Research Topics
Genomes and Genes | Manuel GuzmanSummaryAffiliation: Universidad Complutense Country: Spain Publications
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Publications
Neurons on cannabinoids: dead or alive?Manuel Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Br J Pharmacol 140:439-40. 2003
Cannabinoids: potential anticancer agentsManuel Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Nat Rev Cancer 3:745-55. 2003..Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies. So, could cannabinoids be used to develop new anticancer therapies?..- Cannabinoids and cell fateManuel Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Pharmacol Ther 95:175-84. 2002..Regarding immune cells, low doses of cannabinoids may enhance proliferation, whereas high doses of cannabinoids usually induce growth arrest or apoptosis. The potential therapeutic applications of these findings are discussed... - A new age for MAGLManuel Guzman
Department of Biochemistry and Molecular Biology I and CIBERNED, School of Biology, Complutense University, Madrid, Spain
Chem Biol 17:4-6. 2010..Now Nomura et al. show that cancer cells can hijack MAGL to produce oncogenic lipid messengers. This exciting finding raises important pathophysiological questions... - Is there an astrocyte-neuron ketone body shuttle?M Guzman
Dept Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Trends Endocrinol Metab 12:169-73. 2001..These findings support the notion that astrocytes might supply neurons with ketone bodies in situ, and raise the possibility that astrocyte ketogenesis is a cytoprotective pathway... - Ceramide: a new second messenger of cannabinoid actionM Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain
Trends Pharmacol Sci 22:19-22. 2001..Ceramide in turn mediates cannabinoid-induced apoptosis, as shown by in vitro and in vivo studies. These findings provide a new perspective on how cannabinoids act, and raise exciting physiological and therapeutic questions... - A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiformeM Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid 28040, Spain
Br J Cancer 95:197-203. 2006.... - De novo-synthesized ceramide is involved in cannabinoid-induced apoptosisTeresa Gómez del Pulgar
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Biochem J 363:183-8. 2002..These findings show that de novo-synthesized ceramide is involved in cannabinoid-induced apoptosis of glioma cells... - Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathwayTeresa Gómez del Pulgar
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Biol Chem 277:36527-33. 2002..These findings constitute the first evidence for an "astroprotective" role of cannabinoids... - Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cellsMaria Salazar
Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain
J Clin Invest 119:1359-72. 2009..These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers... - Inhibition of tumor angiogenesis by cannabinoidsCristina Blazquez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
FASEB J 17:529-31. 2003..Inhibition of tumor angiogenesis may allow new strategies for the design of cannabinoid-based antitumoral therapies... - Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomasCristina Blazquez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Cancer Res 64:5617-23. 2004..Because blockade of the VEGF pathway constitutes one of the most promising antitumoral approaches currently available, the present findings provide a novel pharmacological target for cannabinoid-based therapies... 
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expressionCristina Blazquez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Cancer Res 68:1945-52. 2008..As MMP-2 up-regulation is associated with high progression and poor prognosis of gliomas and many other tumors, MMP-2 down-regulation constitutes a new hallmark of cannabinoid antitumoral activity...- Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosisMar Lorente
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Glia 57:1374-85. 2009.... - The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesisTania Aguado
Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
J Biol Chem 282:23892-8. 2007..In summary, our results show the involvement of the CB1 cannabinoid receptor in NP proliferation and neurogenesis induced by excitotoxic injury and support a role for bFGF signaling in this process... - Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell developmentIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Curr Pharm Des 12:2319-25. 2006.... - Cannabinoids and gliomasGuillermo Velasco
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Mol Neurobiol 36:60-7. 2007..The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids... - Hypothesis: cannabinoid therapy for the treatment of gliomas?Guillermo Velasco
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Avenida Complutense, sn, 28040 Madrid, Spain
Neuropharmacology 47:315-23. 2004..Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas... - The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathwayBlanca Herrera
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
Exp Cell Res 312:2121-31. 2006..In summary, results presented here show that CB2 receptor activation signals apoptosis via a ceramide-dependent stimulation of the mitochondrial intrinsic pathway... - The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosisJavier Palazuelos
Department of Biochemistry and Molecular Biology I, Complutense University, 28040 Madrid, Spain
J Biol Chem 283:13320-9. 2008.... - The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cellsTania Aguado
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Neurosci 26:1551-61. 2006..These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function... - Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulationMaría M Caffarel
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Cancer Res 66:6615-21. 2006..Importantly, no significant CB(2) expression was detected in nontumor breast tissue. Taken together, these data might set the bases for a cannabinoid therapy for the management of breast cancer... - Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferationJavier Palazuelos
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
FASEB J 20:2405-7. 2006..These findings provide a novel physiological role for the CB2 cannabinoid receptor and open a novel therapeutic avenue for manipulating neural progenitor cell fate... - Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesisTania Aguado
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Biol Chem 282:6854-62. 2007..Overall, our results demonstrate that cannabinoids target glioma stem-like cells, promote their differentiation, and inhibit gliomagenesis, thus giving further support to their potential use in the management of malignant gliomas... - Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?Cristina Blazquez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Neuropharmacology 54:235-43. 2008..As TIMP-1 up-regulation is associated with high malignancy and negative prognosis of numerous cancers, TIMP-1 down-regulation may be a hallmark of cannabinoid-induced inhibition of glioma progression... - Cannabinoid receptors as novel targets for the treatment of melanomaCristina Blazquez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
FASEB J 20:2633-5. 2006..These findings may contribute to the design of new chemotherapeutic strategies for the management of melanoma... - Detecting autophagy in response to ER stress signals in cancerMaria Salazar
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Methods Enzymol 489:297-317. 2011.... - A combined preclinical therapy of cannabinoids and temozolomide against gliomaSofia Torres
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
Mol Cancer Ther 10:90-103. 2011..Altogether, our findings support that the combined administration of TMZ and cannabinoids could be therapeutically exploited for the management of GBM... - Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's diseaseCristina Blazquez
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Huntington s Disease and Ataxias Collaborative Project, 28040 Madrid, Spain
Brain 134:119-36. 2011.... - CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signalingJavier Palazuelos
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Instituto Universitario de Investigación en Neuroquímica, and Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Biol Chem 287:1198-209. 2012..Altogether, these findings provide a mechanism of action and a rationale for the use of nonpsychotomimetic CB(2) receptor-selective ligands as a novel strategy for the control of NP cell proliferation and neurogenesis... - Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell deathMar Lorente
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Autophagy 7:1071-3. 2011..We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cell death... - The endocannabinoid system and neurogenesis in health and diseaseIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology, José Antonio Novais sn, Complutense University, 28040 Madrid, Spain
Neuroscientist 13:109-14. 2007.... - Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptorIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Mol Pharmacol 62:1385-92. 2002..In conclusion, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision... - Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical developmentJavier Díaz-Alonso
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain
Philos Trans R Soc Lond B Biol Sci 367:3229-41. 2012..In this review the implications of altered CB(1)-receptor-mediated signalling in developmental disorders and particularly in epileptogenesis are briefly discussed... - Cannabinoids: a new hope for breast cancer therapy?María M Caffarel
Dept Biochemistry and Molecular Biology I, School of Biology, Complutense University CIBERNED IRYCIS, Madrid, Spain
Cancer Treat Rev 38:911-8. 2012..This review summarizes our current knowledge on the anti-tumor potential of cannabinoids in breast cancer, which suggests that cannabinoid-based medicines may be useful for the treatment of most breast tumor subtypes... - Towards the use of cannabinoids as antitumour agentsGuillermo Velasco
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, and the Instituto Universitario de Investigación Neuroquímica IUIN, Madrid 28040, Spain
Nat Rev Cancer 12:436-44. 2012..Such knowledge is required for the optimization of preclinical cannabinoid-based therapies and for the preliminary clinical testing that is currently underway... - The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disordersIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, 28040 Madrid, Spain
Eur Arch Psychiatry Clin Neurosci 259:371-82. 2009..g., schizophrenia) and the regulation of neurogenesis in brain depression, are discussed herein... - Mechanisms of control of neuron survival by the endocannabinoid systemIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
Curr Pharm Des 14:2279-88. 2008..Altogether, these findings support that endocannabinoids constitute a new family of lipid mediators that act as instructive signals in the control of neuron survival... - Preface: cannabinoids as new tools for the treatment of neurological disordersJavier Fernandez-Ruiz
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, Madrid 28040, Spain
Mol Neurobiol 36:1-2. 2007 - Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptorsM Llanos Casanova
Project on Cellular and Molecular Biology and Gene Therapy, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid, Spain
J Clin Invest 111:43-50. 2003..Abrogation of EGF-R function was also observed in cannabinoid-treated tumors. These results support a new therapeutic approach for the treatment of skin tumors... - Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent mannerAdriana Barana
Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
Cardiovasc Res 85:56-67. 2010..5 channels, which generate the ultrarapid delayed rectifier current (I(Kur))... - Cannabinoid CB2 receptor: a new target for controlling neural cell survival?Javier Fernandez-Ruiz
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
Trends Pharmacol Sci 28:39-45. 2007.... - Ketone body synthesis in the brain: possible neuroprotective effectsManuel Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Prostaglandins Leukot Essent Fatty Acids 70:287-92. 2004..These findings support the notion that ketone bodies produced by astrocytes may be used in situ as substrates for neuronal metabolism, and raise the possibility that astrocyte ketogenesis is a neuroprotective pathway... - p8 Upregulation sensitizes astrocytes to oxidative stressArkaitz Carracedo
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
FEBS Lett 580:1571-5. 2006..Our results support that serum deprivation sensitizes astrocytes to oxidative stress via a p38 mitogen-activated protein kinase-dependent p8 upregulation that leads in turn to decreased heme oxygenase 1 expression... - Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptorC Sanchez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Cancer Res 61:5784-9. 2001..These results support a therapeutic approach for the treatment of malignant gliomas devoid of psychotropic side effects... - Prospects for cannabinoid therapies in basal ganglia disordersJavier Fernandez-Ruiz
Departamento de Bioquimica y Biologia Molecular III, Instituto Universitario de Investigación en Neuroquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain
Br J Pharmacol 163:1365-78. 2011.... - p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cellsBlanca Herrera
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, C José Antonio Novais s n, 28040 Madrid, Spain
FEBS Lett 579:5084-8. 2005..These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells... - The CB(1) cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolysis through the adaptor protein fanC Sanchez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Mol Pharmacol 59:955-9. 2001..This is the first report showing that a G-protein-coupled receptor induces sphingomyelin hydrolysis through FAN and that the CB(1) cannabinoid receptor may signal independently of G(i/o) proteins... - Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibitionMaría M Caffarel
Dept, Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Mol Cancer 9:196. 2010..We also analyzed the expression of cannabinoid targets in a series of 87 human breast tumors... - The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathwayDaniel Rueda
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Biol Chem 277:46645-50. 2002..These data indicate that endocannabinoids inhibit neuronal progenitor cell differentiation through attenuation of the ERK pathway and suggest that they constitute a new physiological system involved in the regulation of neurogenesis... - The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytesC Blazquez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
FEBS Lett 489:149-53. 2001..Data indicate that AMPK may protect cells from apoptosis induced by stress stimuli... - Effects of cannabinoids on energy metabolismM Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Life Sci 65:657-64. 1999..Anandamide has also been shown to exert metabolic effects in hepatocytes, cells that do not express cannabinoid receptors. The biological role of cannabinoids as modulators of metabolism is as yet unclear... - Control of the cell survival/death decision by cannabinoidsM Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
J Mol Med (Berl) 78:613-25. 2001..Ongoing investigation is in search for cannabinoid-based therapeutic strategies devoid of nondesired psychotropic effects... - Effects of extracellular ATP on hepatic fatty acid metabolismM Guzman
Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, Madrid, Spain
Am J Physiol 270:G701-7. 1996....