Research Topics
Genomes and Genes | Ismael Galve-RoperhSummaryAffiliation: Universidad Complutense Country: Spain Publications
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Publications
The endocannabinoid anandamide inhibits neuronal progenitor cell differentiation through attenuation of the Rap1/B-Raf/ERK pathwayDaniel Rueda
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Biol Chem 277:46645-50. 2002..These data indicate that endocannabinoids inhibit neuronal progenitor cell differentiation through attenuation of the ERK pathway and suggest that they constitute a new physiological system involved in the regulation of neurogenesis...- Mechanisms of control of neuron survival by the endocannabinoid systemIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
Curr Pharm Des 14:2279-88. 2008..Altogether, these findings support that endocannabinoids constitute a new family of lipid mediators that act as instructive signals in the control of neuron survival... 
The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disordersIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Complutense University, 28040 Madrid, Spain
Eur Arch Psychiatry Clin Neurosci 259:371-82. 2009..g., schizophrenia) and the regulation of neurogenesis in brain depression, are discussed herein...- The endocannabinoid system and neurogenesis in health and diseaseIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology, José Antonio Novais sn, Complutense University, 28040 Madrid, Spain
Neuroscientist 13:109-14. 2007.... - Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell developmentIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Curr Pharm Des 12:2319-25. 2006.... - The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cellsTania Aguado
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Neurosci 26:1551-61. 2006..These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function... - The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesisTania Aguado
Department of Biochemistry and Molecular Biology I, School of Biology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Complutense University, 28040 Madrid, Spain
J Biol Chem 282:23892-8. 2007..In summary, our results show the involvement of the CB1 cannabinoid receptor in NP proliferation and neurogenesis induced by excitotoxic injury and support a role for bFGF signaling in this process... - Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferationJavier Palazuelos
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
FASEB J 20:2405-7. 2006..These findings provide a novel physiological role for the CB2 cannabinoid receptor and open a novel therapeutic avenue for manipulating neural progenitor cell fate... - Cannabinoids and gliomasGuillermo Velasco
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Mol Neurobiol 36:60-7. 2007..The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids... - Cannabinoids and cell fateManuel Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Pharmacol Ther 95:175-84. 2002..Regarding immune cells, low doses of cannabinoids may enhance proliferation, whereas high doses of cannabinoids usually induce growth arrest or apoptosis. The potential therapeutic applications of these findings are discussed... - The endocannabinoid system drives neural progenitor proliferationTania Aguado
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
FASEB J 19:1704-6. 2005..Our results demonstrate that endocannabinoids constitute a new group of signaling cues that regulate NP proliferation and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain... 
CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signalingJavier Palazuelos
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Instituto Universitario de Investigación en Neuroquímica, and Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Biol Chem 287:1198-209. 2012..Altogether, these findings provide a mechanism of action and a rationale for the use of nonpsychotomimetic CB(2) receptor-selective ligands as a novel strategy for the control of NP cell proliferation and neurogenesis...- Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesisTania Aguado
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
J Biol Chem 282:6854-62. 2007..Overall, our results demonstrate that cannabinoids target glioma stem-like cells, promote their differentiation, and inhibit gliomagenesis, thus giving further support to their potential use in the management of malignant gliomas... - Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's diseaseCristina Blazquez
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Huntington s Disease and Ataxias Collaborative Project, 28040 Madrid, Spain
Brain 134:119-36. 2011.... - Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptorIsmael Galve-Roperh
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Mol Pharmacol 62:1385-92. 2002..In conclusion, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision... - Cannabinoids and ceramide: two lipids acting hand-by-handGuillermo Velasco
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
Life Sci 77:1723-31. 2005..These findings provide a new conceptual view on how cannabinoids act, and raise interesting physiological and therapeutic questions... - The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosisJavier Palazuelos
Department of Biochemistry and Molecular Biology I, Complutense University, 28040 Madrid, Spain
J Biol Chem 283:13320-9. 2008.... - Hypothesis: cannabinoid therapy for the treatment of gliomas?Guillermo Velasco
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Avenida Complutense, sn, 28040 Madrid, Spain
Neuropharmacology 47:315-23. 2004..Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas... - Endocannabinoids via CB₁ receptors act as neurogenic niche cues during cortical developmentJavier Díaz-Alonso
Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain
Philos Trans R Soc Lond B Biol Sci 367:3229-41. 2012..In this review the implications of altered CB(1)-receptor-mediated signalling in developmental disorders and particularly in epileptogenesis are briefly discussed... - R-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: partial involvement of the CB(2Antonio J Sanchez
Neuroimmunology Unit, Hospital Universitario Puerta de Hierro, Universidad Autonoma de Madrid, San Martin de Porres 4, 28035 Madrid, Spain
Biochem Pharmacol 72:1697-706. 2006..The partial involvement of CB(2) receptors in WIN-2 action may open new therapeutic doors in the management of MS by non-psychoactive selective cannabinoid agonists... - The emerging functions of endocannabinoid signaling during CNS developmentTibor Harkany
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm SE 17177, Sweden
Trends Pharmacol Sci 28:83-92. 2007..Here, we summarize recent findings regarding the ontogeny of the endocannabinoid system in neurons that sculpt the temporal and spatial diversity of cellular functions during CNS development... - Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterningJan Mulder
Department of Neuroscience, Retzius vag 8, and Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles vag 1, Karolinska Institutet, 17177 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:8760-5. 2008..Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis...