Research Topics
| Angel MantecaSummaryAffiliation: Universidad de Oviedo Country: Spain Publications
| Collaborators
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Detail Information
Publications
Quantitative proteome analysis of Streptomyces coelicolor Nonsporulating liquid cultures demonstrates a complex differentiation process comparable to that occurring in sporulating solid culturesAngel Manteca
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK 5230, Odense, Denmark
J Proteome Res 9:4801-11. 2010..The most remarkable protein abundance differences between MII from solid and liquid cultures were associated with the final stages of hyphae compartmentalization and spore formation...- Phosphoproteome analysis of Streptomyces development reveals extensive protein phosphorylation accompanying bacterial differentiationAngel Manteca
Area de Microbiologia, Departamento de Biologia Funcional and IUBA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
J Proteome Res 10:5481-92. 2011..We thus established for the first time the widespread occurrence and dynamic features of Ser/Thr/Tyr protein phosphorylation in a bacteria species and also revealed a previously unrecognized phosphorylation motif "x(pT)xEx"... 
Quantitative proteomics analysis of Streptomyces coelicolor development demonstrates that onset of secondary metabolism coincides with hypha differentiationAngel Manteca
double daggerProtein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
Mol Cell Proteomics 9:1423-36. 2010..Comparative bioinformatics analyses revealed the switch from primary to secondary metabolism between the initial compartmentalized mycelium and the multinucleated hyphae...- A rare case of silicone mammary implant infection by Streptomyces spp. in a patient with breast reconstruction after mastectomy: taxonomic characterization using molecular techniquesAngel Manteca
Departamento de Biologia Funcional, Instituto Universitario de Biotecnologia de Asturias, Universidad de Oviedo, Oviedo, Asturias, Spain
Diagn Microbiol Infect Dis 63:390-3. 2009..isolated from a patient who had had breast reconstruction after a mastectomy was identified at the species level by comparative sequence analysis of 16S ribosomal DNA (rDNA) and the hypervariable alpha-region of the 16S rDNA... - Streptomyces development in colonies and soilsAngel Manteca
Area de Microbiologia, Departamento de Biologia Funcional e IUBA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
Appl Environ Microbiol 75:2920-4. 2009..The mycelial growth rate was much lower than that in standard laboratory cultures, and the life span of the previously named first compartmentalized mycelium was remarkably increased... 
A rare case of lung coinfection by Streptomyces cinereoruber and Haemophilus influenzae in a patient with severe chronic obstructive pulmonary disease: characterization at species level using molecular techniquesAngel Manteca
Area de Microbiologia, Departamento de Biologia Funcional, Instituto Universitario de Biotecnologia de Asturias IUBA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain
Diagn Microbiol Infect Dis 60:307-11. 2008..Restriction fragment length polymorphism, morphologic, and biochemical characteristics have confirmed their identity...- Mycelium differentiation and antibiotic production in submerged cultures of Streptomyces coelicolorAngel Manteca
Area de Microbiologia, Departamento de Biologia Funcional and IUBA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
Appl Environ Microbiol 74:3877-86. 2008..This work is the first to report on the relationship between differentiation processes and secondary metabolite production in submerged Streptomyces cultures... - Mycelium development in Streptomyces antibioticus ATCC11891 occurs in an orderly pattern which determines multiphase growth curvesAngel Manteca
Universidad de Oviedo, Facultad de Medicina, Area de Microbiologia, Departamento de Biologia Funcional, 33006, Julian Claveria s n, Oviedo, Spain
BMC Microbiol 5:51. 2005..Hence, this vertical description assumes that the development in the pre-sporulating phases is more or less homogeneous in all zones of the plate surface... - A proteomic analysis of Streptomyces coelicolor programmed cell deathAngel Manteca
Area de Microbiologia, Departamento de Biologia Funcional and IUBA, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain
Proteomics 6:6008-22. 2006..The increased amounts of several antioxidant proteins suggest oxidative stress as either the cause or consequence of the cell death... - A fatal case of Nocardia otitidiscaviarum pulmonary infection and brain abscess: taxonomic characterization by molecular techniquesAna Isabel Pelaez
Universidad de Oviedo, Area de Microbiologia, Departamento de Biologia Funcional, Facultad de Medicina, Oviedo, Spain
Ann Clin Microbiol Antimicrob 8:11. 2009..Taxonomic identification involved phenotypic testing, restriction fragment length polymorphism (RFLP), and complete 16S rRNA gene sequencing... - Cytological and biochemical evidence for an early cell dismantling event in surface cultures of Streptomyces antibioticusAngel Manteca
, , Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
Res Microbiol 157:143-52. 2006..Calcium-dependent proteolytic activation of a precursor of nucleases and the nucleolytic formation of a ladder of chromosomal bands are conspicuous events associated with the initiation of the death process... - Actinobacteria cyclophilins: phylogenetic relationships and description of new class- and order-specific paraloguesAngel Manteca
Area de Microbiologia, Departamento de Biologia Funcional and IUBA, Universidad de Oviedo, Julian Claveria s/n, Oviedo, 33006, Spain
J Mol Evol 63:719-32. 2006..Southern and Western blot experiments were performed to determine the taxonomic distribution of the different cyclophilins in Actinobacteria... - Streptomyces albus isolated from a human actinomycetoma and characterized by molecular techniquesMaría Cruz Martín
Instituto de Productos Lácteos de Asturias CSIC, Villaviciosa, Oviedo, Spain
J Clin Microbiol 42:5957-60. 2004.... - New method for monitoring programmed cell death and differentiation in submerged Streptomyces culturesPaula Yagüe
Area de Microbiologia, Departamento de Biologia Funcional de IUBA, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
Appl Environ Microbiol 76:3401-4. 2010..The experimental approach described opens the possibility of designing online protocols for automatic monitoring of industrial fermentations... - Pre-sporulation stages of Streptomyces differentiation: state-of-the-art and future perspectivesPaula Yagüe
Area de Microbiologia, Departamento de Biologia Funcional, and IUBA, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain
FEMS Microbiol Lett 342:79-88. 2013..In this work, we review the current knowledge on Streptomyces pre-sporulation stages of Streptomyces differentiation... - A death round affecting a young compartmentalized mycelium precedes aerial mycelium dismantling in confluent surface cultures of Streptomyces antibioticusAngel Manteca
, , Facultad de Medicina, Universidad de Oviedo, , 33006 Oviedo, Spain
Microbiology 151:3689-97. 2005.... - Aerial hyphae in surface cultures of Streptomyces lividans and Streptomyces coelicolor originate from viable segments surviving an early programmed cell death eventAngel Manteca
Departamento de Biologia Funcional e Instituto de Biotecnologia de Asturias IUBA, Universidad de Oviedo, Oviedo, Spain
FEMS Microbiol Lett 274:118-25. 2007.... - Recombinant cyclophilins lack nuclease activityAngel Manteca
Universidad de Oviedo, , Area de Microbiologia, Julian Claveria s/n, Oviedo 33006, Spain
J Bacteriol 186:6325-6. 2004.... - Transcriptomic Analysis of Streptomyces coelicolor Differentiation in Solid Sporulating Cultures: First Compartmentalized and Second Multinucleated Mycelia Have Different and Distinctive TranscriptomesPaula Yagüe
Area de Microbiologia, Departamento de Biología Funcional and Instituto Universitario de Biotecnología de Asturias IUBA, Universidad de Oviedo, Oviedo, Spain
PLoS ONE 8:e60665. 2013.... - Antitumor activity of new hydridotris(pyrazolyl)borate ruthenium(II) complexes containing the phosphanes PTA and 1-CH3-PTAAlmudena García-Fernández
Departamento de Quimica Organica e Inorganica, Instituto de Química Organometálica Enrique Moles Unidad Asociada al C S I C Universidad de Oviedo, 33006, Oviedo, Spain
Dalton Trans 39:10186-96. 2010..Some of these new compounds show promising cytotoxic activity with IC(50) values in the low micromolar range, and display differential effects on cancer and normal cell growth... - Cloning and characterization of a Streptomyces antibioticus ATCC11891 cyclophilin related to Gram negative bacteria cyclophilinsAngel Manteca
, Funcional, Facultad de Medicina, Universidad de Oviedo, Oviedo 33006, Spain
FEBS Lett 572:19-26. 2004..The presence of SanCyp18 in Streptomyces is likely due to horizontal gene transmission from Gram-negative bacteria to Streptomyces...