Sotillos S, Aguilar Aragon M, HombrÃa J. Functional analysis of the Drosophila RhoGAP Cv-c protein and its equivalence to the human DLC3 and DLC1 proteins. Sci Rep. 2018;8:4601 pubmed publisher
..Thus, these RhoGAP proteins are functionally equivalent, opening up the use of Drosophila as an in vivo model to analyse pharmacologically and genetically the human DLC proteins. ..
Sotillos S, de Celis J. Regulation of decapentaplegic expression during Drosophila wing veins pupal development. Mech Dev. 2006;123:241-51 pubmed publisher
Sotillos S, Díaz Meco M, Moscat J, Castelli Gair Hombría J. Polarized subcellular localization of Jak/STAT components is required for efficient signaling. Curr Biol. 2008;18:624-9 pubmed publisher
..Our results also suggest that receptor polarization in the ectoderm cell membrane restricts the cell's response to ligands provided by neighboring cells. ..
Sotillos S, Krahn M, Espinosa Vázquez J, Hombria J. Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. Development. 2013;140:1507-16 pubmed publisher
..This is the first time that a functional link between cell polarity, the JAK/STAT signalling pathway and the Src kinases has been established in a whole organism. ..
Calero Cuenca F, Espinosa Vázquez J, Reina Campos M, Diaz Meco M, Moscat J, Sotillos S. Nuclear fallout provides a new link between aPKC and polarized cell trafficking. BMC Biol. 2016;14:32 pubmed publisher
..We propose a regulatory loop by which Nuf promotes aPKC apical recycling until sufficient levels of active aPKC are reached. Thus, we provide a novel link between cell polarity regulation and traffic control in epithelia. ..