Francesc Calafell

Summary

Affiliation: Universitat Pompeu Fabra
Country: Spain

Publications

  1. ncbi request reprint Consistency of metagenomic assignment programs in simulated and real data
    Koldo Garcia-Etxebarria
    Institut de Biologia Evolutiva CSIC Universitat Pompeu Fabra, Barcelona, Spain
    BMC Bioinformatics 15:90. 2014
  2. pmc Minimizing recombinations in consensus networks for phylogeographic studies
    Laxmi Parida
    Computational Biology Center, IBM T J Watson Research, Yorktown, USA
    BMC Bioinformatics 10:S72. 2009
  3. doi request reprint Evolutionary dynamics of the human ABO gene
    Francesc Calafell
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader, 80, 08003, Barcelona, Catalonia, Spain
    Hum Genet 124:123-35. 2008
  4. doi request reprint [Genetic factors in severe cases of (H1N1) 2009 influenza]
    Francesc Calafell i Majó
    Institut de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra Consejo Superior de Investigaciones Cientificas, Doctor Aiguader 88, Barcelona
    Rev Esp Salud Publica 85:33-6. 2011
  5. doi request reprint A natural history of FUT2 polymorphism in humans
    Anna Ferrer-Admetlla
    Institut de Biologia Evolutiva CSIC UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 26:1993-2003. 2009
  6. pmc Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
  7. doi request reprint Interrogating 11 fast-evolving genes for signatures of recent positive selection in worldwide human populations
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Institut de Biologia Evolutiva UPF CSIC, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 26:2285-97. 2009
  8. ncbi request reprint Comparative genetics of functional trinucleotide tandem repeats in humans and apes
    Aida M Andres
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Mol Evol 59:329-39. 2004
  9. doi request reprint Human pseudogenes of the ABO family show a complex evolutionary dynamics and loss of function
    Ferran Casals
    Institut de Biologia Evolutiva CSIC UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Glycobiology 19:583-91. 2009
  10. ncbi request reprint Mitochondrial DNA of an Iberian Neandertal suggests a population affinity with other European Neandertals
    Carles Lalueza-Fox
    Seccio Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Curr Biol 16:R629-30. 2006

Detail Information

Publications52

  1. ncbi request reprint Consistency of metagenomic assignment programs in simulated and real data
    Koldo Garcia-Etxebarria
    Institut de Biologia Evolutiva CSIC Universitat Pompeu Fabra, Barcelona, Spain
    BMC Bioinformatics 15:90. 2014
    ..In this work, we assess the consistency of three different methods (BLAST + Lowest Common Ancestor, Phymm, and Naïve Bayesian Classifier) in assigning real and simulated sequence reads...
  2. pmc Minimizing recombinations in consensus networks for phylogeographic studies
    Laxmi Parida
    Computational Biology Center, IBM T J Watson Research, Yorktown, USA
    BMC Bioinformatics 10:S72. 2009
    ..To date, this is the best known result for a network consensus problem...
  3. doi request reprint Evolutionary dynamics of the human ABO gene
    Francesc Calafell
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader, 80, 08003, Barcelona, Catalonia, Spain
    Hum Genet 124:123-35. 2008
    ..The time depth of the genealogy was also incompatible with neutral evolution, particularly in the region from exons 6 to 7, which codes for most of the catalytic domain...
  4. doi request reprint [Genetic factors in severe cases of (H1N1) 2009 influenza]
    Francesc Calafell i Majó
    Institut de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra Consejo Superior de Investigaciones Cientificas, Doctor Aiguader 88, Barcelona
    Rev Esp Salud Publica 85:33-6. 2011
    ....
  5. doi request reprint A natural history of FUT2 polymorphism in humans
    Anna Ferrer-Admetlla
    Institut de Biologia Evolutiva CSIC UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 26:1993-2003. 2009
    ..Thus, a convergent phenotype composition has been achieved through different mutations with different evolutionary histories...
  6. pmc Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
    ..Within each gene region and population we use r2 between all possible single nucleotide polymorphism (SNP) pairs as a measure of linkage disequilibrium and focus on the proportion of SNP pairs with r2 greater than 0.8...
  7. doi request reprint Interrogating 11 fast-evolving genes for signatures of recent positive selection in worldwide human populations
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Institut de Biologia Evolutiva UPF CSIC, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 26:2285-97. 2009
    ..Based on these data, it therefore appears that adaptation for human-specific and for population-specific traits may have involved different genes...
  8. ncbi request reprint Comparative genetics of functional trinucleotide tandem repeats in humans and apes
    Aida M Andres
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Mol Evol 59:329-39. 2004
    ..Only two loci (SCA1 and SCA8) show a human specific distribution, with larger alleles than the rest of species. This could account, at the same time, for a human-specific trait and a predisposition to disease through expansion...
  9. doi request reprint Human pseudogenes of the ABO family show a complex evolutionary dynamics and loss of function
    Ferran Casals
    Institut de Biologia Evolutiva CSIC UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Glycobiology 19:583-91. 2009
    ....
  10. ncbi request reprint Mitochondrial DNA of an Iberian Neandertal suggests a population affinity with other European Neandertals
    Carles Lalueza-Fox
    Seccio Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Curr Biol 16:R629-30. 2006
  11. ncbi request reprint Balancing selection is the main force shaping the evolution of innate immunity genes
    Anna Ferrer-Admetlla
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Unitat de Biologia Evolutiva, Barcelona, Catalonia, Spain
    J Immunol 181:1315-22. 2008
    ..However, we also describe evidence from African populations, which may reflect parallel or long-term selective forces acting in different geographic areas...
  12. pmc The prion protein gene in humans revisited: lessons from a worldwide resequencing study
    Marta Soldevila
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Genome Res 16:231-9. 2006
    ....
  13. ncbi request reprint Signatures of selection in the human olfactory receptor OR5I1 gene
    Andres Moreno-Estrada
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Mol Biol Evol 25:144-54. 2008
    ..These results are compatible with positive selection having modeled the pattern of variation found in the OR5I1 gene and with a relatively ancient, mild selective sweep predating the "Out of Africa" expansion of modern humans...
  14. ncbi request reprint Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1
    Jordi Clarimon
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
    J Neurol 250:956-61. 2003
    ....
  15. pmc Geographic stratification of linkage disequilibrium: a worldwide population study in a region of chromosome 22
    Anna Gonzalez-Neira
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Hum Genomics 1:399-409. 2004
    ....
  16. ncbi request reprint Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages
    David Comas
    Unitat de Biologia Evolutiva, Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona 08003, Spain
    Eur J Hum Genet 12:495-504. 2004
    ....
  17. pmc The portability of tagSNPs across populations: a worldwide survey
    Anna Gonzalez-Neira
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Genome Res 16:323-30. 2006
    ..This high degree of portability lends promise to the search for disease association in different populations, once tagSNPs are defined in a few reference populations like those analyzed in the HapMap initiative...
  18. doi request reprint Y-chromosome diversity in Native Mexicans reveals continental transition of genetic structure in the Americas
    Karla Sandoval
    Institut de Biologia Evolutiva, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Am J Phys Anthropol 148:395-405. 2012
    ..This observation is compatible with the idea that present day Mexico might have constituted an area of transition in the diversification of paternal lineages during the colonization of the Americas...
  19. pmc African signatures of recent positive selection in human FOXI1
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Institut de Biologia Evolutiva UPF CSIC, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    BMC Evol Biol 10:267. 2010
    ....
  20. ncbi request reprint Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example
    Michelle Gardner
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain
    Hum Genet 121:759-62. 2007
    ..In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene...
  21. ncbi request reprint Spatial patterns of cystic fibrosis mutation spectra in European populations
    Oscar Lao
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Eur J Hum Genet 11:385-94. 2003
    ..CF-based distances correlated with mtDNA but not with Y-chromosome-based distances, which may be a consequence of the relatively homogeneous CF mutation frequencies in European populations...
  22. ncbi request reprint The west side story: MEFV haplotype in Spanish FMF patients and controls, and evidence of high LD and a recombination "hot-spot" at the MEFV locus
    Anna Aldea
    Servei d Immunologia, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer, Hospital Clinic, Barcelona, Catalonia, Spain
    Hum Mutat 23:399. 2004
    ..On the contrary, the Chueta spectrum was poorer and closer to that of North African Jews, suggesting a direct connection with the Jewish diaspora...
  23. ncbi request reprint Insights into the western Bantu dispersal: mtDNA lineage analysis in Angola
    Stéphanie Plaza
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003, Barcelona, Spain
    Hum Genet 115:439-47. 2004
    ....
  24. pmc Genetic origin, admixture, and asymmetry in maternal and paternal human lineages in Cuba
    Isabel Mendizabal
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    BMC Evol Biol 8:213. 2008
    ....
  25. pmc A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations
    Martin Sikora
    Institut de Biologia Evolutiva UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Eur J Hum Genet 19:84-8. 2011
    ..Finally, we find a strong differentiation of the southeastern Bantu population from Mozambique, which suggests an assimilation of a pre-Bantu substrate by Bantu speakers in the region...
  26. pmc Linguistic and maternal genetic diversity are not correlated in Native Mexicans
    Karla Sandoval
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, 08003 Barcelona, Catalonia, Spain
    Hum Genet 126:521-31. 2009
    ....
  27. ncbi request reprint PKLR- GBA region shows almost complete linkage disequilibrium over 70 kb in a set of worldwide populations
    Eva Mateu
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain
    Hum Genet 110:532-44. 2002
    ..LD and STRP variability in non-Africans are approximately 87% of those in Africans, in contrast with other loci; this implies that the "out of Africa" bottleneck may have had a broad distribution of effects across loci...
  28. pmc Genetic adaptation of the antibacterial human innate immunity network
    Ferran Casals
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    BMC Evol Biol 11:202. 2011
    ..The evolution of the immune system has therefore been influenced by these pressures. Genomic scans have revealed that immune system is one of the functions enriched with genes under adaptive selection...
  29. ncbi request reprint The Mediterranean paradox for susceptibility factors in coronary heart disease extends to genetics
    Oscar Lao
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Ann Hum Genet 72:48-56. 2008
    ....
  30. doi request reprint SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data
    Carlos Morcillo-Suarez
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    Bioinformatics 24:1643-4. 2008
    ..Phenotypic data on the samples can also be easily uploaded. Many different quality control and analysis procedures can be performed either by using built-in SNPator algorithms or by calling standard genetic software...
  31. doi request reprint Genetic and demographic implications of the Bantu expansion: insights from human paternal lineages
    Gemma Berniell-Lee
    Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 26:1581-9. 2009
    ..We also find the intriguing presence of paternal lineages belonging to Eurasian haplogroup R1b1*, which might represent footprints of demographic expansions in central Africa not directly related to the Bantu expansion...
  32. pmc Recent human evolution has shaped geographical differences in susceptibility to disease
    Urko M Marigorta
    Institute of Evolutionary Biology UPF CSIC, PRBB, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain
    BMC Genomics 12:55. 2011
    ..Here, we focus on the world-wide patterns of replicability of published association studies...
  33. ncbi request reprint Prion susceptibility and protective alleles exhibit marked geographic differences
    Marta Soldevila
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Hum Mutat 22:104-5. 2003
    ..The protective 219L allele was restricted to Asian and Pacific populations. Susceptibility alleles exhibit marked geographic differences in frequency, and thus, differences in probability to develop prion diseases...
  34. pmc Sequence variation and genetic evolution at the human F12 locus: mapping quantitative trait nucleotides that influence FXII plasma levels
    Francesc Calafell
    Departament de Ciencies Experimentals i de la Salut, Institute of Evolutionary Biology UPF CSIC, Universitat Pompeu Fabra, Barcelona, Spain
    Hum Mol Genet 19:517-25. 2010
    ..Our study provides a template for future genetic studies of human quantitative traits, as we move beyond QTL localization to the polymorphisms responsible for the variation of important biomedical phenotypes...
  35. pmc Statistical power analysis of neutrality tests under demographic expansions, contractions and bottlenecks with recombination
    Anna Ramírez-Soriano
    Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Genetics 179:555-67. 2008
    ..Nevertheless, they are strongly affected by misestimations of recombination, so they should not be used when recombination levels are unknown. Instead, class I tests, particularly Tajima's D or R2, are recommended...
  36. doi request reprint Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean)
    Gemma Berniell-Lee
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Am J Phys Anthropol 136:100-7. 2008
    ..The absence of genetic diversity within these two major components of the mtDNA gene pool suggests these populations may have witnessed strong founder effects during the colonization process...
  37. pmc A new method for extracting skin microbes allows metagenomic analysis of whole-deep skin
    Marc García-Garcerà
    Institut de Biologia Evolutiva CSIC Consejo Superior de Investigaciones Científicas Universitat Pompeu Fabra, Barcelona, Catalonia, Spain Joint Research Unit on Genomics and Health, Centre for Public Health Research CSISP and Cavanilles Institute for Biodiversity and Evolutionary Biology University of Valencia, Valencia, Spain
    PLoS ONE 8:e74914. 2013
    ..Our method paves the way for the development of skin metagenomics, which will allow a much deeper knowledge of the skin microbiome and its relationship with the host, both in a healthy state and in relation to disease. ..
  38. pmc Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
    Marc García-Garcerà
    Institut de Biologia Evolutiva, CSIC UPF, Barcelona, Spain
    PLoS ONE 6:e24161. 2011
    ..The efficiency of retrieval of endogenous sequences is below 1% in all cases. We have used the non-human samples to identify human sequences (0.35 and 1.4%, respectively), that we positively know are contaminants...
  39. pmc Similarity in recombination rate estimates highly correlates with genetic differentiation in humans
    Hafid Laayouni
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e17913. 2011
    ..This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans...
  40. pmc Reconstructing the Indian origin and dispersal of the European Roma: a maternal genetic perspective
    Isabel Mendizabal
    Institute of Evolutionary Biology CSIC UPF, CEXS UPF PRBB, Barcelona, Spain
    PLoS ONE 6:e15988. 2011
    ....
  41. pmc A new method to reconstruct recombination events at a genomic scale
    Marta Mele
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS Comput Biol 6:e1001010. 2010
    ....
  42. ncbi request reprint Neandertal evolutionary genetics: mitochondrial DNA data from the iberian peninsula
    Carles Lalueza-Fox
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 22:1077-81. 2005
    ..250,000 years ago. This coincides with the full emergence of the "classical" Neandertal morphology and fits chronologically with a proposed speciation event of Homo neanderthalensis...
  43. ncbi request reprint Dynamics of CAG repeat loci revealed by the analysis of their variability
    Aida M Andres
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Hum Mutat 21:61-70. 2003
    ....
  44. ncbi request reprint Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population
    Jordi Clarimon
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Psychiatr Genet 13:85-90. 2003
    ..Most of these studies have examined only one or two polymorphisms in a defined population, which provides a lack of a general view of the Alzheimer's disease genetic component...
  45. doi request reprint A genome-wide survey does not show the genetic distinctiveness of Basques
    Hafid Laayouni
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Genet 127:455-8. 2010
    ..Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised...
  46. doi request reprint FABSIM: a software for generating FST distributions with various ascertainment biases
    Anna Ramírez-Soriano
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB Doctor Aiguader, 88 08003 Barcelona, Catalonia, Spain
    Bioinformatics 24:2790-1. 2008
    ....
  47. doi request reprint Insights into the demographic history of African Pygmies from complete mitochondrial genomes
    Chiara Batini
    Institut de Biologia Evolutiva CSIC UPF, Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 28:1099-110. 2011
    ....
  48. ncbi request reprint Identification of a novel founder mutation in the DYSF gene causing clinical variability in the Spanish population
    Juan J Vilchez
    Servicio de Neurologia, Hospital Universitari La Fe, Valencia, Spain
    Arch Neurol 62:1256-9. 2005
    ..Mutations in the dysferlin (DYSF) gene cause 3 different phenotypes of muscular dystrophies: Miyoshi myopathy, limb-girdle muscular dystrophy type 2B, and distal anterior compartment myopathy...
  49. ncbi request reprint Why names
    Francesc Calafell
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Genome Res 12:219-21. 2002
  50. doi request reprint Genetic analysis of the presumptive blood from Louis XVI, King of France
    Carles Lalueza-Fox
    Institut de Biologia Evolutiva, CSIC UPF, Dr Aiguader 88, 08003 Barcelona, Spain
    Forensic Sci Int Genet 5:459-63. 2011
    ..To confirm the identity of the subject, an analysis of the dried heart of his son, Louis XVII, could be undertaken...
  51. pmc Y-chromosome analysis in individuals bearing the Basarab name of the first dynasty of Wallachian kings
    Begoña Martínez-Cruz
    Institut de Biologia Evolutiva CSIC UPF, Departament de Ciències de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    PLoS ONE 7:e41803. 2012
    ..It can be therefore concluded that the Basarab dynasty was successful in spreading its name beyond the spread of its genes...
  52. pmc Can a place of origin of the main cystic fibrosis mutations be identified?
    Eva Mateu
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Am J Hum Genet 70:257-64. 2002
    ....