Manuel Rodríguez Díaz

Summary

Affiliation: Universidad de La Laguna
Country: Spain

Publications

  1. doi request reprint The role of non-synaptic extracellular glutamate
    Manuel Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Brain Res Bull 93:17-26. 2013
  2. ncbi request reprint Adapting movement planning to motor impairments: the motor-scanning system
    Magdalena Sabate
    Rehabilitation Service, Department of Physical Medicine and Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain
    Neuropsychologia 45:378-86. 2007
  3. ncbi request reprint Motor behavioural changes after intracerebroventricular injection of 6-hydroxydopamine in the rat: an animal model of Parkinson's disease
    M Rodriguez Diaz
    Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, La Laguna, Spain
    Behav Brain Res 122:79-92. 2001
  4. ncbi request reprint Different levodopa actions on the extracellular dopamine pools in the rat striatum
    M Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Synapse 61:61-71. 2007
  5. ncbi request reprint Nigrostriatal cell firing action on the dopamine transporter
    Manuel Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, 38320 Tenerife, Spain
    Eur J Neurosci 25:2755-65. 2007
  6. ncbi request reprint Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease
    Manuel Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Neurobiol Dis 28:316-25. 2007
  7. doi request reprint Integration of auditory and kinesthetic information in motion: alterations in Parkinson's disease
    Magdalena Sabate
    Rehabilitation Service, Department of Physical Medicine and Pharmacology, Faculty of Medicine, University of La Laguna, Canary Islands, Spain
    Neuropsychology 22:462-8. 2008
  8. doi request reprint How similar are motor imagery and movement?
    Manuel Rodriguez
    Department of Physiology, University of La Laguna, Canary Islands, Spain
    Behav Neurosci 122:910-6. 2008
  9. doi request reprint The kinematics of motor imagery: comparing the dynamics of real and virtual movements
    Manuel Rodriguez
    Department of Physiology, University of La Laguna, Tenerife, Canary Islands, Spain
    Neuropsychologia 47:489-96. 2009
  10. ncbi request reprint Heterogeneous dopamine neurochemistry in the striatum: the fountain-drain matrix
    Manuel Rodriguez
    Departamento de Fisiologia, Facultad de Medicina, Universidad de La Laguna, 38320 Tenerife, Canary Islands, Spain
    J Pharmacol Exp Ther 319:31-43. 2006

Collaborators

Detail Information

Publications26

  1. doi request reprint The role of non-synaptic extracellular glutamate
    Manuel Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Brain Res Bull 93:17-26. 2013
    ..This new scenario is expanding present knowledge regarding the role of GLU in the brain under different physiological and pathological conditions. This article is part of a Special Issue entitled 'Extrasynaptic ionotropic receptors'...
  2. ncbi request reprint Adapting movement planning to motor impairments: the motor-scanning system
    Magdalena Sabate
    Rehabilitation Service, Department of Physical Medicine and Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain
    Neuropsychologia 45:378-86. 2007
    ....
  3. ncbi request reprint Motor behavioural changes after intracerebroventricular injection of 6-hydroxydopamine in the rat: an animal model of Parkinson's disease
    M Rodriguez Diaz
    Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, La Laguna, Spain
    Behav Brain Res 122:79-92. 2001
    ....
  4. ncbi request reprint Different levodopa actions on the extracellular dopamine pools in the rat striatum
    M Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Synapse 61:61-71. 2007
    ..This study suggests a different kinetic for levodopa action on the volume transmitter and neurotransmitter DA-pool, showing marked changes in levodopa action in the denervated striatum...
  5. ncbi request reprint Nigrostriatal cell firing action on the dopamine transporter
    Manuel Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, 38320 Tenerife, Spain
    Eur J Neurosci 25:2755-65. 2007
    ..This is the first evidence showing that DAT can be activated by the firing activity in nigrostriatal cells in a direct way and without the participation of pre-synaptic DA receptors...
  6. ncbi request reprint Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson's disease
    Manuel Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Neurobiol Dis 28:316-25. 2007
    ..The precise role of such a cell inflow into the brain requires further study. Nevertheless, this may represent an opportunity to develop neuroprotective therapeutic strategies for PD...
  7. doi request reprint Integration of auditory and kinesthetic information in motion: alterations in Parkinson's disease
    Magdalena Sabate
    Rehabilitation Service, Department of Physical Medicine and Pharmacology, Faculty of Medicine, University of La Laguna, Canary Islands, Spain
    Neuropsychology 22:462-8. 2008
    ....
  8. doi request reprint How similar are motor imagery and movement?
    Manuel Rodriguez
    Department of Physiology, University of La Laguna, Canary Islands, Spain
    Behav Neurosci 122:910-6. 2008
    ..Present data show that the ability of MI to produce "realistic" simulations of motion is not the same for all motor tasks...
  9. doi request reprint The kinematics of motor imagery: comparing the dynamics of real and virtual movements
    Manuel Rodriguez
    Department of Physiology, University of La Laguna, Tenerife, Canary Islands, Spain
    Neuropsychologia 47:489-96. 2009
    ..These data suggest that movements and their MI do not always involve the same cognitive functions, and are particularly different in simple motor tasks requiring low attention levels...
  10. ncbi request reprint Heterogeneous dopamine neurochemistry in the striatum: the fountain-drain matrix
    Manuel Rodriguez
    Departamento de Fisiologia, Facultad de Medicina, Universidad de La Laguna, 38320 Tenerife, Canary Islands, Spain
    J Pharmacol Exp Ther 319:31-43. 2006
    ..The high diversity of DA activity observed in the striatum is a new framework for analyzing experimental and clinical phenomena...
  11. ncbi request reprint How is firing activity of substantia nigra cells regulated? Relevance of pattern-code in the basal ganglia
    Manuel Rodriguez
    Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain
    Synapse 49:216-25. 2003
    ..Disruption of these patterns may play a role in the pathophysiology of basal ganglia disorders such as Parkinson's disease and dyskinesias...
  12. ncbi request reprint Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra
    Manuel Rodriguez Diaz
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Glia 49:134-42. 2005
    ..Taken together, these data indicate that nigral glia releases GLU, which probably performs a volume transmitter role...
  13. ncbi request reprint The deep mesencephalic nucleus as an output center of basal ganglia: morphological and electrophysiological similarities with the substantia nigra
    M Rodriguez
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife 38207, Canary Islands, Spain
    J Comp Neurol 438:12-31. 2001
    ..This suggests that, similarly to the SNR, the DMN acts as an output center of basal ganglia and probably facilitates the inter-hemispheric regulation of these centers...
  14. ncbi request reprint Brain lateralization of motor imagery: motor planning asymmetry as a cause of movement lateralization
    Magdalena Sabate
    Rehabilitation Service, Department of Physical Medicine and Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain
    Neuropsychologia 42:1041-9. 2004
    ..However, two-handed movement tasks suggest a complex interaction during motor planning, an interaction that facilitates motor performance during mirror movements and delays motor execution during non-mirror movements...
  15. ncbi request reprint Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations
    Manuel Rodríguez Díaz
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Mov Disord 18:254-66. 2003
    ....
  16. ncbi request reprint Firing regulation in dopaminergic cells: effect of the partial degeneration of nigrostriatal system in surviving neurons
    Manuel Rodriguez
    Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain
    Eur J Neurosci 18:53-60. 2003
    ..Under these conditions, small fluctuations in firing rate are not compensated for in time, which could be one of the factors responsible for the motor fluctuations often observed in advanced Parkinson's disease...
  17. ncbi request reprint Neuronal activity in the substantia nigra in the anaesthetized rat has fractal characteristics. Evidence for firing-code patterns in the basal ganglia
    M Rodriguez
    Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain
    Exp Brain Res 151:167-72. 2003
    ..The finding of fractal firing patterns may lead to a better understanding of the normal operational mode and pathological manifestations of the basal ganglia...
  18. doi request reprint Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease
    Domingo Afonso-Oramas
    Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, Tenerife, Spain
    Neurobiol Dis 36:494-508. 2009
    ..These results strongly suggest that DAT glycosylation is involved in the differential vulnerability of midbrain DA cells in PD...
  19. ncbi request reprint Aging of the rat mesostriatal system: differences between the nigrostriatal and the mesolimbic compartments
    Ignacio Cruz-Muros
    Department of Anatomy, Faculty of Medicine, University of La Laguna, Laguna, Tenerife, Spain
    Exp Neurol 204:147-61. 2007
    ..These findings suggest that both the nigrostriatal and the mesolimbic systems are vulnerable to aging, but in contrast to what occurs in Parkinson's disease, the mesolimbic system is more vulnerable to aging than the nigrostriatal one...
  20. ncbi request reprint Hand movement distribution in the motor cortex: the influence of a concurrent task and motor imagery
    Manuel Rodriguez
    Department of Physiology, Faculty of Medicine, University of La Laguna, Spain
    Neuroimage 22:1480-91. 2004
    ....
  21. ncbi request reprint Response of the GABAergic and dopaminergic mesostriatal projections to the lesion of the contralateral dopaminergic mesostriatal pathway in the rat
    Tomas Gonzalez-Hernandez
    Departamento de Anatomia, Universidad de La Laguna, La Laguna, Tenerife, Spain
    Mov Disord 19:1029-1042. 2004
    ....
  22. ncbi request reprint Expression of dopamine and vesicular monoamine transporters and differential vulnerability of mesostriatal dopaminergic neurons
    Tomas Gonzalez-Hernandez
    Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife 38320, Spain
    J Comp Neurol 479:198-215. 2004
    ..Furthermore, the difference between DAT mRNA and protein profiles suggests internuclear differences in its posttransductional regulation...
  23. ncbi request reprint Aging effects on the dopamine transporter expression and compensatory mechanisms
    Ignacio Cruz-Muros
    Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, 38207 La Laguna, Tenerife, Spain
    Neurobiol Aging 30:973-86. 2009
    ....
  24. ncbi request reprint Deglycosylation and subcellular redistribution of VMAT2 in the mesostriatal system during normal aging
    Ignacio Cruz-Muros
    Department of Anatomy, Faculty of Medicine, University of La Laguna, 38207 La Laguna, Tenerife, Spain
    Neurobiol Aging 29:1702-11. 2008
    ..These changes may be responsible for the loss of VMAT2 activity during aging and may contribute to the high susceptibility of aged midbrain dopaminergic cells to degeneration...
  25. ncbi request reprint Substantia nigra osmoregulation: taurine and ATP involvement
    Ingrid Morales
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Am J Physiol Cell Physiol 292:C1934-41. 2007
    ..Taken together, present data suggest osmoregulation as a role of the nonsynaptic taurine pool of the SN, a function that also involves glutamate and ATP and that could influence the nigral cell vulnerability in Parkinson's disease...
  26. doi request reprint Osmosensitive response of glutamate in the substantia nigra
    Ingrid Morales
    Laboratory of Neurobiology and Experimental Neurology, Department of Physiology Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain
    Exp Neurol 220:335-40. 2009
    ..The marked action of osmolarity on extracellular Glu suggests osmolarity regulation as a possible source for excitotoxicity in the SN...