Ramon Farre

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. pmc Actual performance of mechanical ventilators in ICU: a multicentric quality control study
    Leonardo Govoni
    TBM Lab, Dipartimento di Bioingegneria, Politecnico di Milano University, Milano, Italy
    Med Devices (Auckl) 5:111-9. 2012
  2. pmc Potential role of adult stem cells in obstructive sleep apnea
    Isaac Almendros
    CIBER Enfermedades Respiratorias Bunyola, Spain
    Front Neurol 3:112. 2012
  3. pmc Changes in oxygen partial pressure of brain tissue in an animal model of obstructive apnea
    Isaac Almendros
    CIBER Enfermedades Respiratorias, Spain
    Respir Res 11:3. 2010
  4. doi request reprint Assessment of upper airway mechanics during sleep
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Respir Physiol Neurobiol 163:74-81. 2008
  5. ncbi request reprint Animal model of unilateral ventilator-induced lung injury
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Spain
    Intensive Care Med 31:487-90. 2005
  6. pmc Performance of mechanical ventilators at the patient's home: a multicentre quality control study
    R Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Thorax 61:400-4. 2006
  7. ncbi request reprint Morbidity due to obstructive sleep apnea: insights from animal models
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Spain
    Curr Opin Pulm Med 14:530-6. 2008
  8. ncbi request reprint Inspiratory flow limitation in obstructive sleep apnoea patients
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Clin Sci (Lond) 106:563-5. 2004
  9. pmc Rat model of chronic recurrent airway obstructions to study the sleep apnea syndrome
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Sleep 30:930-3. 2007
  10. ncbi request reprint Static and dynamic upper airway obstruction in sleep apnea: role of the breathing gas properties
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Am J Respir Crit Care Med 168:659-63. 2003

Collaborators

Detail Information

Publications71

  1. pmc Actual performance of mechanical ventilators in ICU: a multicentric quality control study
    Leonardo Govoni
    TBM Lab, Dipartimento di Bioingegneria, Politecnico di Milano University, Milano, Italy
    Med Devices (Auckl) 5:111-9. 2012
    ..In several cases, the actual delivered mechanical ventilation was considerably different from the set one, suggesting the need for improving quality control procedures for these machines...
  2. pmc Potential role of adult stem cells in obstructive sleep apnea
    Isaac Almendros
    CIBER Enfermedades Respiratorias Bunyola, Spain
    Front Neurol 3:112. 2012
    ..This mini-review is focused on the recent data available on EPCs, VSELs, and MSCs in both animal models and patients with OSA...
  3. pmc Changes in oxygen partial pressure of brain tissue in an animal model of obstructive apnea
    Isaac Almendros
    CIBER Enfermedades Respiratorias, Spain
    Respir Res 11:3. 2010
    ..The objective of this study was to assess whether brain tissue is partially protected from intermittently occurring interruption of O2 supply during recurrent swings in arterial SpO2 in an animal model of OSA...
  4. doi request reprint Assessment of upper airway mechanics during sleep
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Respir Physiol Neurobiol 163:74-81. 2008
    ..The latest developments in these two methods allow them to be easily applied on a routine basis in order to more fully characterize upper airway mechanics in patients with sleep breathing disorders...
  5. ncbi request reprint Animal model of unilateral ventilator-induced lung injury
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Spain
    Intensive Care Med 31:487-90. 2005
    ..To design, implement, and test a selective lung ventilator for setting a rat model of unilateral ventilator-induced lung injury (VILI)...
  6. pmc Performance of mechanical ventilators at the patient's home: a multicentre quality control study
    R Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Thorax 61:400-4. 2006
    ..Quality control procedures vary considerably among the providers of equipment for home mechanical ventilation (HMV)...
  7. ncbi request reprint Morbidity due to obstructive sleep apnea: insights from animal models
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Spain
    Curr Opin Pulm Med 14:530-6. 2008
    ..This review is focused on the most recent advances in our understanding of the consequences of OSA, achieved as a result of animal models...
  8. ncbi request reprint Inspiratory flow limitation in obstructive sleep apnoea patients
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Clin Sci (Lond) 106:563-5. 2004
    ..The results obtained in a bench test and in a pilot study in patients suggest that the flow limitation index proposed may help to better characterize the disturbed breathing events undergone by patients with OSAS...
  9. pmc Rat model of chronic recurrent airway obstructions to study the sleep apnea syndrome
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Sleep 30:930-3. 2007
    ..To implement a chronic rat model of recurrent airway obstructions to study the obstructive sleep apnea (OSA) syndrome...
  10. ncbi request reprint Static and dynamic upper airway obstruction in sleep apnea: role of the breathing gas properties
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Am J Respir Crit Care Med 168:659-63. 2003
    ..19 +/- 2.93 cm H2O). The data demonstrate the role played by the upstream segment of the upper airway and suggest that different mechanisms determine static (Pcrit) and dynamic (Rup) upper airway obstructions in SAHS...
  11. ncbi request reprint Noninvasive monitoring of respiratory mechanics during sleep
    R Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Casanova 143, E 08036 Barcelona, Spain
    Eur Respir J 24:1052-60. 2004
    ..Given the technical and practical limitations of each technique, combining different tools improves the reliability and robustness of patient assessment during sleep...
  12. ncbi request reprint Probing mechanical properties of living cells by atomic force microscopy with blunted pyramidal cantilever tips
    Felix Rico
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Casanova 143, 08036 Barcelona, Spain
    Phys Rev E Stat Nonlin Soft Matter Phys 72:021914. 2005
    ..Cells exhibited viscoelastic behavior with G"/G' approximately 1/4 . Pyramidal tips commonly used for AFM imaging are suitable for probing mechanical properties of soft gels and living cells...
  13. ncbi request reprint Thrombin and histamine induce stiffening of alveolar epithelial cells
    Xavier Trepat
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Casanova 143, 08036 Barcelona, Spain
    J Appl Physiol 98:1567-74. 2005
    ..In the mechanically dynamic environment of the lung, cell stiffening induced by thrombin and histamine increases centripetal tension, which could contribute to alveolar barrier dysfunction...
  14. ncbi request reprint Thrombin-induced contraction in alveolar epithelial cells probed by traction microscopy
    Nuria Gavara
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
    J Appl Physiol 101:512-20. 2006
    ..Thrombin-induced contractile tension might further impair alveolar epithelial barrier integrity in the injured lung...
  15. doi request reprint Biological consequences of oxygen desaturation and respiratory effort in an acute animal model of obstructive sleep apnea (OSA)
    Maria Nacher
    Laboratori de la Son Servei de Pneumologia, Sleep Lab, Hospital Clinic Provincial IDIBAPS, C Casanoves 170, Barcelona, Spain
    Sleep Med 10:892-7. 2009
    ..An animal model mimicking all the factors involved in obstructive sleep apnea (OSA) is useful for investigating mechanisms because the associated comorbidity usually present in such patients is an important limitation...
  16. pmc Rheology of passive and adhesion-activated neutrophils probed by atomic force microscopy
    Pere Roca-Cusachs
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, 08036 Barcelona, Spain
    Biophys J 91:3508-18. 2006
    ..The increase in stiffness with frequency may modulate neutrophil transit, arrest, and transmigration in vascular microcirculation...
  17. ncbi request reprint Viscoelasticity of human alveolar epithelial cells subjected to stretch
    Xavier Trepat
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona Institut d Investigacions Biomèdiques August Pi i Sunyer, 08036 Barcelona, Spain
    Am J Physiol Lung Cell Mol Physiol 287:L1025-34. 2004
    ..Stretch-induced cell stiffening could compromise the balance of forces at the cell-cell and cell-matrix adhesions...
  18. pmc Microrheology of human lung epithelial cells measured by atomic force microscopy
    Jordi Alcaraz
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Spain
    Biophys J 84:2071-9. 2003
    ..This complex dynamics is consistent with the rheology of soft glassy materials close to a glass transition, thereby suggesting that structural disorder and metastability may be fundamental features of cell architecture...
  19. ncbi request reprint Collapsible upper airway segment to study the obstructive sleep apnea/hypopnea syndrome in rats
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Casanova 143, E 08036, Barcelona, Spain
    Respir Physiol Neurobiol 136:199-209. 2003
    ..This collapsible upper airway segment may be a useful tool to implement a rat model of SAHS...
  20. pmc Tissue oxygenation in brain, muscle, and fat in a rat model of sleep apnea: differential effect of obstructive apneas and intermittent hypoxia
    Isaac Almendros
    CIBER Enfermedades Respiratorias, Spain
    Sleep 34:1127-33. 2011
    ....
  21. ncbi request reprint Physiological consequences of prolonged periods of flow limitation in patients with sleep apnea hypopnea syndrome
    Gabriel Calero
    Department of Respitology, Hospital Clinic, Barcelona, c Villarroel 170 08036, 08036 Barcelona, Spain
    Respir Med 100:813-7. 2006
    ..3 vs. 1.66+/-0.4s (P:0.001). It can be concluded that PPFL induces significant physiological changes. Nevertheless, given the scant literature, clinical studies are warranted to elucidate the clinical role of these physiological changes...
  22. doi request reprint Telemetric CPAP titration at home in patients with sleep apnea-hypopnea syndrome
    Raffaele Dellaca
    TBMLab, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    Sleep Med 12:153-7. 2011
    ..Home continuous positive airway pressure (CPAP) titration with automatic devices is not possible in a non-negligible percentage of patients with sleep apnea-hypopnea syndrome (SAHS)...
  23. pmc Obstructive apneas induce early release of mesenchymal stem cells into circulating blood
    Alba Carreras
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Sleep 32:117-9. 2009
    ..To investigate whether noninvasive application of recurrent airway obstructions induces early release of mesenchymal stem cells into the circulating blood in a rat model of obstructive sleep apnea...
  24. ncbi request reprint One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung
    Isaac Almendros
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Respir Physiol Neurobiol 162:100-2. 2008
    ..No detectable levels of circulating and liver TNF-alpha were detected. These data do not support the hypothesis of an early positive feedback in the lung inflammation during the mechanical ventilation...
  25. ncbi request reprint Recurrent obstructive apneas trigger early systemic inflammation in a rat model of sleep apnea
    Maria Nacher
    Sleep Laboratory, Hospital Clinic Provincial IDIBAPS, 08036 Barcelona, Spain
    Respir Physiol Neurobiol 155:93-6. 2007
    ..P-selectin was up-regulated only in the apnea group. This experimental model of recurrent obstruction demonstrates rapid endothelial cell activation, suggesting the onset of an inflammatory response...
  26. pmc Obstructive apneas induce early activation of mesenchymal stem cells and enhancement of endothelial wound healing
    Alba Carreras
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Respir Res 11:91. 2010
    ....
  27. ncbi request reprint Upper-airway inflammation triggered by vibration in a rat model of snoring
    Isaac Almendros
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Sleep 30:225-7. 2007
    ..To determine whether the vibratory mechanical stimulus due to snoring induces upper-airway inflammation in an in-vivo rat model...
  28. pmc Continuous positive airway pressure (CPAP) induces early nasal inflammation
    Isaac Almendros
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Sleep 31:127-31. 2008
    ..To assess whether noninvasive application of nCPAP is a mechanical stimulus inducing early nasal inflammation...
  29. pmc Mapping cell-matrix stresses during stretch reveals inelastic reorganization of the cytoskeleton
    Nuria Gavara
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Biophys J 95:464-71. 2008
    ..These findings indicate that cells use the mechanical energy injected by stretch to rapidly reorganize their structure and redistribute tension...
  30. doi request reprint A bioreactor for subjecting cultured cells to fast-rate intermittent hypoxia
    Theodora Tsapikouni
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Respir Physiol Neurobiol 182:47-52. 2012
    ..The proposed bioreactor can be easily and inexpensively assembled and is of practical use for investigating the effects of high-rate changes in oxygen concentration in the cell culture medium...
  31. ncbi request reprint Bench model to simulate upper airway obstruction for analyzing automatic continuous positive airway pressure devices
    Jordi Rigau
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Chest 130:350-61. 2006
    ....
  32. ncbi request reprint Oscillometric assessment of airway obstruction in a mechanical model of vocal cord dysfunction
    Jordi Rigau
    Unitat de Biofísica i Bioenginyeria Facultat de Medicina, Universitat de Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Casanova 143, Barcelona 08036, Spain
    J Biomech 37:37-43. 2004
    ..93(1/A(VC2)(2)-1/A(VC1)(2))+2.08 cm H(2)Os(2)/l(2); r(2)=0.99. We conclude that FOT could be a useful tool for non-invasively assessing glottic closure in VCD diagnosis, obviating the need for other invasive techniques...
  33. doi request reprint Mesenchymal stem cells reduce inflammation in a rat model of obstructive sleep apnea
    Alba Carreras
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Respir Physiol Neurobiol 172:210-2. 2010
    ..In conclusion, MSC triggered an early anti-inflammatory response in rats subjected to recurrent obstructive apneas, suggesting that these stem cells could play a role in the physiological response to counterbalance inflammation in OSA...
  34. ncbi request reprint Response of automatic continuous positive airway pressure devices to different sleep breathing patterns: a bench study
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina Casanova 143, Universitat de Barcelona, E 08036 Barcelona, Spain
    Am J Respir Crit Care Med 166:469-73. 2002
    ..Testing automatic CPAP devices in a bench study is a useful first step in evaluating the performance of this new type of device in adjusting nasal pressure for each patient...
  35. doi request reprint Sleep breathing flow characteristics as a sign for the detection of wakefulness in patients with sleep apnea
    Arnoldo Guerrero
    Sleep Laboratory, Servei de Pneumologia, Thorax Institute, Hospital Clinic IDIBAPS, Universitat de Barcelona, IDIBAPS, Barcelona, Spain
    Respiration 80:495-9. 2010
    ..To improve the performance of simplified sleep studies, it is essential to properly estimate the sleep time...
  36. doi request reprint Effects of heated humidification on nasal inflammation in a CPAP rat model
    Brígida Martínez-Vidal
    Otorhinolaryngology Department, Hospital Clinic, Barcelona, Spain
    Sleep Med 11:413-6. 2010
    ..Confounding factors such as previous rhinitis or nasal obstruction make it difficult to draw definitive conclusions. Animal models could therefore be useful...
  37. doi request reprint Non-invasive system for applying airway obstructions to model obstructive sleep apnea in mice
    Alba Carreras
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain CIBER Enfermedades Respiratorias, Bunyola, Spain
    Respir Physiol Neurobiol 175:164-8. 2011
    ..4 ± 2.5% nadir, with swings mimicking OSA patients. This novel system, capable of applying controlled recurrent airway obstructions in mice, is an easy-to-use tool for investigating pertinent aspects of OSA...
  38. doi request reprint An in vitro study to assess determinant features associated with fluid sealing in the design of endotracheal tube cuffs and exerted tracheal pressures
    Gianluigi Li Bassi
    Division of Pulmonary and Critical Care, Thorax Institute, Hospital Clinic, Barcelona, Spain
    Crit Care Med 41:518-26. 2013
    ....
  39. doi request reprint Automatic CPAP performance in patients with sleep apnea plus COPD
    Arnoldo Guerrero
    Sleep Laboratory, Servei de Pneumologia i Al lèrgia Respiratoria, Hospital Clinic IDIBAPS, Barcelona, Spain
    COPD 9:382-9. 2012
    ..However, automatic CPAP has not been fully studied in patients with COPD plus SAHS...
  40. pmc Integrin-specific mechanoresponses to compression and extension probed by cylindrical flat-ended AFM tips in lung cells
    Irene Acerbi
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 7:e32261. 2012
    ..Our findings provide new insights on how lung cells probe the mechanochemical properties of the microenvironment, an important process for migration, repair and tissue homeostasis...
  41. ncbi request reprint Oxygen in the alveolar air space mediates lung inflammation in acute pancreatitis
    Susana Granell
    Department of Experimental Pathology, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, 08036 Barcelona, Spain
    Free Radic Biol Med 37:1640-7. 2004
    ..Results indicated that, in the absence of oxygen in the alveolar space, the xanthine oxidase-dependent P-selectin expression did not occur and lung inflammation was significantly reduced...
  42. ncbi request reprint Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position: a randomized trial
    Mauricio Valencia
    Unitat de Cures Intensives I Intermèdies, Servei de Pneumologia, Institut Clinic del Torax, Hospital Clinic, Barcelona, Spain
    Crit Care Med 35:1543-9. 2007
    ..We assessed the efficacy of an automatic, validated device for the continuous regulation of tracheal tube cuff pressure in preventing ventilator-associated pneumonia...
  43. ncbi request reprint Electroencephalographic slowing heralds mild cognitive impairment in idiopathic REM sleep behavior disorder
    Alex Iranzo
    Neurology Service, Multidisciplinary Sleep Unit, Hospital Clinic de Barcelona, Institut D Investigació Biomèdiques August Pi i Sunyer, CIBERNED, Barcelona, Spain
    Sleep Med 11:534-9. 2010
    ..We hypothesized that those IRBD patients who later developed MCI had pronounced cortical EEG slowing at presentation...
  44. doi request reprint Early and mid-term effects of obstructive apneas in myocardial injury and inflammation
    Isaac Almendros
    CIBER Enfermedades Respiratorias, Spain
    Sleep Med 12:1037-40. 2011
    ..The aim of the present study was to investigate whether recurrent obstructive apneas could lead to myocardial injury...
  45. ncbi request reprint Quality control of mechanical ventilation at the patient's home
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Institut Investigacions Biomediques August Pi Sunyer, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
    Intensive Care Med 29:484-6. 2003
    ....
  46. ncbi request reprint Potential rebreathing after continuous positive airway pressure failure during sleep
    Ramon Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Chest 121:196-200. 2002
    ..Because common CPAP systems do not incorporate alarms, failure in the device or in the electric supply could result in rebreathing...
  47. ncbi request reprint Vibration enhances interleukin-8 release in a cell model of snoring-induced airway inflammation
    Ferranda Puig
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Spain
    Sleep 28:1312-6. 2005
    ..To test a cell model of snoring-induced airway inflammation and to assess whether a vibration stimulus simulating the one experienced by airway tissues in snoring patients induces inflammation in airway epithelial cells...
  48. ncbi request reprint Effects of the decellularization method on the local stiffness of acellular lungs
    Esther Melo
    1 Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Tissue Eng Part C Methods 20:412-22. 2014
    ..In conclusion, lung matrix stiffness is considerably inhomogeneous, and conventional decellularization procedures do not result in substantially different local stiffness in the acellular lung...
  49. pmc Cost-effectiveness of a new internet-based monitoring tool for neonatal post-discharge home care
    Valentina Isetta
    Unit of Biophysics and Bioengineering, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    J Med Internet Res 15:e38. 2013
    ..Conventional hospital-based postdischarge monitoring could be improved in terms of costs and clinical effectiveness by using a telemedicine approach...
  50. ncbi request reprint Pre-treatment with mesenchymal stem cells reduces ventilator-induced lung injury
    Laura Chimenti
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Casanova 143, 08036 Barcelona, Spain
    Eur Respir J 40:939-48. 2012
    ..All these indices of VILI moved significantly towards normalisation in the rats treated with MSCs, whether intravenously or intratracheally. Both local and systemic pre-treatment with MSCs reduced VILI in a rat model...
  51. ncbi request reprint Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin
    Xavier Trepat
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Casanova 143, 08036 Barcelona, Spain
    Am J Physiol Lung Cell Mol Physiol 290:L1104-10. 2006
    ..Our findings suggest that thrombin could exacerbate epithelial barrier dysfunction in injured lungs subjected to mechanical ventilation...
  52. pmc Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation
    Pere Roca-Cusachs
    Unitat de Biofisica i Bioenginyeria, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Biophys J 94:4984-95. 2008
    ....
  53. pmc Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells
    Pablo Ramos
    Thorax Institute, Unitat de Fibril lació Auricular, Hospital Clinic, Universitat de Barcelona and Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    Respir Res 15:54. 2014
    ..The aims of this work were to determine whether chronic obstructive sleep apnea (OSA) induces an atrial pro-arrhythmogenic substrate and to explore whether mesenchymal stem cells (MSC) are able to prevent it in a rat model of OSA...
  54. doi request reprint Effects of freezing/thawing on the mechanical properties of decellularized lungs
    Paula N Nonaka
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain Master s and Doctoral Degree Programs in Rehabilitation Sciences, Nove de Julho University, Sao Paulo, Brazil
    J Biomed Mater Res A 102:413-9. 2014
    ..0013). In conclusion, the freezing/thawing process that is commonly used for both organ decellularization and storage induces only minor changes in the ventilation mechanical properties of the organ scaffold...
  55. ncbi request reprint Oxygen diffusion and consumption in extracellular matrix gels: Implications for designing three-dimensional cultures
    Adai Colom
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Biomed Mater Res A 102:2776-84. 2014
    ..2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2776-2784, 2014. ..
  56. ncbi request reprint Cell dynamic adhesion and elastic properties probed with cylindrical atomic force microscopy cantilever tips
    Felix Rico
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    J Mol Recognit 20:459-66. 2007
    ..Taken together, these results suggest that the dynamic adhesion strength is counterbalanced by the dynamic elastic response to keep a constant cell deformation regardless of the applied pulling rate...
  57. doi request reprint Rapid detection of sepsis in rats through volatile organic compounds in breath
    Ana V Guamán
    Institute for Bioengineering of Catalonia IBEC, Baldiri i Rexach 4 08028 BCN, Spain
    J Chromatogr B Analyt Technol Biomed Life Sci 881:76-82. 2012
    ..In this study, performed using a rat sepsis model, we evaluate breath analysis with Ion Mobility Spectrometry (IMS) as a fast, portable and non-invasive strategy...
  58. ncbi request reprint Forced oscillation technique: from theory to clinical applications
    D Navajas
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain
    Monaldi Arch Chest Dis 56:555-62. 2001
    ..Finally, two recent promising applications of FOT are described: monitoring respiratory resistance during invasive and noninvasive mechanical ventilation, and detection of upper airway obstruction during sleep...
  59. ncbi request reprint Automatic regulation of the cuff pressure in endotracheally-intubated patients
    R Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Eur Respir J 20:1010-3. 2002
    ..Routine implementation of this procedure may be useful for protecting the trachea from tissue damage and for reducing the risk of ventilator-associated pneumonia...
  60. ncbi request reprint Analog circuit for real-time computation of respiratory mechanical impedance in sleep studies
    R Farre
    Laboratori Biofisica i Bioenginyeria, Facultat de Medicina, Barcelona, Spain
    IEEE Trans Biomed Eng 44:1156-9. 1997
    ..We concluded that the low-cost analog circuit developed could be a useful tool for facilitating the real-time assessment of airway obstruction in routine sleep studies...
  61. pmc Forced oscillation assessment of respiratory mechanics in ventilated patients
    D Navajas
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Institut d Investigacions Biomèdiques August Pi Sunyer, Universitat de Barcelona, Spain
    Crit Care 5:3-9. 2001
    ..The current methodological and technical experience make possible the implementation of portable and compact computerised FOT systems specifically addressed to its application in the mechanical ventilation setting...
  62. ncbi request reprint A portable forced oscillation device for respiratory home monitoring
    J Rigau
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Spain
    Eur Respir J 19:146-50. 2002
    ..074 +/- 0.025 and 0.005 +/- 0.009 cmH2O x s x L(-1), respectively. This portable forced oscillation technique device could be a useful tool for monitoring respiratory mechanics in ambulatory and home care applications...
  63. ncbi request reprint Respiratory input impedance during high frequency oscillatory ventilation
    D Navajas
    Lab, Biofísica i Bioenginyeria, Facultat de Medicina, Zona Universitaria, Pedralbes, Barcelona, Spain
    Br J Anaesth 63:85S-90S. 1989
    ..We concluded that Zrs measurements may be useful to monitor ventilatory mechanics and to determine the optimum settings of the ventilator during HFOV...
  64. doi request reprint Upper airway collapse and reopening induce inflammation in a sleep apnoea model
    I Almendros
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Eur Respir J 32:399-404. 2008
    ..These results could explain the inflammation observed in the upper airway of obstructive sleep apnoea patients...
  65. ncbi request reprint Relevance of linearizing nasal prongs for assessing hypopneas and flow limitation during sleep
    R Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona and Institut de Pneumologia, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain
    Am J Respir Crit Care Med 163:494-7. 2001
    ..This procedure, which could be readily carried out in routine practice by means of the analog circuit we developed, is of interest in optimizing the assessment of respiratory sleep disturbances in SAHS...
  66. ncbi request reprint Flow-dependent positive airway pressure to maintain airway patency in sleep apnea-hypopnea syndrome
    R Farre
    Lab Biofísica i Bioenginyeria, Facultat de Medicina, Institute d Investigacions Biomèdiques Agusti Pi i Sunyer, Universitat de Barcelona, Spain
    Am J Respir Crit Care Med 157:1855-63. 1998
    ..1 +/- 1.2 cm H2O). The results found in models and in patients suggest that adapting the applied nasal pressure to the instantaneous breathing flow may be of potential practical interest in SAHS...
  67. ncbi request reprint Forced oscillation measurements do not affect upper airway muscle tone or sleep in clinical studies
    J R Badia
    , , Barcelona, Spain
    Eur Respir J 18:335-9. 2001
    ....
  68. ncbi request reprint Oscillatory resistance measured during noninvasive proportional assist ventilation
    R Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Am J Respir Crit Care Med 164:790-4. 2001
    ..These results suggest that FOT could be useful in setting PAV flow assistance and in automatically and continuously updating this setting in accordance with patient resistance...
  69. ncbi request reprint Effectiveness of CPAP treatment in daytime function in sleep apnea syndrome: a randomized controlled study with an optimized placebo
    J M Montserrat
    , , Barcelona, Spain
    Am J Respir Crit Care Med 164:608-13. 2001
    ..5 versus -11.2, p = 0.02). Our study provides strong evidence of the effectiveness of CPAP treatment in improving symptoms and perceived health status in moderate to severe SAHS...
  70. ncbi request reprint Importance of the pulse oximeter averaging time when measuring oxygen desaturation in sleep apnea
    R Farre
    Lab Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Sleep 21:386-90. 1998
    ....
  71. ncbi request reprint Evaluation of a simplified oscillation technique for assessing airway obstruction in sleep apnoea
    R Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Spain
    Eur Respir J 17:456-61. 2001
    ..These results demonstrate that this simplified FOT is applicable for measuring airway obstruction during routine sleep studies in patients with sleep apnoea...