Ismael Galve-Roperh

Summary

Affiliation: Universidad Complutense
Country: Spain

Publications

  1. ncbi request reprint The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway
    Daniel Rueda
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 277:46645-50. 2002
  2. ncbi request reprint Mechanisms of control of neuron survival by the endocannabinoid system
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 14:2279-88. 2008
  3. doi request reprint The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, 28040 Madrid, Spain
    Eur Arch Psychiatry Clin Neurosci 259:371-82. 2009
  4. ncbi request reprint The endocannabinoid system and neurogenesis in health and disease
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, José Antonio Novais sn, Complutense University, 28040 Madrid, Spain
    Neuroscientist 13:109-14. 2007
  5. ncbi request reprint Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 12:2319-25. 2006
  6. ncbi request reprint The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Neurosci 26:1551-61. 2006
  7. ncbi request reprint The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:23892-8. 2007
  8. ncbi request reprint Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    FASEB J 20:2405-7. 2006
  9. ncbi request reprint Cannabinoids and gliomas
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Mol Neurobiol 36:60-7. 2007
  10. ncbi request reprint Cannabinoids and cell fate
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Pharmacol Ther 95:175-84. 2002

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathway
    Daniel Rueda
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 277:46645-50. 2002
    ..These data indicate that endocannabinoids inhibit neuronal progenitor cell differentiation through attenuation of the ERK pathway and suggest that they constitute a new physiological system involved in the regulation of neurogenesis...
  2. ncbi request reprint Mechanisms of control of neuron survival by the endocannabinoid system
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 14:2279-88. 2008
    ..Altogether, these findings support that endocannabinoids constitute a new family of lipid mediators that act as instructive signals in the control of neuron survival...
  3. doi request reprint The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, 28040 Madrid, Spain
    Eur Arch Psychiatry Clin Neurosci 259:371-82. 2009
    ..g., schizophrenia) and the regulation of neurogenesis in brain depression, are discussed herein...
  4. ncbi request reprint The endocannabinoid system and neurogenesis in health and disease
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, José Antonio Novais sn, Complutense University, 28040 Madrid, Spain
    Neuroscientist 13:109-14. 2007
    ....
  5. ncbi request reprint Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 12:2319-25. 2006
    ....
  6. ncbi request reprint The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Neurosci 26:1551-61. 2006
    ..These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function...
  7. ncbi request reprint The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:23892-8. 2007
    ..In summary, our results show the involvement of the CB1 cannabinoid receptor in NP proliferation and neurogenesis induced by excitotoxic injury and support a role for bFGF signaling in this process...
  8. ncbi request reprint Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    FASEB J 20:2405-7. 2006
    ..These findings provide a novel physiological role for the CB2 cannabinoid receptor and open a novel therapeutic avenue for manipulating neural progenitor cell fate...
  9. ncbi request reprint Cannabinoids and gliomas
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Mol Neurobiol 36:60-7. 2007
    ..The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids...
  10. ncbi request reprint Cannabinoids and cell fate
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Pharmacol Ther 95:175-84. 2002
    ..Regarding immune cells, low doses of cannabinoids may enhance proliferation, whereas high doses of cannabinoids usually induce growth arrest or apoptosis. The potential therapeutic applications of these findings are discussed...
  11. ncbi request reprint The endocannabinoid system drives neural progenitor proliferation
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FASEB J 19:1704-6. 2005
    ..Our results demonstrate that endocannabinoids constitute a new group of signaling cues that regulate NP proliferation and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain...
  12. pmc CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling
    Javier Palazuelos
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Instituto Universitario de Investigación en Neuroquímica, and Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 287:1198-209. 2012
    ..Altogether, these findings provide a mechanism of action and a rationale for the use of nonpsychotomimetic CB(2) receptor-selective ligands as a novel strategy for the control of NP cell proliferation and neurogenesis...
  13. ncbi request reprint Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:6854-62. 2007
    ..Overall, our results demonstrate that cannabinoids target glioma stem-like cells, promote their differentiation, and inhibit gliomagenesis, thus giving further support to their potential use in the management of malignant gliomas...
  14. doi request reprint Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease
    Cristina Blazquez
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Huntington s Disease and Ataxias Collaborative Project, 28040 Madrid, Spain
    Brain 134:119-36. 2011
    ....
  15. ncbi request reprint Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Pharmacol 62:1385-92. 2002
    ..In conclusion, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision...
  16. ncbi request reprint Cannabinoids and ceramide: two lipids acting hand-by-hand
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Life Sci 77:1723-31. 2005
    ..These findings provide a new conceptual view on how cannabinoids act, and raise interesting physiological and therapeutic questions...
  17. doi request reprint The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis
    Javier Palazuelos
    Department of Biochemistry and Molecular Biology I, Complutense University, 28040 Madrid, Spain
    J Biol Chem 283:13320-9. 2008
    ....
  18. ncbi request reprint Hypothesis: cannabinoid therapy for the treatment of gliomas?
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Avenida Complutense, sn, 28040 Madrid, Spain
    Neuropharmacology 47:315-23. 2004
    ..Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas...
  19. pmc Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical development
    Javier Díaz-Alonso
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain
    Philos Trans R Soc Lond B Biol Sci 367:3229-41. 2012
    ..In this review the implications of altered CB(1)-receptor-mediated signalling in developmental disorders and particularly in epileptogenesis are briefly discussed...
  20. ncbi request reprint R-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: partial involvement of the CB(2
    Antonio J Sanchez
    Neuroimmunology Unit, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, San Martin de Porres 4, 28035 Madrid, Spain
    Biochem Pharmacol 72:1697-706. 2006
    ..The partial involvement of CB(2) receptors in WIN-2 action may open new therapeutic doors in the management of MS by non-psychoactive selective cannabinoid agonists...
  21. ncbi request reprint The emerging functions of endocannabinoid signaling during CNS development
    Tibor Harkany
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE 17177, Sweden
    Trends Pharmacol Sci 28:83-92. 2007
    ..Here, we summarize recent findings regarding the ontogeny of the endocannabinoid system in neurons that sculpt the temporal and spatial diversity of cellular functions during CNS development...
  22. pmc Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
    Jan Mulder
    Department of Neuroscience, Retzius vag 8, and Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles vag 1, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:8760-5. 2008
    ..Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis...