A Chamorro

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. ncbi request reprint The Early Systemic Prophylaxis of Infection After Stroke study: a randomized clinical trial
    A Chamorro
    Stroke Unit, Hospital Clinic, and Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Stroke 36:1495-500. 2005
  2. ncbi request reprint Immediate anticoagulation for acute stroke in atrial fibrillation: yes
    Angel Chamorro
    Stroke Unit, Department of Neurological Sciences, Instituto de Investigaciones Biomedicas August Pi i Sunyer, Hospital Clinic Barcelona, 170 Villarroel, 08036 Barcelona, Spain
    Stroke 37:3052-3. 2006
  3. ncbi request reprint Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression
    Angel Chamorro
    Stroke Unit, Hospital Clínic and Institut d Investigations biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Stroke 38:1097-103. 2007
  4. pmc Risks and benefits of early antithrombotic therapy after thrombolytic treatment in patients with acute stroke
    Sergio Amaro
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, Barcelona, Spain
    PLoS ONE 8:e71132. 2013
  5. doi request reprint The immunology of acute stroke
    Angel Chamorro
    Comprehensive Stroke Center, Department of Neuroscience, Hospital Clinic, University of Barcelona, 170 Villarroel, 08036 Barcelona, Spain
    Nat Rev Neurol 8:401-10. 2012
  6. pmc Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke
    A Chamorro
    Stroke Unit, Hospital Clinic and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Hospital Clinic, 08036 Barcelona, Spain
    J Neurol Neurosurg Psychiatry 77:1279-81. 2006
  7. doi request reprint Heparin in acute ischemic stroke revisited
    A Chamorro
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, Barcelona, Spain
    Rev Neurol (Paris) 164:815-8. 2008
  8. pmc The harms and benefits of inflammatory and immune responses in vascular disease
    Angel Chamorro
    The Stroke Unit, Institute of Clinical Neurosciences, Hospital Clinic, 08036 Barcelona, Spain
    Stroke 37:291-3. 2006
  9. ncbi request reprint The rapid anticoagulation prevents ischemic damage study in acute stroke--final results from the writing committee
    A Chamorro
    Stroke Unit, Hospital Clinic, Barcelona, Spain
    Cerebrovasc Dis 19:402-4. 2005
  10. ncbi request reprint Catecholamines, infection, and death in acute ischemic stroke
    Angel Chamorro
    Stroke Unit, Hospital Clinic and Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    J Neurol Sci 252:29-35. 2007

Collaborators

Detail Information

Publications61

  1. ncbi request reprint The Early Systemic Prophylaxis of Infection After Stroke study: a randomized clinical trial
    A Chamorro
    Stroke Unit, Hospital Clinic, and Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Stroke 36:1495-500. 2005
    ..Early infection after stroke is frequent but the clinical value of antibiotic prophylaxis in acute stroke has never been explored...
  2. ncbi request reprint Immediate anticoagulation for acute stroke in atrial fibrillation: yes
    Angel Chamorro
    Stroke Unit, Department of Neurological Sciences, Instituto de Investigaciones Biomedicas August Pi i Sunyer, Hospital Clinic Barcelona, 170 Villarroel, 08036 Barcelona, Spain
    Stroke 37:3052-3. 2006
  3. ncbi request reprint Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression
    Angel Chamorro
    Stroke Unit, Hospital Clínic and Institut d Investigations biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Stroke 38:1097-103. 2007
    ..Infection after experimental focal ischemia may result from brain-induced immunodepression, but it is unsettled whether a similar syndrome occurs in human stroke...
  4. pmc Risks and benefits of early antithrombotic therapy after thrombolytic treatment in patients with acute stroke
    Sergio Amaro
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, Barcelona, Spain
    PLoS ONE 8:e71132. 2013
    ..Herein, we report a retrospective analysis of a single-centre experience on the safety and efficacy of antithrombotic therapy (ATT) started before or after 24 h of intravenous thrombolysis in a cohort of acute ischemic stroke patients...
  5. doi request reprint The immunology of acute stroke
    Angel Chamorro
    Comprehensive Stroke Center, Department of Neuroscience, Hospital Clinic, University of Barcelona, 170 Villarroel, 08036 Barcelona, Spain
    Nat Rev Neurol 8:401-10. 2012
    ..Ongoing clinical trials are investigating whether the preventive use of antibiotics improves functional outcome after stroke. This Review discusses the multifaceted role of the immune system in the pathophysiology of acute stroke...
  6. pmc Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke
    A Chamorro
    Stroke Unit, Hospital Clinic and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Hospital Clinic, 08036 Barcelona, Spain
    J Neurol Neurosurg Psychiatry 77:1279-81. 2006
    ..The pathophysiology of stroke-associated infection (SAI) is uncertain. The cytokine profile and peripheral white cell response were assessed in patients with or without SAI...
  7. doi request reprint Heparin in acute ischemic stroke revisited
    A Chamorro
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, Barcelona, Spain
    Rev Neurol (Paris) 164:815-8. 2008
    ..Meanwhile, recommendations against the value of "early" anticoagulation with full dose of weight adjusted UH in the setting of acute ischemic stroke are not based on direct evidence but on extrapolations...
  8. pmc The harms and benefits of inflammatory and immune responses in vascular disease
    Angel Chamorro
    The Stroke Unit, Institute of Clinical Neurosciences, Hospital Clinic, 08036 Barcelona, Spain
    Stroke 37:291-3. 2006
  9. ncbi request reprint The rapid anticoagulation prevents ischemic damage study in acute stroke--final results from the writing committee
    A Chamorro
    Stroke Unit, Hospital Clinic, Barcelona, Spain
    Cerebrovasc Dis 19:402-4. 2005
  10. ncbi request reprint Catecholamines, infection, and death in acute ischemic stroke
    Angel Chamorro
    Stroke Unit, Hospital Clinic and Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    J Neurol Sci 252:29-35. 2007
    ..Moreover, these findings are independent of the blood borne effects of pro- and anti-inflammatory cytokines, and circulating leukocytes...
  11. doi request reprint TP receptor antagonism: a new concept in atherothrombosis and stroke prevention
    Angel Chamorro
    Hospital Clinic of Barcelona, Department of Neurosciences, 170 Villarroel, Barcelona ES 08036, Spain
    Cerebrovasc Dis 27:20-7. 2009
    ..A large trial is currently comparing the efficacy and safety of terutroban versus aspirin in secondary prevention of cardiovascular events in patients who have suffered a stroke or transient ischemic attack (PERFORM Study)...
  12. doi request reprint Dual antiplatelet therapy is not optimal for stroke prevention in patients with atrial fibrillation
    A Chamorro
    Comprehensive Stroke Center, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Int J Stroke 5:28-9. 2010
    ..However, the relative risk of major bleeding was also significantly increased. This article analyses critically the role of dual antiplatelet therapy for stroke prevention in patients with atrial fibrillation...
  13. ncbi request reprint The BC genotype of the VNTR polymorphism of platelet glycoprotein Ibalpha is overrepresented in patients with recurrent stroke regardless of aspirin therapy
    A Cervera
    Stroke Unit, Department of Neurological Sciences, Hospital Clinic, University of Barcelona, and Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Cerebrovasc Dis 24:242-6. 2007
    ..The contribution of genetic factors to aspirin treatment failure (ATF) for secondary prevention is not settled in patients with ischemic stroke...
  14. ncbi request reprint Prevention of ischemic stroke: antithrombotic therapy in cardiac embolism
    A Cervera
    Stroke Unit, Institut of Clinical Neurosciences, Hospital Clinic, University of Barcelona and Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Curr Drug Targets 8:824-31. 2007
    ....
  15. ncbi request reprint Comparison of the acute-phase response in patients with ischemic stroke treated with high-dose heparin or aspirin
    A Chamorro
    Stroke Unit, Neurology Service IDIBAPS Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain
    J Neurol Sci 178:17-22. 2000
    ..This study shows that full-dose UH reduces the acute-phase reaction that follows ischemic stroke more effectively than aspirin. The prognostic implications of such effect seem more notable in patients with nonlacunar stroke...
  16. ncbi request reprint Blood pressure and functional recovery in acute ischemic stroke
    A Chamorro
    Neurology Service IDIBAPS, Hospital Clinic, Barcelona, Spain
    Stroke 29:1850-3. 1998
    ..We aimed to evaluate the rate of functional recovery with relation to early blood pressure management in patients with ischemic stroke...
  17. doi request reprint Harms and benefits of lymphocyte subpopulations in patients with acute stroke
    X Urra
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, and Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Neuroscience 158:1174-83. 2009
    ..Lymphocytes are major players in the development of innate and adaptive immune responses but their behavior in patients with acute stroke has received little attention...
  18. ncbi request reprint The -174G/C polymorphism of the interleukin 6 gene is a hallmark of lacunar stroke and not other ischemic stroke phenotypes
    A Chamorro
    Neurology Service and Institut d Investigació Biomedica August Pi i Sunyer, Hospital Clinic, Pharmacology and Toxicology Department, Barcelona, Spain
    Cerebrovasc Dis 19:91-5. 2005
    ..The CC genotype of the -174 G/C interleukin (IL)-6 polymorphism has been associated with lacunar stroke. However, it remains unsettled whether this polymorphism is also associated with other ischemic stroke phenotypes...
  19. ncbi request reprint Ex vivo response to aspirin differs in stroke patients with single or recurrent events: a pilot study
    A Chamorro
    Neurology Service IDIBAPS, Stroke Unit, Hospital Clinic, Villarroel 170, 08036, Barcelona, Spain
    J Neurol Sci 171:110-4. 1999
    ..It is likely that patients could receive a more efficacious stroke prevention if the dose of aspirin is tailored to individual needs as reflected by laboratory findings...
  20. doi request reprint The response to IV rt-PA in very old stroke patients
    M Gomez-Choco
    Stroke Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain
    Eur J Neurol 15:253-6. 2008
    ..The rates of clinical improvement, mortality, or symptomatic CNS bleeding were also unrelated to age and sex. In conclusion, the response to IV rtPA is not impaired in elderly stroke patients and male and female are equally responsive...
  21. ncbi request reprint [Heparin in acute cerebral ischemia]
    A Chamorro
    Servicio de Neurologia, Hospital Clinic, Barcelona
    Neurologia 14:41-6. 1999
    ..Based on the results shown it is concluded that it is necessary to prospectively evaluate the role of heparin in acute ischemic ictus...
  22. ncbi request reprint Interaction between interleukin-6 and the natural anticoagulant system in acute stroke
    N Vila
    Service of Neurology, Hospital Clinic i Provincial, Barcelona, Spain
    J Interferon Cytokine Res 20:325-9. 2000
    ..However, variations in free PS levels do not have implications for clinical outcome in stroke patients. The link between proinflammatory cytokines and free PS in the acute phase of stroke is not related to the C4BP pathway...
  23. ncbi request reprint Motor behavior in stroke patients with isolated medial frontal ischemic infarction
    A Chamorro
    Neurology Service of the Hospital Clinic University, Barcelona, Spain
    Stroke 28:1755-60. 1997
    ..We analyzed the motor behavior in eight patients with purely medial hemispheric infarctions who had face, arm, and leg involvement...
  24. ncbi request reprint Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke
    Nicolás Vila
    Hospital Clinic, Clinical Institute of Nervous System Diseases, Instituto Investigaciones Biomedicas August Pi i Sunyer, Villaroel 170, 08036 Barcelona, Spain
    Stroke 34:671-5. 2003
    ..Anti-inflammatory cytokines act in a feedback loop to inhibit continued proinflammatory cytokine production. We assessed the implication of interleukin (IL)-10 and IL-4 in deteriorating ischemic stroke...
  25. ncbi request reprint Clinical consequences of infection in patients with acute stroke: is it prime time for further antibiotic trials?
    Martha Vargas
    Infectious Diseases Unit, Hospital Clinic, Barcelona, Spain
    Stroke 37:461-5. 2006
    ..We sought to evaluate the predisposing factors and clinical consequences of SAI to gather additional insight on the need of exploring other antibiotics in acute stroke...
  26. ncbi request reprint Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke
    Angel Chamorro
    Neurology Service and Institut d Investigació Biomedica August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Stroke 33:1048-52. 2002
    ..We sought to assess in 881 consecutive patients with acute ischemic stroke the clinical relevance in regard to functional outcome of the natural antioxidant uric acid measured at hospital admission...
  27. ncbi request reprint Role of inflammation in stroke and atherothrombosis
    Angel Chamorro
    Neurology Service, Hospital Clinic Universitari, Institut Investigacions Biomèdicas August Pi I Sunyer IDIBAPS, Barcelona, Spain
    Cerebrovasc Dis 17:1-5. 2004
    ..Such biomarkers may have clinical utility for refined identification of patients at high risk for atherothrombosis in different arterial beds and for monitoring of therapeutic agents in clinical trials...
  28. doi request reprint Monocytes are major players in the prognosis and risk of infection after acute stroke
    Xabier Urra
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, Barcelona, Spain
    Stroke 40:1262-8. 2009
    ..Monocyte numbers increase in patients with stroke associated infection (SAI) or severe stroke. Whether changes in monocytes are related to specific effects, or simply mark brain damage, remains unsettled...
  29. ncbi request reprint Unfractionated heparin is associated with a lower rise of serum vascular cell adhesion molecule-1 in acute ischemic stroke patients
    Angel Chamorro
    Neurology Service, Hospital Clinic Universitari, 170 Villarroel, 08036, Barcelona, Spain
    Neurosci Lett 328:229-32. 2002
    ..19, 1.1-4.39). These results suggest that adjusted high-dose UFH has anti-inflammatory effects which might improve recovery if administered early after stroke onset...
  30. doi request reprint Neurological picture. Familial Sneddon's syndrome with microbleeds in MRI
    S Llufriu
    Stroke Unit, Hospital Clinic, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 79:962. 2008
  31. ncbi request reprint A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction
    Marian Revilla
    Service of Neurology, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain
    Neurosci Lett 324:29-32. 2002
    ..28; 95% CI, 1.22-15.00). These findings suggest that lacunar stroke might result from genetic susceptibility to inflammation-mediated damage in concert with atherosclerotic risk factors...
  32. pmc Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats
    Fernando J Pérez-Asensio
    Department of Brain Ischemia and Neurodegeneration, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona E 08036, Spain
    J Cereb Blood Flow Metab 30:638-52. 2010
    ..In conclusion, oral CR-6 administration after transient ischemia protects the brain from reperfusion injury...
  33. ncbi request reprint Uric acid administration for neuroprotection in patients with acute brain ischemia
    Angel Chamorro
    Stroke Unit, Neurology Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Villarroel 170, Barcelona 08036, Spain
    Med Hypotheses 62:173-6. 2004
    ..Prospective double blind randomized controlled trials are needed to test the value of uric acid in these clinical settings in which oxyradical formation is prominent...
  34. ncbi request reprint [The shadow of ischemia. Therapeutic window]
    A Chamorro
    Servicio de Neurologia, Hospital Clinic, Barcelona
    Neurologia 14:35-40. 1999
    ..The review that follows tackles on some of the main advances achieved in recent years in this exciting field...
  35. ncbi request reprint Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction
    A Iranzo
    Services of Neurology, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain
    Neurology 58:911-6. 2002
    ..To determine the prevalence of sleep apnea (SA) during the first night after hemispheric ischemic stroke and its influence on clinical presentation, course, and functional outcome at 6 months...
  36. ncbi request reprint Hypocomplementemia in systemic lupus erythematosus and primary antiphospholipid syndrome: prevalence and clinical significance in 667 patients
    M Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Spain
    Lupus 13:777-83. 2004
    ..These results clearly support the routine determination of complement factors in the clinical follow-up of patients with SLE and primary APS...
  37. doi request reprint The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms
    Sergio Amaro
    Comprehensive Stroke Center, Institute of Neurosciences, Hospital Clinic, Institute Investigacions Biomèdicas August Pi I Sunyer, University of Barcelona, Barcelona, Spain
    Int J Stroke 5:325-8. 2010
    ....
  38. doi request reprint Uric acid levels are relevant in patients with stroke treated with thrombolysis
    Sergio Amaro
    Stroke Unit, Institute of Neurosciences, Hospital Clinic Barcelona, Barcelona, Spain
    Stroke 42:S28-32. 2011
    ..Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke...
  39. doi request reprint Multimodal CT-assisted thrombolysis in patients with acute stroke: a cohort study
    Victor Obach
    Unit of Cerebrovascular Diseases, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Stroke 42:1129-31. 2011
    ..The value of multimodal CT to assist thrombolysis has received little attention in stroke...
  40. doi request reprint Translational stroke research of the combination of thrombolysis and antioxidant therapy
    Sergio Amaro
    Functional Unit of Cerebrovascular Diseases, Hospital Clinic, IDIBAPS, University of Barcelona, Villarroel, 170, 08036 Barcelona, Spain
    Stroke 42:1495-9. 2011
    ..The clinical efficacy of uric acid is currently under investigation in a Phase III trial that follows current recommendations of also evaluating surrogate biomarkers of treatment effects...
  41. ncbi request reprint Imaging brain inflammation with [(11)C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats
    Santiago Rojas
    Department of Brain Ischemia and Neurodegeneration, Institut d Investigacions Biomèdiques de Barcelona IIBB Consejo Superior de Investigaciones Científicas CSIC, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Cereb Blood Flow Metab 27:1975-86. 2007
    ..These results show cellular heterogeneity in the level of PBR expression, supporting that PBR is not a simple marker of inflammation, and that the extent of [(11)C]PK11195 binding depends on intrinsic features of the inflammatory cells...
  42. ncbi request reprint Certain forms of matrix metalloproteinase-9 accumulate in the extracellular space after microdialysis probe implantation and middle cerebral artery occlusion/reperfusion
    Anna M Planas
    Departament de Farmacologia i Toxicologia, IDIBAPS, Barcelona, Spain
    J Cereb Blood Flow Metab 22:918-25. 2002
    ....
  43. ncbi request reprint Stroke induced immunodepression syndrome: from bench to bedside
    Xabier Urra
    Institute of Neurosciences, Stroke Unit, Hospital Clinic, Barcelona, Spain
    Curr Mol Med 9:195-202. 2009
    ..Overall, current research suggests that a better understanding of the reciprocal effects between the CNS and the immune system could pave the way to more effective therapies for this devastating condition...
  44. pmc Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke
    Alvaro Cervera
    Comprehensive Stroke Center, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Medical School, University of Barcelona, Barcelona, Spain
    PLoS ONE 5:e8433. 2010
    ..The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs). Here we investigated whether the lectin pathway contributes to stroke outcome in mice and humans...
  45. ncbi request reprint Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke
    Eduardo Romanos
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomèdiques de Barcelona IIBB Consejo Superior de Investigaciones Científicas CSIC, IDIBAPS, Barcelona, Spain
    J Cereb Blood Flow Metab 27:14-20. 2007
    ....
  46. ncbi request reprint Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion
    Sonia Sole
    Departament de Farmacologia i Toxicologia, IIBB CSIC, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Neuropathol Exp Neurol 63:338-49. 2004
    ..In addition, the finding that MMP-3 cleaves brain agrin strongly suggests that ischemia-induced MMP-3 activation causes agrin cleavage...
  47. ncbi request reprint Anti-VCAM-1 antibodies did not protect against ischemic damage either in rats or in mice
    Carles Justicia
    Department of Pharmacology and Toxicology, IIBB CSIC, IDIBAPS, Barcelona, Spain
    J Cereb Blood Flow Metab 26:421-32. 2006
    ..The results show vascular upregulation of VCAM-1 after transient focal ischemia, but no benefits of blocking VCAM-1, suggesting that this is not a therapeutical strategy for stroke treatment...
  48. ncbi request reprint AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway
    Roser Gorina
    Departament de Farmacologia i Toxicologia, IIBB CSIC, IDIBAPS, Rossello 161, Planta 6, 08036 Barcelona, Spain
    J Neurochem 92:505-18. 2005
    ....
  49. doi request reprint Course of matrix metalloproteinase-9 isoforms after the administration of uric acid in patients with acute stroke: a proof-of-concept study
    Sergio Amaro
    Stroke Unit, Institute of Neurosciences, Hospital Clinic, Villarroel, 170, 08036, Barcelona, Spain
    J Neurol 256:651-6. 2009
    ..02) in multivariate models adjusted for age, NIHSS score, and baseline aMMP-9 levels. The decline of aMMP-9 attained after UA administration supports further clinical assessment of UA therapy in patients with acute stroke...
  50. ncbi request reprint Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target
    Mar Castellanos
    Section of Neurology, Hospital Universitari Doctor Josep Trueta, Girona, Spain
    Stroke 33:982-7. 2002
    ..In this study, we sought to investigate the role of proinflammatory molecules in the early worsening and outcome of acute lacunar stroke...
  51. ncbi request reprint A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke
    Sergio Amaro
    Stroke 38:2173-5. 2007
    ..In patients with stroke, increased UA levels have been linked to better stroke recovery, but the clinical safety of dual administration of UA and rt-PA is unknown...
  52. ncbi request reprint Early anticoagulation in acute ischaemic stroke
    Angel Chamorro
    Lancet 359:523; author reply 524. 2002
  53. ncbi request reprint Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial
    Julien Bogousslavsky
    Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Cerebrovasc Dis 14:239-51. 2002
    ..A previous study in acute stroke patients suggested that trafermin was safe and well tolerated when given over a 3-hour period over a wide dose range...
  54. ncbi request reprint European Stroke Initiative Recommendations for Stroke Management-update 2003
    Tom Skyhoj Olsen
    Cerebrovasc Dis 16:311-37. 2003
    ..The recommendations are endorsed by the 3 European societies which are represented in the European Stroke Initiative: the European Stroke Council, the European Neurological Society and the European Federation of Neurological Societies...
  55. ncbi request reprint Organization of stroke care: education, referral, emergency management and imaging, stroke units and rehabilitation. European Stroke Initiative
    Michael Brainin
    Cerebrovasc Dis 17:1-14. 2004
  56. ncbi request reprint Acute treatment of ischaemic stroke. European Stroke Initiative
    Danilo Toni
    Cerebrovasc Dis 17:30-46. 2004
  57. ncbi request reprint Association of specific haplotypes of GAS6 gene with stroke
    Xavier Munoz
    Centre de Genètica Mèdica i Molecular, Institut de Recerca Oncològica IDIBELL, L Hospitalet de Llobregat, Spain
    Thromb Haemost 98:406-12. 2007
    ..From these results we conclude that the A allele of the GAS6 c.834 + 7G > A polymorphism and more specifically, the CACA haplotype, is less prevalent in patients with stroke, suggesting a protective role for stroke of this haplotype...
  58. ncbi request reprint Steady plasma concentration of unfractionated heparin reduces infarct volume and prevents inflammatory damage after transient focal cerebral ischemia in the rat
    Alvaro Cervera
    Stroke Unit, Neurology Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Neurosci Res 77:565-72. 2004
    ..These findings support further testing of the clinical value of parenteral, adjusted, high-dose UH in patients with acute stroke...
  59. pmc Magnetic resonance perfusion diffusion mismatch, thrombolysis, and clinical outcome in acute stroke
    Angel Chamorro
    J Neurol Neurosurg Psychiatry 78:443. 2007
  60. ncbi request reprint Why does acute hyperglycemia worsen the outcome of transient focal cerebral ischemia? Role of corticosteroids, inflammation, and protein O-glycosylation
    Abraham Martin
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas, Institut d Investigacions Biomediques August Pi i Sunyer, Barrcelona, Spain
    Stroke 37:1288-95. 2006
    ..Here we sought to evaluate the negative effects of hyperglycemia on transient focal ischemia in the rat, and to test whether these could be prevented by inhibition of either corticosteroid production or neutrophil infiltration...
  61. ncbi request reprint Intronic c.573 + 79G>A polymorphism of protein Z gene in haemorrhagic and ischaemic stroke
    Victor Obach
    Thromb Haemost 95:1040-1. 2006