Juan Tamargo

Summary

Affiliation: Universidad Complutense
Country: Spain

Publications

  1. ncbi request reprint Pharmacology of cardiac potassium channels
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 62:9-33. 2004
  2. ncbi request reprint Drug-induced atrial fibrillation: does it matter?
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid 28040, Spain
    Discov Med 14:295-9. 2012
  3. doi request reprint Drug-induced atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Expert Opin Drug Saf 11:615-34. 2012
  4. doi request reprint Safety of flecainide
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Drug Saf 35:273-89. 2012
  5. ncbi request reprint Pharmacological approaches in the treatment of atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Curr Med Chem 11:13-28. 2004
  6. doi request reprint Dronedarone
    J Tamargo
    Department of Pharmacology, Universidad Complutense, Madrid, Spain
    Drugs Today (Barc) 47:109-33. 2011
  7. ncbi request reprint [Rationale and clinical evidence for the effects of new pharmacological treatments for heart failure]
    Juan Tamargo
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Rev Esp Cardiol 57:447-64. 2004
  8. ncbi request reprint Genetically engineered mice as a model for studying cardiac arrhythmias
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid
    Front Biosci 12:22-38. 2007
  9. ncbi request reprint Lipid-lowering therapy with statins, a new approach to antiarrhythmic therapy
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Pharmacol Ther 114:107-26. 2007
  10. doi request reprint Cardiac electrophysiological effects of nitric oxide
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 87:593-600. 2010

Detail Information

Publications78

  1. ncbi request reprint Pharmacology of cardiac potassium channels
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 62:9-33. 2004
    ....
  2. ncbi request reprint Drug-induced atrial fibrillation: does it matter?
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid 28040, Spain
    Discov Med 14:295-9. 2012
    ..Meanwhile, when a patient presents a new-onset AF, it is recommended to review his/her medical and pharmacological history to identify whether any of the prescribed drugs may be responsible for the episode...
  3. doi request reprint Drug-induced atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Expert Opin Drug Saf 11:615-34. 2012
    ..A myriad of drugs can induce AF. However, drug-induced AF (DIAF) receives little attention. Thus, this review is an attempt to attract the attention on this adverse effect...
  4. doi request reprint Safety of flecainide
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Drug Saf 35:273-89. 2012
    ..To ensure that the benefits of treatment outweigh any potential risks, careful patient selection and monitoring is required...
  5. ncbi request reprint Pharmacological approaches in the treatment of atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Curr Med Chem 11:13-28. 2004
    ..The advantages and disadvantages of rhythm and rate control, the role pill in a pocket concept and the role of the new ADs are dicussed...
  6. doi request reprint Dronedarone
    J Tamargo
    Department of Pharmacology, Universidad Complutense, Madrid, Spain
    Drugs Today (Barc) 47:109-33. 2011
    ..This review analyzes the electrophysiological and pharmacological properties, as well as the efficacy and safety of dronedarone in patients with atrial fibrillation...
  7. ncbi request reprint [Rationale and clinical evidence for the effects of new pharmacological treatments for heart failure]
    Juan Tamargo
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Rev Esp Cardiol 57:447-64. 2004
    ..We also discuss new strategies for the treatment of diastolic heart failure...
  8. ncbi request reprint Genetically engineered mice as a model for studying cardiac arrhythmias
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid
    Front Biosci 12:22-38. 2007
    ..This article reviews the results of the main genetically modified mice addressing the genesis of cardiac arrhythmias and sudden cardiac death...
  9. ncbi request reprint Lipid-lowering therapy with statins, a new approach to antiarrhythmic therapy
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Pharmacol Ther 114:107-26. 2007
    ....
  10. doi request reprint Cardiac electrophysiological effects of nitric oxide
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 87:593-600. 2010
    ....
  11. ncbi request reprint Cinaciguat, a soluble guanylate cyclase activator for the potential treatment of acute heart failure
    Juan Tamargo
    Universidad Complutense de Madrid, School of Medicine, Department of Pharmacology, Ciudad Universitaria, 28040 Madrid, Spain
    Curr Opin Investig Drugs 11:1039-47. 2010
    ..Thus, caution should be exerted before extrapolating the present preliminary data to the clinical practice...
  12. doi request reprint Novel therapeutic targets for the treatment of heart failure
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Nat Rev Drug Discov 10:536-55. 2011
    ....
  13. ncbi request reprint The safety of digoxin as a pharmacological treatment of atrial fibrillation
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Expert Opin Drug Saf 5:453-67. 2006
    ....
  14. ncbi request reprint I(Kur)/Kv1.5 channel blockers for the treatment of atrial fibrillation
    Juan Tamargo
    Universidad Complutense, School of Medicine, Department of Pharmacology, Madrid, Spain
    Expert Opin Investig Drugs 18:399-416. 2009
    ....
  15. ncbi request reprint Investigational positive inotropic agents for acute heart failure
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Cardiovasc Hematol Disord Drug Targets 9:193-205. 2009
    ..This review describes three new classes of investigational agents: levosimendan, a calcium sensitizer and potassium channel opener, istaroxime, the first new luso-inotropic agent and cardiac myosin activators...
  16. ncbi request reprint New investigational drugs for the management of acute heart failure syndromes
    J Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Curr Med Chem 17:363-90. 2010
    ....
  17. doi request reprint Ranolazine: an antianginal drug with antiarrhythmic properties
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Expert Rev Cardiovasc Ther 9:815-27. 2011
    ..This article reviews the role of the I(NaL) and provides an update on experimental and clinical evidence supporting the efficacy and safety of ranolazine across a broad spectrum of arrhythmias...
  18. doi request reprint Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats
    Ana María Quintela
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Free Radic Biol Med 53:730-41. 2012
    ..This effect seems to be related to an increase in nitric oxide bioavailability as a result of reduced NADPH oxidase-driven superoxide production and downregulation of prepro endothelin-1...
  19. ncbi request reprint Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 66:84-93. 2005
    ..We therefore investigated the role of L-type Ca(2+) channels, protein kinase C (PKC) zeta, voltage-gated K(+) channels (K(V)), and RhoA/Rho kinase in TXA(2)-induced pulmonary vasoconstriction during postnatal maturation...
  20. ncbi request reprint Increased NADPH oxidase activity mediates spontaneous aortic tone in genetically hypertensive rats
    Federica Lodi
    Department of Pharmacology, Institute of Pharmacology and Toxicology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Eur J Pharmacol 544:97-103. 2006
    ..This was associated with an increased expression of p47phox in the medial layer of the aorta...
  21. ncbi request reprint Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism
    Lucía Núñez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 72:80-9. 2006
    ..5, which generates the ultrarapid delayed rectifier current (IKur) that determines the height and duration of atrial action potentials...
  22. ncbi request reprint Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta
    Manuel Sanchez
    Department of Pharmacology, School of Pharmacy, Universidad de Granada, 18071 Granada, Spain
    J Nutr 137:910-5. 2007
    ....
  23. doi request reprint Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension
    Manuel Gómez-Guzmán
    Department of Pharmacology, School of Pharmacy, School of Medicine, University of Granada, Granada, Spain
    Free Radic Biol Med 52:70-9. 2012
    ..In conclusion, epicatechin prevents hypertension, proteinuria, and vascular dysfunction. Epicatechin also induced a reduction in ET-1 release, systemic and vascular oxidative stress, and inhibition of NADPH oxidase activity...
  24. ncbi request reprint The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Cardiovasc Res 73:424-31. 2007
    ..We hypothesized that quercetin might activate BKCa channel in isolated myocytes from rat coronary arteries and that this mechanism might be involved in its coronary artery relaxant effects...
  25. pmc Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 107:15631-6. 2010
    ..Moreover, our findings provide noteworthy clues about the structural determinants of the C terminus cytoplasmic domain of Kir2.1 channels involved in the control of gating and rectification...
  26. doi request reprint In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain
    J Am Coll Cardiol 55:2346-54. 2010
    ..The purpose of this study was to compare the voltage-dependent K(+) currents of human cells of the right and left atria and determine whether electrical remodeling produced by chronic atrial fibrillation (CAF) is chamber-specific...
  27. ncbi request reprint Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Circulation 107:889-95. 2003
    ..In this study, the effects of SP and its metabolite, canrenoic acid (CA), on human ether-a-go-go-related gene (HERG) currents were analyzed...
  28. ncbi request reprint Role of reactive oxygen species in Kv channel inhibition and vasoconstriction induced by TP receptor activation in rat pulmonary arteries
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Ann N Y Acad Sci 1091:41-51. 2006
    ..Activation of NADPH oxidase and the subsequent production of hydrogen peroxide are involved in the Kv channel inhibition and the contractile response induced by TP receptor activation in rat PA...
  29. ncbi request reprint Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels
    Cristina Arias
    Institute of Pharmacology and Toxicology, CSIC UCM, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 57:660-9. 2003
    ..During chronic therapy, it undergoes extensive first-pass hepatic metabolism to 5-hydroxypropafenone. In the present study we have analysed the effects of propafenone and 5-hydroxypropafenone on HERG current...
  30. ncbi request reprint Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization
    Ignacio Moreno
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    J Pharmacol Exp Ther 304:862-73. 2003
    ..In hKv1.5, a receptor site is apparent on each alpha-subunit of the channel, whereas in HERG channels a common binding site is present at the pore...
  31. doi request reprint Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation
    Miguel Romero
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Atherosclerosis 212:78-85. 2010
    ..In conclusion, ET-1 induces NADPH oxidase-driven O(2)(*-) generation through increase of p47(phox) protein expression. The signalling pathway for this effect involves c-Src activation and ERK1/2 phosphorylation...
  32. doi request reprint Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner
    Irene Amorós
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Mol Cell Cardiol 48:201-10. 2010
    ..These results indicate that at low micromolar concentrations the endocannabinoids AEA and 2-AG directly block human cardiac Kv4.3 channels, which represent a novel molecular target for these compounds...
  33. ncbi request reprint Effects of the flavonoid quercetin and its methylated metabolite isorhamnetin in isolated arteries from spontaneously hypertensive rats
    Manuel Ibarra
    Department of Pharmacology, Institute of Pharmacology and Toxicology CSIC, School of Medicine, University Complutense of Madrid, Spain
    Planta Med 69:995-1000. 2003
    ....
  34. ncbi request reprint Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040, Madrid, Spain
    Cardiovasc Res 62:86-95. 2004
    ..In the present study, we examined whether angiotensin II (AngII) regulated the Ito as well as the putative intracellular cascade responsible for the effects...
  35. doi request reprint Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1)
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 80:375-84. 2008
    ..3 (I(Kv4.3)) and on human transient outward K(+) (I(to1)) currents as well as the signalling pathways responsible for them. We also analysed the expression of NO synthase 3 (NOS3) in patients with CAF...
  36. pmc Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 146:146-61. 2005
    ..Blockade of these cardiac K(+) currents, together with the antagonism of the aldosterone proarrhythmic effects produced by SP, might be highly desirable for the treatment of supraventricular arrhythmias...
  37. ncbi request reprint Soluble guanylyl cyclase during postnatal porcine pulmonary maturation
    Laura Moreno
    Dept Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Am J Physiol Lung Cell Mol Physiol 288:L125-30. 2005
    ..In conclusion, an increased expression of sGC in pulmonary conduit arteries from 2-wk-old compared with newborn piglets explains, at least partly, the age-dependent increase in the vasorelaxant response of NO and other activators of sGC...
  38. ncbi request reprint Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats
    Manuel Sanchez
    Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
    J Hypertens 24:75-84. 2006
    ....
  39. ncbi request reprint Postnatal maturation of phosphodiesterase 5 (PDE5) in piglet pulmonary arteries: activity, expression, effects of PDE5 inhibitors, and role of the nitric oxide/cyclic GMP pathway
    Laura Moreno
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    Pediatr Res 56:563-70. 2004
    ..However, PDE5 is not responsible for the maturational increase of NO bioactivity during the first days of extrauterine life...
  40. ncbi request reprint Diltiazem inhibits hKv1.5 and Kv4.3 currents at therapeutic concentrations
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 64:457-66. 2004
    ..5 and Kv4.3 channels that generate the cardiac ultrarapid delayed rectifier (I(Kur)) and the 4-aminopyridine sensitive transient outward (I(to)) K(+) currents, respectively...
  41. ncbi request reprint Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle
    Gustavo Lopez-Lopez
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    Mol Pharmacol 65:851-9. 2004
    ..When the extracellular NO scavenging effect was prevented, quercetin increased the biological activity of NO, an effect related to its O(2)(.) scavenger properties and/or its inhibitory effect on tissue O(2)(.) generation...
  42. doi request reprint Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase
    Rocío López-Sepúlveda
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Clin Sci (Lond) 120:321-33. 2011
    ..The effects of RWPs appear to be independent of ER and PPARγ activation and are related to ERK1/2 inhibition...
  43. ncbi request reprint Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries
    Francisco Perez-Vizcaino
    Department of Pharmacology, Institute of Pharmacology and Toxicology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    J Pharmacol Exp Ther 302:66-72. 2002
    ..In conclusion, quercetin and its metabolites showed vasodilator effects with selectivity toward the resistance vessels. These effects are not due to or modulated by endothelial factors and are unrelated to changes in cytosolic Ca(2+)...
  44. doi request reprint Proteomic changes related to "bewildered" circulating platelets in the acute coronary syndrome
    Antonio J López-Farré
    Cardiovascular Research Unit, Cardiology Department, Hospital Clinico San Carlos, Madrid, Spain
    Proteomics 11:3335-48. 2011
    ..In summary, these results suggest the existence of circulating antioxidant, cytoskeleton and glycolytic-"bewildered" platelets during the acute phase of a coronary event...
  45. doi request reprint Plasma desmoplakin I biomarker of vascular recurrence after ischemic stroke
    Antonio J López-Farré
    Cardiovascular Research Unit, Cardiology Department, Cardiovascular Institute, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos IdISSC, Madrid, Spain
    J Neurochem 121:314-25. 2012
    ....
  46. doi request reprint Nitric oxide increases cardiac IK1 by nitrosylation of cysteine 76 of Kir2.1 channels
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Circ Res 105:383-92. 2009
    ..The cardiac inwardly rectifying K(+) current (I(K1)) plays a critical role in modulating excitability by setting the resting membrane potential and shaping phase 3 of the cardiac action potential...
  47. ncbi request reprint Expert consensus document on angiotensin converting enzyme inhibitors in cardiovascular disease. The Task Force on ACE-inhibitors of the European Society of Cardiology
    Jose Lopez-Sendon
    Cardiology, Hospital Universitario Gregorio Maranon, Madrid, Spain
    Eur Heart J 25:1454-70. 2004
  48. doi request reprint Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats
    Maria José Zarzuelo
    Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
    Hypertension 58:733-43. 2011
    ..We propose PPARβ as a new therapeutic target in hypertension...
  49. doi request reprint Chronic atrial fibrillation up-regulates β1-Adrenoceptors affecting repolarizing currents and action potential duration
    Marta González de la Fuente
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain
    Cardiovasc Res 97:379-88. 2013
    ....
  50. pmc Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block
    Teresa Gonzalez
    Institute of Pharmacology and Toxicology, CSIC UCM, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Br J Pharmacol 137:1269-79. 2002
    ..All these results suggest that: (1) these drugs bind to the open and the inactivated states of HERG channels, (2) they stabilize HERG channels in the inactivated state, and (3) block induced by bupivacaine enantiomers is stereoselective...
  51. doi request reprint Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner
    Adriana Barana
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Cardiovasc Res 85:56-67. 2010
    ..5 channels, which generate the ultrarapid delayed rectifier current (I(Kur))...
  52. doi request reprint Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats
    Miguel Romero
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Eur J Pharmacol 627:242-50. 2010
    ..However, and despite its antioxidant effects, quercetin was unable to improve insulin sensitivity possibly through its specific interference with the insulin signalling pathway...
  53. ncbi request reprint Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels
    Teresa Gonzalez
    Institute of Pharmacology and Toxicology Consejo Superior de Investigaciones Cientificas, School of Medicine, Universidad Complutense, Madrid, Spain
    Mol Pharmacol 62:1456-63. 2002
    ..3 subunit does not modify the affinity of the charged bupivacaine for its external receptor site but markedly reduces the affinity of bupivacaine and quinidine for their internal receptor site in hKv1.5 channels...
  54. ncbi request reprint Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity
    Francisco Perez-Vizcaino
    Department of Pharmacology, Institute of Pharmacology and Toxicology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Am J Physiol Lung Cell Mol Physiol 283:L839-48. 2002
    ..Therefore, the present data suggest that the maturational increase in the vasodilatation of NO in the pulmonary arteries during the first days of extrauterine life involves a cycloxygenase-dependent inhibition of neonatal NO activity...
  55. doi request reprint Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore
    Irene Amorós
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Biochem Pharmacol 86:267-78. 2013
    ....
  56. doi request reprint Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension
    Maria José Zarzuelo
    Department of Pharmacology, School of Pharmacy, University of Granada, Spain
    Cardiovasc Res 99:622-31. 2013
    ..We analysed the chronic effects of the peroxisome proliferator-activated receptor β/δ (PPAR-β) agonist GW0742 on the renin-independent hypertension induced by deoxycorticosterone acetate (DOCA)-salt...
  57. ncbi request reprint Role of protein kinase Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries
    Laura Moreno
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Mol Pharmacol 72:1301-9. 2007
    ..These observations identify PKCzeta and/or p62 as potential therapeutic targets for the treatment of pulmonary hypertension...
  58. doi request reprint Comparative expression of proteins in left and right atrial appendages from patients with mitral valve disease at sinus rhythm and atrial fibrillation
    Javier Modrego
    Cardiovascular Research Unit, Hospital Clinico San Carlos, Madrid, Spain
    J Cardiovasc Electrophysiol 21:859-68. 2010
    ....
  59. pmc Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation
    Pilar Galindo
    Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
    PLoS ONE 7:e32673. 2012
    ..The aim of the study is to analyze whether deconjugation of these metabolites is involved in the blood pressure lowering effect of quercetin...
  60. ncbi request reprint Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction: role of protein kinase Czeta
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Circ Res 93:656-63. 2003
    ..We propose PKCzeta as a link between TP receptor activation and KV channel inhibition...
  61. ncbi request reprint Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats
    Juan Duarte
    University of Granada, Department of Pharmacology, School of Pharmacy, Granada, Spain
    J Hypertens 20:1843-54. 2002
    ..The present study analysed, for the first time, the effects of the flavonoid quercetin in rats after chronic inhibition of nitric oxide (NO) synthesis with Nomega-nitro-L-arginine methyl ester (L-NAME)...
  62. ncbi request reprint New insights in the pharmacological therapy of arterial hypertension
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Av Complutense S N, 28040 Madrid, Spain
    Curr Opin Nephrol Hypertens 14:423-7. 2005
    ..These limitations have stimulated the research and development of new antihypertensive drugs, which we briefly review herein...
  63. pmc Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 138:1475-84. 2003
    ..4. These results point to an important role for S6 valines at positions 402 and 404 in mediating voltage-dependent block by quinidine and flecainide...
  64. ncbi request reprint Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization
    Angel Cogolludo
    Department Pharmacology, School Medicine, Universidad Complutense, Madrid, Spain
    Circ Res 98:931-8. 2006
    ..5 currents via phospholipase C, protein kinase C, tyrosine kinase, and a caveolae pathway. KV channel inhibition accounts, at least partly, for 5-HT-induced pulmonary vasoconstriction and might play a role in PH...
  65. ncbi request reprint Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization
    Eva Delpón
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Trends Pharmacol Sci 26:155-61. 2005
    ....
  66. ncbi request reprint New therapeutic targets for the development of positive inotropic agents
    Juan Tamargo
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, 28040, Spain
    Discov Med 12:381-92. 2011
    ..This review describes the mechanism of action and preliminary clinical results obtained with these new investigational positive inotropic agents...
  67. doi request reprint Functional effects of a missense mutation in HERG associated with type 2 long QT syndrome
    Irene Amorós
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Heart Rhythm 8:463-70. 2011
    ..Congenital LQTS type 2 (LQT2) is due to loss-of-function mutations in the KCNH2 gene encoding Kv11.1 channels responsible for the rapid component of the delayed rectifier current...
  68. ncbi request reprint Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5)
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Cardiovasc Res 56:104-17. 2002
    ..5 channels in a voltage-dependent manner and modified the voltage-dependence of channel activation. The present study was undertaken to localize the putative binding sites involved in the 'agonists' and blocking effects of benzocaine...
  69. ncbi request reprint Expert consensus document on beta-adrenergic receptor blockers
    Jose Lopez-Sendon
    Cardiology, Hospital Universitario Gregorio Maranon, Madrid, Spain
    Eur Heart J 25:1341-62. 2004
  70. ncbi request reprint Hypertension magnitude and management in the elderly population of Spain
    Jose R Banegas
    Department of Preventive Medicine and Public Health, Autonomous University of Madrid, Madrid, Spain
    J Hypertens 20:2157-64. 2002
    ..The present study assessed the prevalence, awareness, treatment and control of hypertension among the elderly population of Spain...
  71. doi request reprint Old and new molecular mechanisms associated with platelet resistance to antithrombotics
    Antonio J López Farré
    Cardiovascular Research Unit, Cardiology Department, Hospital Clinico San Carlos, C Profesor Martin Lagos s n, Madrid, 28040, Spain
    Pharm Res 27:2365-73. 2010
    ..New technologies, such as proteomics and genetic, are beginning to show new unknown biological biomarkers and molecular mechanisms which may be associated with platelet antithrombotic drug resistance...
  72. ncbi request reprint Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria
    Manuel Ibarra
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, Madrid, Spain
    Planta Med 68:307-10. 2002
    ..The arterial, venous and coronary vasodilator effects may contribute to the protective effects of flavonoids in ischaemic heart disease observed in epidemiological studies...
  73. ncbi request reprint Cytosolic Ca2+ and phosphoinositide hydrolysis linked to constitutively active alpha 1D-adrenoceptors in vascular smooth muscle
    Regina Gisbert
    Departamento de Farmacologia, Facultad de Farmacia, Universitat de Valencia, Burjassot, Valencia 46100, Spain
    J Pharmacol Exp Ther 305:1006-14. 2003
    ..e., inositol phosphate formation and Ca2+ entry through L-type channels, which maintains a contractile response once the agonist has been removed...
  74. ncbi request reprint Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
    Lars Ryden
    Department of Cardiology, Karolinska University Hospital, Sweden
    Eur Heart J 28:88-136. 2007
  75. ncbi request reprint [The HERACLES Cardiovascular Network]
    Jaume Marrugat
    Instituto Municipal de Investigación Médica IMIM Hospital del Mar Barcelona España
    Rev Esp Cardiol 61:66-75. 2008
    ..redheracles.net), funding has been received for more than 90 projects in competitive submissions to Spanish and six international bodies, and there is a DNA Biobank...
  76. pmc Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems
    Antonio S Tutor
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Mol Biol Cell 17:4666-74. 2006
    ..Our results suggest that the dynamic association of 14-3-3 proteins to both beta(1)AR and Kv11.1 channels is involved in the adrenergic modulation of this critical regulator of cardiac repolarization and refractoriness...
  77. ncbi request reprint Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology
    Kim Fox
    Department of Cardiology, Royal Brompton Hospital, London, UK
    Eur Heart J 27:1341-81. 2006
  78. ncbi request reprint Relaxant effects of the soluble guanylate cyclase activator and NO sensitizer YC-1 in piglet pulmonary arteries
    Gema Gonzalez-Luis
    Department of Pediatrics, University Hospital Maastricht, Research Institute Growth and Development, Maastricht, The Netherlands
    Biol Neonate 90:66-72. 2006
    ..The indazole derivative YC-1 has been characterized as a nitric oxide (NO)-independent and heme dependent soluble guanylate cyclase (sGC) activator, which also sensitizes sGC to NO...