C Alarcon de la Lastra

Summary

Affiliation: Universidad de Sevilla
Country: Spain

Publications

  1. ncbi request reprint An up-date of olive oil phenols in inflammation and cancer: molecular mechanisms and clinical implications
    A Cárdeno
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Curr Med Chem 20:4758-76. 2013
  2. ncbi request reprint Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications
    C Alarcon de la Lastra
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    Biochem Soc Trans 35:1156-60. 2007
  3. ncbi request reprint Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications
    C Alarcon de la Lastra
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Curr Pharm Des 13:933-62. 2007
  4. ncbi request reprint Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications
    Catalina Alarcón de la Lastra
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    Mol Nutr Food Res 49:405-30. 2005
  5. ncbi request reprint New pharmacological perspectives and therapeutic potential of PPAR-gamma agonists
    C Alarcon de la Lastra
    Departamento de Farmaco logía, Facultad de Farmacia, Universidad de Sevilla, C Profesor García González 2, 41012 Sevilla, Spain
    Curr Pharm Des 10:3505-24. 2004
  6. ncbi request reprint Role of L-arginine in ibuprofen-induced oxidative stress and neutrophil infiltration in gastric mucosa
    M D Jimenez
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain
    Free Radic Res 38:903-11. 2004
  7. ncbi request reprint Protective effect of melatonin on indomethacin-induced gastric injury in rats
    C Alarcon de la Lastra
    Laboratorio de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    J Pineal Res 26:101-7. 1999
  8. ncbi request reprint Extra-virgin olive oil-enriched diets reduce indomethacin-induced gastric oxidative damage in rats
    C Alarcon de la Lastra
    Department of Pharmacology, Faculty of Pharmacy, University of Sevilla, Sevilla, Spain
    Dig Dis Sci 47:2783-90. 2002
  9. ncbi request reprint Effects of cinitapride on gastric ulceration and secretion in rats
    C Alarcon de la Lastra
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Inflamm Res 47:131-6. 1998
  10. doi request reprint Extra-virgin olive oil-enriched diet modulates DSS-colitis-associated colon carcinogenesis in mice
    S Sánchez-Fidalgo
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González Street, 2 41012 Seville, Spain
    Clin Nutr 29:663-73. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint An up-date of olive oil phenols in inflammation and cancer: molecular mechanisms and clinical implications
    A Cárdeno
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Curr Med Chem 20:4758-76. 2013
    ....
  2. ncbi request reprint Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications
    C Alarcon de la Lastra
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    Biochem Soc Trans 35:1156-60. 2007
    ..The present paper is intended to provide the reader up-to-date information on the antioxidant and pro-oxidant properties of resveratrol and its clinical implications...
  3. ncbi request reprint Poly(ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications
    C Alarcon de la Lastra
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Curr Pharm Des 13:933-62. 2007
    ..This review is intended to provide an appreciation of new pharmacological perspectives of these remarkable drugs, summarize novel underlying mechanisms and discuss their potential clinical implications...
  4. ncbi request reprint Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications
    Catalina Alarcón de la Lastra
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    Mol Nutr Food Res 49:405-30. 2005
    ..Also, this review is intended to provide the reader an up-date of the bioavailability and pharmacokinetics of resveratrol and its impact on lifespan...
  5. ncbi request reprint New pharmacological perspectives and therapeutic potential of PPAR-gamma agonists
    C Alarcon de la Lastra
    Departamento de Farmaco logía, Facultad de Farmacia, Universidad de Sevilla, C Profesor García González 2, 41012 Sevilla, Spain
    Curr Pharm Des 10:3505-24. 2004
    ..Further work is needed to establish in detail the anti-proliferative and pro-differentiation mechanisms of PPARgamma activators and their efficacy in certain cancers...
  6. ncbi request reprint Role of L-arginine in ibuprofen-induced oxidative stress and neutrophil infiltration in gastric mucosa
    M D Jimenez
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain
    Free Radic Res 38:903-11. 2004
    ....
  7. ncbi request reprint Protective effect of melatonin on indomethacin-induced gastric injury in rats
    C Alarcon de la Lastra
    Laboratorio de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    J Pineal Res 26:101-7. 1999
    ..These results suggest that the protection afforded by the pineal hormone against indomethacin-induced gastric injury may be, in addition to other possible mechanisms, to its radical scavenging activity...
  8. ncbi request reprint Extra-virgin olive oil-enriched diets reduce indomethacin-induced gastric oxidative damage in rats
    C Alarcon de la Lastra
    Department of Pharmacology, Faculty of Pharmacy, University of Sevilla, Sevilla, Spain
    Dig Dis Sci 47:2783-90. 2002
    ..This effect may be partly due not only to reducing oxidative stress and neutrophil-induced toxicity but also to enhancing the glutathione antioxidant defense system...
  9. ncbi request reprint Effects of cinitapride on gastric ulceration and secretion in rats
    C Alarcon de la Lastra
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Inflamm Res 47:131-6. 1998
    ....
  10. doi request reprint Extra-virgin olive oil-enriched diet modulates DSS-colitis-associated colon carcinogenesis in mice
    S Sánchez-Fidalgo
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González Street, 2 41012 Seville, Spain
    Clin Nutr 29:663-73. 2010
    ..Several studies have shown that extra virgin olive oil (EVOO) might possess anti-inflammatory, antiproliferative and antiapoptotic effects. We have evaluated EVOO diet effects on the severity of repeated colitis-associated CRC...
  11. ncbi request reprint Role of prostaglandins and nitric oxide in gastric damage induced by metamizol in rats
    S Sanchez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Spain
    Inflamm Res 51:385-92. 2002
    ..diclofenac, NSAIDs that present different gastric tolerability and cyclooxygenase (COX) inhibition profiles...
  12. ncbi request reprint The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice
    A R Martin
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Profesor García González Street, 2, 41012, Seville, Spain
    Inflamm Res 54:145-51. 2005
    ..We have evaluated the efficacy of the selective cyclo-oxygenase (COX)-2 inhibitor, rofecoxib, for the prevention of experimental colitis...
  13. ncbi request reprint Gastroprotection and prostaglandin E2 generation in rats by flavonoids of Dittrichia viscosa
    C Alarcon de la Lastra
    Departamento de Farmacia y Tecnologia Farmaceutica, Laboratorio de Farmacodinamia, Facultad de Farmacia, Sevilla, Spain
    Planta Med 59:497-501. 1993
    ..These observations suggest that the gastroprotective effects of the flavonoid fraction from D. viscosa could be partly explained through non-prostaglandin-dependent mechanisms...
  14. ncbi request reprint Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces chronic colonic inflammation in rats
    M Sanchez-Hidalgo
    Department of Pharmacology, Faculty of Pharmacy, University of Sevilla, Profesor García González Street 2, 41012 Seville, Spain
    Biochem Pharmacol 69:1733-44. 2005
    ..We conclude that rosiglitazone represents a novel approach to the treatment of ulcerative colitis...
  15. ncbi request reprint Healing process induced by a flavonic fraction of Bidens aurea on chronic gastric lesion in rat. Role of angiogenesis and neutrophil inhibition
    M Martin Calero
    Laboratorio de Farmacologia, Facultad de Farmacia, Universidad de Sevilla, Espana
    Z Naturforsch C 51:570-7. 1996
    ..These results suggest that the recovery of vascularization of the ulcerated area and the decrease of neutrophil infiltration are involved in the antiulcerogenic effect of the flavonoid fraction of Bidens aurea...
  16. doi request reprint Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model
    Susana Sánchez-Fidalgo
    Department of Pharmacology, School of Pharmacy, University of Seville, Seville, Spain
    Eur J Nutr 51:497-506. 2012
    ..Many of these benefits are, in addition to its high proportion of oleic acid, due to the high content of phenolic compounds...
  17. ncbi request reprint Intestinal immunomodulation. Role of regulative peptides and promising pharmacological activities
    V Motilva
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
    Curr Pharm Des 14:71-95. 2008
    ..These collective findings implicate regulative peptides, receptors, or peptide-levels modulators, as important biological targets for developing intervention strategies against intestinal immunological disorders and cancers...
  18. ncbi request reprint Mediterranean diet and health: biological importance of olive oil
    C Alarcon de la Lastra
    Departamento de Farmacologia, Facultad de Farmacia, C Profesor García GonzAlez s n 41012 Sevilla, Spain
    Curr Pharm Des 7:933-50. 2001
    ..Finally, it has been demonstrated that a diet rich in olive oil is associated with a high percentage of gastric ulcer healing and affords a higher resistance against non steroidal antiinflammatory drugs-induced gastric ulcerogenesis...
  19. ncbi request reprint Gastric toxicity of racemic ketoprofen and its enantiomers in rat: oxygen radical generation and COX-expression
    C Alarcon de la Lastra
    Departamento de Farmacologia, Facultad de Farmacia, Sevilla, Spain
    Inflamm Res 51:51-7. 2002
    ..Changes in prostaglandin synthesis, cyclooxygenase expression and glutathione metabolism were also studied...
  20. ncbi request reprint New issues about melatonin and its effects on the digestive system
    V Motilva
    Departamento de Farmacologia, Facultad de Farmacia, C Profesor García GonzAlez s n 41012 Sevilla, Spain
    Curr Pharm Des 7:909-31. 2001
    ..Moreover, studies have shown that treatment with melatonin reduces the severity of the lesions induced by NSAIDs on gastric mucosa suggesting a beneficial role of melatonin in preventing this gastropathy related to antiinflammatories...