Thomas Schimmang

Summary

Affiliation: Universidad de Valladolid
Country: Spain

Publications

  1. ncbi request reprint Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy
    Vimla S Aggarwal
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Mol Genet 15:3219-28. 2006
  2. doi request reprint Transcription factors that control inner ear development and their potential for transdifferentiation and reprogramming
    Thomas Schimmang
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
    Hear Res 297:84-90. 2013
  3. ncbi request reprint Expression and functions of FGF ligands during early otic development
    Thomas Schimmang
    Institute for Molecular Biology and Genetics, University of Valladolid and Spanish Research Council CSIC, Valladolid, Spain
    Int J Dev Biol 51:473-81. 2007
  4. doi request reprint Roles of Wnt8a during formation and patterning of the mouse inner ear
    Victor Vendrell
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
    Mech Dev 130:160-8. 2013
  5. doi request reprint N-myc controls proliferation, morphogenesis, and patterning of the inner ear
    Elena Dominguez-Frutos
    Institute of Biology and Molecular Genetics, University of Valladolid and Spanish National Research Council, E 47003 Valladolid, Spain
    J Neurosci 31:7178-89. 2011
  6. doi request reprint Generation of inner ear sensory cells from bone marrow-derived human mesenchymal stem cells
    M Beatriz Durán Alonso
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003, Valladolid, Spain
    Regen Med 7:769-83. 2012
  7. doi request reprint Coupling the cell cycle to development and regeneration of the inner ear
    Thomas Schimmang
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, Valladolid, Spain
    Semin Cell Dev Biol 24:507-13. 2013
  8. doi request reprint Tissue-specific requirements for FGF8 during early inner ear development
    Elena Dominguez-Frutos
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, C Sanz y Fores s n, E 47003 Valladolid, Spain
    Mech Dev 126:873-81. 2009
  9. ncbi request reprint Herpes simplex virus type 1-mediated transfer of neurotrophin-3 stimulates survival of chicken auditory sensory neurons
    Estela Carnicero
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, Departamento de Bioquimica, Biologia Molecular y Fisiologia, Facultad de Medicina, 47005 Valladolid, Spain
    Neurosci Lett 321:149-52. 2002
  10. doi request reprint Cell and tissue therapy in regenerative medicine
    Ana Sanchez
    Instituto de Biologia y Genetica Molecular, University of Valladolid and Spanish Research Council, Spain
    Adv Exp Med Biol 741:89-102. 2012

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy
    Vimla S Aggarwal
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Mol Genet 15:3219-28. 2006
    ..This redundancy should be considered when looking at individual FGF genes as modifiers of 22q11DS...
  2. doi request reprint Transcription factors that control inner ear development and their potential for transdifferentiation and reprogramming
    Thomas Schimmang
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
    Hear Res 297:84-90. 2013
    ....
  3. ncbi request reprint Expression and functions of FGF ligands during early otic development
    Thomas Schimmang
    Institute for Molecular Biology and Genetics, University of Valladolid and Spanish Research Council CSIC, Valladolid, Spain
    Int J Dev Biol 51:473-81. 2007
    ....
  4. doi request reprint Roles of Wnt8a during formation and patterning of the mouse inner ear
    Victor Vendrell
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
    Mech Dev 130:160-8. 2013
    ..Further reduction of Wnt signalling by the inactivation of Wnt1 in a Wnt8a mutant background revealed a redundant requirement for both genes during morphogenesis of the dorsal portion of the otic vesicle...
  5. doi request reprint N-myc controls proliferation, morphogenesis, and patterning of the inner ear
    Elena Dominguez-Frutos
    Institute of Biology and Molecular Genetics, University of Valladolid and Spanish National Research Council, E 47003 Valladolid, Spain
    J Neurosci 31:7178-89. 2011
    ..Collectively, our data suggest that N-myc regulates growth, morphogenesis, and pattern formation during the development of the inner ear...
  6. doi request reprint Generation of inner ear sensory cells from bone marrow-derived human mesenchymal stem cells
    M Beatriz Durán Alonso
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003, Valladolid, Spain
    Regen Med 7:769-83. 2012
    ..Hearing loss is the most common sensory disorder in humans, its main cause being the loss of cochlear hair cells. We studied the potential of human mesenchymal stem cells (hMSCs) to differentiate towards hair cells and auditory neurons...
  7. doi request reprint Coupling the cell cycle to development and regeneration of the inner ear
    Thomas Schimmang
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, Valladolid, Spain
    Semin Cell Dev Biol 24:507-13. 2013
    ..Finally, we address the question of whether manipulations of the cell cycle may have the potential to create replacement cells for the damaged inner sensory epithelia. ..
  8. doi request reprint Tissue-specific requirements for FGF8 during early inner ear development
    Elena Dominguez-Frutos
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, C Sanz y Fores s n, E 47003 Valladolid, Spain
    Mech Dev 126:873-81. 2009
    ..This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates...
  9. ncbi request reprint Herpes simplex virus type 1-mediated transfer of neurotrophin-3 stimulates survival of chicken auditory sensory neurons
    Estela Carnicero
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, Departamento de Bioquimica, Biologia Molecular y Fisiologia, Facultad de Medicina, 47005 Valladolid, Spain
    Neurosci Lett 321:149-52. 2002
    ..Therefore, this vector may present a unique entry point to develop therapies preventing or treating hearing impairment caused by the degeneration of auditory neurons...
  10. doi request reprint Cell and tissue therapy in regenerative medicine
    Ana Sanchez
    Instituto de Biologia y Genetica Molecular, University of Valladolid and Spanish Research Council, Spain
    Adv Exp Med Biol 741:89-102. 2012
    ..Other therapies under research, using pluripotent stem cells, have been modest so it is useful to review the protocols and try to improve the outcomes. In this chapter we will review the new advances made in this way...
  11. ncbi request reprint Requirements for FGF3 and FGF10 during inner ear formation
    Yolanda Alvarez
    Center for Molecular Neurobiology Hamburg, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Development 130:6329-38. 2003
    ..We thus created double mutant mice for FGF3 and FGF10, which form severely reduced otic vesicles, suggesting redundant roles of these FGFs, acting in combination as neural signals for otic vesicle formation...
  12. ncbi request reprint Differential requirements for FGF3, FGF8 and FGF10 during inner ear development
    Laura Cecilia Zelarayan
    Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Dev Biol 308:379-91. 2007
    ..Together these results provide important insights into how the spatial and temporal expression of various FGFs controls different steps of inner ear formation during vertebrate development...
  13. pmc An integrated gene regulatory network controls stem cell proliferation in teeth
    Xiu Ping Wang
    Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    PLoS Biol 5:e159. 2007
    ..Subtle variations in this or related regulatory networks may explain the different regenerative capacities of various organs and animal species...
  14. ncbi request reprint FGF signalling controls expression of vomeronasal receptors during embryogenesis
    Oleg Lioubinski
    Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Mech Dev 123:17-23. 2006
    ..The relevance of VR expression in these structures and for formation of the VNO is discussed...
  15. ncbi request reprint Differential roles of fibroblast growth factor-2 during development and maintenance of auditory sensory epithelia
    Estela Carnicero
    Center for Molecular Neurobiology Hamburg, University of Hamburg, Hamburg, Germany
    J Neurosci Res 77:787-97. 2004
    ..In light of these results, the differential roles of FGF2 in the vertebrate inner ear are discussed with respect to its previously postulated functions...