Research Topics
Genomes and Genes | Carlos FloresSummaryAffiliation: Universidad de La Laguna Country: Spain Publications
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Publications
Mitochondrial DNA affinities at the Atlantic fringe of EuropeAna M Gonzalez
Departamento de Genetica, Universidad de La Laguna, 38271 La Laguna, Tenerife, Spain
Am J Phys Anthropol 120:391-404. 2003..001) in this area compared to North Africa (0.006 +/- 0.001), we reject the proposal that only historic events such as the Moslem occupation are the main cause of this gene flow, and instead propose a pre-Neolithic origin for it...
African ancestry is associated with asthma risk in African AmericansCarlos Flores
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
PLoS ONE 7:e26807. 2012..In addition, we examined for the first time whether African ancestry was associated with asthma exacerbations...- A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injuryCarlos Flores
CIBER de Enfermedades Respiratorias Instituto de Salud Carlos III, Carretera Soller km 12, 07110 Mallorca, Spain
Crit Care 12:R130. 2008..We aimed to assess the quality of positive genetic association studies with ALI susceptibility and/or outcome in adults in order to highlight their consistency and major limitations... 
Major genomic mitochondrial lineages delineate early human expansionsN Maca-Meyer
Department of Genetics, Faculty of Biology, University of La Laguna, Tenerife, 38271, Spain
BMC Genet 2:13. 2001..As a new contribution to this study we have phylogenetically analysed complete mitochondrial DNA(mtDNA) sequences from 42 human lineages, representing major clades with known geographic assignation...- Reduced genetic structure of the Iberian peninsula revealed by Y-chromosome analysis: implications for population demographyCarlos Flores
Departamento de Genetica, Universidad de La Laguna, Tenerife E 38271, Spain
Eur J Hum Genet 12:855-63. 2004..These results indicate that neither old or recent Levantine expansions nor North African contacts have influenced the current Iberian Y-chromosome diversity so that geographical patterns can be identified... 
Mitochondrial DNA variation in Jordanians and their genetic relationship to other Middle East populationsAna M Gonzalez
Departamento de Genetica, Facultad de Biologia, Universidad de La Laguna, Tenerife, Spain
Ann Hum Biol 35:212-31. 2008..Although some mitochondrial DNA (mtDNA) studies have been carried out in this region, they have not included the Jordan area. This paper deals with the mtDNA composition of two Jordan populations...- Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injuryMaría Pino-Yanes
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
Am J Respir Cell Mol Biol 45:740-5. 2011..017). Despite the need for replication in independent studies, our data suggest that common SNPs in the IRAK3 gene may be determinants of sepsis-induced ALI... - A common haplotype of the LBP gene predisposes to severe sepsisCarlos Flores
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain
Crit Care Med 37:2759-66. 2009..The lipopolysaccharide-binding protein is an acute-phase protein that plays a dominant role in the genesis of sepsis by initiating signal transduction pathways leading to the activation of the inflammatory host response... - Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury modelJesus Villar
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
Intensive Care Med 36:1049-57. 2010..How these two responses interact when present simultaneously remains to be elucidated. We hypothesized that MV modulates innate host response during sepsis by influencing Toll-like receptor (TLR) signaling... - No association between genetic ancestry and susceptibility to asthma or atopy in Canary IslandersMaría Pino-Yanes
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
Immunogenetics 64:705-11. 2012..Larger studies, examining more genetic variants, would be needed to explore such possibility... - WNT/β-catenin signaling is modulated by mechanical ventilation in an experimental model of acute lung injuryJesus Villar
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Jesús
Intensive Care Med 37:1201-9. 2011.... - Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungsJesus Villar
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
PLoS ONE 6:e23914. 2011..Since activation of Wnt/β-catenin signaling has been suggested to be central to mechanisms of lung healing and fibrosis, we hypothesized that the Wnt/β-catenin signaling plays a role during VILI... - Mitochondrial DNA transit between West Asia and North Africa inferred from U6 phylogeographyNicole Maca-Meyer
Departamento de Genetica, Facultad de Biologia, Universidad de La Laguna, Tenerife, Spain
BMC Genet 4:15. 2003..We report here a more detailed analysis of this lineage, unraveling successive expansions that affected not only Africa but neighboring regions such as the Near East, the Iberian Peninsula and the Canary Islands... - Mitochondrial DNA diversity in 17th-18th century remains from Tenerife (Canary Islands)Nicole Maca-Meyer
, Universidad de La Laguna, 38271 La Laguna, Tenerife, Spain
Am J Phys Anthropol 127:418-26. 2005..59%), has also decreased due to European input. Finally, the presence of Amerindian lineages (1.5%) reveals that the Canary Islands have also received genetic flow from America... - North African influences and potential bias in case-control association studies in the Spanish populationMaría Pino-Yanes
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
PLoS ONE 6:e18389. 2011..Using ancestry informative markers (AIMs), we aimed to measure the African influences in Spanish populations and to explore whether these might introduce statistical bias in population-based association studies... - Common variants of TLR1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsisMaría Pino-Yanes
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
PLoS ONE 5:e13759. 2010..We examined the association of common variants of TLR1 gene with sepsis-derived complications in an independent study and with serum levels for four inflammatory biomarkers among septic patients... - Isolates in a corridor of migrations: a high-resolution analysis of Y-chromosome variation in JordanCarlos Flores
, , Universidad de La Laguna, 38271 Tenerife, Spain
J Hum Genet 50:435-41. 2005..These results demonstrate that, at a fine scale, the smooth, continental clines detected for several Y-chromosome markers are often disrupted by genetically divergent populations... - Injurious mechanical ventilation affects neuronal activation in ventilated ratsMaría Elisa Quilez
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, C Sinesio Delgado 6, Madrid, Spain
Crit Care 15:R124. 2011..We aimed to investigate the effect of the increase of tidal volume (Vt) on brain activation in a rat model... - Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury modelJesus Villar
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Spain
Respir Res 11:27. 2010.... - Ancient mtDNA analysis and the origin of the GuanchesNicole Maca-Meyer
, Universidad de La Laguna, Tenerife, Spain
Eur J Hum Genet 12:155-62. 2004..Although the Berbers are the most probable ancestors of the Guanches, it is deduced that important human movements have reshaped Northwest Africa after the migratory wave to the Canary Islands... - Experimental ventilator-induced lung injury: exacerbation by positive end-expiratory pressureJesus Villar
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
Anesthesiology 110:1341-7. 2009.... - Mutation G47R in the BSND gene causes Bartter syndrome with deafness in two Spanish familiesVictor Garcia-Nieto
Unidad de Investigación Asociada al Centro de Investigaciones Biológicas CSIC, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
Pediatr Nephrol 21:643-8. 2006..Clinical manifestations are moderate in patients with the G47R mutation compared to other published data form patients with BSND. This constitutes the first report of BSND cases in Spain... - Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsisJesus Villar
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
PLoS ONE 4:e6818. 2009.... - The Alu insertion in the CLCN5 gene of a patient with Dent's disease leads to exon 11 skippingFelix Claverie-Martin
Unidad de Investigacion, Asociada al Centro de Investigaciones Biológicas, CSIC, Hospital Universitario Nuestra Senora de Candelaria, 38010, Santa Cruz de Tenerife, Spain
J Hum Genet 50:370-4. 2005..The altered splicing would predict a truncated ClC-5 protein that lacks critical domains for sorting and chloride channel function... - A missense mutation in the chloride/proton ClC-5 antiporter gene results in increased expression of an alternative mRNA form that lacks exons 10 and 11. Identification of seven new CLCN5 mutations in patients with Dent's diseaseElena Ramos-Trujillo
Unidad de Investigacion, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Spain
J Hum Genet 52:255-61. 2007..This type of mutation has not been previously described in the CLCN5 gene. Our results support the importance of a routine analysis at the pre-mRNA level of mutations that are commonly assumed to cause single amino acids alterations... - De novo insertion of an Alu sequence in the coding region of the CLCN5 gene results in Dent's diseaseFelix Claverie-Martin
Research Unit, Nuestra Señora de Candelaria University Hospital, Carretera del Rosario s n, 38010 Santa Cruz de Tenerife, Spain
Hum Genet 113:480-5. 2003..However, this is the first report of a retrotransposon insertion in the CLCN5 gene associated with Dent's disease... - A Basque Country autochthonous population study of 11 Y-chromosome STR lociOscar Garcia
Area de Laboratorio Ertzaintza, Avda Montevideo 3, E 48002 Bilbao, Spain
Forensic Sci Int 145:65-8. 2004..The haplotype diversity (97.49%) and discrimination capacity (52.98%) were calculated. Comparisons were made with previously published haplotype data on other Iberian population samples and significant differences were found... - Efficient repair of DNA breaks in Drosophila: evidence for single-strand annealing and competition with other repair pathwaysChristine R Preston
Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
Genetics 161:711-20. 2002..We conclude that SSA is the preferred repair pathway in Drosophila for DNA breaks between sequence repeats, and it competes with gene conversion by the synthesis-dependent strand annealing (SDSA) pathway... - Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in DrosophilaTilo Schwientek
School of Dentistry, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
J Biol Chem 277:22623-38. 2002.... - Bench-to-bedside review: understanding genetic predisposition to sepsisJesus Villar
Division Critical Care Research, Research Institute, Hospital Universitario NS de Candelaria, Tenerife, Canary Islands, Spain
Crit Care 8:180-9. 2004..We envision a time in the near future when genotyping will be include in the standard evaluation of critically ill patients and will help to prioritize a therapeutic option... - Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major traumaJason D Christie
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Crit Care Med 36:2794-800. 2008..We tested the association of MYLK gene variation in the development of acute lung injury in major trauma patients... - IL6 gene-wide haplotype is associated with susceptibility to acute lung injuryCarlos Flores
Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Ill 60637, USA
Transl Res 152:11-7. 2008..These data support the association of the IL6 gene with ALI susceptibility and illustrate the value of haplotype analysis as a robust approach for evaluating IL6 gene effects in association studies... - Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndromeJesus Villar
Multidisciplinary Organ Dysfunction Evaluation Research Network MODERN, Research Unit, Hospital Universitario Dr Negrin, Barranco de la Ballena, Las Palmas de Gran Canaria, Canary Islands, Spain
Intensive Care Med 34:488-95. 2008..We hypothesized that the I/D polymorphism also confers susceptibility to sepsis and is a predisposing factor for morbidity and mortality of patients with severe sepsis... - Characterization of the first VanB vancomycin-resistant Enterococcus faecium isolated in a Spanish hospitalFabián Lorenzo-Díaz
Molecular Biology Laboratory, Research Unit, Nuestra Señora de Candelaria University Hospital, Santa Cruz de Tenerife, Spain
Curr Microbiol 48:199-203. 2004..Sequence analysis of the vanB gene showed that this isolate belonged to subtype vanB2. Moreover, PCR amplification analysis indicated that the vanB gene cluster was linked to a Tn5382-like transposon... - Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associationsLi Gao
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
Transl Res 150:18-29. 2007..These data, generated via functional genomic and genetic approaches, suggest that MIF is a relevant molecular target in ALI... - The place of the Basques in the European Y-chromosome diversity landscapeSantos Alonso
Dpto Genética, Antropología Física y Fisiología Animal, Fac Ciencia y Tecnología, UPV EHU, Barrio Sarriena s n 48940, Leioa, Bizkaia, Spain
Eur J Hum Genet 13:1293-302. 2005.... - A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsisJesus Villar
Multidisciplinary Organ Dysfunction Evaluation Research Network, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Canary Islands, Spain
Crit Care Med 35:2292-7. 2007..We hypothesized that a tandem repeat polymorphism (AC)n in the CXCL2 gene, previously associated with susceptibility to severe sepsis, contributes to morbidity and mortality in severe sepsis...