Josep M Canals

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. pmc Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
    Noelia Urbán
    Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Neural Dev 5:21. 2010
  2. ncbi request reprint Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    Jose R Pineda
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Spain
    J Neurochem 93:1057-68. 2005
  3. ncbi request reprint Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain
    Silvia Gines
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Eur J Neurosci 23:649-58. 2006
  4. ncbi request reprint BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease
    Juan M García-Martínez
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Barcelona, Spain
    J Neurosci Res 85:2756-69. 2007
  5. doi request reprint Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons
    Raquel Martín-Ibáñez
    Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    J Comp Neurol 518:329-51. 2010
  6. doi request reprint Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease
    Daniel del Toro
    Departament de Biologia Cel lular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 115:153-67. 2010
  7. pmc Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus
    Daniel del Toro
    Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
    Mol Biol Cell 20:1478-92. 2009
  8. ncbi request reprint Interplay of leukemia inhibitory factor and retinoic acid on neural differentiation of mouse embryonic stem cells
    Raquel Martín-Ibáñez
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Spain
    J Neurosci Res 85:2686-701. 2007
  9. ncbi request reprint Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease
    Miquel Bosch
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
    Exp Neurol 190:42-58. 2004
  10. ncbi request reprint Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury
    Anna M Canudas
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Brain Res Mol Brain Res 134:147-54. 2005

Collaborators

Detail Information

Publications15

  1. pmc Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
    Noelia Urbán
    Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Neural Dev 5:21. 2010
    ..Nolz1 is a zinc finger transcription factor whose expression is enriched in the lateral ganglionic eminence (LGE), although its function is still unknown...
  2. ncbi request reprint Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    Jose R Pineda
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Spain
    J Neurochem 93:1057-68. 2005
    ....
  3. ncbi request reprint Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain
    Silvia Gines
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Eur J Neurosci 23:649-58. 2006
    ..Therefore, taken together our findings identify TrkB as an additional component that potentially might contribute to the altered neurotrophic support in HD...
  4. ncbi request reprint BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease
    Juan M García-Martínez
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Barcelona, Spain
    J Neurosci Res 85:2756-69. 2007
    ....
  5. doi request reprint Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons
    Raquel Martín-Ibáñez
    Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    J Comp Neurol 518:329-51. 2010
    ..In conclusion, our findings identify Ikaros-1 as a modulator of cell cycle exit of neural progenitors that gives rise to the neurogenesis of ENK-positive striatal neurons...
  6. doi request reprint Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease
    Daniel del Toro
    Departament de Biologia Cel lular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 115:153-67. 2010
    ..Administration of drugs that recover this effect, such as simvastatin could be beneficial for the treatment of HD...
  7. pmc Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus
    Daniel del Toro
    Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
    Mol Biol Cell 20:1478-92. 2009
    ..Together, our results indicate that mutant huntingtin perturbs post-Golgi trafficking to lysosomal compartments by delocalizing the optineurin/Rab8 complex, which, in turn, affects the lysosomal function...
  8. ncbi request reprint Interplay of leukemia inhibitory factor and retinoic acid on neural differentiation of mouse embryonic stem cells
    Raquel Martín-Ibáñez
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Spain
    J Neurosci Res 85:2686-701. 2007
    ..In conclusion, the present results indicate that RA enhances neuronal differentiation of mES cells in the absence of LIF, although it compromises cell viability and transplantation...
  9. ncbi request reprint Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease
    Miquel Bosch
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
    Exp Neurol 190:42-58. 2004
    ..These data may lend support to the possibility of cell replacement therapies for Huntington's disease using neural stem cells...
  10. ncbi request reprint Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury
    Anna M Canudas
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Brain Res Mol Brain Res 134:147-54. 2005
    ..Thus, our results show that BDNF exerts an autocrine/paracrine protective effect selectively on dopaminergic neurons against the loss of trophic support from the target striatum...
  11. ncbi request reprint Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling
    Jesús F Torres-Peraza
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Neurobiol Dis 29:409-21. 2008
    ..The specific regulation of MAGUKs and alpha CaMKII in striatal neurons may reflect a protective mechanism against expression of mutant huntingtin exon-1...
  12. ncbi request reprint Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism
    Daniel del Toro
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, 08036 Barcelona, Spain
    J Neurosci 26:12748-57. 2006
    ..In addition, our findings reveal a new role for huntingtin in the regulation of the post-Golgi trafficking of the regulated secretory pathway...
  13. ncbi request reprint Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
    Josep M Canals
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
    J Neurosci 24:7727-39. 2004
    ..Hence, administration of exogenous BDNF may delay or stop illness progression...
  14. ncbi request reprint Neurotrophic factors in Huntington's disease
    Jordi Alberch
    Department of Cell Biology and Pathology, Medical School, IDIBAPS, University of Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Prog Brain Res 146:195-229. 2004
    ..Thus, these neurotrophic factors may be suitable for the development of a neuroprotective therapy for neurodegenerative disorders of the basal ganglia...
  15. ncbi request reprint Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum
    Sonia Marco
    Departament de Biologia Cel small middle dotlular i Anatomia Patològica, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Casanova 143, Barcelona, E 08036, Spain
    Exp Neurol 174:243-52. 2002
    ..These changes in mRNA levels and protein localization of GDNF family components could reflect an endogenous trophic response of striatal cells to different excitotoxic insults...