Research Topics
Species | Francisca BarcelóSummaryAffiliation: Universitat de les Illes Balears Country: Spain Publications
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Detail Information
Publications
Interaction of the C-terminal region of the Ggamma protein with model membranesFrancisca Barceló
Laboratory of Molecular and Cellular Biomedicine, Associate Unit of the Instituto de la Grasa Consejo Superior de Investigaciones Científicas, University of the Balearic Islands, E 07122 Palma de Mallorca, Spain
Biophys J 93:2530-41. 2007..These data highlight the relevance of the interaction of the C-terminal region of the Ggamma protein with the cell membrane and its effect on membrane structure...
Mediterranean-style diet effect on the structural properties of the erythrocyte cell membrane of hypertensive patients: the Prevencion con Dieta Mediterranea StudyFrancisca Barceló
Departamento de Biología Fundamental y Ciencias de la Salut, University of the Balearic Islands, Palma de Mallorca, Spain
Hypertension 54:1143-50. 2009..The erythrocyte membrane modulation described provides insight in the structural bases underlying the beneficial effect of a Mediterranean-style diet in hypertensive subjects...
Effects of unsaturated fatty acids and triacylglycerols on phosphatidylethanolamine membrane structureJesús Prades
Molecular and Cellular Biomedicine, Institut Universitari d Investigacions en Ciències de la Salut, Associate Unit of Instituto de la Grasa CSIC, Department of Biology, University of the Balearic Islands, E 07122 Palma de Mallorca, Spain
J Lipid Res 44:1720-7. 2003..Fluorescence polarization data indicated a fluidification effect of OA on the lamellar phase. TO increased the viscosity of the hydrophobic core with a high effect on the HII phase...
Effects of 2-hydroxyoleic acid on the structural properties of biological and model plasma membranesJesús Prades
Molecular and Cellular Biomedicine, Health Sciences Research Institute, University of the Balearic Islands, Palma de Mallorca, Spain
Mol Membr Biol 25:46-57. 2008..These changes in the structural properties of the plasma membrane may modulate the activity of signalling proteins that associate with the cell membrane such as the Galphaq/11 protein and hence, signal transduction...
Thermodynamic characterization of the multivalent binding of chartreusin to DNAFrancisca Barceló
Departament de Biologia Fundamental i Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
Nucleic Acids Res 30:4567-73. 2002..The hydrophobic transfer of the chartreusin chromophore from the solution to the DNA intercalating site is the main contributor to the free energy of binding...
The hypotensive drug 2-hydroxyoleic acid modifies the structural properties of model membranesFrancisca Barceló
Laboratory of Molecular and Cellular Biomedicine, Institut Universitari d Investigacions en Ciències de la Salut IUNICS, Palma de Mallorca, Spain
Mol Membr Biol 21:261-8. 2004..The higher headgroup area at the lipid-water interface in presence of 2OHOA could account for the differential effect of this drug on the phase behaviour of DEPE membranes...
Interaction of transmembrane-spanning segments of the alpha2-adrenergic receptor with model membranesJesús Prades
Laboratory of Molecular and Cellular Biomedicine, University de Les Illes Balears, Palma de Mallorca, Spain
Mol Membr Biol 26:265-78. 2009....
Plant pentacyclic triterpenic acids as modulators of lipid membrane physical propertiesJesús Prades
Clinical and Translational Research Group, IUNICS, University of the Balearic Islands, E 07122 Palma de Mallorca, Spain
Biochim Biophys Acta 1808:752-60. 2011..These results strengthen the relevance of TTP interactions with cell membranes as a molecular mechanism underlying their broad spectrum of biological effects...
Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of minervalJordi Martínez
Laboratory of Molecular and Cellular Biomedicine, Department of Biology, Institut Universitari d Investigacions en Ciències de la Salut, University of the Balearic Islands, Ctra de Valldemossa km 7, 5, E 07122 Palma de Mallorca, Spain
Mol Pharmacol 67:531-40. 2005..The present results support the potential use of Minerval and related compounds in the treatment of tumor pathologies...
Effect of a 2-hydroxylated fatty acid on Cholesterol-rich membrane domainsJesús Prades
Clinical and Translational Research Group, IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
Mol Membr Biol 29:333-43. 2012..The segregation into 2OHOA-rich/Cho-poor and 2OHOA-poor/Cho-rich domains was also observed in PC bilayers...
Elsamicin A binding to DNA. A comparative thermodynamic characterizationFrancisca Barceló
Departament de Biologia Fundamental, i Ciencies de la Salut, Universitat de les Illes Balears, E 07122 Palma de Mallorca, Spain
FEBS Lett 576:68-72. 2004..The results are discussed in terms of the contributions of the disaccharide moieties into the strength of binding...
Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomasVictor Hugo Villar
Clinical and Translational Research Group, Department of Biology, Institut Universitari d Investigacions en Ciències de la Salut IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
PLoS ONE 7:e37735. 2012....
Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinaseRegina Alemany
Laboratory of Molecular and Cellular Biomedicine, Department of Biology, Institut Universitari d Investigacio en Ciencies de la Salut, IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
J Lipid Res 47:1762-70. 2006..Additionally, 2-OHOA completely reversed the pathological overexpression of aortic Rho kinase found in SHRs, suppressing the vasoconstrictory Rho kinase pathway...
