Research Topics
Genomes and Genes
Species | Thomas SchimmangSummaryAffiliation: Universidad de Valladolid Country: Spain Publications
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Detail Information
Publications
Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancyVimla S Aggarwal
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Hum Mol Genet 15:3219-28. 2006..This redundancy should be considered when looking at individual FGF genes as modifiers of 22q11DS...
Transcription factors that control inner ear development and their potential for transdifferentiation and reprogrammingThomas Schimmang
Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
Hear Res 297:84-90. 2013....- Expression and functions of FGF ligands during early otic developmentThomas Schimmang
Institute for Molecular Biology and Genetics, University of Valladolid and Spanish Research Council CSIC, Valladolid, Spain
Int J Dev Biol 51:473-81. 2007.... - N-myc controls proliferation, morphogenesis, and patterning of the inner earElena Dominguez-Frutos
Institute of Biology and Molecular Genetics, University of Valladolid and Spanish National Research Council, E 47003 Valladolid, Spain
J Neurosci 31:7178-89. 2011..Collectively, our data suggest that N-myc regulates growth, morphogenesis, and pattern formation during the development of the inner ear... - Roles of Wnt8a during formation and patterning of the mouse inner earVictor Vendrell
Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003 Valladolid, Spain
Mech Dev 130:160-8. 2013..Further reduction of Wnt signalling by the inactivation of Wnt1 in a Wnt8a mutant background revealed a redundant requirement for both genes during morphogenesis of the dorsal portion of the otic vesicle... - Cell and tissue therapy in regenerative medicineAna Sanchez
Instituto de Biologia y Genetica Molecular, University of Valladolid and Spanish Research Council, Spain
Adv Exp Med Biol 741:89-102. 2012..Other therapies under research, using pluripotent stem cells, have been modest so it is useful to review the protocols and try to improve the outcomes. In this chapter we will review the new advances made in this way... - Tissue-specific requirements for FGF8 during early inner ear developmentElena Dominguez-Frutos
Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, C Sanz y Fores s n, E 47003 Valladolid, Spain
Mech Dev 126:873-81. 2009..This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates... - Generation of inner ear sensory cells from bone marrow-derived human mesenchymal stem cellsM Beatriz Durán Alonso
Instituto de Biologia y Genetica Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, c Sanz y Forés 3, E 47003, Valladolid, Spain
Regen Med 7:769-83. 2012..Hearing loss is the most common sensory disorder in humans, its main cause being the loss of cochlear hair cells. We studied the potential of human mesenchymal stem cells (hMSCs) to differentiate towards hair cells and auditory neurons... - Requirements for FGF3 and FGF10 during inner ear formationYolanda Alvarez
Center for Molecular Neurobiology Hamburg, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
Development 130:6329-38. 2003..We thus created double mutant mice for FGF3 and FGF10, which form severely reduced otic vesicles, suggesting redundant roles of these FGFs, acting in combination as neural signals for otic vesicle formation... - Differential requirements for FGF3, FGF8 and FGF10 during inner ear developmentLaura Cecilia Zelarayan
Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
Dev Biol 308:379-91. 2007..Together these results provide important insights into how the spatial and temporal expression of various FGFs controls different steps of inner ear formation during vertebrate development... 
An integrated gene regulatory network controls stem cell proliferation in teethXiu Ping Wang
Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
PLoS Biol 5:e159. 2007..Subtle variations in this or related regulatory networks may explain the different regenerative capacities of various organs and animal species...- FGF signalling controls expression of vomeronasal receptors during embryogenesisOleg Lioubinski
Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
Mech Dev 123:17-23. 2006..The relevance of VR expression in these structures and for formation of the VNO is discussed... - Differential roles of fibroblast growth factor-2 during development and maintenance of auditory sensory epitheliaEstela Carnicero
Center for Molecular Neurobiology Hamburg, University of Hamburg, Hamburg, Germany
J Neurosci Res 77:787-97. 2004..In light of these results, the differential roles of FGF2 in the vertebrate inner ear are discussed with respect to its previously postulated functions... - Herpes simplex virus type 1-mediated transfer of neurotrophin-3 stimulates survival of chicken auditory sensory neuronsEstela Carnicero
, Universidad de Valladolid y Consejo Superior de Investigaciones Cientificas, , , Facultad de Medicina, 47005 Valladolid, Spain
Neurosci Lett 321:149-52. 2002..Therefore, this vector may present a unique entry point to develop therapies preventing or treating hearing impairment caused by the degeneration of auditory neurons...