López Morales M, Castelló Ruiz M, Burguete M, Jover Mengual T, Aliena Valero A, Centeno J, et al
. Molecular mechanisms underlying the neuroprotective role of atrial natriuretic peptide in experimental acute ischemic stroke. Mol Cell Endocrinol. 2018;472:1-9 pubmed publisher
..Therefore, ANP should be considered as a potential adjunctive neuroprotective agent improving stroke outcome after successful reperfusion interventions. ..
Torregrosa G, Burguete M, Pérez Asensio F, Salom J, Gil J, Alborch E. Pharmacological profile of phytoestrogens in cerebral vessels: in vitro study with rabbit basilar artery. Eur J Pharmacol. 2003;482:227-34 pubmed
..Phytoestrogens act as cerebrovascular relaxants by a mechanism which involves Ca(2+) entry blockade in the vascular smooth muscle rather than stimulation of vasorelaxant endothelium-related mechanisms such as NO/cGMP or prostaglandins. ..
Torregrosa G, Pérez Asensio F, Burguete M, Castelló Ruiz M, Salom J, Alborch E. Chronic intracerebroventricular delivery of the secretory phospholipase A2 inhibitor, 12-epi-scalaradial, does not improve outcome after focal cerebral ischemia-reperfusion in rats. Exp Brain Res. 2007;176:248-59 pubmed
..This, along with its inability to decrease the inflammatory response, does not allow to propose the use of 12-epi-scalardial as a potential drug for stroke therapy. ..
Jover Mengual T, Castelló Ruiz M, Burguete M, Jorques M, López Morales M, Aliena Valero A, et al
. Molecular mechanisms mediating the neuroprotective role of the selective estrogen receptor modulator, bazedoxifene, in acute ischemic stroke: A comparative study with 17?-estradiol. J Steroid Biochem Mol Biol. 2017;171:296-304 pubmed publisher
..This lends mechanistic support to the consideration of BZA as a potential neuroprotective drug in acute ischemic stroke treatment. ..