Regina Alemany

Summary

Affiliation: Universitat de les Illes Balears
Country: Spain

Publications

  1. doi request reprint Olive oils modulate fatty acid content and signaling protein expression in apolipoprotein E knockout mice brain
    Regina Alemany
    Section of Cell Biology, Department of Biology, Institut Universitari d Investigacions en Ciències de la Salut IUNICS, University of the Balearic Islands, Ctra Valldemossa km 7 5, 07122 Palma de Mallorca, Spain
    Lipids 45:53-61. 2010
  2. ncbi request reprint Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase
    Regina Alemany
    Laboratory of Molecular and Cellular Biomedicine, Department of Biology, Institut Universitari d Investigacio en Ciencies de la Salut, IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
    J Lipid Res 47:1762-70. 2006
  3. ncbi request reprint G protein-coupled receptor systems and their lipid environment in health disorders during aging
    Regina Alemany
    Laboratory of Molecular and Cellular Biomedicine, Institut Universitary d Investigació en Ciències de la Salut, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain
    Biochim Biophys Acta 1768:964-75. 2007
  4. ncbi request reprint Effects of 2-hydroxyoleic acid on the structural properties of biological and model plasma membranes
    Jesús Prades
    Molecular and Cellular Biomedicine, Health Sciences Research Institute, University of the Balearic Islands, Palma de Mallorca, Spain
    Mol Membr Biol 25:46-57. 2008
  5. ncbi request reprint 2-hydroxyoleic acid: a new hypotensive molecule
    Regina Alemany
    Laboratory of Molecular and Cellular Biomedicine, IUNICS, Department of Biology, Associate Unit of the Instituto de la Grasa, University of the Balearic Islands, Palma de Mallorca, Spain
    Hypertension 43:249-54. 2004
  6. ncbi request reprint Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of minerval
    Jordi Martínez
    Laboratory of Molecular and Cellular Biomedicine, Department of Biology, Institut Universitari d Investigacions en Ciències de la Salut, University of the Balearic Islands, Ctra de Valldemossa km 7, 5, E 07122 Palma de Mallorca, Spain
    Mol Pharmacol 67:531-40. 2005
  7. doi request reprint Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties
    Jesús Prades
    Clinical and Translational Research Group, IUNICS, University of the Balearic Islands, E 07122 Palma de Mallorca, Spain
    Biochim Biophys Acta 1808:752-60. 2011
  8. pmc Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas
    Victor Hugo Villar
    Clinical and Translational Research Group, Department of Biology, Institut Universitari d Investigacions en Ciències de la Salut IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
    PLoS ONE 7:e37735. 2012
  9. ncbi request reprint Alteration of lipids, G proteins, and PKC in cell membranes of elderly hypertensives
    Pablo V Escriba
    Laboratory of Molecular and Cellular Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain
    Hypertension 41:176-82. 2003
  10. ncbi request reprint The hypotensive drug 2-hydroxyoleic acid modifies the structural properties of model membranes
    Francisca Barceló
    Laboratory of Molecular and Cellular Biomedicine, Institut Universitari d Investigacions en Ciències de la Salut IUNICS, Palma de Mallorca, Spain
    Mol Membr Biol 21:261-8. 2004

Collaborators

  • D Meyer zu Heringdorf
  • Pablo V Escriba
  • Francisca Barceló
  • Sergio S Funari
  • Javier Martín-Broto
  • Javier Martin
  • Qing Yang
  • Oliver Vögler
  • Jesús Prades
  • Jordi Martínez-Serra
  • Antonio Gutierrez
  • Carlos Saus
  • Victor Hugo Villar
  • Rafael Ramos
  • Teresa Ros
  • Joan Besalduch
  • Juan Carlos Amat
  • Valentina Ruiz-Gutierrez
  • Jordi Gines
  • Jordi M Serra
  • Jordi Martínez
  • Silvia Calabuig-Fariñas
  • Matias Diaz
  • Joana M Plazas
  • María Navarro-Palou
  • Elena Maffiotte
  • Teresa Bex
  • Manuel Gomez-Florit
  • Javier S Perona
  • Maria Navarro
  • Antonia Sampol
  • Antonio Galmes
  • Lorenzo Serra-Moisés
  • JESUS CASAS
  • Philip G Kasprzyk
  • Silvia Terés
  • Carmela Baamonde
  • Tunde Nagy

Detail Information

Publications15

  1. doi request reprint Olive oils modulate fatty acid content and signaling protein expression in apolipoprotein E knockout mice brain
    Regina Alemany
    Section of Cell Biology, Department of Biology, Institut Universitari d Investigacions en Ciències de la Salut IUNICS, University of the Balearic Islands, Ctra Valldemossa km 7 5, 07122 Palma de Mallorca, Spain
    Lipids 45:53-61. 2010
    ....
  2. ncbi request reprint Antihypertensive action of 2-hydroxyoleic acid in SHRs via modulation of the protein kinase A pathway and Rho kinase
    Regina Alemany
    Laboratory of Molecular and Cellular Biomedicine, Department of Biology, Institut Universitari d Investigacio en Ciencies de la Salut, IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
    J Lipid Res 47:1762-70. 2006
    ..Additionally, 2-OHOA completely reversed the pathological overexpression of aortic Rho kinase found in SHRs, suppressing the vasoconstrictory Rho kinase pathway...
  3. ncbi request reprint G protein-coupled receptor systems and their lipid environment in health disorders during aging
    Regina Alemany
    Laboratory of Molecular and Cellular Biomedicine, Institut Universitary d Investigació en Ciències de la Salut, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain
    Biochim Biophys Acta 1768:964-75. 2007
    ..Here, we review the involvement of GPCRs and their lipid environment in the development of the major human pathologies associated with aging such as cancer, neurodegenerative disorders and cardiovascular pathologies...
  4. ncbi request reprint Effects of 2-hydroxyoleic acid on the structural properties of biological and model plasma membranes
    Jesús Prades
    Molecular and Cellular Biomedicine, Health Sciences Research Institute, University of the Balearic Islands, Palma de Mallorca, Spain
    Mol Membr Biol 25:46-57. 2008
    ..These changes in the structural properties of the plasma membrane may modulate the activity of signalling proteins that associate with the cell membrane such as the Galphaq/11 protein and hence, signal transduction...
  5. ncbi request reprint 2-hydroxyoleic acid: a new hypotensive molecule
    Regina Alemany
    Laboratory of Molecular and Cellular Biomedicine, IUNICS, Department of Biology, Associate Unit of the Instituto de la Grasa, University of the Balearic Islands, Palma de Mallorca, Spain
    Hypertension 43:249-54. 2004
    ..As a result of this change, a significant reduction in systolic BP was observed. Therefore, BP can be lowered by administration of 2-OHOA, which might represent the first member of a new family of antihypertensive drugs...
  6. ncbi request reprint Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of minerval
    Jordi Martínez
    Laboratory of Molecular and Cellular Biomedicine, Department of Biology, Institut Universitari d Investigacions en Ciències de la Salut, University of the Balearic Islands, Ctra de Valldemossa km 7, 5, E 07122 Palma de Mallorca, Spain
    Mol Pharmacol 67:531-40. 2005
    ..The present results support the potential use of Minerval and related compounds in the treatment of tumor pathologies...
  7. doi request reprint Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties
    Jesús Prades
    Clinical and Translational Research Group, IUNICS, University of the Balearic Islands, E 07122 Palma de Mallorca, Spain
    Biochim Biophys Acta 1808:752-60. 2011
    ..These results strengthen the relevance of TTP interactions with cell membranes as a molecular mechanism underlying their broad spectrum of biological effects...
  8. pmc Nilotinib counteracts P-glycoprotein-mediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas
    Victor Hugo Villar
    Clinical and Translational Research Group, Department of Biology, Institut Universitari d Investigacions en Ciències de la Salut IUNICS, University of the Balearic Islands, Palma de Mallorca, Spain
    PLoS ONE 7:e37735. 2012
    ....
  9. ncbi request reprint Alteration of lipids, G proteins, and PKC in cell membranes of elderly hypertensives
    Pablo V Escriba
    Laboratory of Molecular and Cellular Biomedicine, Department of Biology, University of the Balearic Islands, Palma de Mallorca, Spain
    Hypertension 41:176-82. 2003
    ..We believe that these alterations could be related to the etiopathology of hypertension in elderly subjects or alternatively may correspond to adaptive compensatory mechanisms...
  10. ncbi request reprint The hypotensive drug 2-hydroxyoleic acid modifies the structural properties of model membranes
    Francisca Barceló
    Laboratory of Molecular and Cellular Biomedicine, Institut Universitari d Investigacions en Ciències de la Salut IUNICS, Palma de Mallorca, Spain
    Mol Membr Biol 21:261-8. 2004
    ..The higher headgroup area at the lipid-water interface in presence of 2OHOA could account for the differential effect of this drug on the phase behaviour of DEPE membranes...
  11. doi request reprint Yondelis® (ET-743, Trabectedin) sensitizes cancer cell lines to CD95-mediated cell death: new molecular insight into the mechanism of action
    Jordi Martínez-Serra
    Department of Hematology, University Hospital of Son Dureta, C Andrea Doria, n 55, Palma de Mallorca, Spain
    Eur J Pharmacol 658:57-64. 2011
    ..The study of this important mechanism of action should set up the basis for reassessing clinical therapy with Yondelis® in order to improve antitumor treatment outcome...
  12. doi request reprint Clinical implications of KIT and PDGFRA genotyping in GIST
    Javier Martín-Broto
    Sarcoma and Melanoma Unit, Department of Oncology, Son Dureta Hospital, Palma de Mallorca, Baleares, Spain
    Clin Transl Oncol 12:670-6. 2010
    ....
  13. doi request reprint Inhibition of c-Myc down-regulation by sustained extracellular signal-regulated kinase activation prevents the antimetabolite methotrexate- and gemcitabine-induced differentiation in non-small-cell lung cancer cells
    Jordi M Serra
    Department of Hematology, Institut Universitari d Investigacions en Ciències de la Salut, University Hospital Son Dureta, C Andrea Doria 55, E 07014 Palma de Mallorca, Spain
    Mol Pharmacol 73:1679-87. 2008
    ....
  14. ncbi request reprint Influence of the membrane lipid structure on signal processing via G protein-coupled receptors
    Qing Yang
    Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Mol Pharmacol 68:210-7. 2005
    ..g., 2-hydroxyoleic acid) as well as the molecular bases of the effects of diet fats on human health...
  15. ncbi request reprint Regulation and functional roles of sphingosine kinases
    Regina Alemany
    Institut fur Pharmakologie, Universitat Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 374:413-28. 2007
    ..In this review, our understanding of structure, regulation, and functional roles of SphKs is updated and discussed with regard to their implication in pathophysiological and disease states...