F Mollinedo

Summary

Affiliation: Universidad de Salamanca
Country: Spain

Publications

  1. ncbi request reprint Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis
    Consuelo Gajate
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, Spain
    J Biol Chem 277:41580-9. 2002
  2. ncbi request reprint Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells
    Teresa Nieto-Miguel
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    J Biol Chem 281:14833-40. 2006
  3. ncbi request reprint Survival and apoptotic signals in the action of microtubule-targeting antitumor drugs
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    IDrugs 8:127-43. 2005
  4. pmc Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis
    Consuelo Gajate
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC, Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    J Exp Med 200:353-65. 2004
  5. pmc Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma
    M Reis-Sobreiro
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Blood Cancer J 3:e118. 2013
  6. pmc Lipid raft involvement in yeast cell growth and death
    Faustino Mollinedo
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Científicas Universidad de Salamanca Salamanca, Spain
    Front Oncol 2:140. 2012
  7. pmc In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites
    Rubén E Varela-M
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    PLoS Negl Trop Dis 6:e1612. 2012
  8. pmc Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis
    Vitaly A Selivanov
    Department of Biochemistry and Molecular Biology, Faculty of Biology, Institute of Biomedicine of University of Barcelona IBUB and IDIBAPS, unit associated with CSIC, Barcelona, Spain
    BMC Syst Biol 4:135. 2010
  9. ncbi request reprint In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts
    Faustino Mollinedo
    Instituto de Biologia Molecular, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Spain
    Clin Cancer Res 16:2046-54. 2010
  10. doi request reprint Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
    J Pharmacol Exp Ther 329:439-49. 2009

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis
    Consuelo Gajate
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, Spain
    J Biol Chem 277:41580-9. 2002
    ....
  2. ncbi request reprint Differential targets and subcellular localization of antitumor alkyl-lysophospholipid in leukemic versus solid tumor cells
    Teresa Nieto-Miguel
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    J Biol Chem 281:14833-40. 2006
    ..These data indicate that edelfosine targets two different subcellular structures in a cell type-dependent manner, namely cell surface lipid rafts in leukemic cells and endoplasmic reticulum in solid tumor cells...
  3. ncbi request reprint Survival and apoptotic signals in the action of microtubule-targeting antitumor drugs
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    IDrugs 8:127-43. 2005
    ..Microtubule damage induces both survival and pro-apoptotic signals, and inhibition of survival signaling could improve the efficacy of microtubule-targeting agents...
  4. pmc Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis
    Consuelo Gajate
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC, Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    J Exp Med 200:353-65. 2004
    ..Our data set a framework for the development of more targeted therapies leading to intracellular Fas activation and recruitment of downstream signaling molecules into Fas-enriched rafts...
  5. pmc Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma
    M Reis-Sobreiro
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Blood Cancer J 3:e118. 2013
    ..These results highlight the role of raft-mediated PI3K/Akt signaling in MCL cell survival and chemotherapy, thus becoming a new target for MCL treatment...
  6. pmc Lipid raft involvement in yeast cell growth and death
    Faustino Mollinedo
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Científicas Universidad de Salamanca Salamanca, Spain
    Front Oncol 2:140. 2012
    ..A better insight in raft biology might lead to envisage new raft-mediated approaches to the treatment of human diseases where regulation of cell death and survival is critical, such as cancer and neurodegenerative diseases...
  7. pmc In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites
    Rubén E Varela-M
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    PLoS Negl Trop Dis 6:e1612. 2012
    ..However, its clinical use can be challenged by less impressive efficiency in patients infected with some Leishmania species, including L. braziliensis and L. mexicana, and by proneness to develop drug resistance in vitro...
  8. pmc Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis
    Vitaly A Selivanov
    Department of Biochemistry and Molecular Biology, Faculty of Biology, Institute of Biomedicine of University of Barcelona IBUB and IDIBAPS, unit associated with CSIC, Barcelona, Spain
    BMC Syst Biol 4:135. 2010
    ..This tool can be applied to reveal the metabolic effect of proapoptotic drug edelfosine in leukemia Jurkat cell line, uncovering the mechanisms of induction of apoptosis in cancer cells...
  9. ncbi request reprint In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts
    Faustino Mollinedo
    Instituto de Biologia Molecular, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Spain
    Clin Cancer Res 16:2046-54. 2010
    ..The present study investigates the in vitro and in vivo effect of the phospholipid ether edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) in MCL and CLL...
  10. doi request reprint Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
    J Pharmacol Exp Ther 329:439-49. 2009
    ..Our data identify edelfosine as a novel anti-inflammatory drug by abating neutrophil infiltration through L-selectin shedding and may provide a new therapeutic approach for inflammatory bowel disease free from toxicity...
  11. ncbi request reprint Differential gene expression patterns coupled to commitment and acquisition of phenotypic hallmarks during neutrophil differentiation of human leukaemia HL-60 cells
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas C S I C, Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Gene 419:16-26. 2008
    ....
  12. ncbi request reprint ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Curr Med Chem 11:3163-84. 2004
    ..This novel mechanism of action represents a new way to target tumour cells in cancer chemotherapy and can be of interest as a new framework in designing novel and more selective proapoptotic antitumour drugs...
  13. doi request reprint Lipid raft-targeted therapy in multiple myeloma
    F Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Oncogene 29:3748-57. 2010
    ..Our data reveal cholesterol-containing lipid rafts as a novel and efficient therapeutic target in MM, opening a new avenue in cancer treatment...
  14. pmc Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria
    F Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Cell Death Dis 2:e158. 2011
    ..These observations unveil a new framework in cancer chemotherapy that involves a link between lipid rafts and mitochondria in the mechanism of action of an antitumor drug, thus opening new avenues for cancer treatment...
  15. ncbi request reprint Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Spain
    J Immunol 170:1034-42. 2003
    ..These data indicate that VAMP-2 mediates exocytosis of specific and tertiary granules, and that Q-SNARE/R-SNARE complexes containing VAMP-2 and syntaxin 4 are involved in neutrophil exocytosis...
  16. ncbi request reprint Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy
    Faustino Mollinedo
    Institute of Molecular and Cellular Cancer Biology, Centre for Cancer Research, CSIC University of Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Future Oncol 6:811-21. 2010
    ..The development of drugs that target lipid rafts leading to the formation of clusters of apoptotic signaling molecule-enriched rafts offers new opportunities for therapeutic intervention in cancer therapy...
  17. pmc Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophils
    Faustino Mollinedo
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    J Biol Chem 285:34528-36. 2010
    ..Our data suggest that Leishmania promastigotes modulate their uptake by neutrophils, and regulate granule fusion processes in a rather selective way to favor parasite survival in human neutrophils...
  18. ncbi request reprint Microtubules, microtubule-interfering agents and apoptosis
    F Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Apoptosis 8:413-50. 2003
    ..Thus, sustained modification of signaling routes and changes in the scaffolding properties of microtubules seem to constitute two major processes in the apoptotic response induced by microtubule-interfering agents...
  19. ncbi request reprint Combinatorial SNARE complexes modulate the secretion of cytoplasmic granules in human neutrophils
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
    J Immunol 177:2831-41. 2006
    ....
  20. ncbi request reprint Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid
    I S Marcos
    Departamento de Quimica Organica, Facultad de Ciencias Quimicas, Universidad de Salamanca, Plaza de los Caidos 1 5, Salamanca, Spain
    Bioorg Med Chem 15:5719-37. 2007
    ..The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC(50) in the low micromolar range...
  21. doi request reprint Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions
    M Reis-Sobreiro
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Oncogene 28:3221-34. 2009
    ..These results also highlight the role of recruitment of Fas/CD95 signaling in lipid rafts in antimyeloma and antileukemia chemotherapy...
  22. ncbi request reprint Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis
    B Martin-Martin
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Blood 96:2574-83. 2000
    ..Syntaxin 6 acts as a target for secretion of specific and azurophilic granules, whereas SNAP-23 mediates specific granule secretion...
  23. ncbi request reprint Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes
    P A Lazo
    Instituto de Biologia Molecular y Celular del Cancer, Universidad de Salamanca, Spain
    Hum Genet 108:211-5. 2001
    ..Alterations in the SNAP23 gene might be involved in neurological and other diseases with defects in vesicle-membrane fusion processes that map to 15q15-21...
  24. doi request reprint Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation
    P Basabe
    Departamento de Quimica Organica, Facultad de Ciencias Quimicas, Universidad de Salamanca, Plaza de los Caidos 1 5, 37008 Salamanca, Spain
    Eur J Med Chem 45:4258-69. 2010
    ..The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active...
  25. ncbi request reprint The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells
    C Gajate
    , , CSIC-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Blood 98:3860-3. 2001
    ..This translocation of Fas into membrane rafts may provide a mechanism for amplifying Fas signaling by reorganization of membrane microdomains...
  26. doi request reprint Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum
    C Gajate
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Oncogene 31:2627-39. 2012
    ..Thus, we propose that the ER could be a key target in pancreatic cancer, and edelfosine may constitute a prototype for the development of a new class of antitumor drugs targeting the ER...
  27. ncbi request reprint Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy
    T Nieto-Miguel
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Científicas C S I C Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    Oncogene 27:1779-87. 2008
    ..These data indicate that lipid raft-recruited JNK is ASK1-independent and becomes a novel Hsp90 client protein. Our results reveal a new chaperoning role of Hsp90 on JNK-mediated apoptosis following its recruitment in lipid rafts...
  28. ncbi request reprint Rab27a regulates exocytosis of tertiary and specific granules in human neutrophils
    M Javier Herrero-Turrión
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain
    J Immunol 181:3793-803. 2008
    ..Our data indicate that Rab27a is a major component of the exocytic machinery of human neutrophils, modulating the secretion of tertiary and specific granules that are readily mobilized upon neutrophil activation...
  29. ncbi request reprint Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism
    Consuelo Gajate
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Clin Cancer Res 9:1535-45. 2003
    ....
  30. ncbi request reprint Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety
    Ana B S Maya
    Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    J Med Chem 48:556-68. 2005
    ....
  31. doi request reprint Lipid raft connection between extrinsic and intrinsic apoptotic pathways
    Consuelo Gajate
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Biochem Biophys Res Commun 380:780-4. 2009
    ....
  32. pmc Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells
    Consuelo Gajate
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, Consejo Superior de Investigaciones Cientificas, Universidad de Salamanca, Salamanca, Spain
    PLoS ONE 4:e5044. 2009
    ..Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis...
  33. ncbi request reprint Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin
    Maria Angeles Castro
    Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E 37007 Salamanca, Spain
    J Med Chem 47:1214-22. 2004
    ....
  34. ncbi request reprint Synthesis of an ent-halimanolide from ent-halimic acid
    Isidro S Marcos
    Departamento de Quimica Organica, Universidad de Salamanca, Plaza de los Caidos 1 5, 37008 Salamanca, Spain
    Molecules 13:1120-34. 2008
    ....
  35. doi request reprint Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities
    Ma Angeles Castro
    Departamento de Quimica Farmaceutica, Facultad de Farmacia, Campus Miguel de Unamuno, Universidad de Salamanca, E 37007 Salamanca, Spain
    J Med Chem 53:983-93. 2010
    ..Cell cycle studies and analysis of the microtubule-disrupting capacity have demonstrated the existence of two different mechanisms of cell death induction for compounds with closely related structures...
  36. ncbi request reprint Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy
    Faustino Mollinedo
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Científicas C S I C Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Drug Resist Updat 9:51-73. 2006
    ..These findings set a novel framework for the development of more targeted therapies leading to intracellular Fas activation and recruitment of downstream signaling molecules into Fas-enriched lipid rafts...
  37. doi request reprint Apoptotic mechanisms are involved in the death of Strongyloides venezuelensis after triggering of nitric oxide
    A L Ruano
    Laboratorio de Inmunología y Parasitología Molecular, IBSAL CIETUS, Universidad de Salamanca, Salamanca, Spain
    Parasite Immunol 34:570-80. 2012
    ..Parasites died after NO donor treatment in a dose-dependent manner. Finally, apoptotic mechanisms are involved in the death of S. venezuelensis larvae...
  38. doi request reprint Intracellular location of syntaxin 7 in human neutrophils
    Li xin Xie
    Instituto de Biologia Molecular y Celular del Cancer, Centro de Investigacion del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Immunol Lett 129:72-7. 2010
    ....
  39. ncbi request reprint Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells
    Teresa Nieto-Miguel
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
    Cancer Res 67:10368-78. 2007
    ..Our data also indicate that mitochondria are indispensable for this edelfosine-induced cell death initiated by ER stress...
  40. pmc Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae
    Patricia Lisa-Santamaría
    Instituto de Microbiología Bioquímica y Departamento de Microbiología y Genética, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Biochim Biophys Acta 1793:561-71. 2009
    ..Furthermore, caspase-induced cell death was completely dependent on the proteolytic activation of the enzyme but, in contrast, was not dependent on either of the endogenous yeast apoptotic proteins Aif1 and Mca1 or the mitochondria...
  41. ncbi request reprint Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells
    Consuelo Gajate
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Curr Drug Metab 3:491-525. 2002
    ..ET-18-OCH(3) and some analogues are pleiotropic agents that affect additional biomedical important diseases, including parasitic and autoimmune diseases, suggesting new therapeutic indications for these compounds...
  42. ncbi request reprint Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy
    Consuelo Gajate
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    J Biol Chem 280:11641-7. 2005
    ....
  43. ncbi request reprint Synthesis of bioactive sesterterpenolides from ent-halimic acid. 15-epi-ent-Cladocoran A and B
    I S Marcos
    Departamento de Quimica Organica, Facultad de Ciencias Quimicas, Universidad de Salamanca, Plaza de los Caidos 1 5, 37008 Salamanca, Spain
    J Org Chem 68:7496-504. 2003
    ..The synthesized sesterterpenolids 2, 55, 57, and 59 inhibited cellular proliferation (IC(50) congruent with 2 micro M) of a number of human leukaemic and solid tumor cell lines...
  44. ncbi request reprint Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene
    M Javier Herrero-Turrión
    Centro de Investigacion del Cancer, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Científicas C S I C Universidad de Salamanca, Campus Miguel de Unamuno, E 37007 Salamanca, Spain
    Biochem Biophys Res Commun 340:386-94. 2006
    ..Genomic analyses suggest that human sytdep could derive from a retrotranslocation of a syt XIV transcript into chromosome 4...
  45. doi request reprint Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds
    Raquel Alvarez
    Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno s n, Salamanca E 37007, Spain
    Bioorg Med Chem 17:6422-31. 2009
    ..These results suggest that one carbon bridges with a geminal diaryl substitution can successfully replace the two carbon bridge of combretastatins and that the carbonyl group of phenstatins is not essential for high potency...
  46. ncbi request reprint Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition
    Vanina Zaremberg
    Department of Pediatrics, Atlantic Research Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    J Biol Chem 280:38047-58. 2005
    ..This study points to a novel mode of action for an anti-cancer drug through modification of plasma membrane lipid composition resulting in the displacement of an essential protein from lipid rafts...
  47. ncbi request reprint Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes
    Alejandro Torrecillas
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apartado de Correos 4021, E 30080 Murcia, Spain
    Int J Pharm 318:28-40. 2006
    ....
  48. ncbi request reprint Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding
    Maria Gómez-Gaviro
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 178:8053-63. 2007
    ..All these data support a potential relevant role for ADAM-8 in the function of neutrophils during inflammatory response...
  49. ncbi request reprint DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin
    Marie Hélène David-Cordonnier
    INSERM U 524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Lille 59045, France
    Chem Biol 12:1201-10. 2005
    ..Our data suggest that trabectedin interacts with an additional non-DNA target to raise an effective antitumor response, and that this interaction is favored through trabectedin-DNA complexes...
  50. doi request reprint Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo
    Constantine S Mitsiades
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 68:5216-25. 2008
    ..The profile of the anti-MM activity of Aplidin in our preclinical models provided the framework for its clinical testing in MM, which has already provided favorable preliminary results...
  51. ncbi request reprint Quantitative determination of the antitumor alkyl ether phospholipid edelfosine by reversed-phase liquid chromatography-electrospray mass spectrometry: application to cell uptake studies and characterization of drug delivery systems
    María J Blanco-Prieto
    Department of Pharmacy and Pharmaceutical Technology, Facultad de Farmacia, University of Navarra, C Irunlarrea 1, E 31080 Pamplona, Spain
    J Chromatogr B Analyt Technol Biomed Life Sci 810:85-92. 2004
    ....
  52. ncbi request reprint Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity
    Markus Munder
    Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Blood 105:2549-56. 2005
    ..Our findings demonstrate important differences between murine and human leukocytes with respect to regulation and function of arginine metabolism via arginase...
  53. ncbi request reprint Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
    Consuelo Gajate
    Unidad de Investigacion, Hospital Universitario de Salamanca, Spain
    Blood 109:711-9. 2007
    ..These data uncover a novel lipid raft-mediated therapy in MM involving concentration of death receptors in membrane rafts, with Fas/CD95 playing a major role in ALP-mediated apoptosis...
  54. ncbi request reprint Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine)
    Jon V Busto
    Unidad de Biofisica Centro Mixto CSIC UPV EHU, and Departamento de Bioquimica, Universidad del Pais Vasco, PO Box 644, 48080 Bilbao, Spain
    Biochim Biophys Acta 1768:1855-60. 2007
    ..The surface-active properties of edelfosine are similar to those of other "single-chain" lipids, e.g. lysophosphatidylcholine, palmitoylcarnitine, or N-acetylsphingosine...
  55. ncbi request reprint A comparative study of the effect of the antineoplastic ether lipid 1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine and some homologous compounds on PKC alpha and PKC epsilon
    Pablo Conesa-Zamora
    Departamento de Bioquimica y Biologia Molecular A, Facultad de Veterinaria, Universidad de Murcia, Apartado de Correos 4021, E 30080 Murcia, Spain
    Biochim Biophys Acta 1687:110-9. 2005
    ..The action of ET-18-OCH3 and its homologues, as demonstrated in this paper, may permit the selective inhibition or activation of PKC alpha and PKC epsilon by using the most suitable range of concentrations...
  56. ncbi request reprint Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: development and in vitro characterization
    Ander Estella-Hermoso de Mendoza
    Department of Pharmacy and Pharmaceutical Technology, University of Navarra, Pamplona, Spain
    Eur J Pharm Biopharm 68:207-13. 2008
    ..It was concluded that Compritol presents advantages as a matrix material for the manufacture of the nanoparticles and for the controlled release of edelfosine...
  57. ncbi request reprint Fluorescent phenylpolyene analogues of the ether phospholipid edelfosine for the selective labeling of cancer cells
    Ernesto Quesada
    Instituto de Quimica Organica, C S I C, Juan de la Cierva 3, E 28006 Madrid, Spain
    J Med Chem 47:5333-5. 2004
    ..Fluorescence microscopy experiments show that 6 selectively labels human cancer cells, accumulating into specific domains of the plasma membrane...