Research Topics
| J P BolanosSummaryAffiliation: Universidad de Salamanca Country: Spain Publications
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Detail Information
Publications
Regulation of glycolysis and pentose-phosphate pathway by nitric oxide: impact on neuronal survivalJuan P Bolanos
Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca Instituto de Neurociencias de Castilla y León, Campus Miguel de Unamuno, 37007 Salamanca, Spain
Biochim Biophys Acta 1777:789-93. 2008..This may have important implications for our understanding of the mechanisms controlling neuronal survival during oxidative stress and bioenergetic crisis...
Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxideJ P Bolanos
Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
Biochem Soc Trans 35:1224-7. 2007..This may have implications for our understanding of the mechanisms of neurodegeneration due to oxidative and nitrosative stress...- Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implicationsJuan P Bolanos
Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Spain
Adv Drug Deliv Rev 61:1299-315. 2009..Drug therapies directed toward providing safer mitochondria are currently under both pre- and clinical investigations... - Modulation of astroglial energy metabolism by nitric oxideJuan P Bolanos
Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca Instituto de Neurociencias de Castilla y León, Centro Nacional de Investigaciones Cardiovasculares, Campus Miguel de Unamuno, Salamanca, Spain
Antioxid Redox Signal 8:955-65. 2006..The stimulation of these glucose-metabolizing pathways by NO would represent a transient attempt by the glial cells to compensate for energy impairment and oxidative stress, and thus to emerge from an otherwise pathological outcome... - Regulation of glucose metabolism by nitrosative stress in neural cellsJuan P Bolanos
Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Avda del Campo Charro, 37007 Salamanca, Spain
Mol Aspects Med 25:61-73. 2004.... - Provoking neuroprotection by peroxynitriteJuan P Bolanos
Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
Curr Pharm Des 10:867-77. 2004..In view of the potential cytoprotective function of peroxynitrite, further studies specifically focused on elucidating the possible therapeutic potential of peroxynitrite are sure to appear... - The pentose-phosphate pathway in neuronal survival against nitrosative stressJuan P Bolanos
Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, 37007 Salamanca, Spain
IUBMB Life 62:14-8. 2010..These results suggest that the antioxidant fragility of neurons may be compensated by the PPP at the expense of inhibiting bioenergetic glycolysis... - Glycolysis: a bioenergetic or a survival pathway?Juan P Bolanos
Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Salamanca, Spain
Trends Biochem Sci 35:145-9. 2010.... - Nitric oxide mediates brain mitochondrial damage during perinatal anoxiaJ P Bolanos
Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
Brain Res 787:117-22. 1998..Our results suggest that brain mitochondrial dysfunction leading to energy deficiency during perinatal asphyxia is a .NO-mediated process... 
Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegenerationP Rodríguez-Rodríguez
Departamento de Bioquimica y Biologia Molecular, Instituto de Neurociencias de Castilla y Leon, Universidad de Salamanca, Edificio Departamental, Spain
Cell Death Differ 19:1582-9. 2012..These results reveal that, by inhibition of APC(Cdh1), glutamate receptors activation stabilizes PFKFB3 thus switching neuronal metabolism leading to oxidative damage and neurodegeneration...- Depletion of glutathione up-regulates mitochondrial complex I expression in glial cellsO L Vásquez
Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Spain
J Neurochem 76:1593-6. 2001..These results could offer further insight into the different degree of cellular susceptibility observed in glial vs. neuronal cells against oxidative stress... - Evaluation of the efficacy of potential therapeutic agents at protecting against nitric oxide synthase-mediated mitochondrial damage in activated astrocytesJ P Bolanos
Department of Neurochemistry, Institute of Neurology, London, UK
Brain Res Brain Res Protoc 1:258-62. 1997..On the basis of this phenomenon, we propose that activated astrocytes represent a suitable system for studying the efficacy of potential therapeutic agents at protecting from nitric oxide synthase-mediated mitochondrial damage... - Roles of nitric oxide in brain hypoxia-ischemiaJ P Bolanos
Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007, Salamanca, Spain
Biochim Biophys Acta 1411:415-36. 1999..However, there is a simultaneous compensatory response through eNOS activation within the endothelium of blood vessels, which mediates vasodilation and hence increases blood flow to the damaged brain area... - Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stressJ I Diaz Hernandez
Unidad de Investigacion, Hospital Universitario de Salamanca Instituto de Estudios Ciencias de la Salud de Castilla y León, Salamanca, Spain
Cell Death Differ 14:1211-21. 2007..Thus, in the mild progressive damage likely occur in neurodegenerative diseases, PARP-1 activation plays a neuroprotective role that should be taken into account when considering therapeutic strategies... - Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiationJ Cuende
Unidad de Investigacion, Hospital Universitario de Salamanca, Instituto de Estudios de Ciencias de la Salud de Castilla y Leon, Salamanca, Spain
Oncogene 27:3339-44. 2008..Thus, retinoic acid downregulates Rae1, hence facilitating APC(Cdh1)-mediated Skp2 degradation leading to the arrest of cell cycle progression and neuroblastoma differentiation... - Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytesCinzia Dello Russo
Veterans Affairs Chicago Health Care System West Side Division, Chicago, Illinois, 60680, USA
J Biol Chem 278:5828-36. 2003..These results demonstrate that TZDs modify astrocyte metabolism and mitochondrial function, which could be beneficial in neurological conditions where glucose availability is reduced...