Emilio Fernandez Espejo

Summary

Affiliation: Universidad de Sevilla
Country: Spain

Publications

  1. pmc May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?
    Emilio Fernandez
    Department of Medical Physiology, Laboratory of Molecular Neurology and Neurophysiology BIO127, University of Seville, Seville, Spain
    Antioxid Redox Signal 19:912-8. 2013
  2. ncbi request reprint [The neurobiology of psychostimulant addiction]
    E Fernandez-Espejo
    Departamento de Fisiologia Medica, Universidad de Sevilla Facultad de Medicina, 41009 Sevilla, Spain
    Rev Neurol 43:147-54. 2006
  3. ncbi request reprint Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonism
    Emilio Fernandez-Espejo
    Facultad de Medicina, Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, E 41009 Sevilla, Spain
    Neurobiol Dis 18:591-601. 2005
  4. ncbi request reprint Role for D-serine within the ventral tegmental area in the development of cocaine's sensitization
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica, Universidad de Sevilla, Sevilla, Spain
    Neuropsychopharmacology 33:995-1003. 2008
  5. doi request reprint Role of cannabis and endocannabinoids in the genesis of schizophrenia
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain
    Psychopharmacology (Berl) 206:531-49. 2009
  6. ncbi request reprint Sensorimotor gating in mice is disrupted after AM404, an anandamide reuptake and degradation inhibitor
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, 41009 Sevilla, Spain
    Psychopharmacology (Berl) 175:220-4. 2004
  7. ncbi request reprint Pathogenesis of Parkinson's disease: prospects of neuroprotective and restorative therapies
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, E 41009 Sevilla, Spain
    Mol Neurobiol 29:15-30. 2004
  8. ncbi request reprint Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Sevilla, Spain
    Neuropsychopharmacology 29:1134-42. 2004
  9. ncbi request reprint [Natural "dopaminotrophic" cell transplant: a new concept in antiparkinsonian therapy]
    E Fernandez-Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla Sevilla, Espana
    Rev Neurol 36:540-4. 2003
  10. ncbi request reprint Prefrontocortical dopamine loss in rats delays long-term extinction of contextual conditioned fear, and reduces social interaction without affecting short-term social interaction memory
    Emilio Fernandez Espejo
    Departamento de Fisiologia Medica, Facultad de Medicina, Universidad de Sevilla, Av Sanchez Pizjuan 4, E 41009 Sevilla, Spain
    Neuropsychopharmacology 28:490-8. 2003

Collaborators

  • E F Espejo
  • F Rodriguez De Fonseca
  • M Portavella
  • M P Viveros
  • Miguel Navarro
  • Bart A Ellenbroek
  • Emilio Fernandez-Espejo
  • Juan A Flores
  • E Fernandez-Espejo
  • Beatriz Galan-Rodriguez
  • Belen Ferrer
  • Miguel Angel Gorriti
  • Emilio Fernandez
  • Fadwa El Banoua
  • Isabel Caraballo
  • Ramiro Gonzalez-Aparicio
  • Ana Belén Martín
  • Rosario Moratalla
  • Ainhoa Bilbao
  • Susana Ramiro-Fuentes
  • Yolanda de Diego
  • Francisco Javier Bermudez-Silva
  • Fadwa El-Banoua
  • José Manuel García-Moreno
  • Angel Martín de Pablos
  • Jose Chacon
  • Luis Nunez
  • S Ramiro-Fuentes
  • Rocio Moreno-Paublete
  • Ana Palomino
  • Isolde Gornemann
  • Susana Ramiro
  • Ignacio del Arco
  • Jose A Armengol
  • Fernando Rodriguez de Fonseca
  • F El Banoua
  • J A Flores
  • I Caraballo
  • B Galan

Detail Information

Publications25

  1. pmc May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?
    Emilio Fernandez
    Department of Medical Physiology, Laboratory of Molecular Neurology and Neurophysiology BIO127, University of Seville, Seville, Spain
    Antioxid Redox Signal 19:912-8. 2013
    ....
  2. ncbi request reprint [The neurobiology of psychostimulant addiction]
    E Fernandez-Espejo
    Departamento de Fisiologia Medica, Universidad de Sevilla Facultad de Medicina, 41009 Sevilla, Spain
    Rev Neurol 43:147-54. 2006
    ..During expression, addictive habits are consolidated through changes in the cortico-striato-amygdaloid loop...
  3. ncbi request reprint Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonism
    Emilio Fernandez-Espejo
    Facultad de Medicina, Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, E 41009 Sevilla, Spain
    Neurobiol Dis 18:591-601. 2005
    ..CB1 receptor antagonists that lack psychoactive effects might be of therapeutic value in the control of very advanced stage of Parkinson's disease in humans...
  4. ncbi request reprint Role for D-serine within the ventral tegmental area in the development of cocaine's sensitization
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica, Universidad de Sevilla, Sevilla, Spain
    Neuropsychopharmacology 33:995-1003. 2008
    ..Besides CaMKII activity was otherwise reduced by 7-chlorokynurenate...
  5. doi request reprint Role of cannabis and endocannabinoids in the genesis of schizophrenia
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica, Facultad de Medicina, Universidad de Sevilla, Seville, Spain
    Psychopharmacology (Berl) 206:531-49. 2009
    ..Cannabis abuse and endocannabinoids are associated to schizophrenia...
  6. ncbi request reprint Sensorimotor gating in mice is disrupted after AM404, an anandamide reuptake and degradation inhibitor
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, 41009 Sevilla, Spain
    Psychopharmacology (Berl) 175:220-4. 2004
    ..It is known that cannabinoid CB1 agonists reduce sensorimotor gating in rats, suggesting that the CB1 receptor and the cannabinoid system are involved in sensorimotor gating...
  7. ncbi request reprint Pathogenesis of Parkinson's disease: prospects of neuroprotective and restorative therapies
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, E 41009 Sevilla, Spain
    Mol Neurobiol 29:15-30. 2004
    ....
  8. ncbi request reprint Experimental parkinsonism alters anandamide precursor synthesis, and functional deficits are improved by AM404: a modulator of endocannabinoid function
    Emilio Fernandez-Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Sevilla, Spain
    Neuropsychopharmacology 29:1134-42. 2004
    ..This finding reveals the presence of a homeostatic striatal mechanism emerging after dopaminergic denervation likely tending to enhance low dopamine tone...
  9. ncbi request reprint [Natural "dopaminotrophic" cell transplant: a new concept in antiparkinsonian therapy]
    E Fernandez-Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla Sevilla, Espana
    Rev Neurol 36:540-4. 2003
    ....
  10. ncbi request reprint Prefrontocortical dopamine loss in rats delays long-term extinction of contextual conditioned fear, and reduces social interaction without affecting short-term social interaction memory
    Emilio Fernandez Espejo
    Departamento de Fisiologia Medica, Facultad de Medicina, Universidad de Sevilla, Av Sanchez Pizjuan 4, E 41009 Sevilla, Spain
    Neuropsychopharmacology 28:490-8. 2003
    ....
  11. ncbi request reprint [Neurobiological basis of drug addiction]
    E Fernandez-Espejo
    Departamento de Fisiologia Medica, Universidad de Sevilla, Facultad de Medicina, Sevilla, Espana
    Rev Neurol 34:659-64. 2002
    ..Furthermore, these neural changes appear to subserve the emergence of cravings once the abstinent syndrome has been overcome. Cravings are the main factor leading to relapse, and they are often initiated by exposure to drug related cues...
  12. ncbi request reprint Functional regeneration in a rat Parkinson's model after intrastriatal grafts of glial cell line-derived neurotrophic factor and transforming growth factor beta1-expressing extra-adrenal chromaffin cells of the Zuckerkandl's organ
    E F Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, E 41009 Sevilla, Spain
    J Neurosci 21:9888-95. 2001
    ..This work should stimulate research on the clinical applicability of transplants of the Zuckerkandl's organ in Parkinson's disease...
  13. doi request reprint The absence of a functional peroxisome proliferator-activated receptor-alpha gene in mice enhances motor sensitizing effects of morphine, but not cocaine
    E Fernandez-Espejo
    Departamento de Fisiologia Medica, Universidad de Sevilla, 41009 Sevilla, Spain
    Neuroscience 164:667-75. 2009
    ....
  14. ncbi request reprint Cells of the sympathoadrenal lineage: biological properties as donor tissue for cell-replacement therapies for Parkinson's disease
    Emilio Fernandez-Espejo
    Department of Medical Physiology and Biophysics, University of Seville, Av Sanchez Pizjuan 4, E 41009 Seville, Spain
    Brain Res Brain Res Rev 49:343-54. 2005
    ..The ability of SA extra-adrenal cells to respond to hypoxia, differently to SA sympathetic neurons or adrenal medulla cells, could explain their good survival rate after brain transplantation...
  15. doi request reprint Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor β1 is enhanced after co-infusion in rats
    Ramiro Gonzalez-Aparicio
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Av Sanchez Pizjuan 4, 41009 Sevilla, Spain
    Exp Neurol 226:136-47. 2010
    ..Functional recovery and improvement of TH signal in the nigrostriatal system were long-lasting and sustained, remaining after cessation of trophic infusion...
  16. ncbi request reprint Adrenergic hyperactivity and metanephrine excess in the nucleus accumbens after prefrontocortical dopamine depletion
    E F Espejo
    Departamento de Fisiologia Medica y Biofisica, Facultad de Medicina, Universidad de Sevilla, E 41009 Seville, Spain
    J Neurophysiol 85:1270-4. 2001
    ....
  17. ncbi request reprint Selective dopamine depletion within the medial prefrontal cortex induces anxiogenic-like effects in rats placed on the elevated plus maze
    E F Espejo
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Seville, Spain
    Brain Res 762:281-4. 1997
    ..The findings confirm that prefrontocortical dopamine activation is necessary for coping with an anxiogenic challenge, allowing the animal to display adaptive exploratory responses in a fear-inducing environment...
  18. ncbi request reprint Behavioral expression of opiate withdrawal is altered after prefrontocortical dopamine depletion in rats: monoaminergic correlates
    E F Espejo
    Departmento de Fisiologia Medica, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
    Neuropsychopharmacology 25:204-12. 2001
    ....
  19. ncbi request reprint Effects of weekly or daily exposure to the elevated plus-maze in male mice
    E F Espejo
    Departamento de Fisiologia Medica, Universidad de Sevilla, Spain
    Behav Brain Res 87:233-8. 1997
    ..In conclusion, the findings of the present study support the hypothesis that anxiety is enhanced after test repetition, and indicate that test-retest profiles are far from stable, except for exploratory locomotor activity...
  20. ncbi request reprint Role for dopamine neurons of the rostral linear nucleus and periaqueductal gray in the rewarding and sensitizing properties of heroin
    Juan A Flores
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Sevilla, Spain
    Neuropsychopharmacology 31:1475-88. 2006
    ..D(2) dopamine receptors within the RLi/PAG region participate in these effects...
  21. ncbi request reprint Cannabinoid CB1 receptor antagonism markedly increases dopamine receptor-mediated stereotypies
    Belen Ferrer
    Fundacion IMABIS, Hospital Carlos Haya, Malaga 29010, Spain
    Eur J Pharmacol 559:180-3. 2007
    ..05, 0.1 and 1 mg/kg) and the dopamine D2 receptor agonist quinpirole (0.25 mg/kg). Thus, the endocannabinoid system acts as a brake for abnormal behavior associated with dopaminergic overactivation...
  22. ncbi request reprint Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors
    Ana Belén Martín
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuropsychopharmacology 33:1667-79. 2008
    ..This study indicates that the endocannabinoid system is a relevant negative modulator of both dopamine D1 and D2 receptor-mediated behaviors, a finding that may contribute to our understanding of basal ganglia motor disorders...
  23. ncbi request reprint Effects on turning of microinjections into basal ganglia of D(1) and D(2) dopamine receptors agonists and the cannabinoid CB(1) antagonist SR141716A in a rat Parkinson's model
    Fadwa El-Banoua
    Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, E 41009 Seville, Spain
    Neurobiol Dis 16:377-85. 2004
    ..At the pallidal and subthalamic nucleus levels, motor effects after SR14716A are not associated to modulation of D(1) and D(2) receptor function...
  24. ncbi request reprint Opiate anti-nociception is attenuated following lesion of large dopamine neurons of the periaqueductal grey: critical role for D1 (not D2) dopamine receptors
    Juan A Flores
    Departamento de Fisiologia Medica y Biofisica, Facultad de Medicina, Universidad de Sevilla, Av Sanchez Pizjuan 4, E 41009 Sevilla, Spain
    Pain 110:205-14. 2004
    ..This dopaminergic system should be included as another network within the PAG involved in opiate-induced anti-nociception...
  25. ncbi request reprint Acute delta9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion
    Miguel Angel Gorriti
    Instituto Universitario de Drogodependencias, Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Spain
    Pharmacol Biochem Behav 81:71-7. 2005
    ..These results might be relevant for understanding the effect of cannabinoid exposure in dopamine-related neuropsychiatric disorders...