V Molina

Summary

Affiliation: Universidad de Salamanca
Country: Spain

Publications

  1. ncbi request reprint No association between dorsolateral prefrontal gray matter deficit and N-acetyl aspartate ratios in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Universitario, Salamanca, Spain
    Neuropsychobiology 54:171-8. 2006
  2. ncbi request reprint Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente 58 182, E 37007 Salamanca, Spain
    Eur Psychiatry 22:505-12. 2007
  3. ncbi request reprint Differential clinical, structural and P300 parameters in schizophrenia patients resistant to conventional neuroleptics
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 32:257-66. 2008
  4. ncbi request reprint Hypofrontality in men with first-episode psychosis
    V Molina
    Department of Psychiatry, Hospital Clinico de Salamanca, Paseo de San Vicente 58 182, 37007b Salamanca, Spain
    Br J Psychiatry 186:203-8. 2005
  5. ncbi request reprint Association between excessive frontal cerebrospinal fluid and illness duration in males but not in females with schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, 37007 Salamanca, Spain
    Eur Psychiatry 20:332-8. 2005
  6. ncbi request reprint Marked hypofrontality in clozapine-responsive patients
    V Molina
    Department of Psychiatry, Hospital Universitario, Salamanca, Spain
    Pharmacopsychiatry 40:157-62. 2007
  7. ncbi request reprint Increase in gray matter and decrease in white matter volumes in the cortex during treatment with atypical neuroleptics in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, P S Vicente, 58 182 Salamanca 37007, Spain
    Schizophr Res 80:61-71. 2005
  8. ncbi request reprint Dorsolateral prefrontal and superior temporal volume deficits in first-episode psychoses that evolve into schizophrenia
    Vicente Molina
    Dept of Psychiatry, Hospital Clinico de Salamanca, Paseo de San Vicente, 58 182, 37007, Salamanca, Spain
    Eur Arch Psychiatry Clin Neurosci 256:106-11. 2006
  9. ncbi request reprint Dorsolateral prefrontal cortex contribution to abnormalities of the P300 component of the event-related potential in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, 37007 Salamanca, Spain
    Psychiatry Res 140:17-26. 2005
  10. ncbi request reprint Clozapine may partially compensate for task-related brain perfusion abnormalities in risperidone-resistant schizophrenia patients
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 32:948-54. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint No association between dorsolateral prefrontal gray matter deficit and N-acetyl aspartate ratios in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Universitario, Salamanca, Spain
    Neuropsychobiology 54:171-8. 2006
    ..This was also true for the chronic and first episode groups analyzed separately. These results do not support a neuronal tissue deficit as contributing to the cortical volume deficit in schizophrenia, at least in the DLPF region...
  2. ncbi request reprint Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente 58 182, E 37007 Salamanca, Spain
    Eur Psychiatry 22:505-12. 2007
    ..On the other hand, it is likely that NAA values in schizophrenia may differ in men and women...
  3. ncbi request reprint Differential clinical, structural and P300 parameters in schizophrenia patients resistant to conventional neuroleptics
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 32:257-66. 2008
    ..These data support the notion that biological substrates vary among groups of different psychotic patients, even when they have the same diagnosis, and that those substrates may be related to the response to treatment...
  4. ncbi request reprint Hypofrontality in men with first-episode psychosis
    V Molina
    Department of Psychiatry, Hospital Clinico de Salamanca, Paseo de San Vicente 58 182, 37007b Salamanca, Spain
    Br J Psychiatry 186:203-8. 2005
    ..Decreased metabolic activity in the prefrontal cortex during cognitive activation is a recurrent finding and a likely functional marker of schizophrenia...
  5. ncbi request reprint Association between excessive frontal cerebrospinal fluid and illness duration in males but not in females with schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, 37007 Salamanca, Spain
    Eur Psychiatry 20:332-8. 2005
    ..We hypothesized that the poorer global outcome and treatment response in males with schizophrenia are related to a greater cortical volume loss as compared to females...
  6. ncbi request reprint Marked hypofrontality in clozapine-responsive patients
    V Molina
    Department of Psychiatry, Hospital Universitario, Salamanca, Spain
    Pharmacopsychiatry 40:157-62. 2007
    ....
  7. ncbi request reprint Increase in gray matter and decrease in white matter volumes in the cortex during treatment with atypical neuroleptics in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, P S Vicente, 58 182 Salamanca 37007, Spain
    Schizophr Res 80:61-71. 2005
    ..These GM and WM changes were not related to changes in weight. Thus, treatment with risperidone and clozapine in schizophrenia may have an effect on gray and white matter volume and needs further exploration...
  8. ncbi request reprint Dorsolateral prefrontal and superior temporal volume deficits in first-episode psychoses that evolve into schizophrenia
    Vicente Molina
    Dept of Psychiatry, Hospital Clinico de Salamanca, Paseo de San Vicente, 58 182, 37007, Salamanca, Spain
    Eur Arch Psychiatry Clin Neurosci 256:106-11. 2006
    ..Our findings indicate that subtle structural defects are already found by the time of the first psychotic break in schizophrenia, although clinical implications for these differences seem unclear...
  9. ncbi request reprint Dorsolateral prefrontal cortex contribution to abnormalities of the P300 component of the event-related potential in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, 37007 Salamanca, Spain
    Psychiatry Res 140:17-26. 2005
    ..It is therefore suggested that the prefrontal cortex could be implicated in the P300 amplitude reduction in schizophrenia...
  10. ncbi request reprint Clozapine may partially compensate for task-related brain perfusion abnormalities in risperidone-resistant schizophrenia patients
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 32:948-54. 2008
    ..This comparison is of interest, given the probably different mechanism of action of clozapine in comparison with other atypicals...
  11. doi request reprint Correlation between prepulse inhibition and cortical perfusion during an attentional test in schizophrenia. A pilot study
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario, Institute for Neuroscience of Castilla y León, Universidad de Salamanca, Salamanca, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 33:53-61. 2009
    ..This filtering deficit can be studied by using measures of prepulse inhibition (PPI) of the startle reflex...
  12. doi request reprint Convergent evidence of the contribution of TP53 genetic variation (Pro72Arg) to metabolic activity and white matter volume in the frontal lobe in schizophrenia patients
    Vicente Molina
    Department of Psychiatry, Hospital Clinico de Salamanca, Salamanca, Spain
    Neuroimage 56:45-51. 2011
    ..Our results suggest that TP53 might influence aspects of myelin and white matter integrity which may account for some of the frontal dysfunction features commonly described in these patients...
  13. doi request reprint Optimized voxel brain morphometry: association between brain volumes and the response to atypical antipsychotics
    Vicente Molina
    Servicio de Psiquiatria, Hospital Universitario de Salamanca, Spain
    Eur Arch Psychiatry Clin Neurosci 261:407-16. 2011
    ..This study reveals a pattern of structural alterations in schizophrenia associated with the response to risperidone or olanzapine...
  14. doi request reprint Different gray matter patterns in chronic schizophrenia and chronic bipolar disorder patients identified using voxel-based morphometry
    Vicente Molina
    Department of Psychiatry, Hospital Universitario de Salamanca, Paseo de San Vicente, Spain
    Eur Arch Psychiatry Clin Neurosci 261:313-22. 2011
    ..In this comparison, the BD patients showed a limited cortical and subcortical GM deficit. These results support a partly different pattern of GM deficits associated to chronic Sz and chronic BD, with some degree of overlapping...
  15. doi request reprint Subcortical and cortical gray matter differences between Kraepelinian and non-Kraepelinian schizophrenia patients identified using voxel-based morphometry
    Vicente Molina
    Servicio de Psiquiatria, Hospital Universitario de Salamanca, Salamanca, Spain
    Psychiatry Res 184:16-22. 2010
    ..Thus, Kraepelinian patients may be characterized by a distinct pattern of brain abnormalities, in particular, in subcortical regions...
  16. doi request reprint Prepulse inhibition of the startle reflex in schizophrenia remains stable with short-term quetiapine
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario de Salamanca, Paseo de San Vicente, 58 182, 37007 Salamanca, Spain
    Eur Psychiatry 26:271-5. 2011
    ..To study the short-term effect of treatment with quetiapine on prepulse inhibition (PPI) deficits of the startle reflex in schizophrenia patients...
  17. doi request reprint Voxel-based morphometry comparison between first episodes of psychosis with and without evolution to schizophrenia
    Vicente Molina
    Hospital Universitario de Salamanca, Servicio de Psiquiatria, Spain
    Psychiatry Res 181:204-10. 2010
    ..Taken together, our results support the notion that brain abnormalities may be different in psychotic FE patients depending on their evolution in the medium term...
  18. doi request reprint No association between prepulse inhibition of the startle reflex and neuropsychological deficit in chronic schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Eur Arch Psychiatry Clin Neurosci 260:609-15. 2010
    ..Our results suggest that PPI deficits in schizophrenia patients may not contribute to the cognitive deficits typical of that illness, at least in patients with a non-significant PPI decrease...
  19. doi request reprint Association between cerebral metabolic and structural abnormalities and cognitive performance in schizophrenia
    Vicente Molina
    Dept of Psychiatry, Hospital Universitario, Salamanca, Spain
    Psychiatry Res 173:88-93. 2009
    ..We may conclude that hypofrontality during cognitive activation, and the degree of DLPF structural deficit may be associated to a particular profile of cognitive deficit, including lower processing speed and working memory capacity...
  20. ncbi request reprint Changes in cortical volume with olanzapine in chronic schizophrenia
    V Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Pharmacopsychiatry 40:135-9. 2007
    ..Atypical antipsychotics can affect cortical volume differently from traditional drugs. The study of the outcome of grey matter deficits in schizophrenia with olanzapine may be of particular interest in this context...
  21. doi request reprint Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study
    O Castellano
    Institute for Neuroscience of Castilla y León, Salamanca, Spain Department of Cell Biology and Pathology, University of Salamanca, Salamanca, Spain
    Behav Brain Res 242:178-90. 2013
    ..It may be concluded that the administration of risperidone in the schizophrenia model employed helps to improve the altered functions, with no significant negative effects...
  22. ncbi request reprint Cerebral metabolism and risperidone treatment in schizophrenia
    V Molina
    Department of Psychiatry, Hospital Doce de Octubre, Madrid, Spain
    Schizophr Res 60:1-7. 2003
    ..The pattern of metabolic changes induced by risperidone appears to be different from that produced by typical antipsychotics...
  23. ncbi request reprint Lower prefrontal gray matter volume in schizophrenia in chronic but not in first episode schizophrenia patients
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda De Córdoba, Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 131:45-56. 2004
    ..No significant differences were found between those receiving atypical and typical antipsychotic drugs during the previous year...
  24. ncbi request reprint Chronic administration of risperidone to healthy rats: a behavioural and morphological study
    O Castellano
    Institute for Neuroscience of Castilla y León, Spain
    Behav Brain Res 205:488-98. 2009
    ..Our results indicate that the chronic administration of therapeutic doses of risperidone does not produce any dramatic behavioural or morphological changes in healthy animals...
  25. ncbi request reprint N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration
    Vicente Molina
    Department of Psychiatry, Hospital Clinico, Paseo de S Vicente 58 182, Salamanca 37007, Spain
    Schizophr Res 73:209-19. 2005
    ..Therefore, reduced prefrontal levels of NAA may be limited to chronic schizophrenia patients...
  26. ncbi request reprint Anatomical and functional cerebral variables associated with basal symptoms but not risperidone response in minimally treated schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Avda de Cordoba Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 124:163-75. 2003
    ..We conclude that there is evidence of a significant association between basal symptoms and DLPFC atrophy and limbic hyperactivity at rest in recent-onset schizophrenic patients...
  27. ncbi request reprint Long-term olanzapine treatment and p300 parameters in schizophrenia
    Vicente Molina
    Hospital Clinico Universitario de Salamanca, Salamanca, Spain
    Neuropsychobiology 50:182-8. 2004
    ..Our data also suggest that, in addition to this, some further changes in P300 amplitude might depend on the clinical state of the patients...
  28. ncbi request reprint Olanzapine-induced cerebral metabolic changes related to symptom improvement in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Int Clin Psychopharmacol 20:13-8. 2005
    ..These correlation patterns suggest that the functional mechanism of action of olanzapine may share traits from both typical and atypical neuroleptics...
  29. ncbi request reprint Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda De Córdoba, Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 124:153-61. 2003
    ..We conclude that clinical improvement with clozapine may be related with the anatomy and metabolic activity of specific brain areas, with the structural integrity of the DLPF and temporal regions showing the maximum predictive capacity...
  30. ncbi request reprint Direct association between orbitofrontal atrophy and the response of psychotic symptoms to olanzapine in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico, Salamanca, Spain
    Int Clin Psychopharmacol 19:221-8. 2004
    ....
  31. ncbi request reprint Prefrontal atrophy in first episodes of schizophrenia associated with limbic metabolic hyperactivity
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, E 37007 Salamanca, Spain
    J Psychiatr Res 39:117-27. 2005
    ..These findings support a loss in PF inhibitory capacity as a possible link between anatomical and functional alterations in schizophrenia...
  32. ncbi request reprint Association between relative temporal and prefrontal sulcal cerebrospinal fluid and illness duration in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda De Córdoba, Km 5 4, 28041, Madrid, Spain
    Schizophr Res 58:305-12. 2002
    ..No significant association between CSF volumes and AOS was found in any region. Our findings support the existence of a degenerative process in schizophrenia located in prefrontal and temporal areas...
  33. ncbi request reprint Cerebral metabolic changes induced by clozapine in schizophrenia and related to clinical improvement
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Madrid, Spain
    Psychopharmacology (Berl) 178:17-26. 2005
    ..Clozapine is of special interest, since it is one of the most effective antipsychotic drugs and demonstrates a distinctive mechanism of action in pre-clinical studies with respect to typical neuroleptics...
  34. ncbi request reprint Biochemical changes in the cingulum in patients with schizophrenia and chronic bipolar disorder
    Fernando Sarramea Crespo
    Department of Psychiatry, Complejo Hospitalario, Carretera Bailén Motril sn, Jaen, CP 23009, Spain
    Eur Arch Psychiatry Clin Neurosci 258:394-401. 2008
    ..Such an increase seems to be more intense than in psychosis-free bipolar disorder patients...
  35. ncbi request reprint Cerebral metabolic patterns in chronic and recent-onset schizophrenia
    Manuel Desco
    Department of Experimental Medicine, Hospital General Universitario Gregorio Maranon, Dr Esquerdo 46, E 28007 Madrid, Spain
    Psychiatry Res 122:125-35. 2003
    ..The main effect of the long-term administration of haloperidol seems to be an increase of cerebellar, basal ganglia and motor area metabolism...
  36. ncbi request reprint Effect of interleukin-1beta gene functional polymorphism on dorsolateral prefrontal cortex activity in schizophrenic patients
    Sergi Papiol
    Departament de Biologia Animal, Unitat d Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Am J Med Genet B Neuropsychiatr Genet 144:1090-3. 2007
    ..Genetic variants with influence on brain functionality may account for the neurocognitive heterogeneity observed in schizophrenic patients...
  37. ncbi request reprint An electrophysiological (ERP) component, the recognition potential, in the assessment of brain semantic networks in patients with schizophrenia
    Manuel Martín-Loeches
    Cognitive Neuroscience Unit, Centre for Human Evolution and Behavior, UCM ISCIII, c Sinesio Delgado 4, Pabellón 14, 28029 Madrid, Spain
    Schizophr Res 71:393-404. 2004
    ..RP reduction suggests that a fewer number of networks' elements are activated when an incoming word is processed, thus supporting hypoactivation of the semantic networks as the basis for ThD...
  38. ncbi request reprint Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene
    Sergi Papiol
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 08028 Barcelona, Spain
    Neuroimage 27:1002-6. 2005
    ..01) ventricles. Sex and illness duration were controlled for in the analyses. Our results, though preliminary, suggest that IL-1RN gene might contribute to the ventricular volumetric changes observed in schizophrenic patients...