Guillermo Velasco

Summary

Affiliation: Universidad Complutense
Country: Spain

Publications

  1. doi request reprint Towards the use of cannabinoids as antitumour agents
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, and the Instituto Universitario de Investigación Neuroquímica IUIN, Madrid 28040, Spain
    Nat Rev Cancer 12:436-44. 2012
  2. pmc Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
    Dolores Hernán Pérez de la Ossa
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Complutense University, Madrid, Spain
    PLoS ONE 8:e54795. 2013
  3. pmc Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    Maria Salazar
    Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain
    J Clin Invest 119:1359-72. 2009
  4. doi request reprint Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis
    Mar Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Glia 57:1374-85. 2009
  5. doi request reprint Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Cancer Res 68:1945-52. 2008
  6. ncbi request reprint Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Neuropharmacology 54:235-43. 2008
  7. doi request reprint A combined preclinical therapy of cannabinoids and temozolomide against glioma
    Sofia Torres
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    Mol Cancer Ther 10:90-103. 2011
  8. ncbi request reprint The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
    Blanca Herrera
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    Exp Cell Res 312:2121-31. 2006
  9. ncbi request reprint Cannabinoids and gliomas
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Mol Neurobiol 36:60-7. 2007
  10. ncbi request reprint The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Cell 9:301-12. 2006

Collaborators

Detail Information

Publications27

  1. doi request reprint Towards the use of cannabinoids as antitumour agents
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, and the Instituto Universitario de Investigación Neuroquímica IUIN, Madrid 28040, Spain
    Nat Rev Cancer 12:436-44. 2012
    ..Such knowledge is required for the optimization of preclinical cannabinoid-based therapies and for the preliminary clinical testing that is currently underway...
  2. pmc Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
    Dolores Hernán Pérez de la Ossa
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Complutense University, Madrid, Spain
    PLoS ONE 8:e54795. 2013
    ..Our findings support that THC- and CBD-loaded microparticles could be used as an alternative method of cannabinoid delivery in anticancer therapies...
  3. pmc Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    Maria Salazar
    Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain
    J Clin Invest 119:1359-72. 2009
    ..These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers...
  4. doi request reprint Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis
    Mar Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Glia 57:1374-85. 2009
    ....
  5. doi request reprint Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Cancer Res 68:1945-52. 2008
    ..As MMP-2 up-regulation is associated with high progression and poor prognosis of gliomas and many other tumors, MMP-2 down-regulation constitutes a new hallmark of cannabinoid antitumoral activity...
  6. ncbi request reprint Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Neuropharmacology 54:235-43. 2008
    ..As TIMP-1 up-regulation is associated with high malignancy and negative prognosis of numerous cancers, TIMP-1 down-regulation may be a hallmark of cannabinoid-induced inhibition of glioma progression...
  7. doi request reprint A combined preclinical therapy of cannabinoids and temozolomide against glioma
    Sofia Torres
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    Mol Cancer Ther 10:90-103. 2011
    ..Altogether, our findings support that the combined administration of TMZ and cannabinoids could be therapeutically exploited for the management of GBM...
  8. ncbi request reprint The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
    Blanca Herrera
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    Exp Cell Res 312:2121-31. 2006
    ..In summary, results presented here show that CB2 receptor activation signals apoptosis via a ceramide-dependent stimulation of the mitochondrial intrinsic pathway...
  9. ncbi request reprint Cannabinoids and gliomas
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Mol Neurobiol 36:60-7. 2007
    ..The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids...
  10. ncbi request reprint The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Cell 9:301-12. 2006
    ..Activation of this pathway may constitute a potential therapeutic strategy for inhibiting tumor growth...
  11. doi request reprint Detecting autophagy in response to ER stress signals in cancer
    Maria Salazar
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Methods Enzymol 489:297-317. 2011
    ....
  12. ncbi request reprint Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    Cancer Res 66:6748-55. 2006
    ..These findings may contribute to set the basis for a new therapeutic approach for the treatment of pancreatic cancer...
  13. ncbi request reprint Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:6854-62. 2007
    ..Overall, our results demonstrate that cannabinoids target glioma stem-like cells, promote their differentiation, and inhibit gliomagenesis, thus giving further support to their potential use in the management of malignant gliomas...
  14. doi request reprint The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action
    Maria Salazar
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Biochim Biophys Acta 1831:1573-8. 2013
    ..Altogether, the observations presented here strongly support that TRIB3 plays a crucial role on THC anti-neoplastic activity. This article is part of a Special Issue entitled Lipid Metabolism in Cancer. ..
  15. ncbi request reprint Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway
    Teresa Gómez del Pulgar
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 277:36527-33. 2002
    ..These findings constitute the first evidence for an "astroprotective" role of cannabinoids...
  16. ncbi request reprint Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Pharmacol 62:1385-92. 2002
    ..In conclusion, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision...
  17. ncbi request reprint Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death
    Mar Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Autophagy 7:1071-3. 2011
    ..We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cell death...
  18. pmc Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Biochem J 380:435-40. 2004
    ....
  19. ncbi request reprint Cannabinoid receptors as novel targets for the treatment of melanoma
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    FASEB J 20:2633-5. 2006
    ..These findings may contribute to the design of new chemotherapeutic strategies for the management of melanoma...
  20. ncbi request reprint Cannabinoids and ceramide: two lipids acting hand-by-hand
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Life Sci 77:1723-31. 2005
    ..These findings provide a new conceptual view on how cannabinoids act, and raise interesting physiological and therapeutic questions...
  21. ncbi request reprint Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 12:2319-25. 2006
    ....
  22. ncbi request reprint Hypothesis: cannabinoid therapy for the treatment of gliomas?
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Avenida Complutense, sn, 28040 Madrid, Spain
    Neuropharmacology 47:315-23. 2004
    ..Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas...
  23. ncbi request reprint p8 Upregulation sensitizes astrocytes to oxidative stress
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    FEBS Lett 580:1571-5. 2006
    ..Our results support that serum deprivation sensitizes astrocytes to oxidative stress via a p38 mitogen-activated protein kinase-dependent p8 upregulation that leads in turn to decreased heme oxygenase 1 expression...
  24. ncbi request reprint p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells
    Blanca Herrera
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    FEBS Lett 579:5084-8. 2005
    ..These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells...
  25. ncbi request reprint Cannabinoid CB2 receptor: a new target for controlling neural cell survival?
    Javier Fernandez-Ruiz
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
    Trends Pharmacol Sci 28:39-45. 2007
    ....
  26. pmc De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
    Teresa Gómez del Pulgar
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Biochem J 363:183-8. 2002
    ..These findings show that de novo-synthesized ceramide is involved in cannabinoid-induced apoptosis of glioma cells...