Rogelio Gonzalez-Sarmiento

Summary

Affiliation: Universidad de Salamanca
Country: Spain

Publications

  1. pmc Gamma-heregulin has no biological significance in primary breast cancer
    E A Sánchez-Valdivieso
    Br J Cancer 86:1362-3. 2002
  2. pmc The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy
    Salvador Pastor-Idoate
    Instituto de Oftalmobiología IOBA Retina Group, University of Valladolid, Valladolid, Spain Unidad de Medicina Molecular, Departamento de Medicina, University of Salamanca, Salamanca, Spain
    PLoS ONE 8:e82283. 2013
  3. pmc Molecular analysis of activation-induced cytidine deaminase gene in immunoglobulin-E deficient patients
    Sergio Roa
    Molecular Medicine Unit, Department of Medicine, University of Salamanca, 37007 Salamanca, Spain
    Clin Dev Immunol 2008:146715. 2008
  4. doi request reprint [Analysis of TRPV1 gene polymorphisms in Spanish patients with neuropathic pain]
    Pilar Armero
    Cátedra Extraordinaria del Dolor, Fundación Grünenthal Universidad de Salamanca, Salamanca, Espana
    Med Clin (Barc) 139:1-4. 2012
  5. pmc Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study
    Ignacio Cruz-Gonzalez
    Cardiology Department, University Hospital of Salamanca, Salamanca, Spain
    BMC Cardiovasc Disord 9:35. 2009
  6. ncbi request reprint Interleukin-10 gene polymorphism is associated with alcoholism but not with alcoholic liver disease
    Miguel Marcos
    Servicio de Medicina Interna II, Hospital Universitario de Salamanca, Paseo de San Vicente 58 182, 37007 Salamanca, Spain
    Alcohol Alcohol 43:523-8. 2008
  7. doi request reprint Analysis of DNA repair gene polymorphisms in glioblastoma
    Irene Rodriguez-Hernandez
    Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain IBMCC and IBSAL USAL CSIC University Hospital, Salamanca, Spain
    Gene 536:79-83. 2014
  8. doi request reprint The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: the Retina 4 Project
    Salvador Pastor-Idoate
    Department of Ophthalmology, University Hospital of Valladolid, Valladolid, Spain
    Ophthalmology 120:623-8. 2013
  9. doi request reprint Cannabinoid receptor 1 gene is associated with alcohol dependence
    Miguel Marcos
    Alcoholism Unit, Department of Internal Medicine, University Hospital of Salamanca, Salamanca, Spain
    Alcohol Clin Exp Res 36:267-71. 2012
  10. doi request reprint A new genetic variant involved in genetic susceptibility to alcoholic liver cirrhosis: -330T>G polymorphism of the interleukin-2 gene
    Miguel Marcos
    Alcoholism Unit, Service of Internal Medicine, University Hospital of Salamanca, Salamanca, Spain
    Eur J Gastroenterol Hepatol 20:855-9. 2008

Collaborators

  • Francisco Javier Laso
  • Angel Santos-Briz
  • Jose Angel Perez-Rivera
  • Jesus Perez-Losada
  • Jimena Rojas
  • Robert E MacLaren
  • Juan Luis Garcia
  • Amândio Rocha-Sousa
  • Luis Corral-Gudino
  • Jesús M Hernández-Rivas
  • Veronica Gonzalez-Nunez
  • A Gomez
  • Francisco S Lozano
  • Manuel Sanchez-Martin
  • Angeles Almeida
  • Javier Ortiz
  • Cesar Cobaleda
  • Javier Cañueto
  • Miguel Marcos
  • Irene Rodriguez-Hernandez
  • Isabel Pastor
  • Fernando Cruz-González
  • Salvador Pastor-Idoate
  • Maria Isidoro-Garcia
  • Pilar Armero
  • Isabel J Pastor
  • Clemente Muriel
  • Juan Jesus Cruz
  • Clara Cieza-Borrella
  • Juan Antonio Gómez-Moreta
  • David Charteris
  • Yashin Ramkissoon
  • Itziar Fernandez
  • Steven Harsum
  • Sandra Perdomo
  • Manuela Yuste-Chaves
  • Jose C Gomez-Sanchez
  • Mercedes Nunez
  • Andres Castellanos
  • Ignacio Cruz-Gonzalez
  • Juan Santos
  • Pilar Sanchez-Conde
  • Sergio Roa
  • Ignacio Davila
  • Felix Lorente
  • Elena Laffond
  • Miguel Barrueco
  • Luis A Herraez-Baranda
  • Raquel E Rodriguez
  • Emiliano Hernández-Galilea
  • Lucía Cabrillo-Estévez
  • Gloria López-Valverde
  • E A Sánchez-Valdivieso
  • Jose Carlos Pastor
  • Oscar Toldos-González
  • Jan C Vanmeurs
  • Cristina Cañete-Campos
  • Francisco Escudero-Domínguez
  • Maria T Garcia-Gutierrez
  • José María Ruiz-Moreno
  • Jan Van Meurs
  • Jose María González-Valero
  • Jose M Ruiz-Moreno
  • Javier Martin-Vallejo
  • Aurelio Hernández-Laín
  • Maria Teresa Garcia-Gutierrez
  • L Cabrillo-Estévez
  • Jose C Pastor
  • Cristina de la Calle
  • Monica Lopez
  • Laura Barrio-Real
  • Tomas Sobrino
  • Jose Castillo
  • Maria Delgado-Esteban
  • Pablo Unamuno
  • Silvia Reverte
  • Natalia Perez de la Ossa
  • Juan P Bolanos
  • Sara Ciria
  • Juan Moreta
  • Marta Pérez Prieto
  • Javier Castrodeza
  • José Antonio Mirón Canelo
  • Maria Sanchez-Ledesma
  • Candido Martin-Luengo
  • Sandra Inés
  • Mercedes Gómez-Munuera
  • Angel Sánchez-Rodríguez
  • Esther Corral
  • Francisco J Garcia-Criado

Detail Information

Publications35

  1. pmc Gamma-heregulin has no biological significance in primary breast cancer
    E A Sánchez-Valdivieso
    Br J Cancer 86:1362-3. 2002
  2. pmc The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy
    Salvador Pastor-Idoate
    Instituto de Oftalmobiología IOBA Retina Group, University of Valladolid, Valladolid, Spain Unidad de Medicina Molecular, Departamento de Medicina, University of Salamanca, Salamanca, Spain
    PLoS ONE 8:e82283. 2013
    ..8-19.1). Results indicate that the G allele of rs2279744 is associated with a higher risk of developing PVR in patients undergoing a RD surgery. Further studies are necessary to understand the role of this SNP in the development of PVR. ..
  3. pmc Molecular analysis of activation-induced cytidine deaminase gene in immunoglobulin-E deficient patients
    Sergio Roa
    Molecular Medicine Unit, Department of Medicine, University of Salamanca, 37007 Salamanca, Spain
    Clin Dev Immunol 2008:146715. 2008
    ....
  4. doi request reprint [Analysis of TRPV1 gene polymorphisms in Spanish patients with neuropathic pain]
    Pilar Armero
    Cátedra Extraordinaria del Dolor, Fundación Grünenthal Universidad de Salamanca, Salamanca, Espana
    Med Clin (Barc) 139:1-4. 2012
    ..In an attempt to determine if genotypic variations in TRPV1 gene could be involved in the susceptibility to suffer neuropathic pain we have studied genetic variants of human TRPV1 gene...
  5. pmc Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study
    Ignacio Cruz-Gonzalez
    Cardiology Department, University Hospital of Salamanca, Salamanca, Spain
    BMC Cardiovasc Disord 9:35. 2009
    ..The aim of the present study was to investigate if the -786T>C and G894T (Glu298Asp) polymorphisms of the NOS3 gene were associated with resistant hypertension...
  6. ncbi request reprint Interleukin-10 gene polymorphism is associated with alcoholism but not with alcoholic liver disease
    Miguel Marcos
    Servicio de Medicina Interna II, Hospital Universitario de Salamanca, Paseo de San Vicente 58 182, 37007 Salamanca, Spain
    Alcohol Alcohol 43:523-8. 2008
    ..To determine whether the functional polymorphism -592C>A of the interleukin (IL)-10 gene (IL10) influences the development of alcoholic liver disease or alcoholism in alcoholic Spanish subjects...
  7. doi request reprint Analysis of DNA repair gene polymorphisms in glioblastoma
    Irene Rodriguez-Hernandez
    Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain IBMCC and IBSAL USAL CSIC University Hospital, Salamanca, Spain
    Gene 536:79-83. 2014
    ..We thus aimed to investigate the role of DNA repair polymorphisms in modulating glioblastoma risk...
  8. doi request reprint The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: the Retina 4 Project
    Salvador Pastor-Idoate
    Department of Ophthalmology, University Hospital of Valladolid, Valladolid, Spain
    Ophthalmology 120:623-8. 2013
    ..To compare the distribution of a p53 gene polymorphism among European subjects undergoing primary retinal detachment (RD) surgery in relation to the development of proliferative vitreoretinopathy (PVR)...
  9. doi request reprint Cannabinoid receptor 1 gene is associated with alcohol dependence
    Miguel Marcos
    Alcoholism Unit, Department of Internal Medicine, University Hospital of Salamanca, Salamanca, Spain
    Alcohol Clin Exp Res 36:267-71. 2012
    ..We thus aimed to examine the relationship between 3 allelic variants of CNR1 (rs6454674, rs1049353, and rs806368) and AD...
  10. doi request reprint A new genetic variant involved in genetic susceptibility to alcoholic liver cirrhosis: -330T>G polymorphism of the interleukin-2 gene
    Miguel Marcos
    Alcoholism Unit, Service of Internal Medicine, University Hospital of Salamanca, Salamanca, Spain
    Eur J Gastroenterol Hepatol 20:855-9. 2008
    ..A decrease in serum levels of interleukin-2 (IL-2) is usually found in alcoholic cirrhotics. In this study we examined the relationship between the -330T>G IL-2 gene (IL2) polymorphism and alcoholic liver cirrhosis...
  11. doi request reprint Effect of telomere length on prognosis in men with acute coronary syndrome
    Jose Angel Perez-Rivera
    Department of Cardiology, University Hospital of Salamanca, Salamanca, Spain Institute of Biomedical Research of Salamanca IBSAL, Salamanca, Spain Electronic address
    Am J Cardiol 113:418-21. 2014
    ..In conclusion, telomere length is a good predictor of cardiovascular prognosis in men admitted for acute coronary syndrome, but this relation depends on the chronological age of the population studied...
  12. doi request reprint Paget's disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes
    Luis Corral-Gudino
    Servicio de Medicina Interna, RETICEF, Hospital Universitario de Salamanca, Los Montalvos s n, Salamanca, Spain
    Cytokine 52:146-50. 2010
    ..Cytokines, specially interleukin (IL)-6, play an important role in the differentiation and activation of osteoclasts and might be involved in osteoblast stimulation in Paget's disease of bone (PDB)...
  13. ncbi request reprint Interleukin-1 gene cluster polymorphisms and alcoholism in Spanish men
    Isabel J Pastor
    Unidad de Medicina Molecular, Departamento de Medicina, Salamanca, Spain
    Alcohol Alcohol 40:181-6. 2005
    ..We analysed the distribution of single nucleotide polymorphisms (SNPs) located in the IL1A, IL1B, IL1R1 and IL1RN genes in alcoholic and non-alcoholic Spanish subjects...
  14. ncbi request reprint COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population
    Pilar Armero
    Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Spain
    Eur J Pain 9:229-32. 2005
    ..Our study concludes that functional Val158Met polymorphism of COMT gene is not associated to increased susceptibility to neuropathic pain...
  15. ncbi request reprint Breast cancer, a stem cell disease
    Rogelio Gonzalez-Sarmiento
    Departamento de Medicina, Facultdad de Medicina, Universidad de Salamanca, Campus Miguel de Unamuno s n Salamanca, 37007, Spain
    Curr Stem Cell Res Ther 3:55-65. 2008
    ..Here we review the origin of breast cancer stem cells and their role in the pathogenesis of cancer development, together with their implications in breast cancer progression, treatment and prognosis...
  16. ncbi request reprint [IL4RA gene polymorphism (Q576R) is associated with higher total IgE levels in Spanish patients with family history of atopy]
    Maria Isidoro-Garcia
    Unidad de Medicina Molecular, Departamento de Medicina, Facultad de Medicina, Universidad de Salamanca, Salamanca, Spain
    Med Clin (Barc) 124:211-2. 2005
    ..The aim of this study is to analyze the allelic distribution of the Q576R polymorphism in an atopic and non atopic population and the relationship with total IgE levels and the family history of atopy...
  17. doi request reprint Tumor necrosis factor polymorphisms and alcoholic liver disease: a HuGE review and meta-analysis
    Miguel Marcos
    Servicio de Medicina Interna II, Hospital Universitario de Salamanca, Salamanca, Spain
    Am J Epidemiol 170:948-56. 2009
    ..Given the limited number of studies and the potential biases, more data are needed to confirm the association described for the -238A allele...
  18. ncbi request reprint Common polymorphisms in interleukin genes (IL4, IL6, IL8 and IL12) are not associated with alcoholic liver disease or alcoholism in Spanish men
    Miguel Marcos
    Unidad de Alcoholismo, Servicio de Medicina Interna II, Hospital Universitario de Salamanca, Paseo de San Vicente 58 182, 37007, Salamanca, Spain
    Cytokine 45:158-61. 2009
    ..We thus analyze the association between these diseases and the following polymorphisms: -33T>C IL4, -174 G>C IL6, -251 T>A IL8 and 1188 A>C IL12B...
  19. doi request reprint The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients
    Mercedes Nunez
    Cancer Research Center IBMCC, University of Salamanca CSIC, Salamanca, Spain
    Clin Transl Oncol 12:825-8. 2010
    ..There is evidence to suggest an anti-neoplastic effect of these ligands in glial tissues mediated through stimulation of the receptor...
  20. ncbi request reprint -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone
    Luis Corral-Gudino
    Servicio de Reumatologia, Hospital Universitario de Salamanca, Po San Vicente 58 182, 37007 Salamanca, Spain
    Bone 38:589-94. 2006
    ..We have assessed whether genetic variability in genes coding of proteins from the IL1 pathway clustered in chromosome 2 is associated with clinical characteristics and the therapeutic response of patients with PDB...
  21. pmc The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke
    Jose C Gomez-Sanchez
    Department of Neurology, University Hospital of Salamanca, 37007 Salamanca, Spain
    J Exp Med 208:429-37. 2011
    ..These results suggest that the Tp53 Arg/Arg genotype governs neuronal vulnerability to apoptosis and can be considered as a genetic marker predicting poor functional outcome after stroke...
  22. ncbi request reprint VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population
    Fernando Cruz-González
    Departamento de Oftalmologia, Hospital Universitario de Salamanca, Salamanca, Spain
    Curr Eye Res 38:1274-7. 2013
    ..We have analysed if polymorphisms in genes coding for VEGFA and VEGFR are associated to susceptibility to suffer AMD in a cohort of Spanish subjects...
  23. pmc Integrated analysis of mismatch repair system in malignant astrocytomas
    Irene Rodriguez-Hernandez
    Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain IBMCC and IBSAL, USAL CSIC University Hospital, Salamanca, Spain
    PLoS ONE 8:e76401. 2013
    ..Our findings suggest that MMR system alterations are a frequent event in malignant astrocytomas and might help to define a subgroup of patients with different outcome. ..
  24. ncbi request reprint Identification of two proopiomelanocortin genes in zebrafish (Danio rerio)
    Veronica Gonzalez-Nunez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Salamanca, Salamanca, Spain
    Brain Res Mol Brain Res 120:1-8. 2003
    ..Comparisons between the two zebrafish beta-endorphins and among these peptides and its homologues in other species are also presented...
  25. ncbi request reprint Predictive value of VEGF A and VEGFR2 polymorphisms in the response to intravitreal ranibizumab treatment for wet AMD
    Fernando Cruz-González
    Departamento de Oftalmologia, Hospital Universitario de Salamanca, Salamanca, Spain
    Graefes Arch Clin Exp Ophthalmol 252:469-75. 2014
    ..To determine whether gene polymorphisms of the vascular endothelial growth factor A (VEGF A) and its receptor (VEGFR) influence the response to a variable-dosing treatment regimen with ranibizumab for age-related macular degeneration...
  26. doi request reprint The Emerging Picture of Human Breast Cancer as a Stem Cell-based Disease
    Cesar Cobaleda
    Universidad de Salamanca, Salamanca, Spain
    Stem Cell Rev 4:67-79. 2008
    ..Here, we review the current knowledge about normal and breast cancer stem cells, and their implications in cancer development, together with their consequences in breast cancer susceptibility, dissemination and treatment response...
  27. pmc Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas
    Juan L Garcia
    Department of Medicine, University of Salamanca, Spain
    BMC Cancer 10:454. 2010
    ..This molecular classification could lead to the finding of new potential therapeutic targets for the rationale treatment of high grade GBM...
  28. ncbi request reprint [Study of AZF regions of Y chromosome in males with idiopathic infertility. Analysis of two methods of molecular diagnosis]
    Maria Isidoro-Garcia
    Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain
    Med Clin (Barc) 125:731-3. 2005
    ..The aim of this study was to analyze the presence of chromosome Y microdeletions using 2 different sets of STSs...
  29. doi request reprint The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping
    Pilar Sanchez-Conde
    Department of Anesthesiology, University Hospital of Salamanca, Salamanca, Spain
    Anesth Analg 106:371-8, table of contents. 2008
    ..We compared the effect of propofol with sevoflurane on kidney NFkappaB expression and systemic inflammatory responses induced by aortic clamping...
  30. doi request reprint Genetic association between -93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men
    Isabel J Pastor
    Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Avda de Alfonso X el Sabio s n, 37007 Salamanca, Spain
    Eur Psychiatry 24:191-4. 2009
    ..Fyn tyrosine kinase is a member of the Scr family that phosphorylates the NR2A and NR2B subunits of the NMDA receptors reducing the inhibitory effects of ethanol and therefore may regulate the individual sensitivity to ethanol...
  31. ncbi request reprint Kappa opioid receptor is expressed in the rat cerebellar cortex
    Luis A Herraez-Baranda
    Molecular Medicine Unit, Department of Medicine, Faculty of Medicine, University of Salamanca, Spain
    Cell Tissue Res 320:223-8. 2005
    ..This work contributes to the deeper knowledge of the mechanisms that are involved in cerebellar function and may lead to a better understanding of the relationships between nociceptive activity and drug abuse potential...
  32. ncbi request reprint [Genetic basis of tobacco dependence]
    Miguel Barrueco
    Servicio de Neumologia, Hospital Universitario de Salamanca, Salamanca, Spain
    Med Clin (Barc) 124:223-8. 2005
    ..Here we review the studies performed so far and discuss new perspectives for future studies...
  33. doi request reprint Prognostic value of telomere length in acute coronary syndrome
    Jose Angel Perez-Rivera
    IBSAL University Hospital of Salamanca, Department of Cardiology, Salamanca, Spain
    Mech Ageing Dev 133:695-7. 2012
    ..Two prognostic combined events were defined. Long telomere length was revealed as an independent predictor (protector) of combined event presentation during long term follow up in our patients...
  34. doi request reprint [M129V PRNP gene polymorphism in Castilla y León shows a similar distribution to other Spanish regions and other European countries]
    Andres Castellanos
    Unidad de Medicina Molecular, Departamento de Medicina, Facultad de Medicina, Universidad de Salamanca, Salamanca, Espana
    Med Clin (Barc) 134:254-6. 2010
    ....
  35. doi request reprint Buschke-Ollendorff syndrome with striking phenotypic variation resulting from a novel c.2203C>T nonsense mutation in LEMD3
    Manuela Yuste-Chaves
    Department of Dermatology, University Hospital of Salamanca, Salamanca, Spain
    Pediatr Dermatol 28:447-50. 2011
    ..The mutation induces a change in the 735 arginine codon to a stop codon. This study shows the wide phenotypic variation in BOS and increases the repertory of mutations described to date in LEMD3...