M de la Fuente

Summary

Affiliation: Universidad Complutense
Country: Spain

Publications

  1. pmc Diet supplementation for 5 weeks with polyphenol-rich cereals improves several functions and the redox state of mouse leucocytes
    Pedro Alvarez
    Dept of Animal Physiology, Faculty of Biology, Complutense University of Madrid, Madrid, Spain
    Eur J Nutr 45:428-38. 2006
  2. ncbi request reprint The immune system in the oxidative stress conditions of aging and hypertension: favorable effects of antioxidants and physical exercise
    M de la Fuente
    Department of Physiology Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Antioxid Redox Signal 7:1356-66. 2005
  3. ncbi request reprint Characterization of monoaminergic systems in brain regions of prematurely ageing mice
    Monica De la Fuente
    Departamento de Fisiologia Animal, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, E 28040, Madrid, Spain
    Neurochem Int 43:165-72. 2003
  4. ncbi request reprint Improvement of immune cell functions in aged mice treated for five weeks with soybean isoflavones
    Isabel Baeza
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, 28040 Madrid, Spain
    Ann N Y Acad Sci 1100:497-504. 2007
  5. doi request reprint Vitamin E ingestion improves several immune functions in elderly men and women
    Monica De la Fuente
    Department of Animal Physiology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain
    Free Radic Res 42:272-80. 2008
  6. ncbi request reprint Strategies to improve the functions and redox state of the immune system in aged subjects
    Monica De la Fuente
    Departamento de Fisiologia, Complutense University, Madrid, Spain
    Curr Pharm Des 17:3966-93. 2011
  7. doi request reprint Role of neuroimmunomodulation in aging
    Monica De la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Neuroimmunomodulation 15:213-23. 2008
  8. ncbi request reprint The amount of thiolic antioxidant ingestion needed to improve several immune functions is higher in aged than in adult mice
    M de la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Free Radic Res 36:119-26. 2002
  9. ncbi request reprint An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging
    Monica De la Fuente
    Department of Physiology Animal Physiology II, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 15:3003-26. 2009
  10. ncbi request reprint Effects of antioxidants on immune system ageing
    M de la Fuente
    Departmento de Fisiologia Animal, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain
    Eur J Clin Nutr 56:S5-8. 2002

Collaborators

Detail Information

Publications74

  1. pmc Diet supplementation for 5 weeks with polyphenol-rich cereals improves several functions and the redox state of mouse leucocytes
    Pedro Alvarez
    Dept of Animal Physiology, Faculty of Biology, Complutense University of Madrid, Madrid, Spain
    Eur J Nutr 45:428-38. 2006
    ..However, whether cereal-based dietary supplementation positively affects the immune function and cellular redox state of healthy subjects remains unclear...
  2. ncbi request reprint The immune system in the oxidative stress conditions of aging and hypertension: favorable effects of antioxidants and physical exercise
    M de la Fuente
    Department of Physiology Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Antioxid Redox Signal 7:1356-66. 2005
    ..The present review summarizes a selection of data related to the above from other authors as well as some findings from our own work...
  3. ncbi request reprint Characterization of monoaminergic systems in brain regions of prematurely ageing mice
    Monica De la Fuente
    Departamento de Fisiologia Animal, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, E 28040, Madrid, Spain
    Neurochem Int 43:165-72. 2003
    ..One exception was the hypothalamus where the differences only affected the male mice. The neurochemical alterations found in PAM resemble some changes reported for aged animals and are related with their behavioural features...
  4. ncbi request reprint Improvement of immune cell functions in aged mice treated for five weeks with soybean isoflavones
    Isabel Baeza
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, 28040 Madrid, Spain
    Ann N Y Acad Sci 1100:497-504. 2007
    ....
  5. doi request reprint Vitamin E ingestion improves several immune functions in elderly men and women
    Monica De la Fuente
    Department of Animal Physiology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain
    Free Radic Res 42:272-80. 2008
    ..The present findings suggest that supplementation with vitamin E can produce an improvement of immune functions and therefore of health in aged people...
  6. ncbi request reprint Strategies to improve the functions and redox state of the immune system in aged subjects
    Monica De la Fuente
    Departamento de Fisiologia, Complutense University, Madrid, Spain
    Curr Pharm Des 17:3966-93. 2011
    ..coli lipopolysaccharide, LPS), on several functions and redox parameters are shown. The advantages and possible problems of the use of those interventions to achieve a healthy aging and longevity are discussed...
  7. doi request reprint Role of neuroimmunomodulation in aging
    Monica De la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Neuroimmunomodulation 15:213-23. 2008
    ..Accordingly, the administration of antioxidants improves both the nervous and immune functions, decreasing their oxidative stress, and consequently there is a significant increase in longevity...
  8. ncbi request reprint The amount of thiolic antioxidant ingestion needed to improve several immune functions is higher in aged than in adult mice
    M de la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Free Radic Res 36:119-26. 2002
    ..However, the ingestion of these very high amounts of thiols by aged animals increased the phagocytosis, the NK activity and specially the lymphoproliferative response to the mitogen, a function that is very depressed with aging...
  9. ncbi request reprint An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging
    Monica De la Fuente
    Department of Physiology Animal Physiology II, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Curr Pharm Des 15:3003-26. 2009
    ....
  10. ncbi request reprint Effects of antioxidants on immune system ageing
    M de la Fuente
    Departmento de Fisiologia Animal, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain
    Eur J Clin Nutr 56:S5-8. 2002
    ..Therefore, since the immune system is an indicator of health and a longevity predictor, the protection of this system afforded by dietary antioxidant supplementation may play an important role in order to achieve a healthy ageing...
  11. doi request reprint Models of aging of neuroimmunomodulation: strategies for its improvement
    Monica De la Fuente
    Department of Physiology Animal Physiology II, Faculty of Biology, Complutense University of Madrid, Madrid, Spain
    Neuroimmunomodulation 17:213-6. 2010
    ..Therefore, they retard the aging process and seem to increase the longevity of the individuals...
  12. doi request reprint Murine models of premature ageing for the study of diet-induced immune changes: improvement of leucocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants
    Monica De la Fuente
    Department of Physiology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain
    Proc Nutr Soc 69:651-9. 2010
    ..Thus, an adequate nutrition with antioxidants, even in aged subjects, could be a good strategy to retard ageing...
  13. doi request reprint Improvement of leucocyte functions in mature and old mice after 15 and 30 weeks of diet supplementation with polyphenol-rich biscuits
    Monica De la Fuente
    Department of Physiology Animal Physiology II, Faculty of Biological Sciences, Complutense University, c Jose Antonio Novais no 2, 28040, Madrid, Spain
    Eur J Nutr 50:563-73. 2011
    ..To study the effect of diet supplementation with polyphenols on several functions suffering age-related changes, in peritoneal leucocytes from mature and old mice...
  14. doi request reprint Sulfur-containing antioxidants increase in vitro several functions of lymphocytes from mice
    Monica De la Fuente
    Animal Physiology Department, Faculty of Biological Science, Complutense University of Madrid, Spain
    Int Immunopharmacol 11:661-9. 2011
    ....
  15. ncbi request reprint Changes with ageing in several leukocyte functions of male and female rats
    Monica De la Fuente
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, 28040 Madrid, Spain
    Biogerontology 5:389-400. 2004
    ....
  16. ncbi request reprint Improvement of leukocyte functions in young prematurely aging mice after a 5-week ingestion of a diet supplemented with biscuits enriched in antioxidants
    C Alvarado
    Department of Physiology Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Antioxid Redox Signal 7:1203-10. 2005
    ....
  17. ncbi request reprint Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress
    M de la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Free Radic Res 35:73-84. 2001
    ....
  18. doi request reprint Ovariectomy, a model of menopause in rodents, causes a premature aging of the nervous and immune systems
    I Baeza
    Department of Physiology, Faculty of Biology, Complutense University of Madrid, Madrid, Spain
    J Neuroimmunol 219:90-9. 2010
    ..Therefore, ovariectomy deteriorates homeostasis and may be a model of premature aging...
  19. ncbi request reprint Improvement of the macrophage functions in prematurely ageing mice by a diet supplemented with thiolic antioxidants
    N Guayerbas
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain
    Cell Mol Biol (Noisy-le-grand) 50:OL677-81. 2004
    ..Diet supplementation with these thiolic compounds, namely TP and NAC, seems an effective therapy for protection against early immune decline in prematurely ageing mice...
  20. ncbi request reprint Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice
    M Puerto
    Department of Physiology Animal Physiology II, Faculty of Biological Science, Complutense University of Madrid, Jose Antonio Novais, 2 28040 Madrid, Spain
    J Neuroimmunol 165:33-40. 2005
    ..The effects of neurotransmitters on these functions were different depending on the age of the animals...
  21. ncbi request reprint Effect of aging on the modulation of macrophage functions by neuropeptides
    M de la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Life Sci 67:2125-35. 2000
    ..The decrease of these functions caused by CCK-8s in adult or mature animals continues in old mice. These data suggest that the modulation by neuropeptides of the macrophage function changes with the age of animals...
  22. ncbi request reprint Thiolic antioxidant supplementation of the diet reverses age-related behavioural dysfunction in prematurely ageing mice
    N Guayerbas
    Department of Animal Physiology, Biology Faculty, Universidad Complutense de Madrid, Madrid, Spain
    Pharmacol Biochem Behav 80:45-51. 2005
    ..In conclusion, diet supplementation with thiolic compounds appears to be an effective therapy for protection against early behavioural decline in prematurely ageing mice...
  23. ncbi request reprint Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence
    M de la Fuente
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, Madrid 28040, Spain
    Cell Mol Biol (Noisy-le-grand) 50:OL683-90. 2004
    ..These changes in peritoneal immune cells could contribute to the chronic oxidative stress state linked to senescence...
  24. doi request reprint Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens
    I Baeza
    Department of Physiology, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain
    J Reprod Immunol 80:70-9. 2009
    ..Since the immune system is a marker of health and a predictor of longevity, the results suggest that treatment with hormones could slow down the effects of the ageing process...
  25. ncbi request reprint A diet supplemented with thiolic anti-oxidants improves leucocyte function in two strains of prematurely ageing mice
    N Guayerbas
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain
    Clin Exp Pharmacol Physiol 29:1009-14. 2002
    ..In addition, the ingestion of a diet supplemented with two thiolic anti-oxidants, such as NAC and TP, has been shown to be beneficial to the immune response in PAM...
  26. ncbi request reprint Changes with aging in the modulation by neuropeptide Y of murine peritoneal macrophage functions
    M de la Fuente
    Department of Animal Physiology, Biology Faculty, Complutense University of Madrid, Madrid, Spain
    J Neuroimmunol 116:156-67. 2001
    ....
  27. ncbi request reprint Improvement by several antioxidants of macrophage function in vitro
    M Del Rio
    Department of Animal Physiology, Biology Faculty, Complutense University of Madrid, Spain
    Life Sci 63:871-81. 1998
    ..Thus, the adherence to substrate was raised, after short incubation times, by a-tocopherol and ascorbic acid. Random migration, chemotaxis, ingestion and superoxide anion production were increased by all the antioxidants used...
  28. ncbi request reprint Several functions of immune cells in mice changed by oxidative stress caused by endotoxin
    V M Victor
    Department of Animal Physiology, Complutense University, Madrid, Spain
    Physiol Res 52:789-96. 2003
    ..This oxidative state alters some functional characteristics of leukocytes (proliferation and NK activity)...
  29. ncbi request reprint Phagocytic function and antibody-dependent cellular cytotoxicity of human neutrophils in the presence of N-formimidoyl thienamycin
    A B Rodriguez
    Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain
    Agents Actions 31:86-95. 1990
    ..Imipenem at this dose also presents chemoattractant power for neutrophils and enhances the antibody-dependent cellular cytotoxicity (ADCC)...
  30. ncbi request reprint Anti-oxidants as modulators of immune function
    M de la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Immunol Cell Biol 78:49-54. 2000
    ..These data suggest that anti-oxidants preserve adequate function of immune cells against homeostatic disturbances such as those caused by endotoxic shock and ageing...
  31. ncbi request reprint Changes in macrophage and lymphocyte functions in guinea-pigs after different amounts of vitamin E ingestion
    M de la Fuente
    Department of Animal Physiology, Faculty of Biological Science, Complutense University of Madrid, Spain
    Br J Nutr 84:25-9. 2000
    ..Therefore, diet supplementation with higher than usual levels of vitamin E appears to be beneficial for the immune system...
  32. ncbi request reprint Changes in the ascorbic acid levels of peritoneal lymphocytes and macrophages of mice with endotoxin-induced oxidative stress
    V M Victor
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Free Radic Res 35:907-16. 2001
    ..These results suggest that the immune cells need appropriate levels of antioxidants, such as AA, under oxidative stress conditions, and that while lymphocytes take and accumulate AA, macrophages use it...
  33. ncbi request reprint Changes in the superoxide production and other macrophage functions could be related to the mortality of mice with endotoxin-induced oxidative stress
    V M Victor
    Department Animal Physiology, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Physiol Res 52:101-10. 2003
    ..These data suggest that these changes, mainly the increased production of free radicals even more than the TNFalpha release, could be involved in mouse mortality caused by LPS...
  34. ncbi request reprint Effects of physical exercise and aging on ascorbic acid and superoxide anion levels in peritoneal macrophages from mice and guinea pigs
    M de la Fuente
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    J Comp Physiol B 165:315-9. 1995
    ..In old animals the exhaustive exercise did not change the O2- levels. The results suggest in general a lack of correlation between the intracellular ascorbate and O2- levels in relation to both physical exercise and aging...
  35. ncbi request reprint Comparative study of several lymphocyte functions in two strains of mice with different models of endotoxic shock
    V M Victor
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Physiol Res 51:291-8. 2002
    ..These changes were more significant in mice with lethal than with non-lethal endotoxic shock, a fact that confirms the important role of lymphocytes during endotoxic shock...
  36. ncbi request reprint Leukocyte function and life span in a murine model of premature immunosenescence
    N Guayerbas
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, 28040 Madrid, Spain
    Exp Gerontol 37:249-56. 2002
    ..In summary, we propose the above immunological parameters, that change with aging at a different rate in members of a same population, as useful biomarkers to asses the rate of biological aging in mice...
  37. ncbi request reprint Changes with aging in the modulation of macrophages by norepinephrine
    E Ortega
    Department of Physiology, Faculty of Science, University of Extremadura, Avenida de Elva s n, 06071, Badajoz, Spain
    Mech Ageing Dev 118:103-14. 2000
    ..In conclusion, the results obtained indicate that the modulation of macrophages by NE does not only depend on the concentration of this neurotransmitter, but also on age...
  38. ncbi request reprint Modulation of murine peritoneal macrophage functions by gastrin
    M de la Fuente
    Departamento de Biología Animal II Fisiología Animal, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Spain
    Peptides 17:219-24. 1996
    ..These results suggest that gastrin is a negative modulator of several macrophage functions, and that the inhibition of these activities is carried out through an increase of intracellular cAMP levels...
  39. ncbi request reprint Effects of acetylsalicylic acid on the phagocytic function of human polymorphonuclear leukocytes in vitro
    A B Rodriguez
    Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain
    Gen Pharmacol 20:151-5. 1989
    ..5. No changes are observed in the incorporation of arachidonic acid or in the release of its metabolites...
  40. ncbi request reprint Neuropeptide Y effects on murine natural killer activity: changes with ageing and cAMP involvement
    M de la Fuente
    Departamento de Biologia Animal II, Fisiologia Animal, Facultad de Ciencias Biologicas, Universidad Complutense, Av Complutense E 28040, Madrid, Spain
    Regul Pept 101:73-9. 2001
    ..Furthermore, cAMP levels in leukocytes were found to be decreased by NPY in adult mice, suggesting an involvement of this messenger system in the NK modulation by this neuropeptide...
  41. doi request reprint Effect of growth hormone treatment on lymphocyte functions in old male rats
    Isabel Baeza
    Department of Animal Physiology, Faculty of Biology, Complutense University, Madrid, Spain
    Neuroimmunomodulation 15:279-84. 2008
    ..Furthermore, the endocrine system is also affected by aging, one of the most significant changes being the decrease in the secretion of several hormones such as growth hormone (GH)...
  42. ncbi request reprint Behavioral characterization of a mouse model of premature immunosenescence
    M P Viveros
    Department of Animal Physiology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain
    J Neuroimmunol 114:80-8. 2001
    ..The data supports our claim that slow or hyperemotional mice, in which immune and neurobehavioural functions appear to be impaired, may be a useful model of premature aging...
  43. ncbi request reprint Mechanisms of action involved in the chemoattractant activity of three beta-lactamic antibiotics upon human neutrophils
    A B Rodriguez
    Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain
    Biochem Pharmacol 41:931-6. 1991
    ..Since the involvement of the above-mentioned mechanisms in leukotaxis have been established, the stimulation of neutrophil chemotaxis by the three antibiotics studied could possibly be mediated by one or more of these mechanisms...
  44. ncbi request reprint Relation between exploratory activity and immune function in aged mice: a preliminary study
    M de la Fuente
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Mech Ageing Dev 102:263-77. 1998
    ..The results show that the aged fast mice have better immune functions than the aged slow mice...
  45. doi request reprint Early maternal deprivation in rats: a proposed animal model for the study of developmental neuroimmunoendocrine interactions
    M de la Fuente
    Department of Animal Physiology, Faculty of Biology, Complutense University of Madrid, Madrid, Spain
    Ann N Y Acad Sci 1153:176-83. 2009
    ..In view of our findings we propose the present MD procedure as a potentially useful model to analyze developmental interactions between early psychophysiological stress and immunodeficient states...
  46. ncbi request reprint Stimulation of phagocytic processes and antibody-dependent cellular cytotoxicity of human neutrophils by cefmetazole
    A B Rodriguez
    Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain
    Microbiol Immunol 35:545-56. 1991
    ..Cefmetazole at this dose was a chemotactic agent for neutrophils. Antibody-dependent cellular cytotoxicity (ADCC) was also increased by this anti-microbial agent...
  47. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide (PACAP38) modulates lymphocyte and macrophage functions: stimulation of adherence and opposite effect on mobility
    E Garrido
    Departamento de Biologia Celular, Facultad de Biologia, Universidad Complutense de Madrid, Spain
    Neuropeptides 30:583-95. 1996
    ..The present work reveals an additional link between neuropeptides and the immune system and suggests that the peptide PACAP modulates the immunological function of macrophages and lymphocytes...
  48. doi request reprint Influence of exercise on the circulating levels and macrophage production of IL-1beta and IFNgamma affected by metabolic syndrome: an obese Zucker rat experimental animal model
    L Martín-Cordero
    Department of Physiology, Faculty of Sciences, University of Extremadura, 06071 Badajoz, Spain
    Eur J Appl Physiol 107:535-43. 2009
    ....
  49. ncbi request reprint IR and Raman study on the interactions of the 5'-GMP and 5'-CMP phosphate groups with Mg(II), Ca(II), Sr(II), Ba(II), Cr(III), Co(II), Cu(II), Zn(II), Cd(II), Al(III) and Ga(III)
    M de la Fuente
    Departamento de Ciencias y Tecnicas Fisicoquimicas, Facultad de Ciencias, UNED, c Senda del Rey 9, 28040, Madrid, Spain
    J Biol Inorg Chem 9:973-86. 2004
    ..These results are supported by the behavior of 5'-CMP in aqueous solution in the presence of Mg(II) ions...
  50. ncbi request reprint Dietary supplementation with antioxidants improves functions and decreases oxidative stress of leukocytes from prematurely aging mice
    Carmen Alvarado
    Department of Physiology Animal Physiology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Nutrition 22:767-77. 2006
    ....
  51. pmc Enzymes of mannose metabolism in murine and human lymphocytic leukaemia
    M de la Fuente
    Department of Animal Biology II, Faculty of Biological Sciences, Complutense University, Madrid, Spain
    Br J Cancer 58:567-9. 1988
    ..The utility of analysing MPI activity in leukaemia patients and the use of mannose as an innocuous chemotherapic supporting agent in patients with decreased MPI activity is proposed...
  52. doi request reprint Sex-dependent alterations in response to maternal deprivation in rats
    M P Viveros
    Departamento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, E 28040 Madrid, Spain
    Psychoneuroendocrinology 34:S217-26. 2009
    ..We also emphasize the necessity of analyzing the important influence of sex as regards the specific consequences of early life stress...
  53. doi request reprint Preserved immune functions and controlled leukocyte oxidative stress in naturally long-lived mice: possible role of nuclear factor kappa B
    Lorena Arranz
    Department of Physiology Animal Physiology II, Faculty of Biological Sciences, Madrid Complutense University, Spain
    J Gerontol A Biol Sci Med Sci 65:941-50. 2010
    ....
  54. ncbi request reprint A model of premature aging in mice based on altered stress-related behavioral response and immunosenescence
    Maria Paz Viveros
    Departamento de Fisiología Fisiología Animal II, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain
    Neuroimmunomodulation 14:157-62. 2007
    ....
  55. doi request reprint Impaired immune function in a homeless population with stress-related disorders
    Lorena Arranz
    Department of Physiology Animal Physiology II, Faculty of Biology, Madrid Complutense University, Madrid, Spain
    Neuroimmunomodulation 16:251-60. 2009
    ..The aim of the present work was to study the immune function in a group of homeless people with stress-related disorders and compare it with that of healthy non-homeless controls...
  56. ncbi request reprint Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence
    Noelia Guayerbas
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, Madrid E 28040, Spain
    Behav Brain Res 134:41-8. 2002
    ....
  57. ncbi request reprint Effects of imipenem and cefmetazol on lymphocyte receptors CD2, Fc and C3b of complement
    C Barriga Ibars
    University of Extremadura, Faculty of Science, Department of Physiology, Badajoz, Spain
    Comp Immunol Microbiol Infect Dis 14:297-302. 1991
    ..When the lymphocytes are treated with these antibiotics there is an increase in the receptors capable of binding to fraction C3b of the complement...
  58. doi request reprint Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice
    Lorena Arranz
    Department of Physiology Animal Physiology II, Faculty of Biological Sciences, Madrid Complutense University, Madrid, Spain
    Rejuvenation Res 13:415-28. 2010
    ....
  59. ncbi request reprint Modulation of superoxide anion levels of macrophages from young-adult and old mice by the norepinephrine metabolite, 4-hydroxy-3-methoxyphenyl-glycol
    M C Saez
    Departamento de Fisiologia Animal, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s n, 06071 Badajoz, Spain
    Exp Gerontol 37:395-400. 2002
    ..The effect of NE metabolite will also depend on the age of the animals as there is an age-dependent decreased capacity to respond to low concentrations of HMP-glycol...
  60. ncbi request reprint Behavioral, endocrine and immunological characteristics of a murine model of premature aging
    Laura Pérez-Alvarez
    Departamento de Fisiología Fisiología Animal II, Facultad de Ciencias Biologicas, Universidad Complutense, Ciudad Universitaria, C Jose Antonio Novais, 2, 28040 Madrid, Spain
    Dev Comp Immunol 29:965-76. 2005
    ..The data indicate that certain characteristics of the PAM are already present in animals of very young chronological age and provide new information for a more complete characterization of the PAM from a neuroimmunoendocrine viewpoint...
  61. ncbi request reprint Effect of acupuncture treatment on the immune function impairment found in anxious women
    Lorena Arranz
    Department of Physiology Animal Physiology II, Faculty of Biological Science, Complutense University of Madrid, Spain
    Am J Chin Med 35:35-51. 2007
    ..Acupuncture brought the above mentioned parameters to values closer to those of healthy controls, exerting a modulatory effect on the immune system...
  62. ncbi request reprint Regulation of macrophage function by the antioxidant N-acetylcysteine in mouse-oxidative stress by endotoxin
    Victor Manuel Victor
    Department of Animal Physiology, Faculty of Biological Sciences, Complutense University, 28040 Madrid, Spain
    Int Immunopharmacol 3:97-106. 2003
    ....
  63. ncbi request reprint Oxidative stress in leukocytes from young prematurely aging mice is reversed by supplementation with biscuits rich in antioxidants
    Carmen Alvarado
    Department of Physiology, Animal Physiology II, Faculty of Biological Sciences, Complutense University, 28040 Madrid, Spain
    Dev Comp Immunol 30:1168-80. 2006
    ..Accordingly, supplementation with adequate levels of antioxidants, from an early age, could be useful to preserve health, especially in prematurely aging populations...
  64. ncbi request reprint An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice
    Noelia Guayerbas
    Department of Animal Physiology, Faculty of Biology, Complutense University, José Antonio Novais s n, Madrid, Spain
    Dev Comp Immunol 27:339-50. 2003
    ....
  65. ncbi request reprint Neuroimmunomodulation during exercise: role of catecholamines as 'stress mediator' and/or 'danger signal' for the innate immune response
    Eduardo Ortega
    Department of Physiology, Faculty of Sciences, University of Extremadura, Badajoz, Spain
    Neuroimmunomodulation 14:206-12. 2007
    ..Given this hypothesis, it is also suggested here that catecholamines may be the first 'danger signal' to the immune system during exercise-induced stress...
  66. ncbi request reprint Consequences of polymorphism of 5'-GMP.Na2 in the vibrational spectra of metal complexes and isotopic derivatives
    M de la Fuente
    Fac Ciencias Quimicas, Dpto CC, y TT Fisicoquímicas, Universidad Nacional de Educacion a Distancia, Madrid, Spain
    Nucleosides Nucleotides Nucleic Acids 21:495-503. 2002
    ..Then, attention should be paid to the changes observed in the vibrational spectra of recrystallized mononucleotides, since recrystallization may lead to a considerable phase change, and this can notably alter the vibrational spectra...
  67. doi request reprint The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women
    Lorena Arranz
    Department of Physiology Animal Physiology II, Faculty of Biological Sciences, Madrid Complutense University, Spain
    Free Radic Biol Med 45:1252-62. 2008
    ..Thus, NAC could contribute to maintenance of good health and quality of life in postmenopausal women by decreasing the probability of immune system-related diseases, such as infections, in aging...
  68. ncbi request reprint Impairment of several immune functions in anxious women
    Lorena Arranz
    Department of Physiology Animal Physiology II, Faculty of Biology, Complutense University of Madrid, Madrid, Spain
    J Psychosom Res 62:1-8. 2007
    ..Controversial results concerning immune function changes taking place in anxious subjects have been obtained. The aim of the present work was to study immune function in a group of anxious women...
  69. ncbi request reprint Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing
    Marta Puerto
    Departmento de Fisiologia Animal, Facultad de Biologia, Universidad Complutense, José Antonio Novais s n, E 28040, Madrid, Spain
    Pharmacol Biochem Behav 73:797-804. 2002
    ..The effect of this antioxidant was stronger in the cells from the slow than in those from the fast mice...
  70. ncbi request reprint Influence of aging and enriched environment on motor activity and emotional responses in mice
    Claustro Zambrana
    Departamento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, Ciudad Universitaria, c Jose Antonio Novais 2, 28040 Madrid, Spain
    Ann N Y Acad Sci 1100:543-52. 2007
    ....
  71. ncbi request reprint Early maternal deprivation and neonatal single administration with a cannabinoid agonist induce long-term sex-dependent psychoimmunoendocrine effects in adolescent rats
    Ricardo Llorente
    Departamento de Fisiología Fisiología Animal II, Facultad de Ciencias Biologicas, Universidad Complutense, Ciudad Universitaria, C Jose Antonio Novais, 2 28040 Madrid, Spain
    Psychoneuroendocrinology 32:636-50. 2007
    ..In general, the results show detrimental effects of both treatments as well as intriguing interactions, notably in relation to emotional behaviour and certain immunological responses...
  72. doi request reprint [Social isolation during old age worsens cognitive, behavioral and immune impairment]
    Lorena Arranz
    Departamento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense de Madrid, Madrid, Espana
    Rev Esp Geriatr Gerontol 44:137-42. 2009
    ..Thus, the aim of the present study was to create an animal model of solitude in old age to study the behavioral, cognitive and immunological changes induced by social isolation at this late stage of life...
  73. ncbi request reprint Noradrenaline and its end metabolite 3-methoxy-4-hydroxyphenylglycol inhibit lymphocyte chemotaxis: role of alpha- and beta-adrenoreceptors
    Juan Jose Garcia
    Department of Physiology, University of Extremadura, Badajoz, Spain
    Mol Cell Biochem 254:305-9. 2003
    ....
  74. ncbi request reprint Plasma aminothiol compounds, but not serum tumor necrosis factor receptor II and soluble receptor for advanced glycation end products, are related to the cognitive impairment in Alzheimer's disease and mild cognitive impairment patients
    Angel Hernanz
    Department of Biochemistry, Hospital Universitario La Paz, Madrid, Spain
    Neuroimmunomodulation 14:163-7. 2007
    ..These findings indicate that plasma aminothiol compounds are associated with AD and MCI patients and with their cognitive status...