María Carmen Chillón
Affiliation: Universidad de Salamanca
- Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemiaM C Chillon
Department of Hematology, University Hospital of Salamanca and Institute of Biomedical Research of Salamanca, Salamanca, Spain
Leukemia 26:2360-6. 2012..These findings indicate that high FLT3 expression identifies MLL-AF4+ ALL patients at very high risk of treatment failure and poor survival, emphasizing the value of ongoing/future clinical trials for FLT3 inhibitors...
- Long FLT3 internal tandem duplications and reduced PML-RARα expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patientsMaría Carmen Chillón
Department of Hematology, University Hospital of Salamanca, Paseo San Vicente 58 182, Salamanca, 37007, Spain
Haematologica 95:745-51. 2010..Internal tandem duplications of the FLT3 gene (FLT3-ITDs) are frequent in patients with acute promyelocytic leukemia (APL), however its clinical impact remains controversial...
- The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemiaCarlos Santamaria
Hospital Universitario, Salamanca, Spain
Haematologica 93:1797-805. 2008..The gene for preferentially expressed antigen of melanoma (PRAME) has been shown to be over-expressed in acute promyelocytic leukemia, but its actual incidence and clinical impact are still unknown...
- Using quantification of the PML-RARalpha transcript to stratify the risk of relapse in patients with acute promyelocytic leukemiaCarlos Santamaria
Departament of Hematology, Hospital Universitario de Salamanca, Salamanca, Spain
Haematologica 92:315-22. 2007..Our aim was to analyze any associations between the risk of relapse and RQ-PCR results in different phases of treatment, comparing these data with those yielded by conventional qualitative reverse transcriptase-PCR...