Eduardo Tolosa

Summary

Country: Spain

Publications

  1. ncbi Movement disorders: advances on many fronts
    Eduardo Tolosa
    Movement Disorder Unit, Neurology Service, Hospital Clinic, University of Barcelona
    Lancet Neurol 6:7-8. 2007
  2. ncbi Diagnosis and the premotor phase of Parkinson disease
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Institut Clínic de Neurosciències, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Hospital Clinic de Barcelona, Barcelona 08036, Spain
    Neurology 72:S12-20. 2009
  3. ncbi Efficacy, safety and tolerability of rasagiline as adjunctive therapy in elderly patients with Parkinson's disease
    E Tolosa
    Neurology Service, Hospital Clinic Universitari, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, IDIBAPS, Universitat de Barcelona, Spain
    Eur J Neurol 19:258-64. 2012
  4. ncbi Dystonia in Parkinson's disease
    Eduardo Tolosa
    Neurology Service, Institut de Neurociencies, Hospital Clinic i Universitari de Barcelona, C Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Neurol 253:VII7-13. 2006
  5. ncbi DAT imaging in drug-induced and psychogenic parkinsonism
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clinic Malaltias del Sistema Nervios, Hospital Clinic Universitari, University of Barcelona, Spain
    Mov Disord 18:S28-33. 2003
  6. ncbi [Cabergoline in the treatment of Parkinson's disease]
    P Pastor
    Unidad de Parkinson y Movimientos Anormales Servicio de Neurología, Institut Clinic de Malaties del Sistema Nerviós, IDIBAPS, Hospital Clinic, Facultad de Medicina de la Universidad de Barcelona, Barcelona, Spain
    Neurologia 18:202-9. 2003
  7. ncbi Caribbean parkinsonism and other atypical parkinsonian disorders
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clinic Malaltias del Sistema Nervios, Hospital Clinic Universitari, University of Barcelona, Spain
    Parkinsonism Relat Disord 10:S19-26. 2004
  8. ncbi Accuracy of DaTSCAN (123I-Ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2-year follow-up of an open-label study
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
    Mov Disord 22:2346-51. 2007
  9. ncbi The diagnosis of Parkinson's disease
    Eduardo Tolosa
    Neurology Service, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet Neurol 5:75-86. 2006
  10. ncbi The premotor phase of Parkinson's disease
    E Tolosa
    Neurology Service, 08036 Barcelona, Catalonia, Spain
    Parkinsonism Relat Disord 13:S2-7. 2007

Detail Information

Publications143 found, 100 shown here

  1. ncbi Movement disorders: advances on many fronts
    Eduardo Tolosa
    Movement Disorder Unit, Neurology Service, Hospital Clinic, University of Barcelona
    Lancet Neurol 6:7-8. 2007
  2. ncbi Diagnosis and the premotor phase of Parkinson disease
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Institut Clínic de Neurosciències, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Hospital Clinic de Barcelona, Barcelona 08036, Spain
    Neurology 72:S12-20. 2009
    ..Should a safe and effective treatment with disease-modifying or neuroprotective potential in PD become available, identifying individuals in the premotor phase will become a serious priority...
  3. ncbi Efficacy, safety and tolerability of rasagiline as adjunctive therapy in elderly patients with Parkinson's disease
    E Tolosa
    Neurology Service, Hospital Clinic Universitari, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, IDIBAPS, Universitat de Barcelona, Spain
    Eur J Neurol 19:258-64. 2012
    ..In this post hoc analysis, the efficacy, safety and tolerability of rasagiline as an adjunct to levodopa were compared with placebo in elderly (≥70 years) and younger (<70 years) patients with PD...
  4. ncbi Dystonia in Parkinson's disease
    Eduardo Tolosa
    Neurology Service, Institut de Neurociencies, Hospital Clinic i Universitari de Barcelona, C Villarroel 170, 08036 Barcelona, Catalonia, Spain
    J Neurol 253:VII7-13. 2006
    ....
  5. ncbi DAT imaging in drug-induced and psychogenic parkinsonism
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clinic Malaltias del Sistema Nervios, Hospital Clinic Universitari, University of Barcelona, Spain
    Mov Disord 18:S28-33. 2003
    ..These two conditions normally give normal striatal DAT imaging results; an abnormal result in either case could exclude both conditions, corroborating a diagnosis of organic parkinsonism in uncertain cases...
  6. ncbi [Cabergoline in the treatment of Parkinson's disease]
    P Pastor
    Unidad de Parkinson y Movimientos Anormales Servicio de Neurología, Institut Clinic de Malaties del Sistema Nerviós, IDIBAPS, Hospital Clinic, Facultad de Medicina de la Universidad de Barcelona, Barcelona, Spain
    Neurologia 18:202-9. 2003
    ..Its side effects are seen mainly in the digestive and nervous system (central and peripheral). The efficacy of cabergoline in comparison to other dopaminergic agonists should be tested in future clinical studies...
  7. ncbi Caribbean parkinsonism and other atypical parkinsonian disorders
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clinic Malaltias del Sistema Nervios, Hospital Clinic Universitari, University of Barcelona, Spain
    Parkinsonism Relat Disord 10:S19-26. 2004
    ..In this review we provide an update in etiology, neuropathology, diagnosis and treatment of atypical parkinsonian disorders associated with protein tau deposit, also known as tauopathies...
  8. ncbi Accuracy of DaTSCAN (123I-Ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2-year follow-up of an open-label study
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
    Mov Disord 22:2346-51. 2007
    ..DaTSCAN imaging shows a high rate of agreement with clinical diagnosis after 2-years follow-up. A second scan at 2 years follow-up can reduce remaining diagnostic uncertainty that is present even after a prolonged period of observation...
  9. ncbi The diagnosis of Parkinson's disease
    Eduardo Tolosa
    Neurology Service, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet Neurol 5:75-86. 2006
    ..Also genetic testing and various other ancillary tests, such as olfactory testing, MRI, and dopamine-transporter single-photon-emission computed-tomography imaging, help with clinical diagnostic decisions...
  10. ncbi The premotor phase of Parkinson's disease
    E Tolosa
    Neurology Service, 08036 Barcelona, Catalonia, Spain
    Parkinsonism Relat Disord 13:S2-7. 2007
    ..Diagnostic and therapeutic implications linked to improved identification of these premotor features are discussed...
  11. ncbi Progress in defining the premotor phase of Parkinson's disease
    Eduardo Tolosa
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Universitat de Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Barcelona, Spain
    J Neurol Sci 310:4-8. 2011
    ..The diagnosis of premotor PD remains still elusive but the information becoming available on premotor PD should guide the search for predictive biomarkers and the identification of risk or protective factors for PD...
  12. ncbi Clinicopathological and genetic correlates of frontotemporal lobar degeneration and corticobasal degeneration
    Albert Lladó
    Service of Neurology, Hospital Clínic and Institut d Investigació, Biomedica August Pi i Sunyer, Barcelona, Spain
    J Neurol 255:488-94. 2008
    ..To correlate clinical diagnosis and genetic features with different pathological substrates in patients with frontotemporal lobar degeneration (FTLD) and corticobasal degeneration (CBD)...
  13. ncbi Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration
    Carles Gaig
    Department of Neurology, Hospital Clinic i Universitari de Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Barcelona, Spain
    J Neurol Sci 270:94-8. 2008
    ....
  14. ncbi 123I-MIBG cardiac uptake and smell identification in parkinsonian patients with LRRK2 mutations
    Francesc Valldeoriola
    Movement Disorders Unit, Institut Clinic de Malalties del Sistema Nervios, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Neurol 258:1126-32. 2011
    ..As MIBG cardiac reduced uptake and impaired odor identification are markers of LB pathology, this findings may represent neuropathological heterogeneity among LRRK2 patients...
  15. ncbi Rapidly progressive diffuse Lewy body disease
    Carles Gaig
    Neurology Service, Hospital Clinic of Barcelona, Barcelona, Spain
    Mov Disord 26:1316-23. 2011
    ..Lewy body syndromes (mainly Parkinson's disease and dementia with Lewy bodies) share many clinical features and usually have a slowly progressive course. Some patients may show rapid symptoms progression...
  16. ncbi Hippocampal head atrophy predominance in Parkinson's disease with hallucinations and with dementia
    Naroa Ibarretxe-Bilbao
    Dept of Psychiatry and Clinical, Psychobiology, University of Barcelona, IDIBAPS, Casanova 143, 08036, Barcelona, Spain
    J Neurol 255:1324-31. 2008
    ....
  17. ncbi Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson's disease dementia
    Yaroslau Compta
    Movement Disorders Unit, ICN, IDIBAPS, CIBERNED, Hospital Clinic, C Villarroel 170, 08036, Barcelona, Spain
    Brain 132:3308-17. 2009
    ..Alternatively, mechanisms other than hypocretin cells dysfunction may be responsible for excessive daytime sleepiness and the sleep architecture alterations seen in these patients...
  18. ncbi Olfactory impairment in Parkinson's disease and white matter abnormalities in central olfactory areas: A voxel-based diffusion tensor imaging study
    Naroa Ibarretxe-Bilbao
    Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Hospital Clinic de Barcelona, Barcelona, Spain
    Mov Disord 25:1888-94. 2010
    ..This study demonstrates, for the first time, that microstructural WM reductions are present in the central olfactory system of early stage PD patients and that these reductions are associated with reduced ability to smell...
  19. ncbi Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations
    Naroa Ibarretxe-Bilbao
    Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Hospital Clinic de Barcelona, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 81:650-7. 2010
    ..To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson's disease (PD) with and without visual hallucinations (VH)...
  20. ncbi Lack of association of APOE and tau polymorphisms with dementia in Parkinson's disease
    Mario Ezquerra
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clinic de Barcelona, Department of Medicine, Universitat de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain
    Neurosci Lett 448:20-3. 2008
    ..The lack of association between the APOE 4 allele and PDD suggests that the pathological process involved in the development of dementia in PD is different from the one that occurs in AD...
  21. ncbi Cognitive changes in Parkinson's disease patients with visual hallucinations
    Blanca Ramirez Ruiz
    Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Dement Geriatr Cogn Disord 23:281-8. 2007
    ..To evaluate the decline in specific neuropsychological functions in nondemented Parkinson's disease (PD) patients with a history of visual hallucinations (VH)...
  22. ncbi Long lasting pure freezing of gait preceding progressive supranuclear palsy: a clinicopathological study
    Yaroslau Compta
    Servei de Neurologia, Institut Clínic de Neurociències, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic de Barcelona, Barcelona, Catalonia, Spain
    Mov Disord 22:1954-8. 2007
    ..These 2 cases suggest that PPFG can represent the initial manifestation of a neurodegenerative disease, such as PSP, rather than a differentiated nosological entity...
  23. ncbi Cerebrospinal tau, phospho-tau, and beta-amyloid and neuropsychological functions in Parkinson's disease
    Yaroslau Compta
    Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Centro de Investigación en Red de Enfermedades Neurodegenerativas, Hospital Clinic, Barcelona, Catalonia, Spain
    Mov Disord 24:2203-10. 2009
    ....
  24. ncbi Neuroanatomical correlates of impaired decision-making and facial emotion recognition in early Parkinson's disease
    Naroa Ibarretxe-Bilbao
    Centro de Investigation en Red de Enfermedades Neurodegenerativas CIBERNED, Hospital Clinic de Barcelona, Barcelona, Spain
    Eur J Neurosci 30:1162-71. 2009
    ....
  25. ncbi Dysfunctions of cerebral networks precede recognition memory deficits in early Parkinson's disease
    Naroa Ibarretxe-Bilbao
    Servicio de Neurologia, Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Hospital Clinic, Universidad de Barcelona, Spain
    Neuroimage 57:589-97. 2011
    ..In conclusion, model-free fMRI analysis detected alterations in functional cerebral networks involved in a verbal memory task in PD patients without evident recognition memory deficit...
  26. ncbi Neuropsychological deficits in Parkinson's disease patients with visual hallucinations
    Blanca Ramirez-Ruiz
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Mov Disord 21:1483-7. 2006
    ..We suggest that a wide range of neuropsychological deficits can contribute to the emergence of VH in PD...
  27. ncbi Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study
    Blanca Ramirez-Ruiz
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Mov Disord 23:2335-43. 2008
    ..A dysfunction of the frontal areas associated with the control of attention could predispose to VH through an abnormal processing of relevant and irrelevant visual stimuli...
  28. ncbi LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance
    Carles Gaig
    Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Arch Neurol 63:377-82. 2006
    ..The R1441G mutation is frequent in Spanish patients of Basque ethnicity with PD, and the G2019S mutation is a common mutation found in several populations worldwide...
  29. ncbi Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism: effect on the activity of striatal output pathways
    Jordi Bove
    Laboratori de Neurologia Experimental, Area de Neurociències, Fundació Clínic Hospital Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
    Exp Brain Res 165:362-74. 2005
    ....
  30. ncbi Subclinical nigrostriatal dopaminergic denervation in the cerebellar subtype of multiple system atrophy (MSA-C)
    Esteban Muñoz
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències ICN, Hospital Clinic i Universitari, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Villarroel 170, 08036, Barcelona, Catalunya, Spain
    J Neurol 258:2248-53. 2011
    ..123)I]FP-CIT SPECT shows that most but not all MSA-C patients without parkinsonism have subclinical nigrostriatal dopaminergic denervation which is not related to disease duration, cerebellar dysfunction, or pontine atrophy...
  31. ncbi No evidence of CRHR1 gene involvement in progressive supranuclear palsy
    Jaume Campdelacreu
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic Universitari, Barcelona, Spain
    Neurosci Lett 409:61-4. 2006
    ..Expression pattern of CRHR1 in globus pallidus was similar in all groups. We did not find any coding non-synonymous mutation in the patients analysed. Our results do not support an involvement of CRHR1 gene in PSP pathogenesis...
  32. ncbi Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy
    Mario Ezquerra
    Institut Clínic de Neurociències, Hospital Clinic de Barcelona, Department of Medicine, Universitat de Barcelona, IDIBAPS, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Barcelona, Catalonia, Spain
    Neurobiol Aging 32:547.e11-6. 2011
    ..The location of this polymorphism in the 5' regulatory region of MAPT gene suggests the presence of a functional mechanism involved in the variation of MAPT expression levels...
  33. ncbi High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease
    Yaroslau Compta
    Neurosciences Institute, IDIBAPS, CIBERNED, Hospital Clinic, Barcelona, Catalonia, Spain
    Neurosci Lett 487:169-73. 2011
    ..Such genetic-CSF endophenotypes are probably a reflection of the presence of AD-like molecular changes in part of PD patients in the setting of dementia...
  34. ncbi Use of electroconvulsive therapy in Parkinson disease with residual axial symptoms partially unresponsive to L-dopa: a pilot study
    Luis Pérez Pintor
    Psychiatry Department, Institut de Neurociencies, Hospital Clinic i Provincial de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J ECT 28:87-91. 2012
    ..The aim of this study was to determine the efficacy and safety of ECT in patients with advanced Parkinson disease with symptoms partially unresponsive to L-dopa...
  35. ncbi Amygdalar and hippocampal MRI volumetric reductions in Parkinson's disease with dementia
    Carme Junque
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Mov Disord 20:540-4. 2005
    ..Nondemented PD patients also showed a degree of volumetric reduction in these structures although the differences were not statistically significant...
  36. ncbi Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations
    Hatice Kumru
    Neurology Service, Hospital Clínic de Barcelona and Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Ann Neurol 56:599-603. 2004
    ..In all instances, RBD followed the onset of motor symptoms by several years. Our study shows that RBD is frequent in Park2, suggesting that mechanisms other than synuclein deposition can cause RBD in neurodegenerative disorders...
  37. ncbi Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson's disease and related dementia
    Yaroslau Compta
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències IDIBAPS, Centro de Investigación en Red de Enfermedades Neurodegenerativas, Hospital Clinic, Barcelona, Catalonia, Spain
    Parkinsonism Relat Disord 18:941-7. 2012
    ....
  38. ncbi Comparative cognitive effects of bilateral subthalamic stimulation and subcutaneous continuous infusion of apomorphine in Parkinson's disease
    Montse Alegret
    Parkinson's Disease and Movement Disorders Unit, Service of Neurology, , , IDIBAPS, University of Barcelona, Barcelona, Spain
    Mov Disord 19:1463-9. 2004
    ..Consequently, these findings could be interpreted as being not relevant in deciding the most suitable treatment in a given patient...
  39. ncbi Bilateral subthalamic nucleus lesion reverses L-dopa-induced motor fluctuations and facilitates dyskinetic movements in hemiparkinsonian rats
    Concepcio Marin
    Laboratori de Neurologia Experimental, Fundació Clínic Hospital Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, 08036 Barcelona, Spain
    Synapse 51:140-50. 2004
    ....
  40. ncbi Usefulness of the SINBAR electromyographic montage to detect the motor and vocal manifestations occurring in REM sleep behavior disorder
    Alex Iranzo
    Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain
    Sleep Med 12:284-8. 2011
    ..As a next step, in the present study we evaluated the usefulness of the SINBAR EMG montage to detect the movements and vocalizations occurring in RBD...
  41. ncbi Increase in body weight after pramipexole treatment in Parkinson's disease
    Hatice Kumru
    Neurology Service, , Universitat de Barcelona, Barcelona, Spain
    Mov Disord 21:1972-4. 2006
    ..001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D(3) receptors involved in the control of feeding may be responsible for weight gain in PD...
  42. ncbi Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson's disease
    Joana B Pereira
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Mov Disord 24:1193-9. 2009
    ..Taken together, these findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural GM changes in temporo-parietal cortical regions of PD patients...
  43. ncbi Dual task interference in psychogenic tremor
    Hatice Kumru
    Institute Guttmann, Badalona, Barcelona, Spain
    Mov Disord 22:2077-82. 2007
    ..These observations may be useful in the evaluation of psychogenic movement disorders...
  44. ncbi Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study
    Alex Iranzo
    Neurology Service, Hospital Clinic, Barcelona, Spain
    Lancet Neurol 10:797-805. 2011
    ....
  45. ncbi Clinical and pathological heterogeneity of neuronal intermediate filament inclusion disease
    Laura Molina-Porcel
    Service of Neurology, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, Barcelona, Spain
    Arch Neurol 65:272-5. 2008
    ..To report new cases of neuronal intermediate filament inclusion disease (NIFID)...
  46. ncbi Longitudinal evaluation of cerebral morphological changes in Parkinson's disease with and without dementia
    Blanca Ramirez-Ruiz
    Dept of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    J Neurol 252:1345-52. 2005
    ..To investigate the pattern of brain atrophy across time in a sample of Parkinson's disease (PD) patients with and without dementia using voxelbased morphometry (VBM) analysis...
  47. ncbi Cerebral basis of visual hallucinations in Parkinson's disease: structural and functional MRI studies
    Naroa Ibarretxe-Bilbao
    Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Hospital Clinic de Barcelona, Spain
    J Neurol Sci 310:79-81. 2011
    ....
  48. ncbi Brain structural MRI correlates of cognitive dysfunctions in Parkinson's disease
    Naroa Ibarretxe-Bilbao
    Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Hospital Clinic de Barcelona, Spain
    J Neurol Sci 310:70-4. 2011
    ..In this review, we summarize the papers that have used structural MRI to study the neuroanatomical correlates of cognitive dysfunctions in PD...
  49. ncbi Structural brain changes in Parkinson disease with dementia: a voxel-based morphometry study
    Christopher Summerfield
    Department de Psiquiatria i Psicobiologia, Universitat de Barcelona, Spain
    Arch Neurol 62:281-5. 2005
    ..CONCLUSIONS: The hippocampus, thalamus, and anterior cingulate are the regions most affected in PDD. Our results agree with recent neuropathological findings suggesting the involvement of the limbic and cortical areas in PD...
  50. ncbi Prospective comparative study on cost-effectiveness of subthalamic stimulation and best medical treatment in advanced Parkinson's disease
    Francesc Valldeoriola
    Hospital Clinic, Institut de Neurociències Universitat de Barcelona, Barcelona, Spain
    Mov Disord 22:2183-91. 2007
    ..An ICER of 34,389 euro/QALY is within appropriate limits to consider subthalamic stimulation as an efficient therapy...
  51. ncbi Modulation of the soleus H reflex by electrical subcortical stimuli in humans
    Joao Costa
    EMG and Motor Control Unit, Neurology Department, Hospital Clinic, Universitat de Barcelona, IDIBAPS Institut d Investigació Biomèdica August Pi i Sunyer, Villarroel, 170, 08036, Barcelona, Spain
    Exp Brain Res 212:439-48. 2011
    ..These findings contribute to the discussion of the mechanisms underlying the excitability of the spinal alpha motoneuron pool and the modulation of the H reflex by supraspinal stimuli...
  52. ncbi G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies
    Carles Gaig
    Movement Disorders Unit, Department of Neurology, Institut Clínic de Neurociències, Hospital Clinic i Universitari de Barcelona, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 78:626-8. 2007
    ..A G2019S LRRK2 mutation was eventually detected. The present case confirms that clinical PD caused by G2019S mutations can be associated with non-specific nigral degeneration without Lewy bodies...
  53. ncbi Cognitive dysfunction and dementia in Parkinson disease
    Nuria Caballol
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic Universitari, University of Barcelona, Barcelona, Spain
    Mov Disord 22:S358-66. 2007
    ..Recent evidence suggests that cholinesterase inhibitors are effective in the treatment of dementia and accompanying behavioral symptoms in PD...
  54. ncbi Excessive daytime sleepiness in multiple system atrophy (SLEEMSA study)
    Claudia Moreno-López
    Movement Disorders Unit, Department of Neurology, Hospital Clinic of Barcelona, University of Barcelona Medical School and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, 08036 Barcelona, Spain
    Arch Neurol 68:223-30. 2011
    ..Sleep disorders are common in multiple system atrophy (MSA), but the prevalence of excessive daytime sleepiness (EDS) is not well known...
  55. ncbi Tau and saitohin gene expression pattern in progressive supranuclear palsy
    Mario Ezquerra
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clinic de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Villarroel 170, 08036, Barcelona, Spain
    Brain Res 1145:168-76. 2007
    ..Such abnormalities cause an increase in the 4R/3R ratio and may lead to an overexpression of 0N tau isoforms...
  56. ncbi 123I-Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism
    Carles Gaig
    Movement Disorders Unit, Neurology Service, , , University of Barcelona, Barcelona, Spain
    Mov Disord 21:1994-8. 2006
    ..Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome...
  57. ncbi MRI and cognitive impairment in Parkinson's disease
    Naroa Ibarretxe-Bilbao
    Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Hospital Clinic de Barcelona, Barcelona, Spain
    Mov Disord 24:S748-53. 2009
    ..These findings suggest that cortical atrophy is related to cognitive dysfunction in PD and precedes the development of dementia. Structural MRI might therefore provide an early marker for dementia in PD...
  58. ncbi Transient arrest of psychogenic tremor induced by contralateral ballistic movements
    Hatice Kumru
    Unitat d'EMG, Servei de Neurologia, , Facultad de Medicina, , Universitat de Barcelona, Villarroel, 170, Barcelona 08036, Spain
    Neurosci Lett 370:135-9. 2004
    ..The documentation and quantitation of the effects of a ballistic movement on contralateral rhythmic activity are of clinical relevance for the identification of patients with PT...
  59. ncbi Progression of cortical thinning in early Parkinson's disease
    Naroa Ibarretxe-Bilbao
    Centro de Investigación en Red de Enfermedades Neurodegenerativas, Hospital Clinic de Barcelona, Catalonia, Spain
    Mov Disord 27:1746-53. 2012
    ..In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process...
  60. ncbi Eating-induced facial myoclonic dystonia probably due to a putaminal lesion
    Carles Gaig
    Department of Neurology, Institut Clínic de Neurociències, Hospital Clinic i Universitari, IDIBAPS, Barcelona, Spain
    Mov Disord 22:877-80. 2007
    ....
  61. ncbi Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy
    Jaume Campdelacreu
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clinic de Malalties del Sistema Nervios, Hospital Clinic Universitari, Villarroel 170, 08036 Barcelona, Spain
    Neurosci Lett 340:158-60. 2003
    ..Our results do not support a pathogenic role of the NIK gene in PSP...
  62. ncbi The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies
    Katrin Beyer
    Servicio de Anatomia Patologica, Hospital Universitario Germans Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain
    Brain 133:3724-33. 2010
    ..Furthermore, our findings provide new insights into the pathogenesis of Lewy body diseases that may be important for the understanding of molecular mechanisms involved in these complex diseases...
  63. ncbi When does Parkinson's disease begin?
    Carles Gaig
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clinic de Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Barcelona, Spain
    Mov Disord 24:S656-64. 2009
    ..When and where the neuropathological process develops in PD remains uncertain...
  64. ncbi A novel intronic mutation in the DDP1 gene in a family with X-linked dystonia-deafness syndrome
    Mario Ezquerra
    Movement Disorders Unit, Department of Neurology, Institut Clinic de Malalties del Sistema Nervios, Hospital Clinic Universitari de Barcelona, Barcelona, Spain
    Arch Neurol 62:306-8. 2005
    ..So far, 7 mutations in the coding region of the DDP1 gene have been described. They consist of frameshift, nonsense, missense mutations or deletions...
  65. ncbi Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity
    Josep Saura
    Experimental Neurology Laboratory, Neurological Service, Fundació Clínic, IDIBAPS, Barcelona, Spain
    J Neurochem 85:651-61. 2003
    ..These data show the characterization of a novel model of local astroglial activation in the substantia nigra and support the hypothesis of a neuroprotective role of activated astrocytes in Parkinson's disease...
  66. ncbi Isolated frontal disequilibrium as presenting form of anti-Hu paraneoplastic encephalomyelitis
    Yaroslau Compta
    Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Barcelona, Catalonia, Spain
    Mov Disord 22:736-8. 2007
    ..Only mild residual hyperintensities persist on follow-up MRI. A paraneoplastic syndrome should be considered in the differential diagnosis of subacute, fast progressive gait disorders...
  67. ncbi Ubiquitin-negative mini-pick-like bodies in the dentate gyrus in p301l tauopathy
    Isidro Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain
    J Alzheimers Dis 5:445-54. 2003
    ..Yet the P310L mutation has particular phospho-tau inclusions that are not tag with ubiquitin and appear to be rather soluble when compared with AD...
  68. ncbi Diagnostic cutoff points for ¹²³I-MIBG myocardial scintigraphy in a Caucasian population with Parkinson's disease
    Africa Muxi
    Nuclear Medicine Department, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Eur J Nucl Med Mol Imaging 38:1139-46. 2011
    ..The purpose of this study was to determine diagnostic cutoff points in the quantification of MIBG cardiac uptake in our population of PD patients. We have also calculated the reproducibility over a range of interpretation expertise...
  69. ncbi Pure autonomic failure with altered dopamine transporter imaging
    Yaroslau Compta
    Servei de Neurologia, , Hospital Clinic, Villaroel 170, 08036 Barcelona, Spain
    Arch Neurol 63:604-5. 2006
  70. ncbi Effect of acute and chronic administration of U50,488, a kappa opioid receptor agonist, in 6-OHDA-lesioned rats chronically treated with levodopa
    C Marin
    Laboratori de Neurologia Experimental, Fundació Clínic, IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
    Exp Neurol 183:66-73. 2003
    ..These findings suggest that the stimulation of kappa opioid receptors might confer clinical benefit to parkinsonian patients under levodopa therapy suffering from motor complication syndrome...
  71. ncbi Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene
    P Pastor
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Ann Neurol 49:263-7. 2001
    ..This finding indicates that homozygous mutations in the tau gene may also cause hereditary tauopathies...
  72. ncbi Cognitive effects of unilateral posteroventral pallidotomy: a 4-year follow-up study
    Montse Alegret
    Parkinson s and Movement Disorders Unit, Neurology Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Villaroel 170, 08036 Barcelona, Spain
    Mov Disord 18:323-8. 2003
    ..Our results suggest that unilateral posteroventral pallidotomy may produce transient changes in prefrontal and visuospatial functions, but there is no evidence of permanent neuropsychological effects...
  73. ncbi Clinical overview of the synucleinopathies
    Maria J Marti
    Movement Disorders Unit, Neurology Service, Institut Clinic de Malalties del Sistema Nervios, Hospital Clinic i Universitari, Barcelona, Spain
    Mov Disord 18:S21-7. 2003
    ..Clinicians should attempt to reach standard clinical diagnosis on patients, such as PD, PAF, or MSA...
  74. ncbi Left hemibody myoclonus due to anomalous right vertebral artery
    Miguel Coelho
    Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clinic Malalties del Sistema Nervios, , University of Barcelona, Spain
    Mov Disord 20:72-5. 2005
    ..We hypothesize that the aberrant right vertebral artery induced abnormal activation of descending motor tracts responsible for the myoclonus...
  75. ncbi REM sleep behavior disorder and vocal cord paralysis in Machado-Joseph disease
    Alex Iranzo
    Neurology Service, Institut Clinic Malalties del Sistema Nervios, Hospital Clinic Universitari de Barcelona, Spain
    Mov Disord 18:1179-83. 2003
    ..RBD and VCAP are two potentially injurious conditions that should be considered part of the clinical spectrum of MJD...
  76. ncbi Bilateral subthalamic stimulation monotherapy in advanced Parkinson's disease: long-term follow-up of patients
    Francesc Valldeoriola
    Unitat de Parkinson i Moviments Anormals, Service of Neurology, Institut Clinic de Malalties del Sistema Nervios, Institut d Investigacions Biomèdiques August Pi i Suñer, Hospital Clinic Universitari, Barcelona, Spain
    Mov Disord 17:125-32. 2002
    ..The therapeutic effect of STN-DBS on motor signs can be equipotent to that of levodopa with the additional benefit of avoiding motor fluctuations and dyskinesias...
  77. ncbi Severe cerebral white matter involvement in a case of dentatorubropallidoluysian atrophy studied at autopsy
    Esteban Muñoz
    Neurology Service, Institut Clinic de Malaties del Sistema Nerviós, Hospital Clinic i Universitari, Institut d Investigacions Biomediques August Pi i Sunyer, Brain Bank of the University of Barcelona, Barcelona, Spain
    Arch Neurol 61:946-9. 2004
    ..The pathophysiology of white matter involvement in dentatorubropallidoluysian atrophy (DRPLA) is controversial. Moreover, the clinical repercussions and evolution of these lesions have not been well documented...
  78. ncbi Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease
    M Alegret
    Department of Psychiatry and Clinical Psychobiology, Hospital Clinic Universitari, School of Medicine, University of Barcelona, IDIBAPS, Casanova 143, 08036 Barcelona, Spain
    Arch Neurol 58:1223-7. 2001
    ..The motor state improved in all patients. CONCLUSION: Therapy with STN-DBS improves motor symptoms in PD without any clinically relevant neuropsychological deterioration...
  79. ncbi Analysis of the coding and the 5' flanking regions of the alpha-synuclein gene in patients with Parkinson's disease
    P Pastor
    Parkinson s Disease and Movement Disorders Unit, Neurology Service, Institut Clinic de Malalties del Sistema Nervios, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Mov Disord 16:1115-9. 2001
    ..These results suggest that mutations in the alpha-synuclein gene are a very rare cause of familial PD and that the novel -164insA/C-116G polymorphism in the 5' flanking region does not confer susceptibility to develop PD...
  80. ncbi Examination of motor output pathways in patients with corticobasal ganglionic degeneration using transcranial magnetic stimulation
    J Valls-Sole
    Unitat d EMG, Neurology Service, Hospital Clinic, Universitat de Barcelona, Villarroel, 170 Barcelona 08036, Spain
    Brain 124:1131-7. 2001
    ..Our results indicate an enhanced excitability, or reduced inhibition, of the motor area of the hemisphere contralateral to the AHS. The delay of the ipsilateral responses is compatible with a disinhibited transcallosal input...
  81. ncbi Prefrontal cortex volume reduction on MRI in preclinical Huntington's disease relates to visuomotor performance and CAG number
    B Gomez-Anson
    Department of Radiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Parkinsonism Relat Disord 15:213-9. 2009
    ..To investigate grey matter volumes on magnetic resonance imaging (MRI) in preclinical Huntington's disease (HD), and their relationship to neuropsychology and CAG number...
  82. ncbi Sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulation
    A Iranzo
    Service of Neurology, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 72:661-4. 2002
    ..To evaluate the sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulation (STN-DBS)...
  83. ncbi Relative high frequency of the c.255delA parkin gene mutation in Spanish patients with autosomal recessive parkinsonism
    E Munoz
    Movemente Disorder Unit, Neurology Service, Institut Clinic de Malalties del Sistema Nervios, Villarroel 170, 08036 Barcelona, Spain
    J Neurol Neurosurg Psychiatry 73:582-4. 2002
    ..Autosomal recessive juvenile parkinsonism is a neurodegenerative disorder associated with mutations in the parkin gene...
  84. ncbi Efficacy and safety of pallidal stimulation in primary dystonia: results of the Spanish multicentric study
    F Valldeoriola
    Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 81:65-9. 2010
    ....
  85. ncbi Early administration of entacapone prevents levodopa-induced motor fluctuations in hemiparkinsonian rats
    C Marin
    Laboratori de Neurologia Experimental, Servei de Neurologia, Fundació Clínic Hospital Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Exp Neurol 192:184-93. 2005
    ..The combination of levodopa and entacapone may reduce the likelihood of motor fluctuation development and may thus become a valuable approach to treat Parkinson disease whenever levodopa is needed...
  86. ncbi The kappa opioid agonist U50,488 potentiates 6-hydroxydopamine-induced neurotoxicity on dopaminergic neurons
    C Marin
    Laboratori de Neurologia Experimental, Area de Neurociències, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Exp Neurol 191:41-52. 2005
    ....
  87. ncbi Decreased frontal choline and neuropsychological performance in preclinical Huntington disease
    B Gomez-Anson
    Radiology Department, Diagnostic Imaging Center, Hospital Clinic, Barcelona, Spain
    Neurology 68:906-10. 2007
    ..To study metabolic brain changes in preclinical carriers of Huntington disease (PreHD) using proton magnetic resonance spectroscopy (1H-MRS) and to examine their relationship to neuropsychological performance...
  88. ncbi Long-term effect of CPAP in the treatment of nocturnal stridor in multiple system atrophy
    A Iranzo
    Neurology Service, Hospital Clínic and Instisut d Investigació Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Neurology 63:930-2. 2004
    ..This study shows that in MSA, CPAP is an effective noninvasive long-term therapy for nocturnal stridor...
  89. ncbi [Sleep disorders in multiple system atrophy]
    J Santamaria
    Servicio de Neurologia, Hospital Clinic de Barcelona, Barcelona
    Neurologia 19:307-11. 2004
    ..Nocturnal stridor is associated with decreased survival and its treatment is based on continuous positive air pressure (CPAP) when it occurs only during sleep or tracheostomy when it worsens and becomes also diurnal...
  90. ncbi Sequence analysis of tau 3'untranslated region and saitohin gene in sporadic progressive supranuclear palsy
    M Ezquerra
    Institut Clinic de Malalties del Sistema Nervios, Hospital Clinic Universitari, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 75:155-7. 2004
    ..Recently, a new gene called saitohin (STH), nested within an intron of tau, has been discovered. The Q7R polymorphism of STH appears to be related to late onset Alzheimer's disease...
  91. ncbi Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
    A Iranzo
    Neurology Service, ospital Clínic and Institut d Investigació Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Neurology 65:247-52. 2005
    ..To compare the clinical and video-polysomnographic (VPSG) characteristics of idiopathic REM sleep behavior disorder (RBD) vs the RBD seen in multiple system atrophy (MSA) and Parkinson disease (PD)...
  92. ncbi Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy
    Jose Enrique Martinez Rodriguez
    Neurology Service, Hospital Clínic de Barcelona and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, University of Barcelona Medical School, Barcelona, Spain
    Mov Disord 22:1822-4. 2007
    ..All patients had CSF hypocretin-1 levels in the normal range (>200 pg/mL) suggesting that the hypocretin system is not altered in MSA, at least in patients with a moderately severe disease...
  93. ncbi Pathological description of a non-motor variant of multiple system atrophy
    C Gaig
    Neurology Service, Hospital Clinic de Barcelona, C Villarroel 170, Barcelona 08036, Spain
    J Neurol Neurosurg Psychiatry 79:1399-400. 2008
    ..This case illustrates that MSA may present clinically without its cardinal motor symptoms, and that stridor and RBD may be clues to recognise the disease in a patient with autonomic failure...
  94. ncbi Late-onset frontotemporal dementia associated with a novel PGRN mutation
    A Lladó
    Alzheimer s Disease and Cognitive Disorders Unit, Neurology Service, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neural Transm 114:1051-4. 2007
    ..The A303AfsX57 mutation is consistent with a nucleotide deletion in exon 8 (c908delC). This deletion causes a frameshift at codon 303 that introduces a premature termination codon (A303AfsX57)...
  95. ncbi LY293558, an AMPA glutamate receptor antagonist, prevents and reverses levodopa-induced motor alterations in Parkinsonian rats
    C Marin
    Laboratori de Neurologia Experimental, Fundació Clínic, IDIBAPS, 08036 Barcelona, Spain
    Synapse 42:40-7. 2001
    ....
  96. ncbi Absence of REM sleep, altered NREM sleep and supranuclear horizontal gaze palsy caused by a lesion of the pontine tegmentum
    F Valldeoriola
    Sleep Disorders Unit, Universitat de Barcelona, Hospital Clinic i Provincial, Spain
    Sleep 16:184-8. 1993
    ..Interruption of connections between the tegmentum of the pons and the reticular nuclei of the thalamus could be the cause of the absence of sleep spindles...
  97. ncbi Cerebral atrophy in Parkinson's disease patients with visual hallucinations
    B Ramirez Ruiz
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Eur J Neurol 14:750-6. 2007
    ..Structural changes in these areas involved in higher visual processing may be important in understanding the VH and visual deficits in PD patients...
  98. ncbi Significant changes in the tau A0 and A3 alleles in progressive supranuclear palsy and improved genotyping by silver detection
    R Oliva
    Genetics Service, Institut de Investigacions Biomediques August Pi i Sonyer, Barcelona, Spain
    Arch Neurol 55:1122-4. 1998
    ..Progressive supranuclear palsy (PSP) is characterized by intraneuronal inclusions of neurofibrillary tangles formed by aggregated tau protein. A significant association between the tau gene A0/A0 genotype and PSP recently has been reported...
  99. ncbi Dentatorubropallidoluysian atrophy in a spanish family: a clinical, radiological, pathological, and genetic study
    E Munoz
    Department of Neurology, Hospital Clinic i Universitari, Barcelona, Spain
    J Neurol Neurosurg Psychiatry 67:811-4. 1999
    ..Pathological studies are still necessary to correlate DRPLA brain involvement with the clinical and molecular findings...
  100. ncbi Focal limb dystonia
    C Pont-Sunyer
    Parkinson Disease and Movement Disorders Unit, Neurology Service, Faculty of Medicine, Institut Clínic de Neurociències, Centro de Investigación en Red de Enfermedades Neurodegenerativas, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain
    Eur J Neurol 17:22-7. 2010
    ..In the text that follows, we review the main clinical features of the primary and secondary limb dystonias considering the age at onset and etiology...
  101. ncbi Non-NMDA receptor-mediated mechanisms are involved in levodopa-induced motor response alterations in Parkinsonian rats
    C Marin
    Laboratori de Neurologia Experimental, Servei de Neurologia, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer IDIBAPS, Barcelona, Spain
    Synapse 36:267-74. 2000
    ..The capacity of NBQX to reverse these altered responses suggests that an enhanced synaptic efficacy of striatal AMPA receptors may also participate in the generation of these motor response changes in levodopa-treated parkinsonian rats...