Rodrigo Bermejo

Summary

Affiliation: Insitute For Functional Biology and Genomics
Location: Salamanca, Spain
URL: http://www.imb.usal-csic.es/grupos/rbm.htm
Summary:
Basic research in mechanisms granting genome integrity.

Publications

  1. pmc Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization
    Rodrigo Bermejo
    Department of Biochemistry, Instituto de Investigaciones Biomedicas Alberto Sols, Universidad Autonoma de Madrid, CSIC, Arturo Duperier, 4 28029 Madrid, Spain
    Mol Biol Cell 13:3989-4000. 2002
  2. pmc G-quadruplex-induced instability during leading-strand replication
    Judith Lopes
    Recombinaison et Instabilité Génétique, Institut Curie Centre de Recherche, CNRS UMR3244, Universite Pierre et Marie Curie, Paris Cedex 05, France
    EMBO J 30:4033-46. 2011
  3. pmc The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
    Rodrigo Bermejo
    Fondazione Istituto FIRC di Oncologia Molecolare IFOM at IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Cell 146:233-46. 2011
  4. pmc Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles
    Belén Gómez-González
    Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla CSIC, Sevilla, Spain
    EMBO J 30:3106-19. 2011
  5. pmc Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements
    Daniele Fachinetti
    Fondazione IFOM, Istituto FIRC di Oncologia Molecolare IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Mol Cell 39:595-605. 2010
  6. doi ChIP-on-chip analysis of DNA topoisomerases
    Rodrigo Bermejo
    Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology Foundation, Milan, Italy
    Methods Mol Biol 582:103-18. 2009
  7. doi Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription
    Rodrigo Bermejo
    Fondazione IFOM Istituto FIRC di Oncologia Moleculare IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Cell 138:870-84. 2009
  8. pmc Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation
    Ylli Doksani
    FIRC Institute of Molecular Oncology Foundation IFOM IEO Campus and DSBB Università degli Studi di Milano, Via Adamello 16, 20139 Milan, Italy
    Cell 137:247-58. 2009
  9. doi SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination
    Alix Kerrest
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR 927, 25 rue du Dr Roux, F 75015 Paris, France
    Nat Struct Mol Biol 16:159-67. 2009
  10. pmc Cohesion by topology: sister chromatids interlocked by DNA
    Rodrigo Bermejo
    Fondazione Italiana per la Ricerca sul Cancro FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Genes Dev 22:2297-301. 2008

Collaborators

Detail Information

Publications15

  1. pmc Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization
    Rodrigo Bermejo
    Department of Biochemistry, Instituto de Investigaciones Biomedicas Alberto Sols, Universidad Autonoma de Madrid, CSIC, Arturo Duperier, 4 28029 Madrid, Spain
    Mol Biol Cell 13:3989-4000. 2002
    ..Our results show that both cdt1 and cdc6 are differentially regulated during megakaryocytic differentiation and suggest an active role of cdc6 in endomitosis...
  2. pmc G-quadruplex-induced instability during leading-strand replication
    Judith Lopes
    Recombinaison et Instabilité Génétique, Institut Curie Centre de Recherche, CNRS UMR3244, Universite Pierre et Marie Curie, Paris Cedex 05, France
    EMBO J 30:4033-46. 2011
    ..The asymmetrical behaviour of G-quadruplex prone sequences during replication has implications for their evolutionary dynamics within genomes, including the maintenance of G-rich telomeres...
  3. pmc The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
    Rodrigo Bermejo
    Fondazione Istituto FIRC di Oncologia Molecolare IFOM at IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Cell 146:233-46. 2011
    ....
  4. pmc Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles
    Belén Gómez-González
    Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla CSIC, Sevilla, Spain
    EMBO J 30:3106-19. 2011
    ..Our work establishes a genome-wide function for THO-Sub2 in transcription elongation and mRNP biogenesis that function to prevent the accumulation of transcription-mediated replication obstacles, including R-loops...
  5. pmc Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements
    Daniele Fachinetti
    Fondazione IFOM, Istituto FIRC di Oncologia Molecolare IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Mol Cell 39:595-605. 2010
    ..We propose that in eukaryotes, replication fork barriers, Rrm3, and Top2 coordinate replication fork progression and fusion at TERs, thus counteracting abnormal genomic transitions...
  6. doi ChIP-on-chip analysis of DNA topoisomerases
    Rodrigo Bermejo
    Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology Foundation, Milan, Italy
    Methods Mol Biol 582:103-18. 2009
    ..By using this approach, novel aspects of DNA topoisomerase function in chromosome metabolism might be unmasked...
  7. doi Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription
    Rodrigo Bermejo
    Fondazione IFOM Istituto FIRC di Oncologia Moleculare IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Cell 138:870-84. 2009
    ..We propose that an Hmo1-dependent epigenetic signature together with Top2 mediate an S phase architectural pathway to preserve genome integrity...
  8. pmc Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation
    Ylli Doksani
    FIRC Institute of Molecular Oncology Foundation IFOM IEO Campus and DSBB Università degli Studi di Milano, Via Adamello 16, 20139 Milan, Italy
    Cell 137:247-58. 2009
    ..Our findings have implications for those genome instability syndromes that accumulate DNA breaks during S phase and for forks encountering eroding telomeres...
  9. doi SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination
    Alix Kerrest
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR 927, 25 rue du Dr Roux, F 75015 Paris, France
    Nat Struct Mol Biol 16:159-67. 2009
    ..In the absence of Srs2 or Sgs1, DNA damage accumulates and is processed by homologous recombination, triggering repeat rearrangements...
  10. pmc Cohesion by topology: sister chromatids interlocked by DNA
    Rodrigo Bermejo
    Fondazione Italiana per la Ricerca sul Cancro FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Genes Dev 22:2297-301. 2008
    ..They propose that DNA precatenanes, arising during replication fork progression, hold sister chromatids together...
  11. pmc Top1- and Top2-mediated topological transitions at replication forks ensure fork progression and stability and prevent DNA damage checkpoint activation
    Rodrigo Bermejo
    Fondazione Italiana per la Ricerca sul Cancro FIRC, Institute of Molecular Oncology Foundation IFOM IEO Campus and DSBB Università degli Studi di Milano, 20139 Milan, Italy
    Genes Dev 21:1921-36. 2007
    ..A failure in resolving fork-related topological constrains during S phase may therefore result in abnormal chromosome transitions, DNA damage checkpoint activation, and chromosome breakage during segregation...
  12. pmc A novel E2 box-GATA element modulates Cdc6 transcription during human cells polyploidization
    Nuria Vilaboa
    Department of Biochemistry, Instituto de Investigaciones Biomédicas A Sols, Universidad Autonoma CSIC, Arturo Duperier, 4, 28029 Madrid, Spain
    Nucleic Acids Res 32:6454-67. 2004
    ..Altogether, these data suggest that cdc6 expression could be actively maintained during megakaryocytic differentiation through transcriptional mechanisms involving specific cis- and trans-regulatory elements...
  13. pmc The DNA damage checkpoint response to replication stress: A Game of Forks
    Rachel Jossen
    Instituto de Biología Funcional y Genómica, CSIC USAL Salamanca, Spain
    Front Genet 4:26. 2013
    ..We also highlight the checkpoint function as an anti-cancer barrier preventing cells malignant transformation following oncogene-induced replication stress...
  14. doi Preserving the genome by regulating chromatin association with the nuclear envelope
    Rodrigo Bermejo
    IFOM Fondazione Istituto FIRC di Oncologia Molecolare at the IFOM European Institute of Oncology Campus, Via Adamello 16, 20139 Milan, Italy
    Trends Cell Biol 22:465-73. 2012
    ..Here, we review the interplay between the nuclear envelope, chromatin and DNA damage checkpoint pathways, and discuss the physiological and pathological implications of these associations...
  15. doi Preventing replication stress to maintain genome stability: resolving conflicts between replication and transcription
    Rodrigo Bermejo
    Fondazione Istituto FIRC di Oncologia Molecolare, at IFOM IEO Campus Via Adamello 16, 20139 Milan, Italy
    Mol Cell 45:710-8. 2012
    ..The evolutionary implications of such conflicts on genome dynamics and their potential impact on oncogenic stress are discussed...