Mercedes Dosil

Summary

Affiliation: Universidad de Salamanca
Country: Spain

Publications

  1. pmc Elucidation of the assembly events required for the recruitment of Utp20, Imp4 and Bms1 onto nascent pre-ribosomes
    Jorge Pérez-Fernández
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno s n, E37007 Salamanca, Spain
    Nucleic Acids Res 39:8105-21. 2011
  2. ncbi request reprint Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle
    Mercedes Dosil
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, University of Salamanca CSIC, Campus Unamuno, E 37007 Salamanca, Spain
    J Biol Chem 279:37385-97. 2004
  3. pmc Ribosome synthesis-unrelated functions of the preribosomal factor Rrp12 in cell cycle progression and the DNA damage response
    Mercedes Dosil
    Instituto de Biologia Molecular y Celular del Cancer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    Mol Cell Biol 31:2422-38. 2011
  4. pmc The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism
    Jorge Pérez-Fernández
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    Mol Cell Biol 27:5414-29. 2007
  5. pmc Strategies for isolating constitutively active and dominant-negative pheromone receptor mutants in yeast
    Mercedes Dosil
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, Salamanca, Spain
    Methods Enzymol 485:329-48. 2010
  6. ncbi request reprint Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease
    Romain M Larive
    1 Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Cientificas CSIC University of Salamanca, Campus Unamuno s n, 37007 Salamanca, Spain 2 Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Cientificas CSIC University of Salamanca, Campus Unamuno s n, 37007 Salamanca, Spain 3
    Nat Commun 5:3881. 2014
  7. ncbi request reprint Structural determinants for the biological activity of Vav proteins
    José L Zugaza
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    J Biol Chem 277:45377-92. 2002
  8. ncbi request reprint Functional assays for mammalian G-protein-coupled receptors in yeast
    Pamela E Mentesana
    Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11794, USA
    Methods Enzymol 344:92-111. 2002

Collaborators

Detail Information

Publications8

  1. pmc Elucidation of the assembly events required for the recruitment of Utp20, Imp4 and Bms1 onto nascent pre-ribosomes
    Jorge Pérez-Fernández
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno s n, E37007 Salamanca, Spain
    Nucleic Acids Res 39:8105-21. 2011
    ..These results provide new information about the functional relationships among 90S particle components and the events that are required for their stepwise incorporation onto the primary pre-rRNA...
  2. ncbi request reprint Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle
    Mercedes Dosil
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, University of Salamanca CSIC, Campus Unamuno, E 37007 Salamanca, Spain
    J Biol Chem 279:37385-97. 2004
    ..Taken together, these results indicate that Pwp2 forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90 S pre-ribosome...
  3. pmc Ribosome synthesis-unrelated functions of the preribosomal factor Rrp12 in cell cycle progression and the DNA damage response
    Mercedes Dosil
    Instituto de Biologia Molecular y Celular del Cancer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    Mol Cell Biol 31:2422-38. 2011
    ..I propose that the functional duality of Rrp12 may couple the control of ribosome production to the regulation of other cellular processes during cell cycle progression...
  4. pmc The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism
    Jorge Pérez-Fernández
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    Mol Cell Biol 27:5414-29. 2007
    ..Together, our data identify the mechanism of assembly of the 90S preribosome and offer novel information about its internal architecture...
  5. pmc Strategies for isolating constitutively active and dominant-negative pheromone receptor mutants in yeast
    Mercedes Dosil
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, Salamanca, Spain
    Methods Enzymol 485:329-48. 2010
    ..In support of these conclusions, certain combinations of constitutively active and dominant-negative mutants restore nearly normal signaling properties...
  6. ncbi request reprint Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease
    Romain M Larive
    1 Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Cientificas CSIC University of Salamanca, Campus Unamuno s n, 37007 Salamanca, Spain 2 Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Cientificas CSIC University of Salamanca, Campus Unamuno s n, 37007 Salamanca, Spain 3
    Nat Commun 5:3881. 2014
    ..Our results also suggest that application of long-term R-Ras2 therapies will result in the development of compensatory mechanisms in breast tumours. ..
  7. ncbi request reprint Structural determinants for the biological activity of Vav proteins
    José L Zugaza
    Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, CSIC University of Salamanca, Campus Unamuno, E 37007 Salamanca, Spain
    J Biol Chem 277:45377-92. 2002
    ..Finally, the results obtained are consistent with a new regulatory model for Vav, in which the calponin homology region inhibits the basal activity of Vav through interactions with the zinc finger region...
  8. ncbi request reprint Functional assays for mammalian G-protein-coupled receptors in yeast
    Pamela E Mentesana
    Department of Molecular Genetics and Microbiology, State University of New York, Stony Brook, New York 11794, USA
    Methods Enzymol 344:92-111. 2002