Research Topics
| Xavier BoschSummaryAffiliation: Universitat de Barcelona Country: Spain Publications
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Detail Information
Publications
Antineutrophil cytoplasmic antibodiesXavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
Lancet 368:404-18. 2006..Accurate understanding of the key pathogenic points of ANCA-associated vasculitis can undoubtedly provide a more rational therapeutic approach...
Monoclonal gammopathy related to Sjögren syndrome: a key marker of disease prognosis and outcomesPilar Brito-Zeron
Sjögren Syndrome Research Group AGAUR, Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomediques August Pi i Sunyer, Department of Autoimmune Diseases, ICMiD, Hospital Clinic, Barcelona, Spain
J Autoimmun 39:43-8. 2012....- Comparison of quick diagnosis units and conventional hospitalization for the diagnosis of cancer in Spain: a descriptive cohort studyXavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Oncology 83:283-91. 2012..We compared the value and cost of a QDU and of conventional hospitalization in assessing patients with cancer... - Anti-Ro52 antibody testing influences the classification and clinical characterisation of primary Sjögren's syndromeSoledad Retamozo
Department Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
Clin Exp Rheumatol 30:686-92. 2012..To evaluate how determination of antibodies against the Ro52 antigen influences the classification and clinical characterisation of patients with suspected primary Sjögren's syndrome (SS)... - Hepatitis B virus (HBV) reactivation in patients receiving tumor necrosis factor (TNF)-targeted therapy: analysis of 257 casesRoberto Perez-Alvarez
Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, ICMiD, and Liver Unit, CIBERehd, Hospital Clinic, Barcelona, Spain
Medicine (Baltimore) 90:359-71. 2011..The increasing number of reported cases of HBV reactivation following TNF-targeted therapies and the associated morbidity and mortality demand specific preventive strategies... - Immunotherapy for antineutrophil cytoplasmic antibody-associated vasculitis: challenging the therapeutic status quo?Xavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Trends Immunol 29:280-9. 2008..Therefore, an unmet need for safer and more effective therapies has prompted interest in biological agents. Continuous advances in the knowledge of AAV pathogenesis are paving the way to new biologicals that are now awaiting testing... - Quick diagnosis units or conventional hospitalisation for the diagnostic evaluation of severe anaemia: a paradigm shift in public health systems?Xavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Eur J Intern Med 23:159-64. 2012..Anaemia with haemoglobin levels below 8 g/l has traditionally been a criterion used to hospitalise patients in our centre for diagnosis... - Interstitial lung disease induced or exacerbated by TNF-targeted therapies: analysis of 122 casesRoberto Perez-Alvarez
Department of Internal Medicine, Hospital do Meixoeiro, Vigo, Spain
Semin Arthritis Rheum 41:256-64. 2011..To analyze the clinical characteristics, outcomes, and patterns of association with the different biologic agents used in all reported cases of adult patients developing interstitial lung disease (ILD) after biologic therapy... - Pulmonary disorders induced by monoclonal antibodies in patients with rheumatologic autoimmune diseasesManuel Ramos-Casals
Department of Autoimmune Diseases, Laboratory of Autoimmune Diseases Josep Font, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
Am J Med 124:386-94. 2011..Large, prospective, postmarketing studies including nonbiological agents as controls may help elucidate the real risk of pulmonary disease in patients with rheumatologic autoimmune diseases receiving monoclonal antibodies... - Ischaemic postconditioning revisited: lack of effects on infarct size following primary percutaneous coronary interventionXavier Freixa
Interventional Cardiology Section, Cardiology Department, Thorax Institute, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona 08036, Catalonia, Spain
Eur Heart J 33:103-12. 2012..Previous studies have shown that p-cond during primary percutaneous coronary intervention (PCI) confers protection against ischaemia-reperfusion injury and thus might reduce myocardial infarct size... 
Anti-neutrophil cytoplasmic antibody pathogenesis in small-vessel vasculitis: an updateJosé A Gómez-Puerta
Department of Internal Medicine, Hospital Clinic, Barcelona, Spain
Am J Pathol 175:1790-8. 2009..Understanding the key pathogenic mechanisms of AAV may provide a safer, more rational therapeutic approach than the traditional (ie, corticosteroids and immunosuppressants) treatment strategy...- Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory diseaseJosé A Gómez-Puerta
Departments of Rheumatology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Chest 136:1101-11. 2009..Thus, biological agents are emerging as potential therapies in refractory cases. Notably, rituximab and infliximab have been trialed with apparent initial clinical success... - Topical and systemic medications for the treatment of primary Sjögren's syndromeManuel Ramos-Casals
Sjögren s Syndrome Research Group AGAUR, Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
Nat Rev Rheumatol 8:399-411. 2012..On the basis of this evidence, we provide guidance on the use of these agents in different clinical scenarios... - B-cell depleting agents for ANCA vasculitides: a new therapeutic approachJosé A Gómez-Puerta
Department of Rheumatology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
Autoimmun Rev 11:646-52. 2012..However, issues regarding the use of maintenance therapy after rituximab, the concurrent use of cyclophosphamide and the toxicity of rituximab remain unanswered and should be clarified in ongoing and future randomized controlled trials... - The cryoglobulinaemiasManuel Ramos-Casals
Josep Font Laboratory of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Lancet 379:348-60. 2012..Studies suggest that both combined or sequential antiviral therapies and targeted biological treatments might be more effective than monotherapy... - Vasculitis syndromes: LAMP-2 illuminates pathogenesis of ANCA glomerulonephritisXavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
Nat Rev Nephrol 5:247-9. 2009..The discovery that antibodies to a bacterial antigen can cross-react with a mammalian protein to cause pauci-immune necrotizing and crescentic glomerulonephritis opens up new possibilities for the diagnosis and treatment of this condition... - Treatment of polymyalgia rheumatica: a systematic reviewJosé Hernández-Rodríguez
Department of Internal Medicine, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
Arch Intern Med 169:1839-50. 2009..Our objective was to systematically examine the peer-reviewed literature on PMR therapy, particularly the optimal glucocorticoid type, starting doses, and subsequent reduction regimens as well as glucocorticoid-sparing medications... - [Systemic lupus erythematosus in the elderly]Xavier Bosch
Unidad de Geriatria, Servicio de Medicina Interna, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universidad de Barcelona, Barcelona, Spain
Rev Esp Geriatr Gerontol 47:71-5. 2012..In addition to the need for adopting a multidisciplinary approach, it is fundamental to obtain information about the functional, cognitive and social status of these patients in order to make appropriate healthcare decisions... - Aspiration pneumonia in old patients with dementia. Prognostic factors of mortalityXavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Eur J Intern Med 23:720-6. 2012..Prognostic factors of mortality in elderly patients with dementia with aspiration pneumonia (AP) are scarcely known. We determined the mortality rate and prognostic factors in old patients with dementia hospitalized due to AP... - [Prevalence of atrial fibrillation and related factors in hospitalized old patients: ESFINGE study]Alfonso Lopez Soto
Servicio de Medicina Interna, Instituto Clínico de Medicina y Dermatología, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Espana
Med Clin (Barc) 138:231-7. 2012..The main objective of this study was to assess the prevalence of AF in hospitalized old patients as well as its characteristics and related clinical and therapeutic factors... - Quick diagnosis units: avoiding referrals from primary care to the ED and hospitalizationsXavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain
Am J Emerg Med 31:114-23. 2013..The aim of the present study was to determine whether quick diagnosis units (QDUs) can safely and efficiently avoid emergency department (ED) visits and hospitalizations... - Outpatient Quick Diagnosis Units for the evaluation of suspected severe diseases: an observational, descriptive studyXavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Clinics (Sao Paulo) 66:737-41. 2011..Hospitals in countries with public health systems have recently adopted organizational changes to improve efficiency and resource allocation, and reducing inappropriate hospitalizations has been established as an important goal... - Utility of serum tumor markers as an aid in the differential diagnosis of patients with clinical suspicion of cancer and in patients with cancer of unknown primary siteRafael Molina
Laboratory of Clinical Biochemistry Unit for Cancer Research, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Villarroel 170, Barcelona, 08036, Spain
Tumour Biol 33:463-74. 2012.... - The DWEYS peptide in systemic lupus erythematosusXavier Bosch
Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Spain
Trends Mol Med 18:215-23. 2012..In this review, anti-dsDNA antibodies as a pathogenic factor in SLE and recent efforts for the creation of highly specific, nontoxic therapeutics against an extremely pathogenic subset of such antibodies is discussed... - B-cell-depleting therapy in systemic lupus erythematosusManuel Ramos-Casals
Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
Am J Med 125:327-36. 2012.... - Therapy: Spleen tyrosine kinase inhibitors--novel therapies for RA?José A Gómez-Puerta
Arthritis Unit, Department of Rheumatology, Hospital Clinic, Villarroel 170, Barcelona, Spain
Nat Rev Rheumatol 7:134-6. 2011..Where might these agents fit in the current armamentarium against this disease?.. - Monoclonal antibody therapy-associated neurological disordersXavier Bosch
Department of Internal Medicine, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
Nat Rev Neurol 7:165-72. 2011.... - Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a systematic reviewXavier Bosch
Department of Internal Medicine, Hospital Clinic, Barcelona, Spain
JAMA 298:655-69. 2007..Long-term treatment and disease-related morbidity are major threats. The last decade has seen a collaborative international effort to determine effective treatment... - New insights in the management of cardiogenic shock complicating myocardial infarction: role of urgent heart transplantationDabit Arzamendi
Cardiology Unit, Cardio Thorax Institute Hospital Clinic de Barcelona, Barcelona, Spain
J Heart Lung Transplant 27:984-9. 2008..The primary end-point of the study was mortality at the 1-year follow-up... - Basophils, IgE, and autoantibody-mediated kidney diseaseXavier Bosch
Department of Internal Medicine, Hospital Clinic, Institut d Investigacions Bimoèdiques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain
J Immunol 186:6083-90. 2011..In addition to envisaging exciting therapeutic prospects, these novel findings open the way for the study of basophils in other autoimmune and renal diseases... - Shoshin beriberi mimicking a high-risk non-ST-segment elevation acute coronary syndrome with cardiogenic shock: when the arteries are not guiltyPablo Loma-Osorio
Unidad Coronaria, Servicio de Cardiologia, Hospital Clinic, Barcelona, Spain
J Emerg Med 41:e73-7. 2011..Cardiac acute beriberi (Shoshin syndrome) is a rare disease that may lead to a fatal outcome if not treated specifically... - Usefulness of anti-p155 autoantibody for diagnosing cancer-associated dermatomyositis: a systematic review and meta-analysisErnesto Trallero-Araguás
Vall d Hebron General Hospital, Barcelona, Spain
Arthritis Rheum 64:523-32. 2012..We performed a systematic review and meta-analysis to ascertain the accuracy of anti-p155 testing for the diagnosis of cancer-associated myositis... - Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trialXavier Bosch
Cardiology Department, Thorax Institute, Hospital Clinic, Barcelona, Spain
J Card Fail 17:643-8. 2011.... - Relation of plasma brain natriuretic peptide levels on admission for ST-elevation myocardial infarction to left ventricular end-diastolic volume six months later measured by both echocardiography and cardiac magnetic resonanceAna García-Alvarez
Thorax Clinic Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Am J Cardiol 104:878-82. 2009..The early determination of plasma BNP upon admission for STEMI could be helpful in identifying patients at higher risk for LV dilatation, in whom aggressive management is warranted... - Therapeutic targeting of B cells for rheumatic autoimmune diseasesPablo Engel
Immunology Unit, Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Pharmacol Rev 63:127-56. 2011.... - Left ventricular ejection fraction to predict early mortality in patients with non-ST-segment elevation acute coronary syndromesXavier Bosch
Institut de Malalties Cardiovasculars, Hospital Clinic, , Barcelona, Spain
Am Heart J 150:215-20. 2005..CONCLUSIONS: The TIMI risk score predicts inhospital mortality in a broad population of patients with ACS. The further consideration of EF adds significant prognostic information... - Elevation of serum levels of the anti-inflammatory cytokine interleukin-10 and decreased risk of coronary events in patients with unstable anginaIgnasi Anguera
Institut de Malalties Cardiovasculars, Hospital Clinic, University of Barcelona, Barcelona, Spain
Am Heart J 144:811-7. 2002..Higher levels of the anti-inflammatory cytokine IL-10 may be needed to provide protection in unstable angina... - Prognostic value of clinical variables at presentation in patients with non-ST-segment elevation acute coronary syndromes: results of the Proyecto de Estudio del Pronóstico de la Angina (PEPA)Esteban Lopez de Sa
Hospital General U Gregorio Marañón, Madrid, Spain
Medicine (Baltimore) 81:434-42. 2002....