and the development of HIV-1 therapies...
  20. ncbi Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
    Pere Domingo
    Hospital de la Santa Creu i Sant Pau and Red de Investigación en SIDA, Barcelona, Spain
    AIDS 24:2629-37. 2010
    ..Our goal was to determine the relationship between FGF21 levels and metabolic alterations in these patients...
  21. ncbi Phytanic acid, but not pristanic acid, mediates the positive effects of phytol derivatives on brown adipocyte differentiation
    Agatha Schluter
    , Universitat de Barcelona, Barcelona, Spain
    FEBS Lett 517:83-6. 2002
    ....
  22. ncbi Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha
    M Carmen Carmona
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona E 08028, Spain
    J Biol Chem 277:21489-98. 2002
    ....
  23. ncbi The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism
    Pilar Yubero
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain
    Endocrinology 145:4268-77. 2004
    ....
  24. ncbi TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway
    Julieta Diaz-Delfin
    Department of Biochemistry and Molecular Biology, University of Barcelona, Avda Diagonal 643, 08028 Barcelona, Spain
    Endocrinology 153:4238-45. 2012
    ....
  25. ncbi Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    Elayne Hondares
    Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutricion, 08028 Barcelona, Catalonia, Spain
    J Biol Chem 286:12983-90. 2011
    ..The present findings lead to the recognition of a novel pathway of regulation the FGF21 gene and an endocrine role of brown fat, as a source of FGF21 that may be especially relevant in conditions of activation of thermogenic activity...
  26. ncbi Functional relationship between MyoD and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription
    Gemma Solanes
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, E 08028 Barcelona, Spain
    Mol Endocrinol 17:1944-58. 2003
    ..Therefore the convergence of MyoD and PPAR-dependent pathways provides a molecular mechanism for skeletal muscle specificity and fatty acid regulation of human UCP3 gene...
  27. ncbi Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia
    Gloria Garrabou
    Mitochondrial Research Laboratory, Muscle Research Unit, Internal Medicine Department, Hospital Clinic of Barcelona, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Antimicrob Agents Chemother 51:962-7. 2007
    ..Linezolid inhibits mitochondrial protein synthesis, leading to decreased mitochondrial enzymatic activity, which causes linezolid-related hyperlactatemia, which resolves upon discontinuation of linezolid treatment...
  28. ncbi Lithium inhibits brown adipocyte differentiation
    María Luisa Rodríguez de la Concepción
    Department of Biochemistry and Molecular Biology, University of Barcelona, Spain
    FEBS Lett 579:1670-4. 2005
    ..Brown adipocytes appear as preferential targets of the inhibitory action of lithium on adipocyte differentiation...
  29. ncbi Drug-induced lipotoxicity: lipodystrophy associated with HIV-1 infection and antiretroviral treatment
    Francesc Villarroya
    Department of Biochemistry and Molecular Biology and Institute of Biomedicine of the University of Barcelona IBUB, and Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Biochim Biophys Acta 1801:392-9. 2010
    ....
  30. ncbi Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice
    Joan Villarroya
    Departament de Bioquimica i Biologia Molecular, and Institut de Biomedicina IBUB, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e29691. 2011
    ....
  31. ncbi Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    PLoS ONE 5:e13896. 2010
    ..Uridine has been advocated for the treatment of HIV-1/HAART-associated lipodystrophy (HALS), although its metabolism in HIV-1-infected patients is poorly understood...
  32. ncbi HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy
    Joan Villarroya
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    Antivir Ther 15:1021-8. 2010
    ..We have studied adipose tissues and circulating parameters in mice bearing the HIV-1 transgene as a model to provide insight into the role of HIV-1-infection-related events in fat alterations...
  33. ncbi Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity
    Francesc Villarroya
    Department of Biochemistry and Molecular Biology, University of Barcelona, Spain
    Trends Pharmacol Sci 26:88-93. 2005
    ....
  34. ncbi Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coacti
    Elayne Hondares
    Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain
    Endocrinology 147:2829-38. 2006
    ..These data indicate that some of the effects of TZDs, especially promotion of mitochondrial biogenesis and oxidative pathways in adipose depots, entail PGC-1alpha up-regulation via enhanced transcription of the PGC-1alpha gene...
  35. ncbi Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
    Ana Planavila
    Departament de Bioquimica i Biologia Molecular, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Avda Diagonal 645, Barcelona E 08028, Spain
    Cardiovasc Res 90:276-84. 2011
    ..The objective of the present study was to explore the relationships between Sirt1 and PPARα in the control of hypertrophy, metabolism, and inflammation processes in the heart...
  36. ncbi Uncoupling protein-2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production
    Emmanuel Chevillotte
    Departament de Bioquímica i Biologia Molecular Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain
    Diabetes 56:1042-50. 2007
    ..This provides a physiological mechanism by which the adipose tissue energetic status may determine the extent of adiponectin release and influence systemic insulin sensitivity...
  37. ncbi Pharmacological and gene modification-based models for studying the impact of perinatal metabolic disturbances in adult life
    Francesc Villarroya
    Department of Biochemistry and Molecular Biology and Institut de Biomedicina IBUB, Universitat de Barcelona, Barcelona, Spain
    Adv Exp Med Biol 646:141-8. 2009
    ....
  38. ncbi Adipogenic/lipid, inflammatory, and mitochondrial parameters in subcutaneous adipose tissue of untreated HIV-1-infected long-term nonprogressors: significant alterations despite low viral burden
    Francesc Vidal
    Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    J Acquir Immune Defic Syndr 61:131-7. 2012
    ..Our objectives were to determine whether adipocyte differentiation/lipid, inflammatory, and mitochondrial parameters are perturbed in abdominal wall subcutaneous adipose tissue of untreated HIV-1-infected patients LTNPs...
  39. ncbi Altered expression of master regulatory genes of adipogenesis in lipomas from patients bearing tRNA(Lys) point mutations in mitochondrial DNA
    Jordi P Guallar
    , Universitat de Barcelona, Spain
    Mol Genet Metab 89:283-5. 2006
    ....
  40. ncbi Upregulatory mechanisms compensate for mitochondrial DNA depletion in asymptomatic individuals receiving stavudine plus didanosine
    Oscar Miro
    Mitochondrial Research Laboratory, Muscle Research Unit, Department of Internal Medicine, Hospital Clinic, Institut d Investigations Bioiuèdiques August Pi I Sunyer, Barcelona, Spain
    J Acquir Immune Defic Syndr 37:1550-5. 2004
    ..These data suggest that upregulatory transcriptional or posttranscriptional mechanisms compensate for mtDNA depletion caused by d4T + ddI before profound mtDNA depletion occurs...
  41. ncbi Epitope mapping of mitochondrial adenine nucleotide translocase-1 in idiopathic dilated cardiomyopathy
    Carlos Manchado
    , Facultat de Biologia, Universitat de Barcelona, Spain
    J Mol Cell Cardiol 34:571-82. 2002
    ..The most significant epitopes belong to the M2 and M3 hydrophilic loops of ANT suggesting that apart from being essential for its activity, these loops are highly immunogenic...
  42. ncbi PPARs in the Control of Uncoupling Proteins Gene Expression
    Francesc Villarroya
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona 585 08007, Spain
    PPAR Res 2007:74364. 2007
    ..This review summarizes the current understanding of the role of PPARs in UCPs gene expression in normal conditions and also in the context of type-2 diabetes or obesity...
  43. ncbi HIV-1 Infection and the PPARgamma-Dependent Control of Adipose Tissue Physiology
    Marta Giralt
    Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain
    PPAR Res 2009:607902. 2009
    ....
  44. ncbi Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation
    Agatha Schluter
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Facultat de Biologia, Avda Diagonal 645, Barcelona 08028, Spain
    Biochem J 362:61-9. 2002
    ..In conclusion, phytanic acid is a natural product of phytol metabolism that activates brown adipocyte thermogenic function. It constitutes a potential nutritional signal linking dietary status to adaptive thermogenesis...
  45. ncbi HIV-1-infected long-term non-progressors have milder mitochondrial impairment and lower mitochondrially-driven apoptosis in peripheral blood mononuclear cells than typical progressors
    Joaquim Peraire
    Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain
    Curr HIV Res 5:467-73. 2007
    ..Mitochondrial damage is associated with increased PBMC apoptosis in patients with active HIV-1 replication (TP). These abnormalities are slight or not present in LTNP...
  46. ncbi Uncoupling protein 1 gene expression implicates brown adipocytes in highly active antiretroviral therapy-associated lipomatosis
    María L Rodríguez de la Concepción
    AIDS 18:959-60. 2004
  47. ncbi In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells
    Francesc Vidal
    Infectious Diseases and AIDS Section, Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Mallafre Guasch, 4, 43007 Tarragona, Spain
    Antimicrob Agents Chemother 50:3824-32. 2006
    ..Together, these in vitro results indicate that combination with other antiretrovirals does not significantly increase the toxic potential of TFV in RPTECs...