J P Bolanos

Summary

Affiliation: Universidad de Salamanca
Country: Spain

Publications

  1. pmc γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor
    Ruben Quintana-Cabrera
    Department of Biochemistry and Molecular Biology, Institute of Neurosciences of Castile and Leon, University of Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Nat Commun 3:718. 2012
  2. pmc Persistent mitochondrial damage by nitric oxide and its derivatives: neuropathological implications
    Juan P Bolanos
    Department of Biochemistry and Molecular Biology, Institute of Neurosciences of Castilla Leon, University of Salamanca Salamanca, Spain
    Front Neuroenergetics 2:1. 2010
  3. doi request reprint Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3
    Juan P Bolanos
    Institute of Functional Biology and Genomics IBFG, University of Salamanca CSIC, Zacarias Gonzalez 2, 37007 Salamanca, Spain
    Biochem J 452:e7-9. 2013
  4. ncbi request reprint Regulation of glucose metabolism by nitrosative stress in neural cells
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Avda del Campo Charro, 37007 Salamanca, Spain
    Mol Aspects Med 25:61-73. 2004
  5. doi request reprint The pentose-phosphate pathway in neuronal survival against nitrosative stress
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, 37007 Salamanca, Spain
    IUBMB Life 62:14-8. 2010
  6. doi request reprint Glycolysis: a bioenergetic or a survival pathway?
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Salamanca, Spain
    Trends Biochem Sci 35:145-9. 2010
  7. doi request reprint Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Spain
    Adv Drug Deliv Rev 61:1299-315. 2009
  8. ncbi request reprint Provoking neuroprotection by peroxynitrite
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Curr Pharm Des 10:867-77. 2004
  9. ncbi request reprint Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide
    J P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Biochem Soc Trans 35:1224-7. 2007
  10. ncbi request reprint Modulation of astroglial energy metabolism by nitric oxide
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca Instituto de Neurociencias de Castilla y León, Centro Nacional de Investigaciones Cardiovasculares, Campus Miguel de Unamuno, Salamanca, Spain
    Antioxid Redox Signal 8:955-65. 2006

Collaborators

Detail Information

Publications19

  1. pmc γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor
    Ruben Quintana-Cabrera
    Department of Biochemistry and Molecular Biology, Institute of Neurosciences of Castile and Leon, University of Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Nat Commun 3:718. 2012
    ..Thus, γ-glutamylcysteine takes over the antioxidant and neuroprotective functions of glutathione by acting as glutathione peroxidase-1 cofactor...
  2. pmc Persistent mitochondrial damage by nitric oxide and its derivatives: neuropathological implications
    Juan P Bolanos
    Department of Biochemistry and Molecular Biology, Institute of Neurosciences of Castilla Leon, University of Salamanca Salamanca, Spain
    Front Neuroenergetics 2:1. 2010
    ..Thus, such irreversible inhibition of CcO by peroxynitrite may be a plausible mechanism for the neuronal death associated with neurodegenerative diseases, in which the activation of astrocytes plays a crucial role...
  3. doi request reprint Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3
    Juan P Bolanos
    Institute of Functional Biology and Genomics IBFG, University of Salamanca CSIC, Zacarias Gonzalez 2, 37007 Salamanca, Spain
    Biochem J 452:e7-9. 2013
    ..These results reveal a novel pathway through which MK2 co-ordinates metabolic adaptation to cell proliferation in cancer and highlight PFKFB3 as a potential therapeutic target in this devastating disease...
  4. ncbi request reprint Regulation of glucose metabolism by nitrosative stress in neural cells
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Avda del Campo Charro, 37007 Salamanca, Spain
    Mol Aspects Med 25:61-73. 2004
    ....
  5. doi request reprint The pentose-phosphate pathway in neuronal survival against nitrosative stress
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, 37007 Salamanca, Spain
    IUBMB Life 62:14-8. 2010
    ..These results suggest that the antioxidant fragility of neurons may be compensated by the PPP at the expense of inhibiting bioenergetic glycolysis...
  6. doi request reprint Glycolysis: a bioenergetic or a survival pathway?
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Salamanca, Spain
    Trends Biochem Sci 35:145-9. 2010
    ....
  7. doi request reprint Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Spain
    Adv Drug Deliv Rev 61:1299-315. 2009
    ..Drug therapies directed toward providing safer mitochondria are currently under both pre- and clinical investigations...
  8. ncbi request reprint Provoking neuroprotection by peroxynitrite
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Curr Pharm Des 10:867-77. 2004
    ..In view of the potential cytoprotective function of peroxynitrite, further studies specifically focused on elucidating the possible therapeutic potential of peroxynitrite are sure to appear...
  9. ncbi request reprint Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide
    J P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Biochem Soc Trans 35:1224-7. 2007
    ..This may have implications for our understanding of the mechanisms of neurodegeneration due to oxidative and nitrosative stress...
  10. ncbi request reprint Modulation of astroglial energy metabolism by nitric oxide
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca Instituto de Neurociencias de Castilla y León, Centro Nacional de Investigaciones Cardiovasculares, Campus Miguel de Unamuno, Salamanca, Spain
    Antioxid Redox Signal 8:955-65. 2006
    ..The stimulation of these glucose-metabolizing pathways by NO would represent a transient attempt by the glial cells to compensate for energy impairment and oxidative stress, and thus to emerge from an otherwise pathological outcome...
  11. ncbi request reprint Regulation of glycolysis and pentose-phosphate pathway by nitric oxide: impact on neuronal survival
    Juan P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca Instituto de Neurociencias de Castilla y León, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Biochim Biophys Acta 1777:789-93. 2008
    ..This may have important implications for our understanding of the mechanisms controlling neuronal survival during oxidative stress and bioenergetic crisis...
  12. ncbi request reprint Nitric oxide mediates brain mitochondrial damage during perinatal anoxia
    J P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Brain Res 787:117-22. 1998
    ..Our results suggest that brain mitochondrial dysfunction leading to energy deficiency during perinatal asphyxia is a .NO-mediated process...
  13. pmc Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
    P Rodríguez-Rodríguez
    Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Edificio Departamental, Spain
    Cell Death Differ 19:1582-9. 2012
    ..These results reveal that, by inhibition of APC(Cdh1), glutamate receptors activation stabilizes PFKFB3 thus switching neuronal metabolism leading to oxidative damage and neurodegeneration...
  14. ncbi request reprint Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress
    J I Diaz-Hernandez
    Unidad de Investigacion, Hospital Universitario de Salamanca Instituto de Estudios Ciencias de la Salud de Castilla y León, Salamanca, Spain
    Cell Death Differ 14:1211-21. 2007
    ..Thus, in the mild progressive damage likely occur in neurodegenerative diseases, PARP-1 activation plays a neuroprotective role that should be taken into account when considering therapeutic strategies...
  15. ncbi request reprint Depletion of glutathione up-regulates mitochondrial complex I expression in glial cells
    O L Vásquez
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Spain
    J Neurochem 76:1593-6. 2001
    ..These results could offer further insight into the different degree of cellular susceptibility observed in glial vs. neuronal cells against oxidative stress...
  16. ncbi request reprint Evaluation of the efficacy of potential therapeutic agents at protecting against nitric oxide synthase-mediated mitochondrial damage in activated astrocytes
    J P Bolanos
    Department of Neurochemistry, Institute of Neurology, London, UK
    Brain Res Brain Res Protoc 1:258-62. 1997
    ..On the basis of this phenomenon, we propose that activated astrocytes represent a suitable system for studying the efficacy of potential therapeutic agents at protecting from nitric oxide synthase-mediated mitochondrial damage...
  17. ncbi request reprint Roles of nitric oxide in brain hypoxia-ischemia
    J P Bolanos
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain
    Biochim Biophys Acta 1411:415-36. 1999
    ..However, there is a simultaneous compensatory response through eNOS activation within the endothelium of blood vessels, which mediates vasodilation and hence increases blood flow to the damaged brain area...
  18. doi request reprint Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation
    J Cuende
    Unidad de Investigacion, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Leon, Salamanca, Spain
    Oncogene 27:3339-44. 2008
    ..Thus, retinoic acid downregulates Rae1, hence facilitating APC(Cdh1)-mediated Skp2 degradation leading to the arrest of cell cycle progression and neuroblastoma differentiation...
  19. ncbi request reprint Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytes
    Cinzia Dello Russo
    Veterans Affairs Chicago Health Care System West Side Division, Chicago, Illinois, 60680, USA
    J Biol Chem 278:5828-36. 2003
    ..These results demonstrate that TZDs modify astrocyte metabolism and mitochondrial function, which could be beneficial in neurological conditions where glucose availability is reduced...