Josep M Argiles

Summary

Affiliation: Universitat de Barcelona
Country: Spain

Publications

  1. ncbi request reprint Muscle wasting in cancer and ageing: cachexia versus sarcopenia
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Adv Gerontol 18:39-54. 2006
  2. ncbi request reprint [Physiology of sarcopenia. Similarities and differences with neoplasic cachexia (muscle impairments in cancer and ageing)]
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
    Nutr Hosp 21:38-45. 2006
  3. ncbi request reprint TNF and pregnancy: the paradigm of a complex interaction
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Cytokine Growth Factor Rev 8:181-8. 1997
  4. ncbi request reprint The role of uncoupling proteins in pathophysiological states
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Biochem Biophys Res Commun 293:1145-52. 2002
  5. ncbi request reprint Cancer cachexia: the molecular mechanisms
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071, Barcelona, Spain
    Int J Biochem Cell Biol 35:405-9. 2003
  6. ncbi request reprint Cancer-associated malnutrition
    J M Argiles
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    Eur J Oncol Nurs 9:S39-50. 2005
  7. ncbi request reprint The pivotal role of cytokines in muscle wasting during cancer
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Int J Biochem Cell Biol 37:2036-46. 2005
  8. ncbi request reprint The pivotal role of cytokines in muscle wasting during cancer
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Int J Biochem Cell Biol 37:1609-19. 2005
  9. ncbi request reprint Mediators involved in the cancer anorexia-cachexia syndrome: past, present, and future
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Nutrition 21:977-85. 2005
  10. ncbi request reprint Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Int J Biochem Cell Biol 37:1084-104. 2005

Collaborators

  • Vanessa Almendro
  • Esther Barreiro
  • Paola Costelli
  • LeBris S Quinn
  • Joaquim Gea
  • Robert J Isfort
  • Raquel Martinez
  • Feng Wang
  • Francisco Sanchez
  • Giovanni Mantovani
  • X Guirao
  • Roberto A Rabinovich
  • Maria T Quiles
  • A Felipe
  • Silvia Busquets
  • Francisco J Lopez-Soriano
  • Maite Figueras
  • Gemma Fuster
  • Mireia Olivan
  • Rodrigo Moore-Carrasco
  • Miriam Toledo
  • Elisabet Ametller
  • Neus Carbó
  • Marcel Orpi
  • Belen Alvarez
  • Cibely Cristine Fontes-Oliveira
  • Sònia Sirisi
  • Roberto Serpe
  • Cibely Cristine Fontes de Oliveira
  • Joaquin Lopez-Soriano
  • Maria T Figueras
  • Angelica Sette
  • Rubén Vicente
  • Joana Coutinho
  • Judith Marin-Corral
  • Mireia Coma
  • Moorthy Palanki
  • Celia Garcia-Martinez
  • Ana Paula Silva
  • Fabio Penna
  • Maria Paz Aylwin
  • Albert Garcia
  • Maria Inés Genovese
  • Angélica Betancourt
  • Eva Capdevila
  • Clelia Madeddu
  • Fabrizio Pin
  • Enrica Marmonti
  • Antonio Maccio
  • Cibely Fontes de Oliveira
  • Pablo Barberis
  • Katarzyna Korzeniewska
  • Paula Ventura da Silva
  • Sergi Pascual-Guardia
  • Cibely C Fontes
  • Paul A Grimaldi
  • Chris Deans
  • Kenneth C H Fearon
  • Viktoria Raab
  • Sebastiaan Meijsing
  • Vicent Ribas
  • Francesco M Baccino
  • Michael M Tamkun
  • Rolf H Drivdahl
  • Sijlvia Busquets

Detail Information

Publications82

  1. ncbi request reprint Muscle wasting in cancer and ageing: cachexia versus sarcopenia
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Adv Gerontol 18:39-54. 2006
    ....
  2. ncbi request reprint [Physiology of sarcopenia. Similarities and differences with neoplasic cachexia (muscle impairments in cancer and ageing)]
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
    Nutr Hosp 21:38-45. 2006
    ....
  3. ncbi request reprint TNF and pregnancy: the paradigm of a complex interaction
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Cytokine Growth Factor Rev 8:181-8. 1997
    ..We also present evidence supporting the idea that TNF acts as a negative regulator of pregnancy, or does not play any significant role in gestation at all...
  4. ncbi request reprint The role of uncoupling proteins in pathophysiological states
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Biochem Biophys Res Commun 293:1145-52. 2002
    ..At this point, we hope that the knowledge presented in the present review will not only stimulate a debate about the role of the UCP family in disease but also lead to applications beneficial for human health...
  5. ncbi request reprint Cancer cachexia: the molecular mechanisms
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071, Barcelona, Spain
    Int J Biochem Cell Biol 35:405-9. 2003
    ..The main aim of the present review is to summarise and evaluate the different catabolic mediators (both humoural and tumoural) involved in cancer cachexia since they may represent targets for future promising clinical investigations...
  6. ncbi request reprint Cancer-associated malnutrition
    J M Argiles
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    Eur J Oncol Nurs 9:S39-50. 2005
    ..EPA has been shown to interfere with multiple mechanisms implicated in the pathogenesis of cancer cachexia, and in clinical studies, has been associated with reversal of cachexia and improved survival...
  7. ncbi request reprint The pivotal role of cytokines in muscle wasting during cancer
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Int J Biochem Cell Biol 37:2036-46. 2005
    ..The main aim of the present review is to summarize and evaluate the different molecular mechanisms and catabolic mediators involved in cancer cachexia since they may represent targets for future promising clinical investigations...
  8. ncbi request reprint The pivotal role of cytokines in muscle wasting during cancer
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Int J Biochem Cell Biol 37:1609-19. 2005
    ..The main aim of the present review is to summarize and evaluate the different molecular mechanisms and catabolic mediators involved in cancer cachexia since they may represent targets for future promising clinical investigations...
  9. ncbi request reprint Mediators involved in the cancer anorexia-cachexia syndrome: past, present, and future
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Nutrition 21:977-85. 2005
    ....
  10. ncbi request reprint Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Int J Biochem Cell Biol 37:1084-104. 2005
    ....
  11. ncbi request reprint The pharmacological treatment of cachexia
    Josep M Argiles
    Department de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Curr Drug Targets 5:265-77. 2004
    ..The aim of the present article is to review the different therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure...
  12. ncbi request reprint Catabolic proinflammatory cytokines
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Curr Opin Clin Nutr Metab Care 1:245-51. 1998
    ..Additionally, it reviews the role of one of these mediators in the induction of insulin resistance by dealing with some of the most recent publications on this topic...
  13. ncbi request reprint Was tumour necrosis factor-alpha responsible for the fetal malformations associated with thalidomide in the early 1960s?
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Med Hypotheses 50:313-8. 1998
    ..Evidence is presented here suggesting that the embryonic action of thalidomide was mediated by TNF-alpha, since the drug is a powerful inhibitor of the synthesis of this cytokine...
  14. ncbi request reprint Host metabolism: a target in clinical oncology?
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Med Hypotheses 51:411-5. 1998
    ..The present study emphasizes the fact that neutralizing some of the metabolic changes in the patient may be an essential therapeutic strategy in controlling tumour growth and improving survival...
  15. ncbi request reprint The role of cytokines in cancer cachexia
    J M Argiles
    Department de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Med Res Rev 19:223-48. 1999
    ..It is the balance between these two cytokine types that finally seems to have a key role in cancer cachexia...
  16. ncbi request reprint Prevention of cancer and cardiovascular diseases: a common strategy?
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
    Med Res Rev 18:139-48. 1998
    ..This could be taken into consideration in future studies related to the molecular mechanisms leading to these diseases as well as with the chemopreventive potential of some dietary components...
  17. ncbi request reprint The divergent effects of tumour necrosis factor-alpha on skeletal muscle: implications in wasting
    J M Argiles
    Cancer Research Group, Unitat de Bioquímica i Biologia Molecular B, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Eur Cytokine Netw 11:552-9. 2000
    ..However, the results found are relatively divergent, therefore the main aim of the present review has been to clarify and reconcile some of the most contradictory studies concerning the effects of TNF on metabolism in skeletal muscle...
  18. ncbi request reprint Cancer cachexia: a therapeutic approach
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Med Res Rev 21:83-101. 2001
    ..The aim of the present study is to review the different therapeutic approaches that have been designed to fight and counteract cancer cachexia...
  19. ncbi request reprint Insulin and cancer (Review)
    J M Argiles
    Departament de Bioquimica i Biologia Molecular B, Facultat de Biologia, Universitat de Barcelona, Diagonal 65, 08071 Barcelona, Spain
    Int J Oncol 18:683-7. 2001
    ..We review the involvement of insulin in cancer from a multidisciplinary point of view, with the aim of encouraging the design of future therapeutic options for cancer treatment...
  20. ncbi request reprint Metabolic interrelationships between liver and skeletal muscle in pathological states
    J M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Life Sci 69:1345-61. 2001
    ..Carbohydrate, fat and nitrogen metabolism between the parenchymal liver and skeletal muscle are considered and interrelated together with the possible mediators involved in pathological conditions...
  21. ncbi request reprint Resveratrol does not ameliorate muscle wasting in different types of cancer cachexia models
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Clin Nutr 26:239-44. 2007
    ..We decided to investigate the potential anti-wasting properties of resveratrol on different models of cancer cachexia in experimental animals...
  22. ncbi request reprint Activation of UCPs gene expression in skeletal muscle can be independent on both circulating fatty acids and food intake. Involvement of ROS in a model of mouse cancer cachexia
    Silvia Busquets
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    FEBS Lett 579:717-22. 2005
    ..In addition, the present work suggests that UCPs might participate in a counter-regulatory mechanism to lower the production of ROS...
  23. doi request reprint Megestrol acetate: its impact on muscle protein metabolism supports its use in cancer cachexia
    Silvia Busquets
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Clin Nutr 29:733-7. 2010
    ..The aim of the present investigation was to examine the effect of megestrol acetate (MA) in cachectic tumour-bearing animals analyzing changes in muscle proteolysis and in parameters related with quality of life...
  24. ncbi request reprint Are peroxisome proliferator-activated receptors involved in skeletal muscle wasting during experimental cancer cachexia? Role of beta2-adrenergic agonists
    Gemma Fuster
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Cancer Res 67:6512-9. 2007
    ....
  25. ncbi request reprint Effects of CRF2R agonist on tumor growth and cachexia in mice implanted with Lewis lung carcinoma cells
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Muscle Nerve 37:190-5. 2008
    ....
  26. ncbi request reprint Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Int J Mol Med 16:471-6. 2005
    ..The results suggest that the main mechanism involved in the anabolic effects of IL-15 in skeletal muscle relies on a decrease in the proteolytic rate...
  27. ncbi request reprint Interleukin-15 decreases lipid intestinal absorption
    Vanessa Almendro
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Int J Mol Med 15:963-7. 2005
    ..In conclusion, intestinal absorption may be an additional mechanism to take into consideration to explain the 'anti-fat' effect of this cytokine...
  28. ncbi request reprint Impaired voltage-gated K+ channel expression in brain during experimental cancer cachexia
    Mireia Coma
    Molecular Physiology Laboratory, Departament de Bioqui mica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
    FEBS Lett 536:45-50. 2003
    ..The results suggest that brain function is impaired during cancer cachexia, and may account for the cancer-induced anorectic response and other neurological alterations...
  29. ncbi request reprint The AP-1/CJUN signaling cascade is involved in muscle differentiation: implications in muscle wasting during cancer cachexia
    Rodrigo Moore-Carrasco
    Departament de Bioquimica i Biologia Molecular, Cancer Research Group, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    FEBS Lett 580:691-6. 2006
    ..In conclusion, the gene therapy approach presented here clearly suggests an important role for AP-1 in muscle signaling during catabolic states...
  30. ncbi request reprint Both oxidative and nitrosative stress are associated with muscle wasting in tumour-bearing rats
    Esther Barreiro
    Muscle and Respiratory System Research Unit, IMIM and CEXS, Universitat Pompeu Fabra, Barcelona, Spain
    FEBS Lett 579:1646-52. 2005
    ....
  31. ncbi request reprint Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting
    Silvia Busquets
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Cancer Res 64:6725-31. 2004
    ....
  32. doi request reprint Interleukin-15 affects differentiation and apoptosis in adipocytes: implications in obesity
    Gemma Fuster
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Cancer Research Group, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain
    Lipids 46:1033-42. 2011
    ..Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies...
  33. ncbi request reprint Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue
    Maite Figueras
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Int J Oncol 27:855-60. 2005
    ....
  34. ncbi request reprint Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states?
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    J Cell Physiol 191:283-9. 2002
    ..Finally, leucine addition (10 mM), although not able to revert the increased proteolytic rate, resulted in a decrease in the gene expression for ubiquitin, C8 proteasome subunit and cathepsin B...
  35. doi request reprint Effects of IL-15 on rat brown adipose tissue: uncoupling proteins and PPARs
    Vanessa Almendro
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
    Obesity (Silver Spring) 16:285-9. 2008
    ..The aim of this study was to investigate the effects of IL-15 on brown adipose tissue (BAT), and in particular on genes related to lipid metabolism in this tissue...
  36. ncbi request reprint Interleukin-15 is able to suppress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats
    Maite Figueras
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    FEBS Lett 569:201-6. 2004
    ..In conclusion, IL-15 seems to be able to reduce/suppress protein loss and apoptosis related to muscle wasting during cancer cachexia in experimental animals...
  37. ncbi request reprint Effects of interleukin-15 on lipid oxidation: disposal of an oral [(14)C]-triolein load
    Vanessa Almendro
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1761:37-42. 2006
    ..Altogether, the results presented here suggest that IL-15 alters exogenous lipid partitioning, limiting adipose tissue uptake and favouring oxidation...
  38. ncbi request reprint Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue
    Belen Alvarez
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1570:33-7. 2002
    ....
  39. ncbi request reprint Mitochondrial and sarcoplasmic reticulum abnormalities in cancer cachexia: altered energetic efficiency?
    Cibely Cristine Fontes-Oliveira
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645 08028 Barcelona, Spain
    Biochim Biophys Acta 1830:2770-8. 2013
    ..Cachexia is a wasting condition that manifests in several types of cancer, and the main characteristic is the profound loss of muscle mass...
  40. ncbi request reprint Interleukin-15 increases calcineurin expression in 3T3-L1 cells: possible involvement on in vivo adipocyte differentiation
    Vanessa Almendro
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Int J Mol Med 24:453-8. 2009
    ..These data suggest that IL-15 directly inhibits adipogenesis, possibly by upregulating alpha-calcineurin and preventing the induction of adipocyte differentiation...
  41. ncbi request reprint Overexpression of UCP3 in both murine and human myotubes is linked with the activation of proteolytic systems: a role in muscle wasting?
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Biochim Biophys Acta 1760:253-8. 2006
    ..Although the function of the UCP3 protein is not completely understood (uncoupling, oxidative stress), these results suggest a possible relation between these main mechanisms involved in muscle wasting during cancer...
  42. ncbi request reprint Rat liver lipogenesis is modulated by interleukin-15
    Joaquin Lopez-Soriano
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Int J Mol Med 13:817-9. 2004
    ..Thus, IL-15 seems to be able to modulate de novo fatty acid synthesis, possibly by influencing citrate tissue levels, an allosteric activator of the key lipogenic enzyme acetyl-CoA carboxylase...
  43. doi request reprint L-Carnitine: an adequate supplement for a multi-targeted anti-wasting therapy in cancer
    Silvia Busquets
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Clin Nutr 31:889-95. 2012
    ..Tumour growth is associated with weight loss resulting from both adipose and muscle wasting...
  44. ncbi request reprint Interleukin-15 increases glucose uptake in skeletal muscle. An antidiabetogenic effect of the cytokine
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1760:1613-7. 2006
    ..In conclusion, the data presented here indicate that IL-15 facilitates glucose metabolism in skeletal muscle and, therefore, a possible role of the cytokine as an antidiabetogenic drug merits future investigations...
  45. doi request reprint Effects of formoterol on protein metabolism in myotubes during hyperthermia
    Elisabet Ametller
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona 08028, Spain
    Muscle Nerve 43:268-73. 2011
    ..It can be concluded that hyperthermia is a suitable model for studying the anti-proteolytic potential of drugs used in the treatment of muscle wasting...
  46. ncbi request reprint Cross-talk between skeletal muscle and adipose tissue: a link with obesity?
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Med Res Rev 25:49-65. 2005
    ..IL-15 (a cytokine highly-expressed in skeletal muscle), TNF-alpha, and leptin could play a decisive role in the suggested "conversation" between adipose tissue and skeletal muscle...
  47. ncbi request reprint The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathways
    Rubén Vicente
    Molecular Physiology Laboratory, Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
    FEBS Lett 572:189-94. 2004
    ....
  48. ncbi request reprint Both AP-1 and NF-kappaB seem to be involved in tumour growth in an experimental rat hepatoma
    Rodrigo Moore-Carrasco
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Anticancer Res 29:1315-7. 2009
    ..This could, in future, allow for the development of new therapeutic strategies for cancer patients...
  49. doi request reprint Nutraceutical inhibition of muscle proteolysis: a role of diallyl sulphide in the treatment of muscle wasting
    Mireia Olivan
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Clin Nutr 30:33-7. 2011
    ..The aim of the present investigation was to examine the anti-wasting effects of some nutraceuticals such as genistein, resveratrol, epigallocatechin gallate and diallyl sulphide (DAS)...
  50. ncbi request reprint The AP-1/NF-kappaB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia
    Rodrigo Moore-Carrasco
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Int J Oncol 30:1239-45. 2007
    ....
  51. ncbi request reprint TNF-alpha modulates cytokine and cytokine receptors in C2C12 myotubes
    Belen Alvarez
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain
    Cancer Lett 175:181-5. 2002
    ..The results suggest that other cytokines may be involved in mediating TNF-alpha action in skeletal muscle and that anti-inflammatory cytokines may be released as a counter-regulatory mechanism...
  52. ncbi request reprint Sepsis induces DNA fragmentation in rat skeletal muscle
    Vanessa Almendro
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Eur Cytokine Netw 14:256-9. 2003
    ....
  53. ncbi request reprint Effect of c-ski overexpression on the development of cachexia in mice bearing the Lewis lung carcinoma
    Neus Carbó
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Int J Mol Med 14:719-23. 2004
    ....
  54. ncbi request reprint Effects of the PPARgamma agonist GW1929 on muscle wasting in tumour-bearing mice
    Rodrigo Moore-Carrasco
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, 08028 Barcelona, Spain
    Oncol Rep 19:253-6. 2008
    ..Collectively, the results presented suggest a potential clinical application - possibly in combination with other anabolic strategies - of GW1929 in restoring muscle waste during cancer cachexia...
  55. ncbi request reprint Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model
    Silvia Busquets
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Cancer Lett 245:144-8. 2007
    ..These results suggest that resveratrol could be tentatively given as a preventive agent in cancer patients undergoing radiotherapy or chemotherapy...
  56. doi request reprint Patterns of gene expression in muscle and fat in tumor-bearing rats: effects of CRF2R agonist on cachexia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Muscle Nerve 42:936-49. 2010
    ....
  57. doi request reprint UCP3 overexpression neutralizes oxidative stress rather than nitrosative stress in mouse myotubes
    Esther Barreiro
    Muscle and Respiratory System Research Unit Pneumology Department, IMIM Hospital del Mar, Centro de Investigación en Red de Enfermedades Respiratorias CibeRes, CEXS, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Barcelona, Spain
    FEBS Lett 583:350-6. 2009
    ..We conclude that protein oxidation rather than nitration is neutralized by UPC3 overexpression in mouse myotubes exposed to abundant reactive oxygen species...
  58. ncbi request reprint Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Clin Nutr 26:614-8. 2007
    ..Previous studies of our research group have shown that apoptosis is present in skeletal muscle of tumour-bearing animals subject to cachexia. For this reason we decided to investigate the apoptosis in skeletal muscle of cancer patients...
  59. doi request reprint Mechanisms to explain wasting of muscle and fat in cancer cachexia
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Curr Opin Support Palliat Care 1:293-8. 2007
    ..To describe the most relevant recent findings concerning the molecular mechanisms involved in both fat and muscle tissues in cachectic cancer patients...
  60. ncbi request reprint Cytokines as mediators and targets for cancer cachexia
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Cancer Treat Res 130:199-217. 2006
    ....
  61. doi request reprint Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status
    Maite Figueras
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Obesity (Silver Spring) 19:362-9. 2011
    ..The data suggest that EPA treatment to diabetic rats clearly improves lipid metabolism although the evidences on insulin sensitization are less clear...
  62. ncbi request reprint Targets in clinical oncology: the metabolic environment of the patient
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    Front Biosci 12:3024-51. 2007
    ..Additionally, an overview of the main therapeutic approaches for the treatment of the cachectic syndrome is presented...
  63. ncbi request reprint PPARdelta mediates IL15 metabolic actions in myotubes: effects of hyperthermia
    Gemma Fuster
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Int J Mol Med 24:63-8. 2009
    ..The present study also suggests that the effects of IL15 on lipid oxidation could be mediated by PPARdelta...
  64. doi request reprint A new look at an old drug for the treatment of cancer cachexia: megestrol acetate
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Clin Nutr 32:319-24. 2013
    ....
  65. ncbi request reprint Antiproteolytic effects of plasma from hibernating bears: a new approach for muscle wasting therapy?
    Gemma Fuster
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Clin Nutr 26:658-61. 2007
    ..Taking all these into account, the aim of this study is to test if hibernating bear plasma has any antiproteolytic effect on incubated rat skeletal muscle...
  66. ncbi request reprint Catabolic mediators as targets for cancer cachexia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Drug Discov Today 8:838-44. 2003
    ....
  67. doi request reprint Myostatin: more than just a regulator of muscle mass
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Drug Discov Today 17:702-9. 2012
    ..Moreover, we highlight the possible role of the myostatin system in the cross-talk between skeletal muscle and adipose tissue, an important aspect that deserves consideration in wasting diseases...
  68. ncbi request reprint Plasma from pregnant rats has anti-tumoural activity
    Neus Carbó
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Oncol Rep 12:885-7. 2004
    ....
  69. ncbi request reprint Cytokines in the pathogenesis of cancer cachexia
    Josep M Argiles
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain
    Curr Opin Clin Nutr Metab Care 6:401-6. 2003
    ..The aim of the present review is to summarize and update the role of different cytokines in the pathogenesis of cancer cachexia and to provide therapeutic strategies based on cytokine action...
  70. doi request reprint Redox balance and carbonylated proteins in limb and heart muscles of cachectic rats
    Judith Marin-Corral
    Pulmonology Department, Universitat Autonoma de Barcelona, Barcelona, Spain
    Antioxid Redox Signal 12:365-80. 2010
    ..Additionally, it induces a reduction in type II fiber size in the gastrocnemius, which is associated with increased protein oxidation...
  71. doi request reprint Anti-inflammatory therapies in cancer cachexia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Eur J Pharmacol 668:S81-6. 2011
    ..In many cases these cytokines exhibit synergic effects when administered together. Therefore, therapeutic strategies - either nutritional or pharmacological - have been based on either blocking their synthesis or their action...
  72. ncbi request reprint Emerging drugs for cancer cachexia
    Josep M Argiles
    Universitat de Barcelona, Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Diagonal 645, 08071 Barcelona, Spain
    Expert Opin Emerg Drugs 12:555-70. 2007
    ..The aim of the present article is to review the different therapeutic approaches and emerging drugs that have been designed to fight and counteract cachexia associated with cancer...
  73. doi request reprint Novel approaches to the treatment of cachexia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
    Drug Discov Today 13:73-8. 2008
    ..The aim of the present article is to review the recent therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure...
  74. doi request reprint The role of cytokines in cancer cachexia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Curr Opin Support Palliat Care 3:263-8. 2009
    ..The present investigation is devoted to uncovering the different signaling pathways - particularly transcriptional factors - involved in muscle wasting...
  75. doi request reprint Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposity
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Drug Discov Today 14:208-13. 2009
    ..The present review summarises the metabolic effects of IL-15 at different target tissues and the possibilities and potential for therapeutic interventions based on the cytokine's roles in obesity and wasting...
  76. doi request reprint Apoptosis signalling is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, 08028 Barcelona, Spain
    Int J Biochem Cell Biol 40:1674-8. 2008
    ..In addition, the role of the different proteolytic systems and their relation with apoptosis is emphasized. Altogether, the data presented could be used for the design of new approaches for the treatment of muscle wasting diseases...
  77. ncbi request reprint Cancer cachexia: physical activity and muscle force in tumour-bearing rats
    Miriam Toledo
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
    Oncol Rep 25:189-93. 2011
    ....
  78. pmc Are there any benefits of exercise training in cancer cachexia?
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 643, 08028, Barcelona, Spain
    J Cachexia Sarcopenia Muscle 3:73-6. 2012
    ..This editorial is aimed at stimulating the debate on the suitability of including exercise training in a multi-functional approach against cachexia taking into consideration both limitations and advantages...
  79. ncbi request reprint Counteracting inflammation: a promising therapy in cachexia
    Josep M Argiles
    Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
    Crit Rev Oncog 17:253-62. 2012
    ..In many cases these cytokines exhibit synergic effects when administered together. Therefore, therapeutic strategies- either nutritional or pharmacological-have been based on either blocking their synthesis or their action...
  80. pmc Optimal management of cancer anorexia-cachexia syndrome
    Josep M Argiles
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Cancer Manag Res 2:27-38. 2010
    ..The objectives of any therapeutic combination are two-fold: an anticatabolic aim directed towards both fat and muscle catabolism and an anabolic objective leading to the synthesis of macromolecules such as contractile proteins...
  81. ncbi request reprint Tumor necrosis factor-alpha exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cells
    Belen Alvarez
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
    Biochim Biophys Acta 1542:66-72. 2002
    ..These findings indicate that the effects of TNF on muscle protein synthesis are mediated by IL-6, but that TNF exerts IL-6-independent effects on proliferation of murine skeletal myoblasts...
  82. ncbi request reprint Training depletes muscle glutathione in patients with chronic obstructive pulmonary disease and low body mass index
    Roberto A Rabinovich
    Servei de Pneumologia, Hospital Clinic, Facultat de Medicina, Barcelona, Spain
    Respiration 73:757-61. 2006
    ..A physiological increase in muscle glutathione after training is not seen in patients with chronic obstructive pulmonary disease (COPD), indicating abnormal peripheral muscle adaptations to exercise...