Elena Bosch

Summary

Affiliation: Universitat Pompeu Fabra
Country: Spain

Publications

  1. doi request reprint Evolutionary and functional evidence for positive selection at the human CD5 immune receptor gene
    Elena Carnero-Montoro
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    Mol Biol Evol 29:811-23. 2012
  2. pmc Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
  3. doi request reprint Interrogating 11 fast-evolving genes for signatures of recent positive selection in worldwide human populations
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Institut de Biologia Evolutiva UPF CSIC, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 26:2285-97. 2009
  4. pmc African signatures of recent positive selection in human FOXI1
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Institut de Biologia Evolutiva UPF CSIC, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    BMC Evol Biol 10:267. 2010
  5. ncbi request reprint Balancing selection is the main force shaping the evolution of innate immunity genes
    Anna Ferrer-Admetlla
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Unitat de Biologia Evolutiva, Barcelona, Catalonia, Spain
    J Immunol 181:1315-22. 2008
  6. doi request reprint SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data
    Carlos Morcillo-Suarez
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    Bioinformatics 24:1643-4. 2008
  7. ncbi request reprint Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example
    Michelle Gardner
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain
    Hum Genet 121:759-62. 2007
  8. doi request reprint Genetic and demographic implications of the Bantu expansion: insights from human paternal lineages
    Gemma Berniell-Lee
    Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 26:1581-9. 2009
  9. pmc Copy number variation analysis in the great apes reveals species-specific patterns of structural variation
    Elodie Gazave
    Institute of Evolutionary Biology UPF CSIC, PRBB, 08003 Barcelona, Spain
    Genome Res 21:1626-39. 2011
  10. doi request reprint Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean)
    Gemma Berniell-Lee
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Am J Phys Anthropol 136:100-7. 2008

Collaborators

Detail Information

Publications14

  1. doi request reprint Evolutionary and functional evidence for positive selection at the human CD5 immune receptor gene
    Elena Carnero-Montoro
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    Mol Biol Evol 29:811-23. 2012
    ..Taken together, the results provide evidence for the hypothesis of an adaptive role of the A471V substitution to environmental challenges, most likely infectious pathogens, in East Asian populations...
  2. pmc Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD
    Elena Bosch
    Institut de Biologia Evolutiva UPF CSIC, Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    BMC Genomics 10:338. 2009
    ..Within each gene region and population we use r2 between all possible single nucleotide polymorphism (SNP) pairs as a measure of linkage disequilibrium and focus on the proportion of SNP pairs with r2 greater than 0.8...
  3. doi request reprint Interrogating 11 fast-evolving genes for signatures of recent positive selection in worldwide human populations
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Institut de Biologia Evolutiva UPF CSIC, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 26:2285-97. 2009
    ..Based on these data, it therefore appears that adaptation for human-specific and for population-specific traits may have involved different genes...
  4. pmc African signatures of recent positive selection in human FOXI1
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Institut de Biologia Evolutiva UPF CSIC, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    BMC Evol Biol 10:267. 2010
    ....
  5. ncbi request reprint Balancing selection is the main force shaping the evolution of innate immunity genes
    Anna Ferrer-Admetlla
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Unitat de Biologia Evolutiva, Barcelona, Catalonia, Spain
    J Immunol 181:1315-22. 2008
    ..However, we also describe evidence from African populations, which may reflect parallel or long-term selective forces acting in different geographic areas...
  6. doi request reprint SNP analysis to results (SNPator): a web-based environment oriented to statistical genomics analyses upon SNP data
    Carlos Morcillo-Suarez
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    Bioinformatics 24:1643-4. 2008
    ..Many different quality control and analysis procedures can be performed either by using built-in SNPator algorithms or by calling standard genetic software. AVAILABILITY: Access is granted from the SNPator webpage http://www.snpator.org...
  7. ncbi request reprint Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example
    Michelle Gardner
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Doctor Aiguader 88, Barcelona, 08003, Spain
    Hum Genet 121:759-62. 2007
    ..In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene...
  8. doi request reprint Genetic and demographic implications of the Bantu expansion: insights from human paternal lineages
    Gemma Berniell-Lee
    Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas UPF, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Mol Biol Evol 26:1581-9. 2009
    ..We also find the intriguing presence of paternal lineages belonging to Eurasian haplogroup R1b1*, which might represent footprints of demographic expansions in central Africa not directly related to the Bantu expansion...
  9. pmc Copy number variation analysis in the great apes reveals species-specific patterns of structural variation
    Elodie Gazave
    Institute of Evolutionary Biology UPF CSIC, PRBB, 08003 Barcelona, Spain
    Genome Res 21:1626-39. 2011
    ..Finally, we identified a number of interesting genomic regions that present high-frequency CNVs in all great apes, while containing only very rare or even pathogenic structural variants in humans...
  10. doi request reprint Admixture and sexual bias in the population settlement of La Réunion Island (Indian Ocean)
    Gemma Berniell-Lee
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Am J Phys Anthropol 136:100-7. 2008
    ..The absence of genetic diversity within these two major components of the mtDNA gene pool suggests these populations may have witnessed strong founder effects during the colonization process...
  11. ncbi request reprint Signatures of selection in the human olfactory receptor OR5I1 gene
    Andres Moreno-Estrada
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Mol Biol Evol 25:144-54. 2008
    ..These results are compatible with positive selection having modeled the pattern of variation found in the OR5I1 gene and with a relatively ancient, mild selective sweep predating the "Out of Africa" expansion of modern humans...
  12. pmc Recent human evolution has shaped geographical differences in susceptibility to disease
    Urko M Marigorta
    Institute of Evolutionary Biology UPF CSIC, PRBB, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain
    BMC Genomics 12:55. 2011
    ..Here, we focus on the world-wide patterns of replicability of published association studies...
  13. ncbi request reprint SNPlexing the human Y-chromosome: a single-assay system for major haplogroup screening
    Gemma Berniell-Lee
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Electrophoresis 28:3201-6. 2007
    ....
  14. pmc Similarity in recombination rate estimates highly correlates with genetic differentiation in humans
    Hafid Laayouni
    IBE, Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e17913. 2011
    ..This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans...