Research Topics
Genomes and Genes | Josep M ArgilesSummaryAffiliation: Universitat de Barcelona Country: Spain Publications
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Publications
Muscle wasting in cancer and ageing: cachexia versus sarcopeniaJ M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Diagonal 645, 08028 Barcelona, Spain
Adv Gerontol 18:39-54. 2006....- [Physiology of sarcopenia. Similarities and differences with neoplasic cachexia (muscle impairments in cancer and ageing)]Josep M Argiles
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
Nutr Hosp 21:38-45. 2006.... - Cancer cachexia: the molecular mechanismsJosep M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071, Barcelona, Spain
Int J Biochem Cell Biol 35:405-9. 2003..The main aim of the present review is to summarise and evaluate the different catabolic mediators (both humoural and tumoural) involved in cancer cachexia since they may represent targets for future promising clinical investigations... - The pharmacological treatment of cachexiaJosep M Argiles
Department de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Curr Drug Targets 5:265-77. 2004..The aim of the present article is to review the different therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure... - Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopeniaJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
Int J Biochem Cell Biol 37:1084-104. 2005.... - The pivotal role of cytokines in muscle wasting during cancerJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Int J Biochem Cell Biol 37:1609-19. 2005..The main aim of the present review is to summarize and evaluate the different molecular mechanisms and catabolic mediators involved in cancer cachexia since they may represent targets for future promising clinical investigations... - Mediators involved in the cancer anorexia-cachexia syndrome: past, present, and futureJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Nutrition 21:977-85. 2005.... - The pivotal role of cytokines in muscle wasting during cancerJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Int J Biochem Cell Biol 37:2036-46. 2005..The main aim of the present review is to summarize and evaluate the different molecular mechanisms and catabolic mediators involved in cancer cachexia since they may represent targets for future promising clinical investigations... - Cancer-associated malnutritionJ M Argiles
Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
Eur J Oncol Nurs 9:S39-50. 2005..EPA has been shown to interfere with multiple mechanisms implicated in the pathogenesis of cancer cachexia, and in clinical studies, has been associated with reversal of cachexia and improved survival... - The role of uncoupling proteins in pathophysiological statesJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Biochem Biophys Res Commun 293:1145-52. 2002..At this point, we hope that the knowledge presented in the present review will not only stimulate a debate about the role of the UCP family in disease but also lead to applications beneficial for human health... - Cancer cachexia: a therapeutic approachJ M Argiles
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Med Res Rev 21:83-101. 2001..The aim of the present study is to review the different therapeutic approaches that have been designed to fight and counteract cancer cachexia... - TNF and pregnancy: the paradigm of a complex interactionJ M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
Cytokine Growth Factor Rev 8:181-8. 1997..We also present evidence supporting the idea that TNF acts as a negative regulator of pregnancy, or does not play any significant role in gestation at all... - Prevention of cancer and cardiovascular diseases: a common strategy?J M Argiles
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
Med Res Rev 18:139-48. 1998..This could be taken into consideration in future studies related to the molecular mechanisms leading to these diseases as well as with the chemopreventive potential of some dietary components... - Was tumour necrosis factor-alpha responsible for the fetal malformations associated with thalidomide in the early 1960s?J M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
Med Hypotheses 50:313-8. 1998..Evidence is presented here suggesting that the embryonic action of thalidomide was mediated by TNF-alpha, since the drug is a powerful inhibitor of the synthesis of this cytokine... - Host metabolism: a target in clinical oncology?J M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
Med Hypotheses 51:411-5. 1998..The present study emphasizes the fact that neutralizing some of the metabolic changes in the patient may be an essential therapeutic strategy in controlling tumour growth and improving survival... - The role of cytokines in cancer cachexiaJ M Argiles
Department de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
Med Res Rev 19:223-48. 1999..It is the balance between these two cytokine types that finally seems to have a key role in cancer cachexia... - Catabolic proinflammatory cytokinesJ M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
Curr Opin Clin Nutr Metab Care 1:245-51. 1998..Additionally, it reviews the role of one of these mediators in the induction of insulin resistance by dealing with some of the most recent publications on this topic... - The divergent effects of tumour necrosis factor-alpha on skeletal muscle: implications in wastingJ M Argiles
Cancer Research Group, Unitat de Bioquímica i Biologia Molecular B, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Eur Cytokine Netw 11:552-9. 2000..However, the results found are relatively divergent, therefore the main aim of the present review has been to clarify and reconcile some of the most contradictory studies concerning the effects of TNF on metabolism in skeletal muscle... - Metabolic interrelationships between liver and skeletal muscle in pathological statesJ M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
Life Sci 69:1345-61. 2001..Carbohydrate, fat and nitrogen metabolism between the parenchymal liver and skeletal muscle are considered and interrelated together with the possible mediators involved in pathological conditions... - Insulin and cancer (Review)J M Argiles
Departament de Bioquimica i Biologia Molecular B, Facultat de Biologia, Universitat de Barcelona, Diagonal 65, 08071 Barcelona, Spain
Int J Oncol 18:683-7. 2001..We review the involvement of insulin in cancer from a multidisciplinary point of view, with the aim of encouraging the design of future therapeutic options for cancer treatment... - Activation of UCPs gene expression in skeletal muscle can be independent on both circulating fatty acids and food intake. Involvement of ROS in a model of mouse cancer cachexiaSilvia Busquets
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
FEBS Lett 579:717-22. 2005..In addition, the present work suggests that UCPs might participate in a counter-regulatory mechanism to lower the production of ROS... - Resveratrol does not ameliorate muscle wasting in different types of cancer cachexia modelsSilvia Busquets
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Clin Nutr 26:239-44. 2007..We decided to investigate the potential anti-wasting properties of resveratrol on different models of cancer cachexia in experimental animals... - Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states?Silvia Busquets
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
J Cell Physiol 191:283-9. 2002..Finally, leucine addition (10 mM), although not able to revert the increased proteolytic rate, resulted in a decrease in the gene expression for ubiquitin, C8 proteasome subunit and cathepsin B... - Are peroxisome proliferator-activated receptors involved in skeletal muscle wasting during experimental cancer cachexia? Role of beta2-adrenergic agonistsGemma Fuster
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Cancer Res 67:6512-9. 2007.... - Effects of CRF2R agonist on tumor growth and cachexia in mice implanted with Lewis lung carcinoma cellsJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
Muscle Nerve 37:190-5. 2008.... 
Megestrol acetate: its impact on muscle protein metabolism supports its use in cancer cachexiaSilvia Busquets
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Clin Nutr 29:733-7. 2010..The aim of the present investigation was to examine the effect of megestrol acetate (MA) in cachectic tumour-bearing animals analyzing changes in muscle proteolysis and in parameters related with quality of life...- Interleukin-15 decreases proteolysis in skeletal muscle: a direct effectSilvia Busquets
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
Int J Mol Med 16:471-6. 2005..The results suggest that the main mechanism involved in the anabolic effects of IL-15 in skeletal muscle relies on a decrease in the proteolytic rate... - Anticachectic effects of formoterol: a drug for potential treatment of muscle wastingSilvia Busquets
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Cancer Res 64:6725-31. 2004.... - Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissueBelen Alvarez
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Biochim Biophys Acta 1570:33-7. 2002.... - Rat liver lipogenesis is modulated by interleukin-15Joaquin Lopez-Soriano
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Int J Mol Med 13:817-9. 2004..Thus, IL-15 seems to be able to modulate de novo fatty acid synthesis, possibly by influencing citrate tissue levels, an allosteric activator of the key lipogenic enzyme acetyl-CoA carboxylase... - Interleukin-15 affects differentiation and apoptosis in adipocytes: implications in obesityGemma Fuster
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Cancer Research Group, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain
Lipids 46:1033-42. 2011..Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies... - Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissueMaite Figueras
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Int J Oncol 27:855-60. 2005.... - Effects of IL-15 on rat brown adipose tissue: uncoupling proteins and PPARsVanessa Almendro
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
Obesity (Silver Spring) 16:285-9. 2008..The aim of this study was to investigate the effects of IL-15 on brown adipose tissue (BAT), and in particular on genes related to lipid metabolism in this tissue... - TNF-alpha modulates cytokine and cytokine receptors in C2C12 myotubesBelen Alvarez
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain
Cancer Lett 175:181-5. 2002..The results suggest that other cytokines may be involved in mediating TNF-alpha action in skeletal muscle and that anti-inflammatory cytokines may be released as a counter-regulatory mechanism... - Interleukin-15 increases calcineurin expression in 3T3-L1 cells: possible involvement on in vivo adipocyte differentiationVanessa Almendro
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Int J Mol Med 24:453-8. 2009..These data suggest that IL-15 directly inhibits adipogenesis, possibly by upregulating alpha-calcineurin and preventing the induction of adipocyte differentiation... - Overexpression of UCP3 in both murine and human myotubes is linked with the activation of proteolytic systems: a role in muscle wasting?Silvia Busquets
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Biochim Biophys Acta 1760:253-8. 2006..Although the function of the UCP3 protein is not completely understood (uncoupling, oxidative stress), these results suggest a possible relation between these main mechanisms involved in muscle wasting during cancer... - L-Carnitine: an adequate supplement for a multi-targeted anti-wasting therapy in cancerSilvia Busquets
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Clin Nutr 31:889-95. 2012..Tumour growth is associated with weight loss resulting from both adipose and muscle wasting... - Interleukin-15 increases glucose uptake in skeletal muscle. An antidiabetogenic effect of the cytokineSilvia Busquets
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Biochim Biophys Acta 1760:1613-7. 2006..In conclusion, the data presented here indicate that IL-15 facilitates glucose metabolism in skeletal muscle and, therefore, a possible role of the cytokine as an antidiabetogenic drug merits future investigations... - Effects of formoterol on protein metabolism in myotubes during hyperthermiaElisabet Ametller
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona 08028, Spain
Muscle Nerve 43:268-73. 2011..It can be concluded that hyperthermia is a suitable model for studying the anti-proteolytic potential of drugs used in the treatment of muscle wasting... - Catabolic mediators as targets for cancer cachexiaJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Drug Discov Today 8:838-44. 2003.... - Cross-talk between skeletal muscle and adipose tissue: a link with obesity?Josep M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Med Res Rev 25:49-65. 2005..IL-15 (a cytokine highly-expressed in skeletal muscle), TNF-alpha, and leptin could play a decisive role in the suggested "conversation" between adipose tissue and skeletal muscle... - Effect of c-ski overexpression on the development of cachexia in mice bearing the Lewis lung carcinomaNeus Carbó
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Int J Mol Med 14:719-23. 2004.... - Both AP-1 and NF-kappaB seem to be involved in tumour growth in an experimental rat hepatomaRodrigo Moore-Carrasco
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Anticancer Res 29:1315-7. 2009..This could, in future, allow for the development of new therapeutic strategies for cancer patients... - Nutraceutical inhibition of muscle proteolysis: a role of diallyl sulphide in the treatment of muscle wastingMireia Olivan
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
Clin Nutr 30:33-7. 2011..The aim of the present investigation was to examine the anti-wasting effects of some nutraceuticals such as genistein, resveratrol, epigallocatechin gallate and diallyl sulphide (DAS)... - Effects of the PPARgamma agonist GW1929 on muscle wasting in tumour-bearing miceRodrigo Moore-Carrasco
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, 08028 Barcelona, Spain
Oncol Rep 19:253-6. 2008..Collectively, the results presented suggest a potential clinical application - possibly in combination with other anabolic strategies - of GW1929 in restoring muscle waste during cancer cachexia... - Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patientsSilvia Busquets
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Clin Nutr 26:614-8. 2007..Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients... - The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathwaysRubén Vicente
Molecular Physiology Laboratory, Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
FEBS Lett 572:189-94. 2004.... - The AP-1/NF-kappaB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexiaRodrigo Moore Carrasco
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Int J Oncol 30:1239-45. 2007.... - Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer modelSilvia Busquets
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Cancer Lett 245:144-8. 2007..These results suggest that resveratrol could be tentatively given as a preventive agent in cancer patients undergoing radiotherapy or chemotherapy... - Mechanisms to explain wasting of muscle and fat in cancer cachexiaJosep M Argiles
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Curr Opin Support Palliat Care 1:293-8. 2007..To describe the most relevant recent findings concerning the molecular mechanisms involved in both fat and muscle tissues in cachectic cancer patients... - Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing ratsMaite Figueras
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
FEBS Lett 569:201-6. 2004..In conclusion, IL-15 seems to be able to reduce/suppress protein loss and apoptosis related to muscle wasting during cancer cachexia in experimental animals... - Patterns of gene expression in muscle and fat in tumor-bearing rats: effects of CRF2R agonist on cachexiaJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
Muscle Nerve 42:936-49. 2010..quot;.. - UCP3 overexpression neutralizes oxidative stress rather than nitrosative stress in mouse myotubesEsther Barreiro
Muscle and Respiratory System Research Unit Pneumology Department, IMIM Hospital del Mar, Centro de Investigación en Red de Enfermedades Respiratorias CibeRes, CEXS, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Barcelona, Spain
FEBS Lett 583:350-6. 2009..We conclude that protein oxidation rather than nitration is neutralized by UPC3 overexpression in mouse myotubes exposed to abundant reactive oxygen species... - Cytokines as mediators and targets for cancer cachexiaJosep M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Cancer Treat Res 130:199-217. 2006.... - PPARdelta mediates IL15 metabolic actions in myotubes: effects of hyperthermiaGemma Fuster
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Int J Mol Med 24:63-8. 2009..The present study also suggests that the effects of IL15 on lipid oxidation could be mediated by PPARdelta... - Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory statusMaite Figueras
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Obesity (Silver Spring) 19:362-9. 2011..The data suggest that EPA treatment to diabetic rats clearly improves lipid metabolism although the evidences on insulin sensitization are less clear... - Antiproteolytic effects of plasma from hibernating bears: a new approach for muscle wasting therapy?Gemma Fuster
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Clin Nutr 26:658-61. 2007..Taking all these into account, the aim of this study is to test if hibernating bear plasma has any antiproteolytic effect on incubated rat skeletal muscle... - Targets in clinical oncology: the metabolic environment of the patientJosep M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
Front Biosci 12:3024-51. 2007..Additionally, an overview of the main therapeutic approaches for the treatment of the cachectic syndrome is presented... - Myostatin: more than just a regulator of muscle massJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Drug Discov Today 17:702-9. 2012..Moreover, we highlight the possible role of the myostatin system in the cross-talk between skeletal muscle and adipose tissue, an important aspect that deserves consideration in wasting diseases... - Plasma from pregnant rats has anti-tumoural activityNeus Carbó
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Oncol Rep 12:885-7. 2004.... - Cytokines in the pathogenesis of cancer cachexiaJosep M Argiles
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
Curr Opin Clin Nutr Metab Care 6:401-6. 2003..The aim of the present review is to summarize and update the role of different cytokines in the pathogenesis of cancer cachexia and to provide therapeutic strategies based on cytokine action... - Redox balance and carbonylated proteins in limb and heart muscles of cachectic ratsJudith Marin-Corral
Pulmonology Department, Universitat Autonoma de Barcelona, Barcelona, Spain
Antioxid Redox Signal 12:365-80. 2010..Additionally, it induces a reduction in type II fiber size in the gastrocnemius, which is associated with increased protein oxidation... - Anti-inflammatory therapies in cancer cachexiaJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Eur J Pharmacol 668:S81-6. 2011..In many cases these cytokines exhibit synergic effects when administered together. Therefore, therapeutic strategies - either nutritional or pharmacological - have been based on either blocking their synthesis or their action... - The role of cytokines in cancer cachexiaJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
Curr Opin Support Palliat Care 3:263-8. 2009..The present investigation is devoted to uncovering the different signaling pathways - particularly transcriptional factors - involved in muscle wasting... - Emerging drugs for cancer cachexiaJosep M Argiles
Universitat de Barcelona, Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Diagonal 645, 08071 Barcelona, Spain
Expert Opin Emerg Drugs 12:555-70. 2007..The aim of the present article is to review the different therapeutic approaches and emerging drugs that have been designed to fight and counteract cachexia associated with cancer... - Novel approaches to the treatment of cachexiaJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
Drug Discov Today 13:73-8. 2008..The aim of the present article is to review the recent therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure... - Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposityJosep M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Drug Discov Today 14:208-13. 2009..The present review summarises the metabolic effects of IL-15 at different target tissues and the possibilities and potential for therapeutic interventions based on the cytokine's roles in obesity and wasting... - Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditionsJosep M Argiles
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, 08028 Barcelona, Spain
Int J Biochem Cell Biol 40:1674-8. 2008..In addition, the role of the different proteolytic systems and their relation with apoptosis is emphasized. Altogether, the data presented could be used for the design of new approaches for the treatment of muscle wasting diseases... - Cancer cachexia: physical activity and muscle force in tumour-bearing ratsMiriam Toledo
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
Oncol Rep 25:189-93. 2011.... 
Are there any benefits of exercise training in cancer cachexia?Josep M Argiles
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028, Barcelona, Spain
J Cachexia Sarcopenia Muscle 3:73-6. 2012..This editorial is aimed at stimulating the debate on the suitability of including exercise training in a multi-functional approach against cachexia taking into consideration both limitations and advantages...- Counteracting inflammation: a promising therapy in cachexiaJosep M Argiles
Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
Crit Rev Oncog 17:253-62. 2012..In many cases these cytokines exhibit synergic effects when administered together. Therefore, therapeutic strategies- either nutritional or pharmacological-have been based on either blocking their synthesis or their action... - Optimal management of cancer anorexia-cachexia syndromeJosep M Argiles
Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
Cancer Manag Res 2:27-38. 2010..The objectives of any therapeutic combination are two-fold: an anticatabolic aim directed towards both fat and muscle catabolism and an anabolic objective leading to the synthesis of macromolecules such as contractile proteins... - Tumor necrosis factor-alpha exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cellsBelen Alvarez
Cancer Research Group, , Universitat de Barcelona, Spain
Biochim Biophys Acta 1542:66-72. 2002..These findings indicate that the effects of TNF on muscle protein synthesis are mediated by IL-6, but that TNF exerts IL-6-independent effects on proliferation of murine skeletal myoblasts... - Training depletes muscle glutathione in patients with chronic obstructive pulmonary disease and low body mass indexRoberto A Rabinovich
Servei de Pneumologia, Hospital Clinic, Facultat de Medicina, Barcelona, Spain
Respiration 73:757-61. 2006..A physiological increase in muscle glutathione after training is not seen in patients with chronic obstructive pulmonary disease (COPD), indicating abnormal peripheral muscle adaptations to exercise...