A Arnaiz-Villena

Summary

Affiliation: Universidad Complutense
Country: Spain

Publications

  1. ncbi The origin of Palestinians and their genetic relatedness with other Mediterranean populations
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Hum Immunol 62:889-900. 2001
  2. ncbi Phylogeography of crossbills, bullfinches, grosbeaks, and rosefinches
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Cell Mol Life Sci 58:1159-66. 2001
  3. ncbi Historic genomics: an emergent discipline
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology Hospital 12 de Octubre, Universidad Complutense 28041, Madrid, Spain
    Hum Immunol 62:869-70. 2001
  4. ncbi HLA genes in Macedonians and the sub-Saharan origin of the Greeks
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 57:118-27. 2001
  5. ncbi The correlation between languages and genes: the Usko-Mediterranean peoples
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, 28041, Madrid, Spain
    Hum Immunol 62:1051-61. 2001
  6. ncbi HLA genes in Mexican Mazatecans, the peopling of the Americas and the uniqueness of Amerindians
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 56:405-16. 2000
  7. ncbi The evolution of the MHC-G gene does not support a functional role for the complete protein
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunol Rev 183:65-75. 2001
  8. ncbi Population genetic relationships between Mediterranean populations determined by HLA allele distribution and a historic perspective
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, Universidad Complutense, Madrid, Spain
    Tissue Antigens 60:111-21. 2002
  9. ncbi HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians
    P Sanchez-Velasco
    Department of Immunology and Molecular Biology, Hosp 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 61:384-92. 2003
  10. ncbi High polymorphism of Mhc-E locus in non-human primates: alleles with identical exon 2 and 3 are found in two different species
    M Alvarez
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 49:160-7. 1997

Collaborators

Detail Information

Publications78

  1. ncbi The origin of Palestinians and their genetic relatedness with other Mediterranean populations
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Hum Immunol 62:889-900. 2001
    ..This flow overtly contradicts the demic diffusion model of western Mediterranean populations substitution by agriculturalists coming from the Middle East in the Mesolithic-Neolithic transition...
  2. ncbi Phylogeography of crossbills, bullfinches, grosbeaks, and rosefinches
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Cell Mol Life Sci 58:1159-66. 2001
    ....
  3. ncbi Historic genomics: an emergent discipline
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology Hospital 12 de Octubre, Universidad Complutense 28041, Madrid, Spain
    Hum Immunol 62:869-70. 2001
    ..The study of diseased genes in populations will also give rise to epidemiological genomics, which will have a remarkable impact in the predictive medicine of future societies...
  4. ncbi HLA genes in Macedonians and the sub-Saharan origin of the Greeks
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 57:118-27. 2001
    ..The time period when these relationships might have occurred was ancient but uncertain and might be related to the displacement of Egyptian-Ethiopian people living in pharaonic Egypt...
  5. ncbi The correlation between languages and genes: the Usko-Mediterranean peoples
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, 28041, Madrid, Spain
    Hum Immunol 62:1051-61. 2001
    ..Therefore, the correlation between genes and languages may exist at a macrogeographical level, but not when more precise microgeographical studies are done, as shown in the present "usko-Mediterranean" peoples model...
  6. ncbi HLA genes in Mexican Mazatecans, the peopling of the Americas and the uniqueness of Amerindians
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 56:405-16. 2000
    ..Meso and South American Amerindians tend to remain isolated in the Neighbor-Joining, correspondence and plane genetic distance analyses...
  7. ncbi The evolution of the MHC-G gene does not support a functional role for the complete protein
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunol Rev 183:65-75. 2001
    ..Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele are healthy and do not show birth pathologies...
  8. ncbi Population genetic relationships between Mediterranean populations determined by HLA allele distribution and a historic perspective
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, Universidad Complutense, Madrid, Spain
    Tissue Antigens 60:111-21. 2002
    ..5) Iberians, including Basques, are related to north-African Berbers. 6) Present-day Algerian and Moroccan urban and country people show an indistinguishable Berber HLA profile...
  9. ncbi HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians
    P Sanchez-Velasco
    Department of Immunology and Molecular Biology, Hosp 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 61:384-92. 2003
    ..These populations have been compared with neighbouring ones and other Mediterraneans by using neighbour-joining dendrograms and plane genetic distances...
  10. ncbi High polymorphism of Mhc-E locus in non-human primates: alleles with identical exon 2 and 3 are found in two different species
    M Alvarez
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 49:160-7. 1997
    ..In addition, two Macaca mulatta individuals show an Mhc-E locus duplication. Finally, phylogenetic tree analysis shows that Mhc class I molecules found in Saguinus oedipus (described as Mhc-G homologues) are closer to Mhc-E sequences...
  11. ncbi HLA-E polymorphism in Amerindians from Mexico (Mazatecans), Colombia (Wayu) and Chile (Mapuches): evolution of MHC-E gene
    A Arnaiz-Villena
    Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:132-5. 2007
    ....
  12. ncbi Allelic diversity at the primate Mhc-G locus: exon 3 bears stop codons in all Cercopithecinae sequences
    M J Castro
    Department of Immunology, Hospital Universitario, Universidad Complutense, Madrid, Spain
    Immunogenetics 43:327-36. 1996
    ..The G proteins may also be different. This indicates that the Mhc-G function may not be peptide presentation to the clonotypic T-cell receptor...
  13. ncbi Homozygous HLA-G*0105N healthy individuals indicate that membrane-anchored HLA-G1 molecule is not necessary for survival
    M J Casro
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 56:232-9. 2000
    ..Also, individuals homozygous for HLA-G*0105N are healthy and with no indications of immunodeficiency or autoimmunity...
  14. ncbi Allelic diversity at the primate MHC-DMB locus: presence of a conserved tyrosine inhibitory motif in the cytoplasmic tail
    M Alvarez
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 51:174-82. 1998
    ..Finally, a clade grouping human and gorilla DMB cDNA sequences is obtained using a dendrogram (as for C4d trees); this is in contrast to others' results that obtain a human/chimpanzee clade using different DNA sequences...
  15. ncbi Origin of Mayans according to HLA genes and the uniqueness of Amerindians
    E Gomez-Casado
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, 28041 Madrid, Spain
    Tissue Antigens 61:425-36. 2003
    ..Meso and South American Amerindians tend to remain isolated in the neighbour joining analyses...
  16. ncbi Description of a new HLA-E (E*01031) allele and its frequency in the Spanish population
    E Gomez-Casado
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Hum Immunol 54:69-73. 1997
    ..However, the intron 2 sequence of the E*0102 allele bears a two-base deletion not found in apes...
  17. ncbi HLA molecular markers in Tuvinians: a population with both Oriental and Caucasoid characteristics
    J Martinez-Laso
    Department of Immunology and Molecular Biology, Universidad Complutense, Madrid, Spain
    Ann Hum Genet 65:245-61. 2001
    ..The 'more than one wave' model for the peopling of the Americas is supported...
  18. ncbi The origin of Cretan populations as determined by characterization of HLA alleles
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 53:213-26. 1999
    ..C., when desert desiccation began. They also could be part of the stock that gave rise to Sumerians, Cretans and Iberians; this is supported by both linguistic and HLA genetic data...
  19. ncbi Evolution of MHC-G in primates: a different kind of molecule for each group of species
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    J Reprod Immunol 43:111-25. 1999
    ..The data are concordant with the postulated immune inhibitory function for MHC-G in Old World monkeys, anthropoids and humans both at placental and inflammatory level...
  20. ncbi Evolutionary relationships between HLA-B alleles as indicated by an analysis of intron sequences
    E Gomez-Casado
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 53:153-60. 1999
    ..Finally, the precise knowledge of these non-coding regions could be important for developing DNA base typing strategies for the HLA-B alleles...
  21. ncbi New species-specific alleles at the primate MHC-G locus
    A Corell
    Department of Immunology, 12th of October University Hospital, Complutense University of Madrid, Spain
    Hum Immunol 41:52-5. 1994
    ..Finally, phylogenetic relationships among the six MHC-G alleles, tamarins G-"like" alleles, and other human class I genes (both "classical" and "nonclassic") are discussed...
  22. ncbi Three new HLA-G alleles and their linkage disequilibria with HLA-A
    P Morales
    Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 38:323-31. 1993
    ..It may be inferred from preliminary data that in primates HLA-A/G haplotypes bearing G*II may have appeared later than those bearing G*I...
  23. ncbi HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 57:308-17. 2001
    ..e. Anatolian Hittite and Hurrian groups (older than 2000 B.C.). These may have given rise to present-day Kurdish, Armenian and Turkish populations...
  24. doi HLA genes in Uros from Titikaka Lake, Peru: origin and relationship with other Amerindians and worldwide populations
    A Arnaiz-Villena
    Department of Immunology, University Complutense, The Madrid Regional Blood Center, Madrid, Spain
    Int J Immunogenet 36:159-67. 2009
    ....
  25. ncbi Generation of the HLA-B35, -B5, -B16, and B15 groups of alleles studied by intron 1 and 2 sequence analysis
    E Gomez-Casado
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 46:469-76. 1997
    ..Intronic sequences are also potentially useful to design DNA typing strategies...
  26. ncbi Complete cDNA sequences of the DRB6 gene from humans and chimpanzees: a possible model of a stop codon readingthrough mechanism in primates
    M A Moreno-Pelayo
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera Andalucia, 28041 Madrid, Spain
    Immunogenetics 49:843-50. 1999
    ....
  27. ncbi A new HLA-Cw allele (Cw*0808) found in a Colombian Mestizo individual possibly generated by an intralocus/interloci gene conversion
    C Silvera-Redondo
    Departamento de Inmunologia y Biologia Molecular, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 51:1053-7. 2000
  28. ncbi Lack of MHC-G4 and soluble (G5, G6) isoforms in the higher primates, Pongidae
    M J Castro
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Hum Immunol 61:1164-8. 2000
    ....
  29. doi HLA in Jaidukama: an Amerindian secluded Colombian population with new haplotypes and Asian and Pacific-shared alleles
    J Martinez-Laso
    Unidad de Inmunoterapia Celular, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    Mol Biol Rep 38:3689-701. 2011
    ..This work may also be useful for future transplant programs in the area...
  30. ncbi Allelic diversity at the primate major histocompatibility complex DRB6 locus
    A Corell
    Department of Immunology, Hospital 12 de Octubre, Madrid, Spain
    Immunogenetics 36:33-8. 1992
    ..Also, data are presented supporting that DRB6 may be one of the eldest genes of the DRB family, thus one of the first to diverge from the ancestral DRB gene...
  31. ncbi Description of HLA-A*6803 and A*68N in Mazatecan Indians from Mexico
    G Vargas-Alarcon
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera de Andalucia, 28041 Madrid, Spain
    Immunogenetics 46:446-7. 1997
  32. ncbi Lack of HLA-G soluble isoforms in Graves-Basedow thyrocytes and complete cDNA sequence of the HLA-G*01012 allele
    M J Castro
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Eur J Immunogenet 25:311-5. 1998
    ....
  33. ncbi C4d DNA sequences of two infrequent human allotypes (C4A13 and C4B12) and the presence of signal sequences enhancing recombination
    N Martinez-Quiles
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera de Andalucia, Madrid, Spain
    J Immunol 161:3438-43. 1998
    ....
  34. ncbi The Old World sparrows (genus Passer) phylogeography and their relative abundance of nuclear mtDNA pseudogenes
    L M Allende
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, 28041 Spain
    J Mol Evol 53:144-54. 2001
    ..European and American Emberizinae sparrows are closely related to each other and seem to be the earliest species that radiated among the studied songbirds (all in the Miocene Epoch)...
  35. ncbi Description of a novel HLA-B35 (B*3514) allele found in a Mexican family of Nahua Aztec descent
    G Vargas-Alarcon
    Department of Immunology, Universidad Complutense, Madrid, Spain
    Hum Immunol 45:148-51. 1996
    ....
  36. ncbi C4 gene polymorphism in primates: evolution, generation, and Chido and Rodgers antigenicity
    E Paz-Artal
    Immunología Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 40:381-96. 1994
    ..Finally, further data have been obtained that support trans-species conservation of A-ness and B-ness and the existence of trans-specifically conserved allelic motifs, both in intronic and exonic sequences...
  37. doi The peopling of Madeira Archipelago (Portugal) according to HLA genes
    A Arnaiz-Villena
    Department of Immunology, University Complutense, The Madrid Regional Blood Center, Madrid, Spain
    Int J Immunogenet 36:9-14. 2009
    ....
  38. ncbi Complete cDNA sequence of the HLA-DRB1*09012 allele
    N Martinez-Quiles
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Eur J Immunogenet 25:307-9. 1998
    ..In the DR9 antigen, two synonymous allelic variants (DRB1*09011 and 09012) were officially recognized, though it was later found that the first one contained an error and both sequences were, thus, identical...
  39. ncbi A novel HLA-A*6816 allele possible generated by a point mutation in a Chilean from Punta Arenas (Magellan Strait)
    E Gomez-Casado
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 51:257-60. 2000
  40. ncbi MHC-F DNA sequences in bonobo, gorilla and orangutan
    R Rojo
    Department of Inmunologia, H 12 Octubre, H Clinico San Carlos, Universidad Complutense, Madrid, Spain
    Tissue Antigens 66:277-83. 2005
    ..The evolutionary pathway of the six-base-pair deletion at exon 2 existing in some primates is put forward...
  41. ncbi HLA-G polymorphism and evolution
    A Arnaiz-Villena
    Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:156-9. 2007
    ..This seems to suggest that MHC-G genes in New World primates are not orthologous and that their function may be similar to that of classical presenting MHC genes...
  42. doi A novel allele, HLA-G*010114, with a non-coding DNA base change in exon 2
    A Arnaiz-Villena
    Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain
    Tissue Antigens 71:258-9. 2008
    ..This relatively high HLA-G DNA polymorphism in comparison with their protein polymorphism suggests that evolutionary forces are acting upon HLA-G for invariance. This may be related to the immunotolerogenic function postulated for HLA-G...
  43. ncbi Description of seven new non-human primate MHC-B alleles
    J Martinez-Laso
    Immunology Research Unit, Department of Microbiology, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 67:85-8. 2006
  44. ncbi Generation of the B*41 group of alleles as indicated by intron sequences
    J Martinez-Laso
    Immunology Research Unit, Department of Microbiology, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 67:70-4. 2006
    ..B*4105 and B*4106 could be generated from B*4101 allele by point mutations, and B*4103 generation is unclear due to the lack of intron 2. The importance of introns in HLA-B allele polymorphism generation is stressed...
  45. ncbi Differences in intron 2 sequences between B*39061 and B*39062 in Amerindians: comparison with those of B*3901, B*5101, and B*52012 alleles
    G Vargas-Alarcon
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera de Andalucia, 28041 Madrid, Spain
    Immunogenetics 45:436-9. 1997
  46. ncbi A new HLA-B15 allele (B*1541) found in a Mexican of Nahua (Aztec) descent
    A Olivo-Díaz
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera de Andalucia, E 28041 Madrid, Spain
    Immunogenetics 48:148-51. 1998
  47. ncbi Description of a new HLA-B40 allele (B*4011) found in a Mexican individual of Nahua (Aztec) descent
    G Vargas-Alarcon
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera Andalucia, 28041 Madrid, Spain
    Immunogenetics 46:359-60. 1997
  48. ncbi Origin of Aymaras from Bolivia and their relationship with other Amerindians according to HLA genes
    A Arnaiz-Villena
    Department of Immunology, Universidad Complutense, Madrid, Spain
    Tissue Antigens 65:379-90. 2005
    ..Moreover, it is observed a closer relatedness of Aymaras with Amerindians from the Amazon Basin and Chaco lowlands, compared to Quechuans...
  49. ncbi Primate Mhc-E and -G alleles
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera Andalucia, E 28041 Madrid, Spain
    Immunogenetics 46:251-66. 1997
  50. ncbi Transcription and weak expression of HLA-DRB6: a gene with anomalies in exon 1 and other regions
    V M Fernandez-Soria
    Department of Immunology, Hospital Universitario 12 de Octubre, Universidad Complutense, Carretera de Andalucia, E 28041 Madrid, Spain
    Immunogenetics 48:16-21. 1998
    ..e., in HLA-G). Finally, the presence of mature HLA-DRB6 mRNA molecules supports the notion that splicing may take place even in the absence of a canonical 3'UT polyadenylation signal...
  51. ncbi Exon 2 DNA sequence of the HLA-DRw13b allele obtained from genomes of five different individuals
    A Corell
    Department of Immunology, Hospital Doce de Octubre, Madrid, Spain
    Mol Immunol 27:313-6. 1990
    ..1 as donors and in addition, a non-conservative point mutation at base 221. The relationship between this HLA sequence characteristics and certain diseases susceptibility is discussed...
  52. pmc A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function-associated antigen-1 functional association in humans
    L M Allende
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain
    Immunology 99:440-50. 2000
    ..It may also be used in the future in cellular models for in vitro gene-therapy trials...
  53. pmc Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia
    M A Garcia-Perez
    Department of Immunology, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain
    Clin Exp Immunol 123:472-80. 2001
    ..The possible link among specific ATM mutations and abnormal immune responses is unknown...
  54. ncbi A new HLA-B35 (B*3516) allele found in a Mexican of Nahua (Aztec) descent
    G Vargas-Alarcon
    Department of Immunology and Rheumatology, Hospital 12 de Octubre, Universidad Complutense, Carretera Andalucia, 28041 Madrid, Spain
    Immunogenetics 43:244-5. 1996
  55. ncbi Successful in vitro immortalization of human intestinal mucosal lymphocytes with Herpesvirus saimiri
    J M Martin-Villa
    Departamento de Inmunologia, Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 52:430-4. 1998
    ..CD80 expression was found on 80-90% of the cells. These immortal cell lines of intestinal origin may be useful in future experiments aimed at elucidating the role of mucosal lymphocytes in health and disease...
  56. ncbi Coeliac- and enteropathy-associated autoantibodies in Spanish insulin-dependent diabetes mellitus patients and their relation to HLA antigens
    J M Martin-Villa
    Departament of Immunology, Hospital 12 de Octubre, Universidad Complutense de Madrid, 28041 Madrid, Spain
    J Diabetes Complications 15:38-43. 2001
    ....
  57. ncbi HLA-G, -E and -F: allelism, function and evolution
    J Moscoso
    Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain
    Transpl Immunol 17:61-4. 2006
    ..A strong positive directional selection is acting for maintaining the observed low polymorphism on E, F and G loci in human and apes. Invariance must be important for this non-classical class I proteins function...
  58. ncbi A new HLA-G allele (HLA-G*0105N) and its distribution in the Spanish population
    M B Suárez
    Department of Immunology, Hospital 12 de Octobre, Universidad Complutense, Carretera de Andalucia, 28041 Madrid, Spain
    Immunogenetics 45:464-5. 1997
  59. ncbi Cathepsin C gene: First compound heterozygous patient with Papillon-Lefèvre syndrome and a novel symptomless mutation
    L M Allende
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Hum Mutat 17:152-3. 2001
    ..On the other hand, PLS patients are ameliorated by retinoids, which indicates that retinoids may be used as therapeutic agents in this immune system deficiency...
  60. pmc A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency
    L M Allende
    Department of Immunology, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, 28041 Madrid, Spain
    Clin Diagn Lab Immunol 8:133-7. 2001
    ..Future research on these nontruncating mutations will make it possible to develop new therapeutical alternatives in this group of patients...
  61. ncbi Description of two new HLA-DRB alleles (DRB1*0310 and DRB3*01012) found in a Spanish infant
    N Martinez-Quiles
    Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 49:658-61. 1997
  62. ncbi A new HLA-B15 allele (B*1522) found in Bari-Motilones Amerindians in Venezuela: comparison of its intron 2 sequence with those of B*1501 and B*3504
    J Martinez-Laso
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 43:108-9. 1996
  63. ncbi MHC-F polymorphism and evolution
    J Moscoso
    Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:136-9. 2007
    ..It is possible that the MHC-F protein could be involved, together with MHC-G and MHC-E, in the natural killer cell activity regulation, although rhesus macaque cannot express complete surface MHC-G orthologue molecules...
  64. ncbi Higher incidence of autoantibodies in X-linked chronic granulomatous disease carriers: random X-chromosome inactivation may be related to autoimmunity
    J M Martin-Villa
    Inmunologia, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Spain
    Autoimmunity 31:261-4. 1999
    ..It appears then as if random inactivation of the X-chromosome in these pathologies, may favor the expression of an autoimmune phenotype in patients and carriers...
  65. ncbi T-lymphocyte dysfunctions occurring together with apical gut epithelial cell autoantibodies
    J M Martin-Villa
    Department of Immunology, Hospital 12 de Octubre, Madrid, Spain
    Gastroenterology 101:390-7. 1991
    ....
  66. ncbi A novel HLA-G allele (HLA-G*0108) with an alpha-3 domain amino acid change
    J Moscoso
    Department of Immunology, Universidad Complutense, Madrid Regional Blood Center, Madrid, Spain
    Tissue Antigens 70:171-3. 2007
    ..HLA-G molecules give negative signals to Natural Killer and T lymphocytes. In the present paper, a new allele, HLA-G*08, is described, which may be useful for monitoring transplants and for HLA and disease studies...
  67. ncbi 14th International HLA and Immunogenetics Workshop: report on non-classical class I genes
    A Arnaiz-Villena
    Departamento de Inmunologia, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:130-1. 2007
    ..In the present Workshop, several papers were presented addressing detection, evolutive and functional issues of these proteins. The general inhibitory immunological function of these proteins is put forward...
  68. ncbi Biochemical basis of a novel T lymphocyte receptor immunodeficiency by immunohistochemistry. A possible CD3 gamma abnormality
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Madrid, Spain
    Lab Invest 64:675-81. 1991
    ..The disrupted TCR thus formed, containing Ti alpha beta heterodimers and CD3 epsilon and CD3 delta subunits, but lacking normal CD3 gamma, would in this scheme lack the conformational framework determinants recognized by WT31 and BMA031...
  69. ncbi Brief report: primary immunodeficiency caused by mutations in the gene encoding the CD3-gamma subunit of the T-lymphocyte receptor
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense de Madrid, Spain
    N Engl J Med 327:529-33. 1992
  70. ncbi Polymorphism and distribution of HLA-DR2 alleles in Mexican populations
    G Vargas-Alarcon
    Cellular Biology Section, Physiology Department, Instituto Nacional de la Nutricion Salvador Zubiran, D F, Mexico, Mexico
    Hum Immunol 62:286-91. 2001
    ....
  71. ncbi Both morphological and molecular characters support speciation of South American siskins by sexual selection
    R van den Elzen
    Alexander Koenig Research Institute and Zoological Museum, Bonn, Germany
    Cell Mol Life Sci 58:2117-28. 2001
    ..Each of the three amino acid changes occur in each of the three postulated evolutionary groups...
  72. ncbi HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, UK
    Tissue Antigens 63:555-61. 2004
    ..In addition, knowing which alleles do/do not occur in this population will aid in the distinction of ambiguities which result from the use of many of the typing kits available...
  73. ncbi The origin and spread of the HFE-C282Y haemochromatosis mutation
    S Distante
    Hepatology Unit, Aker University Hospital, Oslo, Norway
    Hum Genet 115:269-79. 2004
    ..We conclude that the HFE C282Y mutation occurred in mainland Europe before 4,000 BC...
  74. ncbi Class II allele and haplotype frequencies in Mexican systemic lupus erythematosus patients: the relevance of considering homologous chromosomes in determining susceptibility
    G Vargas-Alarcon
    Cellular Biology Section, Physiology Department, Instituto Nacional de Cardiologia Ignacio Chavez, Tlalpan, Mexico
    Hum Immunol 62:814-20. 2001
    ....
  75. ncbi Lack of association between the polymorphism at the heat-shock protein (HSP70-2) gene and systemic lupus erythematosus (SLE) in the Mexican mestizo population
    G Vargas-Alarcon
    Cellular Biology Section, Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Tlalpan 14080, Mexico City
    Genes Immun 1:367-70. 2000
    ....
  76. ncbi High-resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population
    J E Garcia-Ortiz
    Departamento de Inmunobiología Molecular, Centro de Investigacion Biomedica, Facultad de Medicina, Universidad Autonoma de Coahuila, 27000 Torreón, Mexico
    Tissue Antigens 68:135-46. 2006
    ....
  77. ncbi Killer immunoglobulin receptor gene and allele frequencies in Caucasoid, Oriental and Black populations from different continents
    D Middleton
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Tissue Antigens 71:105-13. 2008
    ..allelefrequencies.net). In total, 5134 individuals were analysed and the populations grouped, with some exceptions, according to a geographical gradient...
  78. ncbi Cell surface phenotype and cytokine secretion in Caco-2 cell cultures: increased RANTES production and IL-2 transcription upon stimulation with IL-1beta
    C Rodriguez-Juan
    Inmunologia, Fac Medicina, Universidad Complutense de Madrid, Spain
    Tissue Cell 33:570-9. 2001
    ..Cytokine analysis showed an increased RANTES synthesis and IL-2 transcription upon stimulation with IL-1beta. Finally, amongst RANTES receptors, CCR1 is found on Caco-2 cells, whereas CCR3 and CCR5 are not...