Research Topics
Genomes and Genes | Josep M CanalsSummaryAffiliation: Universitat de Barcelona Country: Spain Publications
| Collaborators
|
Detail Information
Publications
Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signalingNoelia Urbán
Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
Neural Dev 5:21. 2010..Nolz1 is a zinc finger transcription factor whose expression is enriched in the lateral ganglionic eminence (LGE), although its function is still unknown...
Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's diseaseJose R Pineda
Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Spain
J Neurochem 93:1057-68. 2005....- Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brainSilvia Gines
Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, E 08036 Barcelona, Spain
Eur J Neurosci 23:649-58. 2006..Therefore, taken together our findings identify TrkB as an additional component that potentially might contribute to the altered neurotrophic support in HD... - BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's diseaseJuan M García Martínez
Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Barcelona, Spain
J Neurosci Res 85:2756-69. 2007.... 
Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neuronsRaquel Martín-Ibáñez
Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
J Comp Neurol 518:329-51. 2010..In conclusion, our findings identify Ikaros-1 as a modulator of cell cycle exit of neural progenitors that gives rise to the neurogenesis of ENK-positive striatal neurons...- Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's diseaseDaniel del Toro
Departament de Biologia Cel lular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
J Neurochem 115:153-67. 2010..Administration of drugs that recover this effect, such as simvastatin could be beneficial for the treatment of HD... - Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatusDaniel del Toro
Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
Mol Biol Cell 20:1478-92. 2009..Together, our results indicate that mutant huntingtin perturbs post-Golgi trafficking to lysosomal compartments by delocalizing the optineurin/Rab8 complex, which, in turn, affects the lysosomal function... - Interplay of leukemia inhibitory factor and retinoic acid on neural differentiation of mouse embryonic stem cellsRaquel Martín Ibáñez
Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Spain
J Neurosci Res 85:2686-701. 2007..In conclusion, the present results indicate that RA enhances neuronal differentiation of mES cells in the absence of LIF, although it compromises cell viability and transplantation... - Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's diseaseMiquel Bosch
, Facultat de Medicina, , Universitat de Barcelona, E-08036 Barcelona, Spain
Exp Neurol 190:42-58. 2004..These data may lend support to the possibility of cell replacement therapies for Huntington's disease using neural stem cells... - Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injuryAnna M Canudas
, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E-08036 Barcelona, Spain
Brain Res Mol Brain Res 134:147-54. 2005..Thus, our results show that BDNF exerts an autocrine/paracrine protective effect selectively on dopaminergic neurons against the loss of trophic support from the target striatum... - Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signalingJesús F Torres-Peraza
Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
Neurobiol Dis 29:409-21. 2008..The specific regulation of MAGUKs and alpha CaMKII in striatal neurons may reflect a protective mechanism against expression of mutant huntingtin exon-1... - Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphismDaniel del Toro
Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, 08036 Barcelona, Spain
J Neurosci 26:12748-57. 2006..In addition, our findings reveal a new role for huntingtin in the regulation of the post-Golgi trafficking of the regulated secretory pathway... - Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's diseaseJosep M Canals
Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
J Neurosci 24:7727-39. 2004..Hence, administration of exogenous BDNF may delay or stop illness progression... - Neurotrophic factors in Huntington's diseaseJordi Alberch
Department of Cell Biology and Pathology, Medical School, IDIBAPS, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
Prog Brain Res 146:195-229. 2004..Thus, these neurotrophic factors may be suitable for the development of a neuroprotective therapy for neurodegenerative disorders of the basal ganglia... - Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatumSonia Marco
Departament de Biologia Cel small middle dotlular i Anatomia Patològica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Casanova 143, Barcelona, E 08036, Spain
Exp Neurol 174:243-52. 2002..These changes in mRNA levels and protein localization of GDNF family components could reflect an endogenous trophic response of striatal cells to different excitotoxic insults...