Carlos Martinez-Salgado

Summary

Affiliation: Universidad de Salamanca
Country: Spain

Publications

  1. pmc Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients
    Ana M Blázquez-Medela
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Universidad de Salamanca, Salamanca, Spain
    BMC Med 8:86. 2010
  2. ncbi request reprint Gentamicin induces Jun-AP1 expression and JNK activation in renal glomeruli and cultured mesangial cells
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Paseo de San Vicente 58 132, 37007 Salamanca, Spain
    Life Sci 77:2285-98. 2005
  3. ncbi request reprint Glomerular nephrotoxicity of aminoglycosides
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Toxicol Appl Pharmacol 223:86-98. 2007
  4. ncbi request reprint Effect of adenosine in extracellular matrix synthesis in human and rat mesangial cells
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007, Salamanca, Spain
    Mol Cell Biochem 305:163-9. 2007
  5. ncbi request reprint ALK1 heterozygosity increases extracellular matrix protein expression, proliferation and migration in fibroblasts
    José M Muñoz-Félix
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain Instituto de Investigación Biomédica de Salamanca IBSAL, Salamanca, Spain
    Biochim Biophys Acta 1843:1111-22. 2014
  6. doi request reprint H-Ras isoform modulates extracellular matrix synthesis, proliferation, and migration in fibroblasts
    Isabel Fuentes-Calvo
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain
    Am J Physiol Cell Physiol 302:C686-97. 2012
  7. ncbi request reprint Involvement of reactive oxygen species on gentamicin-induced mesangial cell activation
    Carlos Martinez-Salgado
    Departamento de Fisiología y Farmacología and Instituto Reina Sofía de Investigación Nefrológica, Universidad de Salamanca, Salamanca, Spain
    Kidney Int 62:1682-92. 2002
  8. doi request reprint The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts
    Isabel Fuentes-Calvo
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain Instituto de Investigación Biomédica de Salamanca IBSAL, Salamanca, Spain
    Biochim Biophys Acta 1833:2734-44. 2013
  9. doi request reprint Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice
    M Teresa Grande
    Departamento de Fisiologia y Farmacologia, Instituto Reina Sofia de Investigacion Nefrologica, Universidad de Salamanca, Salamanca 37007, Spain
    Kidney Int 77:509-18. 2010
  10. doi request reprint Osteoprotegerin is associated with cardiovascular risk in hypertension and/or diabetes
    Ana M Blázquez-Medela
    Renal and Cardiovascular Pathophysiology Unit, Institute Queen Sofía of Nephrological Research, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Eur J Clin Invest 42:548-56. 2012

Collaborators

Detail Information

Publications22

  1. pmc Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients
    Ana M Blázquez-Medela
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Universidad de Salamanca, Salamanca, Spain
    BMC Med 8:86. 2010
    ..Thus, we studied the relationship between plasma levels of soluble endoglin and cardiovascular alterations associated with hypertension and diabetes...
  2. ncbi request reprint Gentamicin induces Jun-AP1 expression and JNK activation in renal glomeruli and cultured mesangial cells
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Paseo de San Vicente 58 132, 37007 Salamanca, Spain
    Life Sci 77:2285-98. 2005
    ..These reactive oxygen molecules and increased intracellular free calcium may mediate the increase in Jun-AP1 expression and JNK activation induced by G treatment in MC...
  3. ncbi request reprint Glomerular nephrotoxicity of aminoglycosides
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007 Salamanca, Spain
    Toxicol Appl Pharmacol 223:86-98. 2007
    ..The main goal of this review is to provide an actualized and mechanistic vision of pathways involved in glomerular toxic effects of aminoglycosides...
  4. ncbi request reprint Effect of adenosine in extracellular matrix synthesis in human and rat mesangial cells
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Paseo San Vicente 58 182, 37007, Salamanca, Spain
    Mol Cell Biochem 305:163-9. 2007
    ..Neither ADO nor A1 or A2 receptor stimulation induce significant changes in total collagen synthesis. These data suggest that ADO is not a major regulator of ECM synthesis in rat and human mesangial cells...
  5. ncbi request reprint ALK1 heterozygosity increases extracellular matrix protein expression, proliferation and migration in fibroblasts
    José M Muñoz-Félix
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain Instituto de Investigación Biomédica de Salamanca IBSAL, Salamanca, Spain
    Biochim Biophys Acta 1843:1111-22. 2014
    ..Therefore, we suggest that ALK1 plays an important role in the regulation of ECM protein expression, proliferation and migration. ..
  6. doi request reprint H-Ras isoform modulates extracellular matrix synthesis, proliferation, and migration in fibroblasts
    Isabel Fuentes-Calvo
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain
    Am J Physiol Cell Physiol 302:C686-97. 2012
    ..TGF-β1 stimulated ECM synthesis and proliferation, although ECM synthesis was higher and proliferation lower in H-ras(-/-) than in WT fibroblasts. Hence, H-Ras activation seems to play a key role in the regulation of these effects...
  7. ncbi request reprint Involvement of reactive oxygen species on gentamicin-induced mesangial cell activation
    Carlos Martinez-Salgado
    Departamento de Fisiología y Farmacología and Instituto Reina Sofía de Investigación Nefrológica, Universidad de Salamanca, Salamanca, Spain
    Kidney Int 62:1682-92. 2002
    ..Our previous study reported that Genta induces concentration-dependent MC contraction and proliferation in vitro...
  8. doi request reprint The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts
    Isabel Fuentes-Calvo
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain Instituto de Investigación Biomédica de Salamanca IBSAL, Salamanca, Spain
    Biochim Biophys Acta 1833:2734-44. 2013
    ..N-Ras also regulates TGF-β1-induced collagen I and fibronectin expression through Erk-independent pathways. ..
  9. doi request reprint Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice
    M Teresa Grande
    Departamento de Fisiologia y Farmacologia, Instituto Reina Sofia de Investigacion Nefrologica, Universidad de Salamanca, Salamanca 37007, Spain
    Kidney Int 77:509-18. 2010
    ..As expected, we found lower levels of activated Akt in the kidneys and cultured fibroblasts of the knockout. Whether Ras inhibition will turn out to prevent progression of renal fibrosis will require more direct studies...
  10. doi request reprint Osteoprotegerin is associated with cardiovascular risk in hypertension and/or diabetes
    Ana M Blázquez-Medela
    Renal and Cardiovascular Pathophysiology Unit, Institute Queen Sofía of Nephrological Research, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    Eur J Clin Invest 42:548-56. 2012
    ..We studied in type 2 diabetic and/or hypertensive patients the relationship between serum OPG and vascular alterations associated with these pathologies...
  11. pmc Analysis of k-ras nuclear expression in fibroblasts and mesangial cells
    Isabel Fuentes-Calvo
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Universidad de Salamanca, Salamanca, Spain
    PLoS ONE 5:e8703. 2010
    ..Ras GTPases are considered cytoplasmic proteins that must be localized to cell membranes for activation, and there are few evidences of the presence of any Ras isoform in nuclei of eukaryotic cells...
  12. ncbi request reprint Gentamicin treatment induces simultaneous mesangial proliferation and apoptosis in rats
    Carlos Martinez-Salgado
    Departamento de Fisiologia y Farmacologia, Instituto Reina Sofia de Investigacion Nefrologica, Universidad de Salamanca, Salamanca, Spain
    Kidney Int 65:2161-71. 2004
    ..We studied whether G promotes mesangial cell apoptosis in vitro, and if apoptosis and proliferation in parallel may occur in glomerular cells in vivo after a renal damage induced by G treatment...
  13. pmc Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications
    Jose M Lopez-Novoa
    Unidad de Fisiopatología Renal y Cardiovascular, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Spain
    J Transl Med 9:13. 2011
    ..Finally clinical implications and future experimental and therapeutic perspectives are discussed...
  14. pmc Therapeutic implications of selecting the SCORE (European) versus the D'AGOSTINO (American) risk charts for cardiovascular risk assessment in hypertensive patients
    Manuel A Gómez-Marcos
    Primary Care Research Unit, La Alamedilla Health Centre, REDIAPP, Salamanca, Spain
    BMC Cardiovasc Disord 9:17. 2009
    ....
  15. doi request reprint Functional specific roles of H-ras and N-ras. A proteomic approach using knockout cell lines
    Laura Ferreira
    Unidad de Investigacion, Hospital Universitario de Salamanca, Spain
    Electrophoresis 33:1385-96. 2012
    ....
  16. doi request reprint Common pathophysiological mechanisms of chronic kidney disease: therapeutic perspectives
    Jose M Lopez-Novoa
    Unidad de Fisiopatología Renal y Cardiovascular, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain
    Pharmacol Ther 128:61-81. 2010
    ....
  17. doi request reprint Pulse pressure and nocturnal fall in blood pressure are predictors of vascular, cardiac and renal target organ damage in hypertensive patients (LOD-RISK study)
    Luís García-Ortiz
    Primary Care Research Unit of La Alamedilla Health Centre, Salamanca University Hospital, Salamanca, Spain
    Blood Press Monit 14:145-51. 2009
    ..To analyse the relationship between various parameters derived from ambulatory blood pressure monitoring (ABPM) and vascular, cardiac and renal target organ damage...
  18. ncbi request reprint Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis
    Carlos Martinez-Salgado
    Unidad de Investigacion, Hospital Universitario de Salamanca, Salamanca, Spain
    Exp Cell Res 312:2093-106. 2006
    ..PI3K-Akt pathway activation may be involved in the increase in ECM synthesis observed in the absence of H- and N-Ras...
  19. pmc Peripheral and central arterial pressure and its relationship to vascular target organ damage in carotid artery, retina and arterial stiffness. Development and validation of a tool. The Vaso risk study
    Luís García-Ortiz
    Unidad de Investigación de Atención Primaria La Alamedilla, Salamanca, Spain
    BMC Public Health 11:266. 2011
    ..In turn, software is developed and validated for measuring retinal vessel thickness and automatically estimating the arteriovenous index...
  20. doi request reprint Heterozygous disruption of activin receptor-like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy
    José M Muñoz-Félix
    1 Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Salamanca, Spain 2 Instituto de Investigación Biomédica de Salamanca IBSAL, Salamanca, Spain
    Kidney Int 85:319-32. 2014
    ..Thus, ALK1 modulates obstruction-induced renal fibrosis by increased extracellular matrix synthesis in myofibroblasts, but without differences in myofibroblast number. ..
  21. ncbi request reprint Mechanisms involved in the genesis of diabetic nephropathy
    Ana M Blázquez-Medela
    Unidad de Fisiopatología Renal y Cardiovascular, Instituto Reina Sofia de Investigacion Nefrologica, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, 37007 Salamanca, Spain
    Curr Diabetes Rev 6:68-87. 2010
    ..All of these facts have encouraged many scientists to perform their research on mechanism causing DN, improving our knowledge of its pathogenesis. In this review we summarize the most relevant facts on the physiopathology of DN...
  22. doi request reprint [Subclinical and established kidney disease in recently diagnosed hypertensive patients]
    Manuel Angel Gómez-Marcos
    Unidad de Investigacion, Centro de Salud La Alamedilla, Salamanca, Espana
    Med Clin (Barc) 134:246-53. 2010
    ..To estimate renal disease in recently diagnosed hypertensive patients, and to identify factors related to renal disease...