Research Topics
| Fernando ClimentSummaryAffiliation: Universitat de Barcelona Country: Spain Publications
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Detail Information
Publications
Red cell glycolytic enzyme disorders caused by mutations: an updateFernando Climent
Departament de Ciències Fisiològiques I, Unitat de Bioquimica, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
Cardiovasc Hematol Disord Drug Targets 9:95-106. 2009..Understanding of the crystal structure of enzymes permits molecular modelling studies which, in turn, reveal how mutations can affect enzyme structure and function...
Effects of thyroid hormone and hypoxia on 2,3-bisphosphoglycerate, bisphosphoglycerate synthase and phosphoglycerate mutase in rabbit erythroblasts and reticulocytes in vivoNuria Gonzalez-Cinca
Unitat de Bioquimica, Departament de Ciències Fisiològiques I, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
Horm Res 62:191-6. 2004....
Enzymatic and metabolic characterization of the phosphoglycerate kinase deficiency associated with chronic hemolytic anemia caused by the PGK-Barcelona mutationMaría José Ramírez-Bajo
Unitat de Bioquímica i Biologia Molecular, Departament de Ciències Fisiològiques I, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
Blood Cells Mol Dis 46:206-11. 2011..The increase of 2,3-bisphosphoglycerate and the decrease of ATP RBC levels are the only detected metabolic changes that could cause hemolytic anemia...
Red cell glucose phosphate isomerase (GPI): a molecular study of three novel mutations associated with hereditary nonspherocytic hemolytic anemiaAda Repiso
Unitat de Bioquimica, Departament de Ciències Fisiològiques I, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
Hum Mutat 27:1159. 2006..341A>T (p.Asp113Val) in exon 4 and c.663T>G (p.Asn220Lys) in exon 7. Molecular modeling using the human crystal structure of GPI as a model was performed to determine how these mutations could affect enzyme structure and function...
Characterization of the first described mutation of human red blood cell phosphoglycerate mutasePedro de Atauri
, , Facultat de Medicina, , Universitat de Barcelona, Spain
Biochim Biophys Acta 1740:403-10. 2005..However, the implication of a change of the k(cat) produced by the mutation cannot be discarded, since we could not determine the k(cat) value of the mutated PGAM...
Effects of hypoxia and thyroid hormone on mRNA levels and activity of phosphoglycerate mutase in rabbit tissuesNuria Gonzalez-Cinca
Departament de Ciències Fisiològiques I, Institut d Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina, Universitat de Barcelona, Spain
Horm Res 59:16-20. 2003..In the present work, we studied the effects of hypoxia and triiodothyronine (T(3)) on phosphoglycerate mutase (PGAM) activity and expression in rabbit liver, brain, and skeletal muscle under in vivo conditions...
Red blood cell phosphosphoglycerate mutase. Description of the first human BB isoenzyme mutationAda Repiso
, , Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036-Barcelona, Spain
Haematologica 88:ECR07. 2003
Glucose phosphate isomerase deficiency: enzymatic and familial characterization of Arg346His mutationAda Repiso
, , Facultat de Medicina, , Universitat de Barcelona, Spain
Biochim Biophys Acta 1740:467-71. 2005....
Effects of thyroid hormone on mRNAs of phosphoglycerate mutase subunits in rat muscle during developmentNuria Gonzalez-Cinca
Unitat de Bioquimica, Departament de Ciències Fisiològiques I, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Spain
Horm Res 57:48-52. 2002..We previously showed that triiodothyronine (T3) stimulates muscle phosphoglycerate mutase (PGAM) activity and isozyme transition in rat skeletal and cardiac muscles...
Triosephosphate isomerase deficiency. genetic, enzymatic and metabolic characterization of a new case from SpainAda Repiso
, , Facultat de Medicina, , Universitat de Barcelona, Casanovas 143, 08036 Barcelona, Spain
Haematologica 87:ECR12. 2002
