M Lopez-Lazaro

Summary

Affiliation: Universidad de Sevilla
Country: Spain

Publications

  1. ncbi request reprint Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Cancer Lett 252:1-8. 2007
  2. ncbi request reprint Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death
    José M Calderón-Montaño
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González 2, 41012, Seville, Spain
    Pharmacol Rep 64:1515-25. 2012
  3. ncbi request reprint Pro-oxidant natural products as anticancer agents
    Carmen Martín-Cordero
    Department of Pharmacology, Faculty of Pharmacy, Sevilla, Spain
    Curr Drug Targets 13:1006-28. 2012
  4. ncbi request reprint Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, c Prof Garcia Gonzalez, 41011, Sevilla, Spain
    Cancer Epidemiol Biomarkers Prev 15:2332-5. 2006
  5. ncbi request reprint Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved
    Miguel López-Lázaro
    University of Seville, Department of Pharmacology, Faculty of Pharmacy, Sevilla, Spain
    Expert Opin Ther Targets 11:1043-53. 2007
  6. ncbi request reprint Why do tumors metastasize?
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, C Professor Garcia Gonzalez, Seville 41012, Spain
    Cancer Biol Ther 6:141-4. 2007
  7. doi request reprint Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Sevilla, Spain
    Mol Nutr Food Res 52:S103-27. 2008
  8. ncbi request reprint Granulocyte colony-stimulating factor (G-CSF): a novel anticancer therapy based on the "universal dynamics of tumor growth"?
    M Lopez-Lazaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Exp Oncol 28:249-51. 2006
  9. ncbi request reprint HIF-1: hypoxia-inducible factor or dysoxia-inducible factor?
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, C Professor Garcia Gonzalez, 41011, Sevilla, Spain
    FASEB J 20:828-32. 2006
  10. ncbi request reprint Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41011, Seville, Spain
    Leuk Res 30:895-8. 2006

Collaborators

  • Santiago Mateos
  • E Navarro
  • F Cortes
  • Santiago Castanys
  • Jose Luis Fernandez
  • Manuel Medarde
  • C Perez-Guerrero
  • C Martín-Cordero
  • A J León-Gonzalez
  • R de la Puerta
  • José M Calderón-Montaño
  • Carmen Martín-Cordero
  • Estefanía Burgos-Morón
  • J M Calderón-Montaño
  • Esther Caballero
  • N Acero
  • D Muñoz-Mingarro
  • M A Fernández-Arche
  • M D Garcia
  • José Manuel Calderón-Montaño
  • Nuria Pastor
  • Antonio Jose Leon-Gonzalez
  • Caroline A Austin
  • Manuel L Orta
  • E Burgos-Morón
  • M J Ayuso
  • Fernando Tomé
  • Suzanne Calderón
  • Maria Jesús Ayuso
  • Heidi Sahagún
  • Marta Adeva
  • M A Agudo
  • J Trujillo
  • J L Espartero

Detail Information

Publications26

  1. ncbi request reprint Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Cancer Lett 252:1-8. 2007
    ..An understanding of this dual role of H(2)O(2) in cancer might be exploited for the development of cancer chemopreventive and therapeutic strategies...
  2. ncbi request reprint Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death
    José M Calderón-Montaño
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González 2, 41012, Seville, Spain
    Pharmacol Rep 64:1515-25. 2012
    ..Phenylglyoxal is a dicarbonyl compound known to react with guanidine groups such as that of the DNA base guanine, therefore suggesting that phenylglyoxal could induce DNA damage and have anticancer activity...
  3. ncbi request reprint Pro-oxidant natural products as anticancer agents
    Carmen Martín-Cordero
    Department of Pharmacology, Faculty of Pharmacy, Sevilla, Spain
    Curr Drug Targets 13:1006-28. 2012
    ..This article provides an overview of natural products with pro-oxidant and anticancer activities, with special focus on plant secondary metabolites, and discusses their possible use as cancer chemotherapeutic agents...
  4. ncbi request reprint Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, c Prof Garcia Gonzalez, 41011, Sevilla, Spain
    Cancer Epidemiol Biomarkers Prev 15:2332-5. 2006
    ..Successful implementation of these strategies might turn the great promise of cancer chemoprevention into a fundamental tool for reducing the burden of this disease...
  5. ncbi request reprint Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved
    Miguel López-Lázaro
    University of Seville, Department of Pharmacology, Faculty of Pharmacy, Sevilla, Spain
    Expert Opin Ther Targets 11:1043-53. 2007
    ..Finally, whether or not there is enough evidence to support the clinical evaluation of digitoxin in patients with cancer is discussed...
  6. ncbi request reprint Why do tumors metastasize?
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, C Professor Garcia Gonzalez, Seville 41012, Spain
    Cancer Biol Ther 6:141-4. 2007
    ..This new model might help develop cancer chemopreventive strategies for preventing tumor metastasis and thus reduce cancer mortality...
  7. doi request reprint Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Sevilla, Spain
    Mol Nutr Food Res 52:S103-27. 2008
    ..Several considerations that may help develop curcumin as an anticancer agent are also discussed...
  8. ncbi request reprint Granulocyte colony-stimulating factor (G-CSF): a novel anticancer therapy based on the "universal dynamics of tumor growth"?
    M Lopez-Lazaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Exp Oncol 28:249-51. 2006
    ..The merits of G-CSF for being tested in clinical trials with cancer patients are finally evaluated...
  9. ncbi request reprint HIF-1: hypoxia-inducible factor or dysoxia-inducible factor?
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, C Professor Garcia Gonzalez, 41011, Sevilla, Spain
    FASEB J 20:828-32. 2006
    ..This may have relevance, for instance, to cancer, as HIF-1 overexpression is observed in many human cancers and has been associated with increased patient mortality...
  10. ncbi request reprint Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41011, Seville, Spain
    Leuk Res 30:895-8. 2006
    ..This may lead to a reduction in the anticancer effect of these two topoisomerase II poisons when they are used in the clinic concurrently with digitoxin...
  11. ncbi request reprint Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41011, Seville, Spain
    J Nat Prod 68:1642-5. 2005
    ..Using the individual cell assay TARDIS, cells exposed to 1 for 30 min showed low but statistically significant levels of DNA-topoisomerase II cleavable complexes; however these complexes disappeared after 24 h exposure...
  12. ncbi request reprint Distribution and biological activities of the flavonoid luteolin
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain C Profesor Garcia Gonzalez, 41011, Sevilla, Spain
    Mini Rev Med Chem 9:31-59. 2009
    ....
  13. ncbi request reprint Flavonoids as anticancer agents: structure-activity relationship study
    M Lopez-Lazaro
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Curr Med Chem Anticancer Agents 2:691-714. 2002
    ....
  14. ncbi request reprint Role of oxygen in cancer: looking beyond hypoxia
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Anticancer Agents Med Chem 9:517-25. 2009
    ..Interestingly, this switch in oxygen metabolism occurs under both hypoxic and normoxic conditions and may be exploited therapeutically...
  15. pmc A new view of carcinogenesis and an alternative approach to cancer therapy
    Miguel López-Lázaro
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    Mol Med 16:144-53. 2010
    ..The utility of this novel approach for the development of therapies that selectively target tumor cells is discussed...
  16. ncbi request reprint The warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen?
    Miguel López-Lázaro
    Department of Pharmacology, University of Seville, Spain
    Anticancer Agents Med Chem 8:305-12. 2008
    ..Several strategies and drugs that may interfere with the glycolytic metabolism of cancer cells are also shown. This information may help develop anticancer approaches that may have clinical relevance...
  17. ncbi request reprint Flavonoids as DNA topoisomerase I poisons
    M Lopez-Lazaro
    Facultad de Farmacia, Departamento de Farmacologia, Universidad de Sevilla, Spain
    J Enzyme Inhib Med Chem 17:25-9. 2002
    ..Taking into account our previous research, structural requisites implicated in the topoisomerase poisoning are discussed...
  18. ncbi request reprint Retamatrioside, a new flavonol triglycoside from Retama sphaerocarpa
    C Martín-Cordero
    Laboratorio de Farmacognosia, Departamento de Farmacologia, Facultad de Farmacia, c P García González, 41012 Seville, Spain
    J Nat Prod 63:248-50. 2000
    ..The structure of 1 has been determined as rhamnazin 3-O-beta-D-glucopyranosyl-(1-->5)-[beta-D-apiofuranosyl(1-->2)]-al pha -L-arabinofuranoside, using spectroscopic methods...
  19. ncbi request reprint Cytotoxic compounds from Annonaceus species as DNA topoisomerase I poisons
    M Lopez-Lazaro
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Anticancer Res 21:3493-7. 2001
    ....
  20. ncbi request reprint Two new flavonol glycosides as DNA topoisomerase I poisons
    M Lopez-Lazaro
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Espana
    Z Naturforsch C 55:898-902. 2000
    ..Two new rhamnazin glycosides were found to have the ability to stabilize the cleavage complex human DNA topoisomerase I at concentrations in the 100-250 microM range, acting as topoisomersase I poisons...
  21. ncbi request reprint A cytotoxic diarylheptanoid from Viscum cruciatum
    C Martín-Cordero
    Laboratorio de Farmacognosia, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain
    Phytochemistry 58:567-9. 2001
    ..This compound showed cytotoxic activity against melanoma (UACC-62), renal (TK-10) and breast (MCF-7) cancer cell lines...
  22. doi request reprint Antioxidant and cytotoxic activities of Sideritis perezlarae (Borja) Roselló, Stübing and Peris
    R de la Puerta
    Department of Pharmacology, School of Pharmacy, 41012 Sevilla, Spain
    Nat Prod Res 27:1602-6. 2013
    ..59 ± 0.02 mg g(-1)). The cytotoxic activity of the extract against a human adenocarcinoma cell line HT-29 presented an IC50 = 69.47 ± 4.64 µg mL(-1)...
  23. ncbi request reprint Cytotoxic activity of hirsutanone, a diarylheptanoid isolated from Alnus glutinosa leaves
    A J León-Gonzalez
    Department of Pharmacology, Faculty of Pharmacy, Sevilla University, 41012 Sevilla, Spain
    Phytomedicine 21:866-70. 2014
    ..Because natural products are a significant source of anticancer drugs, it is important to explore cytotoxic activity of novel compounds from natural origin...
  24. ncbi request reprint Cytotoxic activity of flavonoids and extracts from Retama sphaerocarpa Boissier
    M Lopez-Lazaro
    Departamento de Farmacologia, Falcultad de Farmacia, Universidad de Sevilla, Espana
    Z Naturforsch C 55:40-3. 2000
    ..They produce a dose-dependent inhibition of cell growth at concentrations in the 10(-6)-10(-4) M and 25-250 microg/ml range for the flavonoids and extracts respectively, being the flavonol rhamnazin the most cytotoxic...
  25. ncbi request reprint A review on the dietary flavonoid kaempferol
    J M Calderón-Montaño
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, C Profesor García González, No 2, 41012, Sevilla, Spain
    Mini Rev Med Chem 11:298-344. 2011
    ..This information may help understand the health benefits of kaempferol-containing plants and may contribute to develop this flavonoid as a possible agent for the prevention and treatment of some diseases...
  26. ncbi request reprint Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues
    Esther Caballero
    Laboratorio de Qui mica Orgánica y Farmacéutica, Facultad de Farmacia, 37007, Salamanca, Spain
    Bioorg Med Chem 11:3413-21. 2003
    ..Some representative compounds display interesting cytotoxic profiles...