- Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stabilityVarvara Trachana
Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Darwin 3, Campus de Cantoblanco, E 28049 Madrid, Spain
Proc Natl Acad Sci U S A 104:2691-6. 2007..Dido gene malfunction thus is reported to be part of an impaired signaling cascade that results in a defective mitotic checkpoint, leading to chromosome instability...
- Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindleAstrid Alonso Guerrero
Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Cantoblanco Campus, 28049 Madrid, Spain
Proc Natl Acad Sci U S A 107:4159-64. 2010..Comparable defects were found in APC mutant cell lines, an independent system for spindle defects. On the basis of these results, we propose a model for break formation in which spindle defects lead to centromere shearing...
- Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosisIgnacio Prieto
Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Darwin 3, 28049 Madrid, Spain
Chromosoma 118:617-32. 2009..Our results indicate that histone H3 lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex...