Varvara Trachana

Summary

Country: Spain

Publications

  1. pmc Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability
    Varvara Trachana
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Darwin 3, Campus de Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 104:2691-6. 2007
  2. pmc Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle
    Astrid Alonso Guerrero
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Cantoblanco Campus, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 107:4159-64. 2010
  3. pmc Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice
    Ricardo Villares
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 112:4803-8. 2015
  4. doi Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis
    Ignacio Prieto
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Darwin 3, 28049 Madrid, Spain
    Chromosoma 118:617-32. 2009

Collaborators

  • Anna Kouznetsova
  • Carlos Martinez-A
  • Agnes Fütterer
  • Astrid Alonso Guerrero
  • Ricardo Villares
  • Cristina Pacios-Bras
  • Karel H M van Wely
  • Mercedes Cano Gamero
  • Ignacio Prieto
  • Julio Gutierrez
  • Fernando Gutiérrez Del Burgo
  • Juan Cruz Cigudosa
  • Nuria Panadero Díaz-Concha
  • Jose Luis Barbero
  • Esther Leonardo
  • Juan Pablo Albar
  • Mónica Garcia-Gallo
  • Antonio Serrano
  • Fernando Roncal
  • Herve Leh
  • Leonor Kremer
  • Malcolm Buckle

Detail Information

Publications4

  1. pmc Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability
    Varvara Trachana
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Darwin 3, Campus de Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 104:2691-6. 2007
    ..Dido gene malfunction thus is reported to be part of an impaired signaling cascade that results in a defective mitotic checkpoint, leading to chromosome instability...
  2. pmc Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle
    Astrid Alonso Guerrero
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Cantoblanco Campus, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 107:4159-64. 2010
    ..Comparable defects were found in APC mutant cell lines, an independent system for spindle defects. On the basis of these results, we propose a model for break formation in which spindle defects lead to centromere shearing...
  3. pmc Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice
    Ricardo Villares
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 112:4803-8. 2015
    ..These mice can be considered a model for the study of ciliopathies and provide information for assessing diagnosis and therapy of genetic disorders linked to the deregulation of primary cilia. ..
  4. doi Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis
    Ignacio Prieto
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Darwin 3, 28049 Madrid, Spain
    Chromosoma 118:617-32. 2009
    ..Our results indicate that histone H3 lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex...