Research Topics
Genomes and GenesSpecies | F MollinedoSummaryAffiliation: Universidad de Salamanca Country: Spain Publications
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Detail Information
Publications
Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosisConsuelo Gajate
, , Consejo Superior de Investigaciones Cientificas-Universidad de Salamanca, Campus Miguel de Unamuno, Spain
J Biol Chem 277:41580-9. 2002....- Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cellsTeresa Nieto-Miguel
, , , Campus Miguel de Unamuno, E-37007 Salamanca, Spain
J Biol Chem 281:14833-40. 2006..These data indicate that edelfosine targets two different subcellular structures in a cell type-dependent manner, namely cell surface lipid rafts in leukemic cells and endoplasmic reticulum in solid tumor cells... 
Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosisVitaly A Selivanov
Department of Biochemistry and Molecular Biology, Faculty of Biology, Institute of Biomedicine of University of Barcelona IBUB and IDIBAPS, unit associated with CSIC, Barcelona, Spain
BMC Syst Biol 4:135. 2010..This tool can be applied to reveal the metabolic effect of proapoptotic drug edelfosine in leukemia Jurkat cell line, uncovering the mechanisms of induction of apoptosis in cancer cells...- Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophilsFaustino Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
J Immunol 177:2831-41. 2006.... 
Differential gene expression patterns coupled to commitment and acquisition of phenotypic hallmarks during neutrophil differentiation of human leukaemia HL-60 cellsFaustino Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas C S I C, Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Gene 419:16-26. 2008....- Survival and apoptotic signals in the action of microtubule-targeting antitumor drugsFaustino Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
IDrugs 8:127-43. 2005..Microtubule damage induces both survival and pro-apoptotic signals, and inhibition of survival signaling could improve the efficacy of microtubule-targeting agents... - Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitisFaustino Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
J Pharmacol Exp Ther 329:439-49. 2009..Our data identify edelfosine as a novel anti-inflammatory drug by abating neutrophil infiltration through L-selectin shedding and may provide a new therapeutic approach for inflammatory bowel disease free from toxicity... - ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptorFaustino Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Curr Med Chem 11:3163-84. 2004..This novel mechanism of action represents a new way to target tumour cells in cancer chemotherapy and can be of interest as a new framework in designing novel and more selective proapoptotic antitumour drugs... - Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapyFaustino Mollinedo
Institute of Molecular and Cellular Cancer Biology, Centre for Cancer Research, CSIC University of Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
Future Oncol 6:811-21. 2010..The development of drugs that target lipid rafts leading to the formation of clusters of apoptotic signaling molecule-enriched rafts offers new opportunities for therapeutic intervention in cancer therapy... - In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid raftsFaustino Mollinedo
Instituto de Biologia Molecular, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Spain
Clin Cancer Res 16:2046-54. 2010..The present study investigates the in vitro and in vivo effect of the phospholipid ether edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) in MCL and CLL... - Lipid raft-targeted therapy in multiple myelomaF Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
Oncogene 29:3748-57. 2010..Our data reveal cholesterol-containing lipid rafts as a novel and efficient therapeutic target in MM, opening a new avenue in cancer treatment... - Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophilsFaustino Mollinedo
Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
J Biol Chem 285:34528-36. 2010..Our data suggest that Leishmania promastigotes modulate their uptake by neutrophils, and regulate granule fusion processes in a rather selective way to favor parasite survival in human neutrophils... - Microtubules, microtubule-interfering agents and apoptosisF Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Apoptosis 8:413-50. 2003..Thus, sustained modification of signaling routes and changes in the scaffolding properties of microtubules seem to constitute two major processes in the apoptotic response induced by microtubule-interfering agents... - Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary Faustino Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Spain
J Immunol 170:1034-42. 2003..These data indicate that VAMP-2 mediates exocytosis of specific and tertiary granules, and that Q-SNARE/R-SNARE complexes containing VAMP-2 and syntaxin 4 are involved in neutrophil exocytosis... - Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondriaF Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Cell Death Dis 2:e158. 2011..These observations unveil a new framework in cancer chemotherapy that involves a link between lipid rafts and mitochondria in the mechanism of action of an antitumor drug, thus opening new avenues for cancer treatment... - Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acidI S Marcos
Departamento de Quimica Organica, Facultad de Ciencias Quimicas, Universidad de Salamanca, Plaza de los Caidos 1 5, Salamanca, Spain
Bioorg Med Chem 15:5719-37. 2007..The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC(50) in the low micromolar range... - Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actionsM Reis-Sobreiro
Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
Oncogene 28:3221-34. 2009..These results also highlight the role of recruitment of Fas/CD95 signaling in lipid rafts in antimyeloma and antileukemia chemotherapy... - Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluationP Basabe
Departamento de Quimica Organica, Facultad de Ciencias Quimicas, Universidad de Salamanca, Plaza de los Caidos 1 5, 37008 Salamanca, Spain
Eur J Med Chem 45:4258-69. 2010..The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active... - Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processesP A Lazo
Instituto de Biologia Molecular y Celular del Cancer, Universidad de Salamanca, Spain
Hum Genet 108:211-5. 2001..Alterations in the SNAP23 gene might be involved in neurological and other diseases with defects in vesicle-membrane fusion processes that map to 15q15-21... - The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cellsC Gajate
, , CSIC-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
Blood 98:3860-3. 2001..This translocation of Fas into membrane rafts may provide a mechanism for amplifying Fas signaling by reorganization of membrane microdomains... - Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosisB Martin-Martin
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
Blood 96:2574-83. 2000..Syntaxin 6 acts as a target for secretion of specific and azurophilic granules, whereas SNAP-23 mediates specific granule secretion... - Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulumC Gajate
Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
Oncogene 31:2627-39. 2012..Thus, we propose that the ER could be a key target in pancreatic cancer, and edelfosine may constitute a prototype for the development of a new class of antitumor drugs targeting the ER... - Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapyT Nieto-Miguel
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Científicas C S I C Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
Oncogene 27:1779-87. 2008..These data indicate that lipid raft-recruited JNK is ASK1-independent and becomes a novel Hsp90 client protein. Our results reveal a new chaperoning role of Hsp90 on JNK-mediated apoptosis following its recruitment in lipid rafts... - Rab27a regulates exocytosis of tertiary and specific granules in human neutrophilsM Javier Herrero-Turrión
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
J Immunol 181:3793-803. 2008..Our data indicate that Rab27a is a major component of the exocytic machinery of human neutrophils, modulating the secretion of tertiary and specific granules that are readily mobilized upon neutrophil activation... - Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanismConsuelo Gajate
, , , Campus Miguel de Unamuno, E-37007 Salamanca, Spain
Clin Cancer Res 9:1535-45. 2003.... - Further naphthylcombretastatins. An investigation on the role of the naphthalene moietyAna B S Maya
, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, E-37007 Salamanca, Spain
J Med Chem 48:556-68. 2005.... - Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapyFaustino Mollinedo
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Científicas C S I C Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Drug Resist Updat 9:51-73. 2006..These findings set a novel framework for the development of more targeted therapies leading to intracellular Fas activation and recruitment of downstream signaling molecules into Fas-enriched lipid rafts... - Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxinMaria Angeles Castro
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E 37007 Salamanca, Spain
J Med Chem 47:1214-22. 2004.... - Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosisConsuelo Gajate
, , CSIC, Universidad de Salamanca, Campus Miguel de Unamuno, E-37007 Salamanca, Spain
J Exp Med 200:353-65. 2004..Our data set a framework for the development of more targeted therapies leading to intracellular Fas activation and recruitment of downstream signaling molecules into Fas-enriched rafts... - Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activitiesMa Angeles Castro
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Campus Miguel de Unamuno, Universidad de Salamanca, E 37007 Salamanca, Spain
J Med Chem 53:983-93. 2010..Cell cycle studies and analysis of the microtubule-disrupting capacity have demonstrated the existence of two different mechanisms of cell death induction for compounds with closely related structures... - Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cellsConsuelo Gajate
Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas, Universidad de Salamanca, Salamanca, Spain
PLoS ONE 4:e5044. 2009..Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis... - Lipid raft connection between extrinsic and intrinsic apoptotic pathwaysConsuelo Gajate
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Biochem Biophys Res Commun 380:780-4. 2009.... - Synthesis of an ent-halimanolide from ent-halimic acidIsidro S Marcos
Departamento de Quimica Organica, Universidad de Salamanca, Plaza de los Caidos 1 5, 37008 Salamanca, Spain
Molecules 13:1120-34. 2008.... - Apoptotic mechanisms are involved in the death of Strongyloides venezuelensis after triggering of nitric oxideA L Ruano
Laboratorio de Inmunología y Parasitología Molecular, IBSAL CIETUS, Universidad de Salamanca, Salamanca, Spain
Parasite Immunol 34:570-80. 2012..Parasites died after NO donor treatment in a dose-dependent manner. Finally, apoptotic mechanisms are involved in the death of S. venezuelensis larvae... - Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cellsTeresa Nieto-Miguel
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
Cancer Res 67:10368-78. 2007..Our data also indicate that mitochondria are indispensable for this edelfosine-induced cell death initiated by ER stress... - Intracellular location of syntaxin 7 in human neutrophilsLi xin Xie
Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Immunol Lett 129:72-7. 2010.... - Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapyConsuelo Gajate
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
J Biol Chem 280:11641-7. 2005.... - Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiaePatricia Lisa-Santamaría
Instituto de Microbiología Bioquímica y Departamento de Microbiología y Genética, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Biochim Biophys Acta 1793:561-71. 2009..Furthermore, caspase-induced cell death was completely dependent on the proteolytic activation of the enzyme but, in contrast, was not dependent on either of the endogenous yeast apoptotic proteins Aif1 and Mca1 or the mitochondria... - Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cellsConsuelo Gajate
, , CSIC-Universidad de Salamanca, , E-37007 Salamanca, Spain
Curr Drug Metab 3:491-525. 2002..ET-18-OCH(3) and some analogues are pleiotropic agents that affect additional biomedical important diseases, including parasitic and autoimmune diseases, suggesting new therapeutic indications for these compounds... - Synthesis of bioactive sesterterpenolides from ent-halimic acid. 15-epi-ent-Cladocoran A and BI S Marcos
, , Universidad de Salamanca, , 37008 Salamanca, Spain
J Org Chem 68:7496-504. 2003..The synthesized sesterterpenolids 2, 55, 57, and 59 inhibited cellular proliferation (IC(50) congruent with 2 micro M) of a number of human leukaemic and solid tumor cell lines... - Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compoundsRaquel Alvarez
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno s n, Salamanca E 37007, Spain
Bioorg Med Chem 17:6422-31. 2009..These results suggest that one carbon bridges with a geminal diaryl substitution can successfully replace the two carbon bridge of combretastatins and that the carbonyl group of phenstatins is not essential for high potency... - Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related geneM Javier Herrero-Turrión
Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Científicas C S I C Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
Biochem Biophys Res Commun 340:386-94. 2006..Genomic analyses suggest that human sytdep could derive from a retrotranslocation of a syt XIV transcript into chromosome 4... - Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid raftsConsuelo Gajate
Unidad de Investigacion, Hospital Universitario de Salamanca, Spain
Blood 109:711-9. 2007..These data uncover a novel lipid raft-mediated therapy in MM involving concentration of death receptors in membrane rafts, with Fas/CD95 playing a major role in ALP-mediated apoptosis... - DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedinMarie Hélène David-Cordonnier
INSERM U 524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Lille 59045, France
Chem Biol 12:1201-10. 2005..Our data suggest that trabectedin interacts with an additional non-DNA target to raise an effective antitumor response, and that this interaction is favored through trabectedin-DNA complexes... - Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranesAlejandro Torrecillas
, Facultad de Veterinaria, Universidad de Murcia, Apartado de Correos 4021, E-30080 Murcia, Spain
Int J Pharm 318:28-40. 2006.... - Quantitative determination of the antitumor alkyl ether phospholipid edelfosine by reversed-phase liquid chromatography-electrospray mass spectrometry: application to cell uptake studies and characterization of drug delivery systemsMaría J Blanco-Prieto
Department of Pharmacy and Pharmaceutical Technology, Facultad de Farmacia, University of Navarra, C Irunlarrea 1, E 31080 Pamplona, Spain
J Chromatogr B Analyt Technol Biomed Life Sci 810:85-92. 2004.... - Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin sheddingMaria Gómez-Gaviro
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
J Immunol 178:8053-63. 2007..All these data support a potential relevant role for ADAM-8 in the function of neutrophils during inflammatory response... - Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activityMarkus Munder
Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Blood 105:2549-56. 2005..Our findings demonstrate important differences between murine and human leukocytes with respect to regulation and function of arginine metabolism via arginase... - Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft compositionVanina Zaremberg
Department of Pediatrics, Atlantic Research Centre, Dalhousie University, Halifax, Nova Scotia, Canada
J Biol Chem 280:38047-58. 2005..This study points to a novel mode of action for an anti-cancer drug through modification of plasma membrane lipid composition resulting in the displacement of an essential protein from lipid rafts... - Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivoConstantine S Mitsiades
Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cancer Res 68:5216-25. 2008..The profile of the anti-MM activity of Aplidin in our preclinical models provided the framework for its clinical testing in MM, which has already provided favorable preliminary results... - Fluorescent phenylpolyene analogues of the ether phospholipid edelfosine for the selective labeling of cancer cellsErnesto Quesada
, C.S.I.C, Juan de la Cierva 3, E-28006 Madrid, Spain
J Med Chem 47:5333-5. 2004..Fluorescence microscopy experiments show that 6 selectively labels human cancer cells, accumulating into specific domains of the plasma membrane... - Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: development and in vitro characterizationAnder Estella-Hermoso de Mendoza
Department of Pharmacy and Pharmaceutical Technology, University of Navarra, Pamplona, Spain
Eur J Pharm Biopharm 68:207-13. 2008..It was concluded that Compritol presents advantages as a matrix material for the manufacture of the nanoparticles and for the controlled release of edelfosine... - A comparative study of the effect of the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine and some homologous compounds on PKC alpha and PKC epsilonPablo Conesa-Zamora
, Facultad de Veterinaria, Universidad de Murcia, Apartado de Correos 4021, E-30080-Murcia, Spain
Biochim Biophys Acta 1687:110-9. 2005..The action of ET-18-OCH3 and its homologues, as demonstrated in this paper, may permit the selective inhibition or activation of PKC alpha and PKC epsilon by using the most suitable range of concentrations... - Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine)Jon V Busto
Unidad de Biofisica Centro Mixto CSIC UPV EHU, and Departamento de Bioquimica, Universidad del Pais Vasco, PO Box 644, 48080 Bilbao, Spain
Biochim Biophys Acta 1768:1855-60. 2007..The surface-active properties of edelfosine are similar to those of other "single-chain" lipids, e.g. lysophosphatidylcholine, palmitoylcarnitine, or N-acetylsphingosine...