C Martinez

Summary

Affiliation: Universidad Complutense
Country: Spain

Publications

  1. ncbi VIP and PACAP enhance the in vivo generation of memory TH2 cells by inhibiting peripheral deletion of antigen-specific effectors
    M Delgado
    Rutgers University, Newark, NJ, USA
    Arch Physiol Biochem 109:372-6. 2001
  2. ncbi VIP and PACAP induce shift to a Th2 response by upregulating B7.2 expression
    M Delgado
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    Ann N Y Acad Sci 921:68-78. 2000
  3. ncbi Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases
    M Delgado
    Departamento Biologia Celular, Facultad de Biologia, Universidad Complutense, Madrid 28040, Spain
    J Mol Med (Berl) 80:16-24. 2002
  4. ncbi Inhibition of endotoxin-induced macrophage chemokine production by VIP and PACAP in vitro and in vivo
    M Delgado
    Rutgers University, Newark, NJ, USA
    Arch Physiol Biochem 109:377-82. 2001
  5. ncbi Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease
    M Delgado
    Department Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Nat Med 7:563-8. 2001
  6. ncbi Pituitary adenylate cyclase-activating polypeptide inhibits collagen-induced arthritis: an experimental immunomodulatory therapy
    C Abad
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    J Immunol 167:3182-9. 2001
  7. ncbi VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts
    I Gutierrez-Cañas
    Servicio de Reumatologia, Hospital 12 de Octubre, Avda de Córdoba s n 28041, Madrid, Spain
    Rheumatology (Oxford) 45:527-32. 2006
  8. ncbi VIP decreases TLR4 expression induced by LPS and TNF-alpha treatment in human synovial fibroblasts
    Y Juarranz
    Departamento de Biologia Celular, Facultad de Biologia, UCM, 28040 Madrid, Spain
    Ann N Y Acad Sci 1070:359-64. 2006
  9. ncbi Peptides targeting Toll-like receptor signalling pathways for novel immune therapeutics
    R P Gomariz
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Curr Pharm Des 16:1063-80. 2010
  10. pmc Recombinant vaccine for canine parvovirus in dogs
    J A López de Turiso
    INGENASA, Madrid, Spain
    J Virol 66:2748-53. 1992

Collaborators

Detail Information

Publications32

  1. ncbi VIP and PACAP enhance the in vivo generation of memory TH2 cells by inhibiting peripheral deletion of antigen-specific effectors
    M Delgado
    Rutgers University, Newark, NJ, USA
    Arch Physiol Biochem 109:372-6. 2001
    ..To our knowledge, this is the first report describing the role of a neuropeptide present in the lymphoid microenvironment on the generation and maintenance of long-lived memory T cells...
  2. ncbi VIP and PACAP induce shift to a Th2 response by upregulating B7.2 expression
    M Delgado
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    Ann N Y Acad Sci 921:68-78. 2000
    ....
  3. ncbi Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases
    M Delgado
    Departamento Biologia Celular, Facultad de Biologia, Universidad Complutense, Madrid 28040, Spain
    J Mol Med (Berl) 80:16-24. 2002
    ..Therefore, VIP has been proposed as a promising candidate alternative treatment for acute and chronic inflammatory and autoimmune diseases such as septic shock, arthritis, multiple sclerosis, Crohn disease, or autoimmune diabetes...
  4. ncbi Inhibition of endotoxin-induced macrophage chemokine production by VIP and PACAP in vitro and in vivo
    M Delgado
    Rutgers University, Newark, NJ, USA
    Arch Physiol Biochem 109:377-82. 2001
    ..These findings support the proposed role of VIP and PACAP as key endogenous anti-inflammatory agents, and describe a novel mechanism, i.e., the inhibition of the production of macrophage-derived chemokines...
  5. ncbi Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease
    M Delgado
    Department Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Nat Med 7:563-8. 2001
    ..The therapeutic effect of VIP was associated with downregulation of both inflammatory and autoimmune components of the disease. Our data indicate VIP as a viable candidate for the development of treatments for RA...
  6. ncbi Pituitary adenylate cyclase-activating polypeptide inhibits collagen-induced arthritis: an experimental immunomodulatory therapy
    C Abad
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    J Immunol 167:3182-9. 2001
    ..With this study, PACAP emerges as a promising candidate for the treatment of a pathology with a high world incidence but currently no effective treatment...
  7. ncbi VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts
    I Gutierrez-Cañas
    Servicio de Reumatologia, Hospital 12 de Octubre, Avda de Córdoba s n 28041, Madrid, Spain
    Rheumatology (Oxford) 45:527-32. 2006
    ..We investigated the potential effects of VIP in the regulation of Toll-like receptor (TLR) expression and function in synovial fibroblasts from patients with rheumatoid arthritis (RA) and osteoarthritis (OA)...
  8. ncbi VIP decreases TLR4 expression induced by LPS and TNF-alpha treatment in human synovial fibroblasts
    Y Juarranz
    Departamento de Biologia Celular, Facultad de Biologia, UCM, 28040 Madrid, Spain
    Ann N Y Acad Sci 1070:359-64. 2006
    ..Our results add a new step for the use of VIP, as a promising candidate, for the treatment of rheumatoid arthritis...
  9. ncbi Peptides targeting Toll-like receptor signalling pathways for novel immune therapeutics
    R P Gomariz
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Curr Pharm Des 16:1063-80. 2010
    ..This review shows current advances in the understanding of TLR modulation by VIP that could contribute to the use of this natural peptide as a therapeutic tool...
  10. pmc Recombinant vaccine for canine parvovirus in dogs
    J A López de Turiso
    INGENASA, Madrid, Spain
    J Virol 66:2748-53. 1992
    ..The results indicate that these viruslike particles can be used to protect dogs from CPV infection...
  11. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP38) modulates lymphocyte and macrophage functions: stimulation of adherence and opposite effect on mobility
    E Garrido
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense de Madrid, Spain
    Neuropeptides 30:583-95. 1996
    ..The present work reveals an additional link between neuropeptides and the immune system and suggests that the peptide PACAP modulates the immunological function of macrophages and lymphocytes...
  12. ncbi Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activation polypeptide (PACAP) protect mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-6
    M Delgado
    Department of Cellular Biology, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    J Immunol 162:1200-5. 1999
    ..Thus, the neuropeptides VIP/PACAP protect from the lethal effect of high endotoxemia, presumably by down-regulating TNF-alpha and IL-6 production, and may offer an alternative in the treatment of human septic shock syndrome...
  13. ncbi Vasoactive intestinal peptide as a healing mediator in Crohn's disease
    A Arranz
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense de Madrid, Madrid, Spain
    Neuroimmunomodulation 15:46-53. 2008
    ..Finally, the most recent data validate its therapeutic role through the modulation of TLR2 and 4 receptors...
  14. ncbi Murine T-lymphocytes express vasoactive intestinal peptide receptor 1 (VIP-R1) mRNA
    M C Johnson
    Department of Biological Sciences, Rutgers University, New York, NJ 07102, USA
    J Neuroimmunol 68:109-19. 1996
    ....
  15. ncbi Regulation of TLR expression, a new perspective for the role of VIP in immunity
    R P Gomariz
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Peptides 28:1825-32. 2007
    ..In this review we have summarized recent information about VIP modulation of TLR function, and we suggest that VIP represents a new therapeutic option in the management of several pathologies...
  16. ncbi VIP and tolerance induction in autoimmunity
    F Rosignoli
    Dept Biologia Celular, Facultad de Biologia, UCM 28040 Madrid, Spain
    Ann N Y Acad Sci 1070:525-30. 2006
    ..These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells...
  17. ncbi Vasoactive intestinal peptide modulates proinflammatory mediator synthesis in osteoarthritic and rheumatoid synovial cells
    M G Juarranz
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense de Madrid, Spain
    Rheumatology (Oxford) 43:416-22. 2004
    ..We investigate its potential to modulate the release of proinflammatory cytokines and chemokines by human synovial cells from patients with rheumatoid arthritis (RA)...
  18. ncbi Ras activation leads to cell proliferation or apoptotic cell death upon interleukin-2 stimulation or lymphokine deprivation, respectively
    J Gomez
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma, Madrid, Spain
    Eur J Immunol 27:1610-8. 1997
    ..IL-4-induced cell survival is Ras- and Bcl-2 independent. These results are compatible with a model in which cell proliferation requires the simultaneous induction of at least two pathways which act in combination to prevent cell death...
  19. ncbi Immunology of VIP: a review and therapeutical perspectives
    R P Gomariz
    Dept Cell Biology, Faculty of Biology, Complutense University, Madrid 28040, Spain
    Curr Pharm Des 7:89-111. 2001
    ..A broad field of perspectives is actually open, and further investigations will help us to definitively understand the immunology of this very important peptide...
  20. ncbi Differential expression of vasoactive intestinal peptide receptors 1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes
    M Delgado
    Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
    J Neuroimmunol 68:27-38. 1996
    ..Differential expression and regulation of the two VIP receptors in T lymphocytes suggests different physiological roles in mediating the immunomodulatory activities of VIP and related neuropeptides...
  21. ncbi VIP-PACAP system in immunity: new insights for multitarget therapy
    R P Gomariz
    Department of Cell Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Ann N Y Acad Sci 1070:51-74. 2006
    ..Our more recent data open a hopeful door for the therapeutic use of VIP/PACAP in humans...
  22. ncbi Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation
    J Gomez
    Centro Nacional de Biotecnologia, Universidad Autonoma, Madrid, Spain
    Eur J Immunol 26:1781-7. 1996
    ..This kinase activity is also blocked when zeta PKC expression is inhibited by antisense oligonucleotide. Inhibition of phosphatidylinositol 3 kinase activity by wortmannin does not abolish zeta PKC association...
  23. ncbi A potential immune escape mechanism by melanoma cells through the activation of chemokine-induced T cell death
    M Mellado
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, CSIC UAM, Campus de Cantoblanco, E 28049, Madrid, Spain
    Curr Biol 11:691-6. 2001
    ..The model assigns a role to the CXC chemokine CXCL12 (SDF-1alpha) in this process, as this melanoma cell-produced chemokine upregulates CCL5 production by TIL, initiating TIL cell death...
  24. ncbi Activation of MAP kinase by insulin and vanadate in adipocytes from young and old rats
    J C Molero
    Departamento de Biologia Molecular, Facultad de Ciencias, Centro de Biología Molecular Severo Ochoa CSIC, Universidad Autonoma, 28049, Madrid, Spain
    Mol Cell Endocrinol 189:77-84. 2002
    ....
  25. ncbi CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, and dendritic cells
    M A Garcia-Lopez
    Department of Endocrinology, Hospital de la Princesa, Universidad Autonoma, Madrid, Spain
    Lab Invest 81:409-18. 2001
    ..The CXCR3 chemokine receptor may play a role in the regulation of leukocyte migration to inflammatory sites...
  26. ncbi Production of porcine parvovirus empty capsids with high immunogenic activity
    C Martinez
    Inmunologia y Genetica Aplicada SA Ingenasa, Madrid, Spain
    Vaccine 10:684-90. 1992
    ..The amount of recombinant antigen needed in a vaccine dose was only 3 micrograms in a primary dose and 1.5 micrograms in the booster...
  27. ncbi A single injection of Staphylococcus aureus enterotoxin B reduces autoimmunity in MRL/lpr mice
    J A Gonzalo
    Centro de Biologia Molecular, CSIC, Madrid, Spain
    Clin Immunol Immunopathol 71:176-82. 1994
    ....
  28. ncbi Bcl-2 targets protein phosphatase 1 alpha to Bad
    V Ayllon
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Campus de Cantoblanco, Madrid, Spain
    J Immunol 166:7345-52. 2001
    ..Disruption of Bcl-2/PP1alpha association strongly decreased Bcl-2 and Bad-associated phosphatase activity and formation of the trimolecular complex. These results suggest that Bcl-2 targets PP1alpha to Bad...
  29. ncbi Conserved regulation of proximodistal limb axis development by Meis1/Hth
    N Mercader
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia, CSIC UAM, Madrid, Spain
    Nature 402:425-9. 1999
    ..We suggest that restriction of Meis1/Hth to proximal regions of the vertebrate and insect limb is essential to specify cell fates and differentiation patterns along the P-D axis of the limb...
  30. doi Exercise training and cytokines in breast cancer survivors
    A M Gomez
    Hospital Infantil Universitario Nino Jesus, Oncologia, Madrid, Spain
    Int J Sports Med 32:461-7. 2011
    ..A combined (aerobic+strength) 8-week exercise training intervention did not induce major changes in the basal cytokine levels of breast cancer survivors...
  31. ncbi Attenuation of autoimmune disease and lymphocyte accumulation in MRL/lpr mice by treatment with anti-V beta 8 antibodies
    I M de Alboran
    Centro de Biologia Molecular CSIC, Universidad Autonoma, Madrid, Spain
    Eur J Immunol 22:2153-8. 1992
    ..1 and resulted in long-term amelioration of autoimmunity and lymphadenopathy. Thus, a strategy aimed at specifically reducing the frequency of a subset of lpr cells proved successful in mitigating the autoimmune process...
  32. ncbi Treatment with IL2/vaccinia recombinant virus leads to serologic, histologic and phenotypic normalization of autoimmune MRL/lpr-lpr mice
    J C Gutierrez-Ramos
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    Autoimmunity 10:15-25. 1991
    ..Collectively, these results suggest that diseases showing a selective expansion of DN cells should be envisaged as possible targets for the treatment described here...