F Ciruela

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. doi request reprint G protein-coupled receptor oligomerization and brain integration: focus on adenosinergic transmission
    Francisco Ciruela
    Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, 08907 Barcelona, Spain
    Brain Res 1476:86-95. 2012
  2. ncbi request reprint Muscarinic acetylcholine receptor-interacting proteins (mAChRIPs): targeting the receptorsome
    D O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Curr Drug Targets 13:53-71. 2012
  3. pmc Lighting up multiprotein complexes: lessons from GPCR oligomerization
    Francisco Ciruela
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL Universitat de Barcelona, 08907 Barcelona, Spain
    Trends Biotechnol 28:407-15. 2010
  4. doi request reprint Fluorescence-based methods in the study of protein-protein interactions in living cells
    Francisco Ciruela
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina Campus de Bellvitge, IDIBELL Universitat de Barcelona, 08907 L Hospitalet del Llobregat, Barcelona, Spain
    Curr Opin Biotechnol 19:338-43. 2008
  5. doi request reprint Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling
    Francisco Ciruela
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina Bellvitge, Pavelló de Govern, Universitat de Barcelona, 08907 L Hospitalet del Llobregat, Barcelona, Spain
    Biochim Biophys Acta 1798:9-20. 2010
  6. ncbi request reprint Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function
    Francisco Ciruela
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, 08028 Barcelona, Spain
    J Mol Neurosci 26:277-92. 2005
  7. doi request reprint G protein-coupled receptor oligomerization for what?
    Francisco Ciruela
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL Universitat de Barcelona, 08907 Barcelona, Spain
    J Recept Signal Transduct Res 30:322-30. 2010
  8. doi request reprint Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits
    Francisco Ciruela
    Unitat de Farmacologia 4102, Departament Patologia i Terapèutica Experimental, Facultat de Medicina Bellvitge, Universitat de IDIBELL Universitat de Barcelona, L Hospitalet de Llobregat, Barcelona, Spain
    Eur J Neurosci 32:1265-77. 2010
  9. doi request reprint Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain
    Francisco Ciruela
    Departament de Patologia i Terapèutica Experimental, Universitat de Barcelona, 08097 L Hospitalet de Llobregat, Spain
    Biochim Biophys Acta 1808:1245-55. 2011
  10. ncbi request reprint Heterodimeric adenosine receptors: a device to regulate neurotransmitter release
    F Ciruela
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Avda Diagonal, 645, 08028, Barcelona, Spain
    Cell Mol Life Sci 63:2427-31. 2006

Collaborators

Detail Information

Publications57

  1. doi request reprint G protein-coupled receptor oligomerization and brain integration: focus on adenosinergic transmission
    Francisco Ciruela
    Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, 08907 Barcelona, Spain
    Brain Res 1476:86-95. 2012
    ..This article is part of a Special Issue entitled: Brain Integration...
  2. ncbi request reprint Muscarinic acetylcholine receptor-interacting proteins (mAChRIPs): targeting the receptorsome
    D O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Curr Drug Targets 13:53-71. 2012
    ....
  3. pmc Lighting up multiprotein complexes: lessons from GPCR oligomerization
    Francisco Ciruela
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL Universitat de Barcelona, 08907 Barcelona, Spain
    Trends Biotechnol 28:407-15. 2010
    ..Here we provide a comprehensive update on all the biotechnological aspects, including the strengths and weaknesses, of new fluorescence- and luminescence-based methodologies, with a specific focus on their application for studying PPIs...
  4. doi request reprint Fluorescence-based methods in the study of protein-protein interactions in living cells
    Francisco Ciruela
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina Campus de Bellvitge, IDIBELL Universitat de Barcelona, 08907 L Hospitalet del Llobregat, Barcelona, Spain
    Curr Opin Biotechnol 19:338-43. 2008
    ..Here we address the individual strengths and weaknesses of these methods when applied to the study of protein-protein interactions...
  5. doi request reprint Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling
    Francisco Ciruela
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina Bellvitge, Pavelló de Govern, Universitat de Barcelona, 08907 L Hospitalet del Llobregat, Barcelona, Spain
    Biochim Biophys Acta 1798:9-20. 2010
    ....
  6. ncbi request reprint Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function
    Francisco Ciruela
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, 08028 Barcelona, Spain
    J Mol Neurosci 26:277-92. 2005
    ..Finally, given the complexity of neurological disorders such as ischemic stroke, Alzheimer's disease, and epilepsy, exploitation of these HSMR-associated interactions might prove to be efficient in the treatment of such disorders...
  7. doi request reprint G protein-coupled receptor oligomerization for what?
    Francisco Ciruela
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL Universitat de Barcelona, 08907 Barcelona, Spain
    J Recept Signal Transduct Res 30:322-30. 2010
    ..Overall, the rationale of receptor oligomerization might lie in the cellular need of sensing complex extracellular signals and to translate into a simple computational mode...
  8. doi request reprint Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits
    Francisco Ciruela
    Unitat de Farmacologia 4102, Departament Patologia i Terapèutica Experimental, Facultat de Medicina Bellvitge, Universitat de IDIBELL Universitat de Barcelona, L Hospitalet de Llobregat, Barcelona, Spain
    Eur J Neurosci 32:1265-77. 2010
    ....
  9. doi request reprint Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain
    Francisco Ciruela
    Departament de Patologia i Terapèutica Experimental, Universitat de Barcelona, 08097 L Hospitalet de Llobregat, Spain
    Biochim Biophys Acta 1808:1245-55. 2011
    ....
  10. ncbi request reprint Heterodimeric adenosine receptors: a device to regulate neurotransmitter release
    F Ciruela
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Avda Diagonal, 645, 08028, Barcelona, Spain
    Cell Mol Life Sci 63:2427-31. 2006
    ....
  11. pmc The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane
    S Sarrió
    Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain
    Mol Cell Biol 20:5164-74. 2000
    ..These results open the interesting possibility that signaling via G protein-coupled receptors may be regulated by heat shock proteins...
  12. ncbi request reprint Adenosine deaminase interacts with A1 adenosine receptors in pig brain cortical membranes
    C Saura
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Catalonia, Spain
    J Neurochem 66:1675-82. 1996
    ..Thus, it seems that adenosine deaminase is necessary for coupling A1 adenosine receptors to heterotrimeric G proteins...
  13. ncbi request reprint The cluster-arranged cooperative model: a model that accounts for the kinetics of binding to A1 adenosine receptors
    R Franco
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, Catalonia, Spain
    Biochemistry 35:3007-15. 1996
    ..Our model can likely explain the behavior of a number of heptaspanning and tyrosine-kinase receptors exhibiting complex binding kinetics...
  14. ncbi request reprint Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors
    F Ciruela
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Spain
    FEBS Lett 380:219-23. 1996
    ..These findings demonstrate that, apart from the cleavage of adenosine, a further role of ecto-adenosine deaminase on the cell surface is to facilitate the signal transduction via A1R...
  15. ncbi request reprint Receptor-receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins
    R Franco
    Molecular Neurobiology Unit, Department of Biochemistry and Molecular Biology, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Neural Transm 114:93-104. 2007
    ..Overall, the knowledge of the reason why such complex networks of receptor-receptor and receptor-protein interactions occur in striatal cells is crucial to develop new strategies to combat neurological and neuropsychiatric diseases...
  16. ncbi request reprint Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line
    S Gines
    Departament de Bioquimica i Biologia Molecular, Facultat de Química Universitat de Barcelona, Spain
    Mol Pharmacol 59:1314-23. 2001
    ..These results indicate that A(1)R and ADA form a stable complex in the cell surface of LLC-PK(1) cells and that agonist-induced internalization of the A(1) adenosine receptor and ADA is mediated by clathrin-independent endocytosis...
  17. ncbi request reprint Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells
    C Herrera
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, Barcelona, Spain
    Mol Pharmacol 59:127-34. 2001
    ..Therefore, in lymphocytes, cell surface ADA, apart from degrading extracellular adenosine, regulates those actions of adenosine that are mediated via adenosine receptors of the A2B subtype...
  18. pmc G-protein-coupled receptor heteromers: function and ligand pharmacology
    R Franco
    Departament de Bioquimica i Biologia Molecular, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Br J Pharmacol 153:S90-8. 2008
    ..This fact should be taken into account in the development of new drugs...
  19. ncbi request reprint Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes
    F Ciruela
    Department of Biochemistry, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 276:18345-51. 2001
    ....
  20. pmc Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain
    S Gonzalez
    Department of Biochemistry and Molecular Biology, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, Barcelona, Spain
    Mol Psychiatry 17:650-62. 2012
    ..It is therefore postulated that dysfunctional D(2S)-D(4.7) heteromers may impair presynaptic dopaminergic control of corticostriatal glutamatergic neurotransmission and explain functional deficits associated with ADHD...
  21. ncbi request reprint Cell surface adenosine deaminase: much more than an ectoenzyme
    R Franco
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Catalonia, Spain
    Prog Neurobiol 52:283-94. 1997
    ..On the other hand, ectoADA might act as a bridge between two different cells thus raising the possibility that it may be important for the development of the nervous system...
  22. doi request reprint Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice
    Víctor Fernández-Dueñas
    Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, 08907 Barcelona, Spain
    Eur J Pharmacol 638:72-7. 2010
    ..Overall, our results clearly show that R-(alpha)-methylhistamine enhances fentanyl effects at peripheral sites, and that the control of substance P levels might be one of the mechanisms responsible of such interaction...
  23. ncbi request reprint Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
    Meritxell Canals
    Department of Biochemistry and Molecular Biology, University of Barcelona, Martí y Franquès 1, E 08028 Barcelona, Spain
    J Biol Chem 278:46741-9. 2003
    ..In the most probable one, helix 5 and/or helix 6 and the N-terminal portion of I3 from D2R approached helix 4 and the C-terminal portion of the C-tail from the A2AR, respectively...
  24. ncbi request reprint The two-state dimer receptor model: a general model for receptor dimers
    Rafael Franco
    Dept Bioquimica i Biologia Molecular, Universitat de Barcelona, Av Diagonal 645, 08028 Barcelona, Spain
    Mol Pharmacol 69:1905-12. 2006
    ..In summary, the two-state dimer receptor model is good for fitting data of binding to dimeric receptors displaying either linear, concave upward, or concave downward Scatchard plots...
  25. ncbi request reprint Partners for adenosine A1 receptors
    Rafael Franco
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    J Mol Neurosci 26:221-32. 2005
    ..There is even the possibility of linking together GPCR heteromeric complexes with ion channel receptors in a receptor mosaic that might have special integrative value and might constitute the molecular basis for learning and memory...
  26. doi request reprint Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain
    Víctor Fernández-Dueñas
    Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, L Hospitalet de Llobregat, 08907 Barcelona, Spain
    Pharmacol Biochem Behav 98:331-6. 2011
    ..Overall, the triple combination of fentanyl-trazodone-paracetamol induced a potent synergistic antinociceptive effect, which could be of interest for optimal multimodal clinical analgesia...
  27. ncbi request reprint Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling
    Marisol Escriche
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, 08028, Barcelona, Spain
    Exp Cell Res 285:72-90. 2003
    ..These results give insight into the spatiotemporal regulation and traffic of A(1)R and RAMPs...
  28. ncbi request reprint Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization
    Jorge Gandia
    Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, Spain
    Bioessays 30:82-9. 2008
    ..In the present review, we address the individual strengths and weaknesses of both RET approaches, providing information on their possible future use in the study of G protein-coupled receptor oligomerization...
  29. ncbi request reprint Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
    Meritxell Canals
    Department of Biochemistry and Molecular Biology of the University of Barcelona, Barcelona, Spain
    J Neurochem 88:726-34. 2004
    ..As A2AR and dopamine D2 receptors do indeed interact, these results indicate that A2AR homodimers are the functional species at the cell surface and that they coexist with A2AR/D2 receptor heterodimers...
  30. doi request reprint Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells
    Nuria Cabello
    IDIBAPS, CIBERNED and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 109:1497-507. 2009
    ....
  31. doi request reprint Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer
    Gemma Navarro
    Institut d Investigacions Biomèdiques August Pi i Sunyer Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, y Departamento de Bioquímica y Biología Molecular, Facultad de Biologia, Universitat de Barcelona, Spain
    ScientificWorldJournal 8:1088-97. 2008
    ..Here a combination of bimolecular fluorescence complementation and bioluminescence energy transfer techniques was used to identify the occurrence of D2R-CB1R-A2AR hetero-oligomers in living cells...
  32. doi request reprint Detection of heteromerization of more than two proteins by sequential BRET-FRET
    Paulina Carriba
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, University of Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain
    Nat Methods 5:727-33. 2008
    ..SRET is an invaluable technique to identify heteromeric complexes of more than two neurotransmitter receptors, which will allow us to better understand how signals are integrated at the molecular level...
  33. doi request reprint Regulation of α₂-adrenoceptor gene expression by chronic lithium treatment in rat brain
    M L Cuffí
    Department of Pathology and Experimental Therapeutics, School of Medicine, University of Barcelona, L Hospitalet de Llobregat, Spain
    Methods Find Exp Clin Pharmacol 32:721-5. 2010
    ..Lithium produced an overexpression of the Adra2A gene after chronic treatment that made the neuron ready to produce α₂-adrenoceptors to deal with their inactivation...
  34. doi request reprint The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function
    Laia Canela
    IDIBAPS, CIBERNED and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 111:555-67. 2009
    ..Overall, these findings indicate that NECAB2 by its physical interaction with mGlu(5b) receptor modulates receptor function...
  35. doi request reprint Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique
    Jorge Gandia
    Departament Patologia i Terapèutica Experimental, Facultat de Medicina, Universitat de Barcelona, Pavelló de Govern, L Hospitalet de Llobregat, 08907 Barcelona, Spain
    FEBS Lett 582:2979-84. 2008
    ..These results provide new insights into the molecular composition of G protein-coupled receptor oligomers...
  36. ncbi request reprint Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain
    Lydia Gimenez-Llort
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, School of Medicine, Institute of Neuroscience, Autonomous University of Barcelona, Barcelona, Spain
    Neurobiol Learn Mem 87:42-56. 2007
    ....
  37. ncbi request reprint Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors
    Francisco Ciruela
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, E 08028, Spain
    Anal Chem 76:5354-63. 2004
    ..The present results are the first example of epitope-epitope electrostatic interaction underlying receptor heteromerization, a new, expanding area of protein-protein interactions...
  38. ncbi request reprint Dimer-based model for heptaspanning membrane receptors
    Rafael Franco
    Department Bioquímica i Biologia Molecular, Universitat de Barcelona, A Diagonal, 645 08028 Barcelona, Spain
    Trends Biochem Sci 30:360-6. 2005
    ..This model can aid our understanding of the operation of heptaspanning receptors and receptor channels, and, potentially, be important for improving the treatment of cardiovascular, neurological and neuropsychyatric diseases...
  39. ncbi request reprint The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor
    Laia Canela
    Institut d Investigacions Biomèdiques August Pi i Sunyer and Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Mol Cell Neurosci 36:1-12. 2007
    ..Overall, these results show that A(2A)R interacts with NECAB2 in striatal neurones co-expressing the two proteins and that the interaction is relevant for A(2A)R function...
  40. ncbi request reprint The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin
    Javier Burgueno
    Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 278:37545-52. 2003
    ..These findings suggest an alpha-actinin-dependent association between the actin cytoskeleton and A2AR trafficking...
  41. ncbi request reprint Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers
    Francisco Ciruela
    Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain
    J Neurosci 26:2080-7. 2006
    ....
  42. ncbi request reprint Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions
    Javier Burgueno
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 86:785-91. 2003
    ..Overall, these results clearly show a molecular and functional association of mGlu1alpha receptor with caveolins...
  43. ncbi request reprint Glutamate released by dendritic cells as a novel modulator of T cell activation
    Rodrigo Pacheco
    Department of Biochemistry and Molecular Biology, Faculty of Biology and Institut d Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Immunol 177:6695-704. 2006
    ..These data suggest that, during T cell-DC interaction, glutamate is a novel and highly effective regulator in the initiation of T cell-mediated immune responses...
  44. ncbi request reprint Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor
    Nuria Cabello
    Institut d Investigacions Biomèdiques August Pi i Sunyer and Department of Biochemistry and Molecular Biology, University of Barcelona, Facultat de Biologia, Avda Diagonal 645, Barcelona 08028, Spain
    J Biol Chem 282:12143-53. 2007
    ..Together, these findings indicate that there is an alpha-actinin-1-dependent mGlu(5b) receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning...
  45. ncbi request reprint Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids
    Paulina Carriba
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    Neuropsychopharmacology 32:2249-59. 2007
    ..These biochemical and behavioral findings demonstrate that the profound motor effects of cannabinoids depend on physical and functional interactions between striatal A2A and CB1 receptors...
  46. ncbi request reprint Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation
    Rodrigo Pacheco
    Department of Biochemistry and Molecular Biology, University of Barcelona, 08028 Barcelona, Spain
    J Biol Chem 279:33352-8. 2004
    ..This is a novel non-inhibitory action mechanism for glutamate in lymphocyte activation. mGlu1R and mGlu5R thus mediate opposite glutamate effects in human lymphocytes...
  47. ncbi request reprint Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation
    Davide Quarta
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurochem 91:873-80. 2004
    ..Furthermore, these results underscore the role of A(1) vs. A(2A) receptor antagonism in the central effects of caffeine...
  48. ncbi request reprint The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration
    Carolina Ladera
    Departamento de Bioquimica, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    J Neurochem 103:2314-26. 2007
    ....
  49. ncbi request reprint Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    Front Biosci 13:2391-9. 2008
    ..The analysis of the function of A1-A2A receptor heteromers during chronic treatment with caffeine gives new clues about the well-known phenomenon of tolerance to the psychostimulant effects of caffeine...
  50. ncbi request reprint Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity
    Javier Burgueno
    Department of Biochemistry and Molecular Biology University of Barcelona Barcelona, Spain
    Exp Cell Res 300:23-34. 2004
    ..Interestingly, we provide evidence that caveolin-1 is not just acting as a scaffolding protein for the mGlu1alpha receptor but that also regulates mGlu1alpha receptor constitutive activity...
  51. ncbi request reprint Adenosine receptor heteromers and their integrative role in striatal function
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    ScientificWorldJournal 7:74-85. 2007
    ..For instance, the adenosine A2A-dopamine D2 receptor heteromers work as integrators of two different neurotransmitters in the striatal spine module...
  52. ncbi request reprint Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index
    Vincent Casadó
    IDIBAPS and CIBERNED Centro de Investigación en Red sobre Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain
    Pharmacol Ther 116:343-54. 2007
    ..The new procedure can be applied to any receptor forming dimers; from receptor tyrosine kinases to intracellular receptors (e.g., estrogen receptor) and in general for ligand binding to proteins forming dimers...
  53. ncbi request reprint Role of electrostatic interaction in receptor-receptor heteromerization
    Amina S Woods
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    J Mol Neurosci 26:125-32. 2005
    ....
  54. ncbi request reprint Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA
    J Integr Neurosci 4:445-64. 2005
    ....
  55. ncbi request reprint Regulation of heptaspanning-membrane-receptor function by dimerization and clustering
    Rafael Franco
    Department of Biochemistry and Molecular Biology of the University of Barcelona, Martí Franques 1, Spain
    Trends Biochem Sci 28:238-43. 2003
    ..This concept gives a new perspective to the understanding of neurotransmission and neuronal plasticity...
  56. pmc Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, U SA
    Proc Natl Acad Sci U S A 99:11940-5. 2002
    ..The results suggest that a functional mGluR5/A2AR interaction is required to overcome the well-known strong tonic inhibitory effect of dopamine on striatal adenosine A2AR function...
  57. ncbi request reprint Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release
    Leif Hove-Madsen
    Cell Physiology Laboratory, Cardiology Department, Hospital de la Santa Creu i Sant Pau, Institut Català de Ciencies Cardiovasculars, Universitat Autonoma de Barcelona, St Antoni M a Claret 167, 08025 Barcelona, Spain
    Cardiovasc Res 72:292-302. 2006
    ..While the adenosine A(2A) receptor (A(2A)R) is known to regulate cyclic AMP levels, expression and function of this receptor in human cardiac myocytes has not been investigated...