Manuel Guzman

Summary

Affiliation: Universidad Complutense
Country: Spain

Publications

  1. pmc Neurons on cannabinoids: dead or alive?
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Br J Pharmacol 140:439-40. 2003
  2. ncbi Cannabinoids: potential anticancer agents
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Nat Rev Cancer 3:745-55. 2003
  3. ncbi Cannabinoids and cell fate
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Pharmacol Ther 95:175-84. 2002
  4. pmc A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid 28040, Spain
    Br J Cancer 95:197-203. 2006
  5. ncbi A new age for MAGL
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I and CIBERNED, School of Biology, Complutense University, Madrid, Spain
    Chem Biol 17:4-6. 2010
  6. ncbi Is there an astrocyte-neuron ketone body shuttle?
    M Guzman
    Dept Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Trends Endocrinol Metab 12:169-73. 2001
  7. ncbi Ceramide: a new second messenger of cannabinoid action
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain
    Trends Pharmacol Sci 22:19-22. 2001
  8. ncbi Inhibition of tumor angiogenesis by cannabinoids
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FASEB J 17:529-31. 2003
  9. ncbi The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Cell 9:301-12. 2006
  10. ncbi The endocannabinoid system drives neural progenitor proliferation
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FASEB J 19:1704-6. 2005

Collaborators

Detail Information

Publications62

  1. pmc Neurons on cannabinoids: dead or alive?
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Br J Pharmacol 140:439-40. 2003
  2. ncbi Cannabinoids: potential anticancer agents
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Nat Rev Cancer 3:745-55. 2003
    ..Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies. So, could cannabinoids be used to develop new anticancer therapies?..
  3. ncbi Cannabinoids and cell fate
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Pharmacol Ther 95:175-84. 2002
    ..Regarding immune cells, low doses of cannabinoids may enhance proliferation, whereas high doses of cannabinoids usually induce growth arrest or apoptosis. The potential therapeutic applications of these findings are discussed...
  4. pmc A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid 28040, Spain
    Br J Cancer 95:197-203. 2006
    ....
  5. ncbi A new age for MAGL
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I and CIBERNED, School of Biology, Complutense University, Madrid, Spain
    Chem Biol 17:4-6. 2010
    ..Now Nomura et al. show that cancer cells can hijack MAGL to produce oncogenic lipid messengers. This exciting finding raises important pathophysiological questions...
  6. ncbi Is there an astrocyte-neuron ketone body shuttle?
    M Guzman
    Dept Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Trends Endocrinol Metab 12:169-73. 2001
    ..These findings support the notion that astrocytes might supply neurons with ketone bodies in situ, and raise the possibility that astrocyte ketogenesis is a cytoprotective pathway...
  7. ncbi Ceramide: a new second messenger of cannabinoid action
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain
    Trends Pharmacol Sci 22:19-22. 2001
    ..Ceramide in turn mediates cannabinoid-induced apoptosis, as shown by in vitro and in vivo studies. These findings provide a new perspective on how cannabinoids act, and raise exciting physiological and therapeutic questions...
  8. ncbi Inhibition of tumor angiogenesis by cannabinoids
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FASEB J 17:529-31. 2003
    ..Inhibition of tumor angiogenesis may allow new strategies for the design of cannabinoid-based antitumoral therapies...
  9. ncbi The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Cell 9:301-12. 2006
    ..Activation of this pathway may constitute a potential therapeutic strategy for inhibiting tumor growth...
  10. ncbi The endocannabinoid system drives neural progenitor proliferation
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FASEB J 19:1704-6. 2005
    ..Our results demonstrate that endocannabinoids constitute a new group of signaling cues that regulate NP proliferation and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain...
  11. pmc Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    Maria Salazar
    Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain
    J Clin Invest 119:1359-72. 2009
    ..These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers...
  12. ncbi Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway
    Teresa Gómez del Pulgar
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 277:36527-33. 2002
    ..These findings constitute the first evidence for an "astroprotective" role of cannabinoids...
  13. ncbi Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Cancer Res 64:5617-23. 2004
    ..Because blockade of the VEGF pathway constitutes one of the most promising antitumoral approaches currently available, the present findings provide a novel pharmacological target for cannabinoid-based therapies...
  14. doi Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Cancer Res 68:1945-52. 2008
    ..As MMP-2 up-regulation is associated with high progression and poor prognosis of gliomas and many other tumors, MMP-2 down-regulation constitutes a new hallmark of cannabinoid antitumoral activity...
  15. doi Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis
    Mar Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Glia 57:1374-85. 2009
    ....
  16. pmc De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
    Teresa Gómez del Pulgar
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Biochem J 363:183-8. 2002
    ..These findings show that de novo-synthesized ceramide is involved in cannabinoid-induced apoptosis of glioma cells...
  17. ncbi The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:23892-8. 2007
    ..In summary, our results show the involvement of the CB1 cannabinoid receptor in NP proliferation and neurogenesis induced by excitotoxic injury and support a role for bFGF signaling in this process...
  18. ncbi Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 12:2319-25. 2006
    ....
  19. ncbi Cannabinoids and gliomas
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Mol Neurobiol 36:60-7. 2007
    ..The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids...
  20. pmc Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Biochem J 380:435-40. 2004
    ....
  21. doi The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, Complutense University, 28040 Madrid, Spain
    J Biol Chem 283:13320-9. 2008
    ....
  22. ncbi The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Neurosci 26:1551-61. 2006
    ..These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function...
  23. doi Detecting autophagy in response to ER stress signals in cancer
    Maria Salazar
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Methods Enzymol 489:297-317. 2011
    ....
  24. ncbi The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
    Blanca Herrera
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    Exp Cell Res 312:2121-31. 2006
    ..In summary, results presented here show that CB2 receptor activation signals apoptosis via a ceramide-dependent stimulation of the mitochondrial intrinsic pathway...
  25. ncbi Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    Cancer Res 66:6748-55. 2006
    ..These findings may contribute to set the basis for a new therapeutic approach for the treatment of pancreatic cancer...
  26. ncbi Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:6854-62. 2007
    ..Overall, our results demonstrate that cannabinoids target glioma stem-like cells, promote their differentiation, and inhibit gliomagenesis, thus giving further support to their potential use in the management of malignant gliomas...
  27. ncbi Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    FASEB J 20:2405-7. 2006
    ..These findings provide a novel physiological role for the CB2 cannabinoid receptor and open a novel therapeutic avenue for manipulating neural progenitor cell fate...
  28. doi The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action
    Maria Salazar
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Biochim Biophys Acta 1831:1573-8. 2013
    ..Altogether, the observations presented here strongly support that TRIB3 plays a crucial role on THC anti-neoplastic activity. This article is part of a Special Issue entitled Lipid Metabolism in Cancer. ..
  29. pmc CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling
    Javier Palazuelos
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Instituto Universitario de Investigación en Neuroquímica, and Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 287:1198-209. 2012
    ..Altogether, these findings provide a mechanism of action and a rationale for the use of nonpsychotomimetic CB(2) receptor-selective ligands as a novel strategy for the control of NP cell proliferation and neurogenesis...
  30. ncbi Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation
    María M Caffarel
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Res 66:6615-21. 2006
    ..Importantly, no significant CB(2) expression was detected in nontumor breast tissue. Taken together, these data might set the bases for a cannabinoid therapy for the management of breast cancer...
  31. ncbi Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Neuropharmacology 54:235-43. 2008
    ..As TIMP-1 up-regulation is associated with high malignancy and negative prognosis of numerous cancers, TIMP-1 down-regulation may be a hallmark of cannabinoid-induced inhibition of glioma progression...
  32. ncbi Cannabinoid receptors as novel targets for the treatment of melanoma
    Cristina Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    FASEB J 20:2633-5. 2006
    ..These findings may contribute to the design of new chemotherapeutic strategies for the management of melanoma...
  33. doi A combined preclinical therapy of cannabinoids and temozolomide against glioma
    Sofia Torres
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    Mol Cancer Ther 10:90-103. 2011
    ..Altogether, our findings support that the combined administration of TMZ and cannabinoids could be therapeutically exploited for the management of GBM...
  34. doi Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease
    Cristina Blazquez
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Huntington s Disease and Ataxias Collaborative Project, 28040 Madrid, Spain
    Brain 134:119-36. 2011
    ....
  35. ncbi Hypothesis: cannabinoid therapy for the treatment of gliomas?
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Avenida Complutense, sn, 28040 Madrid, Spain
    Neuropharmacology 47:315-23. 2004
    ..Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas...
  36. ncbi Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death
    Mar Lorente
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Autophagy 7:1071-3. 2011
    ..We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cell death...
  37. ncbi Cannabinoids and ceramide: two lipids acting hand-by-hand
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Life Sci 77:1723-31. 2005
    ..These findings provide a new conceptual view on how cannabinoids act, and raise interesting physiological and therapeutic questions...
  38. ncbi The endocannabinoid system and neurogenesis in health and disease
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, José Antonio Novais sn, Complutense University, 28040 Madrid, Spain
    Neuroscientist 13:109-14. 2007
    ....
  39. ncbi Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Pharmacol 62:1385-92. 2002
    ..In conclusion, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision...
  40. pmc Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical development
    Javier Díaz-Alonso
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain
    Philos Trans R Soc Lond B Biol Sci 367:3229-41. 2012
    ..In this review the implications of altered CB(1)-receptor-mediated signalling in developmental disorders and particularly in epileptogenesis are briefly discussed...
  41. doi Cannabinoids: a new hope for breast cancer therapy?
    María M Caffarel
    Dept Biochemistry and Molecular Biology I, School of Biology, Complutense University CIBERNED IRYCIS, Madrid, Spain
    Cancer Treat Rev 38:911-8. 2012
    ..This review summarizes our current knowledge on the anti-tumor potential of cannabinoids in breast cancer, which suggests that cannabinoid-based medicines may be useful for the treatment of most breast tumor subtypes...
  42. doi Towards the use of cannabinoids as antitumour agents
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, and the Instituto Universitario de Investigación Neuroquímica IUIN, Madrid 28040, Spain
    Nat Rev Cancer 12:436-44. 2012
    ..Such knowledge is required for the optimization of preclinical cannabinoid-based therapies and for the preliminary clinical testing that is currently underway...
  43. doi The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, 28040 Madrid, Spain
    Eur Arch Psychiatry Clin Neurosci 259:371-82. 2009
    ..g., schizophrenia) and the regulation of neurogenesis in brain depression, are discussed herein...
  44. ncbi Mechanisms of control of neuron survival by the endocannabinoid system
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 14:2279-88. 2008
    ..Altogether, these findings support that endocannabinoids constitute a new family of lipid mediators that act as instructive signals in the control of neuron survival...
  45. doi Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner
    Adriana Barana
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Cardiovasc Res 85:56-67. 2010
    ..5 channels, which generate the ultrarapid delayed rectifier current (I(Kur))...
  46. pmc Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
    M Llanos Casanova
    Project on Cellular and Molecular Biology and Gene Therapy, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid, Spain
    J Clin Invest 111:43-50. 2003
    ..Abrogation of EGF-R function was also observed in cannabinoid-treated tumors. These results support a new therapeutic approach for the treatment of skin tumors...
  47. ncbi Cannabinoid CB2 receptor: a new target for controlling neural cell survival?
    Javier Fernandez-Ruiz
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
    Trends Pharmacol Sci 28:39-45. 2007
    ....
  48. ncbi p8 Upregulation sensitizes astrocytes to oxidative stress
    Arkaitz Carracedo
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    FEBS Lett 580:1571-5. 2006
    ..Our results support that serum deprivation sensitizes astrocytes to oxidative stress via a p38 mitogen-activated protein kinase-dependent p8 upregulation that leads in turn to decreased heme oxygenase 1 expression...
  49. ncbi Ketone body synthesis in the brain: possible neuroprotective effects
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Prostaglandins Leukot Essent Fatty Acids 70:287-92. 2004
    ..These findings support the notion that ketone bodies produced by astrocytes may be used in situ as substrates for neuronal metabolism, and raise the possibility that astrocyte ketogenesis is a neuroprotective pathway...
  50. ncbi Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
    C Sanchez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Cancer Res 61:5784-9. 2001
    ..These results support a therapeutic approach for the treatment of malignant gliomas devoid of psychotropic side effects...
  51. ncbi Preface: cannabinoids as new tools for the treatment of neurological disorders
    Javier Fernandez-Ruiz
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, Madrid 28040, Spain
    Mol Neurobiol 36:1-2. 2007
  52. pmc Prospects for cannabinoid therapies in basal ganglia disorders
    Javier Fernandez-Ruiz
    Departamento de Bioquimica y Biologia Molecular III, Instituto Universitario de Investigación en Neuroquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 163:1365-78. 2011
    ....
  53. ncbi p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells
    Blanca Herrera
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
    FEBS Lett 579:5084-8. 2005
    ..These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells...
  54. ncbi The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fan
    C Sanchez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Pharmacol 59:955-9. 2001
    ..This is the first report showing that a G-protein-coupled receptor induces sphingomyelin hydrolysis through FAN and that the CB(1) cannabinoid receptor may signal independently of G(i/o) proteins...
  55. doi Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, IUIN, CIBERNED and IRYCIS, 28040 Madrid, Spain Electronic address
    Prog Lipid Res 52:633-50. 2013
    ..The developmental regulation of cannabinoid receptor expression and cellular/subcellular localization, together with their role in progenitor/stem cell biology, may have important implications in human health and disease. ..
  56. doi Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy
    Maria J Casarejos
    Department of Neurobiology, Ramon y Cajal University Hospital, Ctra de Colmenar Km 9, Madrid, Spain
    J Alzheimers Dis 35:525-39. 2013
    ....
  57. pmc Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
    María M Caffarel
    Dept, Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Cancer 9:196. 2010
    ..We also analyzed the expression of cannabinoid targets in a series of 87 human breast tumors...
  58. ncbi The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway
    Daniel Rueda
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 277:46645-50. 2002
    ..These data indicate that endocannabinoids inhibit neuronal progenitor cell differentiation through attenuation of the ERK pathway and suggest that they constitute a new physiological system involved in the regulation of neurogenesis...
  59. ncbi Effects of cannabinoids on energy metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Life Sci 65:657-64. 1999
    ..Anandamide has also been shown to exert metabolic effects in hepatocytes, cells that do not express cannabinoid receptors. The biological role of cannabinoids as modulators of metabolism is as yet unclear...
  60. ncbi The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes
    C Blazquez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FEBS Lett 489:149-53. 2001
    ..Data indicate that AMPK may protect cells from apoptosis induced by stress stimuli...
  61. ncbi Control of the cell survival/death decision by cannabinoids
    M Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    J Mol Med (Berl) 78:613-25. 2001
    ..Ongoing investigation is in search for cannabinoid-based therapeutic strategies devoid of nondesired psychotropic effects...
  62. ncbi Effects of extracellular ATP on hepatic fatty acid metabolism
    M Guzman
    Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, Madrid, Spain
    Am J Physiol 270:G701-7. 1996
    ....