Manuel Tena-Sempere

Summary

Country: Spain

Publications

  1. ncbi request reprint KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, Physiology Section, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 83:275-81. 2006
  2. ncbi request reprint Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis
    Manuel Tena-Sempere
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004, Cordoba, Spain
    Vitam Horm 77:285-300. 2008
  3. ncbi request reprint Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin
    Victor M Navarro
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Avda Menendez Pidal s n, 14004, Cordoba, Spain
    Rev Endocr Metab Disord 8:11-20. 2007
  4. doi request reprint Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis
    D García-Galiano
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Endocrinology 153:1959-71. 2012
  5. pmc Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids
    F Ruiz-Pino
    Department of Cell Biology, University of Cordoba, 14004 Cordoba, Spain
    Endocrinology 153:4818-29. 2012
  6. ncbi request reprint Generation of multi-oocyte follicles in the peripubertal rat ovary: link to the invasive capacity of granulosa cells?
    Francisco Gaytan
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Cordoba, Spain CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain Instituto Maimónides de Investigaciones Biomédicas Hospital Universitario Reina Sofia, Cordoba, Spain Electronic address
    Fertil Steril 101:1467-76. 2014
  7. ncbi request reprint Emerging roles of NUCB2/nesfatin-1 in the metabolic control of reproduction
    David García-Galiano
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Curr Pharm Des 19:6966-72. 2013
  8. doi request reprint Metabolic programming of puberty: sexually dimorphic responses to early nutritional challenges
    M A Sanchez-Garrido
    Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avenida Menéndez Pidal s n 14004 Córdoba, Spain
    Endocrinology 154:3387-400. 2013
  9. doi request reprint Keeping puberty on time: novel signals and mechanisms involved
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Curr Top Dev Biol 105:299-329. 2013
  10. doi request reprint Ghrelin, the gonadal axis and the onset of puberty
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, CIBER Fisiopatologia de la Obesidad y Nutricion, ES 14004 Córdoba, Spain
    Endocr Dev 25:69-82. 2013

Collaborators

Detail Information

Publications79

  1. ncbi request reprint KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, Physiology Section, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 83:275-81. 2006
    ....
  2. ncbi request reprint Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis
    Manuel Tena-Sempere
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004, Cordoba, Spain
    Vitam Horm 77:285-300. 2008
    ..Altogether, those findings document a novel reproductive facet of ghrelin, which may cooperate with other neuroendocrine integrators, as leptin, in the joint control of energy balance and reproduction...
  3. ncbi request reprint Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin
    Victor M Navarro
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Avda Menendez Pidal s n, 14004, Cordoba, Spain
    Rev Endocr Metab Disord 8:11-20. 2007
    ..Whether the KiSS-1 system is the trigger for puberty onset and/or it operates as integrator and effector of up-stream regulatory factors warrants further investigation...
  4. doi request reprint Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis
    D García-Galiano
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Endocrinology 153:1959-71. 2012
    ..Our observations expand the reproductive dimension of nesfatin-1, which may operate directly at the testicular level to link energy homeostasis, puberty onset, and gonadal function...
  5. pmc Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids
    F Ruiz-Pino
    Department of Cell Biology, University of Cordoba, 14004 Cordoba, Spain
    Endocrinology 153:4818-29. 2012
    ..Altogether, our data provide a deeper insight into relevant aspects of NKB function as major regulator of the gonadotropic axis in the rat, including maturational changes, sexual dimorphism, and differential regulation by sex steroids...
  6. ncbi request reprint Generation of multi-oocyte follicles in the peripubertal rat ovary: link to the invasive capacity of granulosa cells?
    Francisco Gaytan
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Cordoba, Spain CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain Instituto Maimónides de Investigaciones Biomédicas Hospital Universitario Reina Sofia, Cordoba, Spain Electronic address
    Fertil Steril 101:1467-76. 2014
    ..To assess the presence and numbers of multi-oocyte follicles (MOFs) in the rat ovary at different stages of postnatal maturation...
  7. ncbi request reprint Emerging roles of NUCB2/nesfatin-1 in the metabolic control of reproduction
    David García-Galiano
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Curr Pharm Des 19:6966-72. 2013
    ..These findings illustrate our as yet limited understanding of this aspect of nesfatin-1 physiology, whose relevance in the joint control of metabolism and reproduction in health and disease warrants further investigation. ..
  8. doi request reprint Metabolic programming of puberty: sexually dimorphic responses to early nutritional challenges
    M A Sanchez-Garrido
    Department of Cell Biology, Physiology, and Immunology, Faculty of Medicine, University of Cordoba, Avenida Menéndez Pidal s n 14004 Córdoba, Spain
    Endocrinology 154:3387-400. 2013
    ..Our data disclose important sex differences in the impact of various early nutritional challenges on the timing of puberty, which may help to explain the different trends of altered puberty and related comorbidities between sexes. ..
  9. doi request reprint Keeping puberty on time: novel signals and mechanisms involved
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Curr Top Dev Biol 105:299-329. 2013
    ..This will permit a better understanding of the physiological mechanisms responsible for pubertal timing and will help to decipher the pathophysiological basis for pubertal alterations in humans and wildlife species. ..
  10. doi request reprint Ghrelin, the gonadal axis and the onset of puberty
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, CIBER Fisiopatologia de la Obesidad y Nutricion, ES 14004 Córdoba, Spain
    Endocr Dev 25:69-82. 2013
    ....
  11. doi request reprint Deciphering puberty: novel partners, novel mechanisms
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Eur J Endocrinol 167:733-47. 2012
    ..Characterization of these novel players and regulatory mechanisms will improve our understanding of the basis of normal puberty and its eventual alterations in various pathological conditions...
  12. doi request reprint Comparative insights of the kisspeptin/kisspeptin receptor system: lessons from non-mammalian vertebrates
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Instituto Maimonides de Investigaciones Biomédicas de Córdoba and CIBER Fisiopatología de la Obesidad y Nutrición, 14004 Cordoba, Spain
    Gen Comp Endocrinol 175:234-43. 2012
    ....
  13. ncbi request reprint The KiSS-1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic-pituitary unit?
    Victor M Navarro
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Int J Androl 31:224-32. 2008
    ..We review herein the physiological basis and initial, albeit so far scarce, experimental evidence supporting such possibility...
  14. doi request reprint Ghrelin as a pleotrophic modulator of gonadal function and reproduction
    Manuel Tena-Sempere
    Faculty of Medicine, University of Córdoba and National Research Center CIBER Fisiopatología de la Nutrición y Obesidad of the Instituto de Salud Carlos III, Cordoba, Spain
    Nat Clin Pract Endocrinol Metab 4:666-74. 2008
    ....
  15. doi request reprint KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction
    F Gaytan
    Department of Cell Biology, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Am J Physiol Endocrinol Metab 296:E520-31. 2009
    ..Altogether, our results are suggestive of a conserved role of local KiSS-1 in the direct control of ovarian functions in mammals...
  16. doi request reprint Kisspeptin signaling in the brain: recent developments and future challenges
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Mol Cell Endocrinol 314:164-9. 2010
    ....
  17. doi request reprint Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function
    M Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Córdoba CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III and Instituto Maimónides de Investigaciones Biomédicas, Cordoba, Spain
    Int J Androl 33:360-8. 2010
    ..The potential interaction of xeno-hormones with other environmental modulators (e.g., nutritional state) of the Kiss1 system warrants further investigation...
  18. doi request reprint Roles of kisspeptins in the control of hypothalamic-gonadotropic function: focus on sexual differentiation and puberty onset
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Endocr Dev 17:52-62. 2010
    ....
  19. doi request reprint Kisspeptins and the metabolic control of reproduction: physiologic roles and physiopathological implications
    M Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    Ann Endocrinol (Paris) 71:201-2. 2010
    ....
  20. ncbi request reprint Exploring the role of ghrelin as novel regulator of gonadal function
    Manuel Tena-Sempere
    Physiology Section, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Growth Horm IGF Res 15:83-8. 2005
    ....
  21. ncbi request reprint Roles of ghrelin and leptin in the control of reproductive function
    Manuel Tena-Sempere
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 86:229-41. 2007
    ....
  22. ncbi request reprint GPR54 and kisspeptin in reproduction
    Manuel Tena-Sempere
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Hum Reprod Update 12:631-9. 2006
    ..This review comprehensively examines the experimental evidence obtained to date supporting a pivotal role of kisspeptins and GPR54 in the control of reproduction...
  23. ncbi request reprint Homologous and heterologous down-regulation of leptin receptor messenger ribonucleic acid in rat adrenal gland
    M Tena-Sempere
    Department of Physiology, University of Cordoba, 14004 Cordoba, Spain
    J Endocrinol 167:479-86. 2000
    ..Furthermore, our data showing down-regulation of Ob-R mRNA expression by its cognate ligand may well be relevant to leptin physiology and its alteration in various disease states...
  24. ncbi request reprint The roles of kisspeptins and G protein-coupled receptor-54 in pubertal development
    Manuel Tena-Sempere
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Curr Opin Pediatr 18:442-7. 2006
    ..This review summarizes the experimental data demonstrating the fundamental role of kisspeptins and their G protein-coupled receptor GPR54 in the control of reproduction, with special emphasis on their function at puberty...
  25. ncbi request reprint Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary
    M Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    Biol Reprod 70:671-8. 2004
    ..Differential regulation of ER isoforms may represent a relevant system for the self-tuning of estrogen responsiveness in female pituitary...
  26. ncbi request reprint Ghrelin: novel regulator of gonadal function
    M Tena-Sempere
    Physiology Section, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    J Endocrinol Invest 28:26-9. 2005
    ..Overall, it is proposed that, through systemic and local actions, ghrelin may cooperate with other key regulatory signals, such as leptin, in the integrated control of energy balance and gonadal function...
  27. ncbi request reprint Biological role of pituitary estrogen receptors ERalpha and ERbeta on progesterone receptor expression and action and on gonadotropin and prolactin secretion in the rat
    Jose E Sanchez-Criado
    Department of Cell Biology, Physiology and Inmunology, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 79:247-58. 2004
    ....
  28. doi request reprint Obesity-induced hypogonadism in the male: premature reproductive neuroendocrine senescence and contribution of Kiss1-mediated mechanisms
    Miguel Angel Sánchez-Garrido
    Department of Cell Biology, Physiology, and Immunology CIBERobn Fisiopatología de la Obesidad y Nutrición Department of Cell Biology, Physiology, and Immunology and Instituto Maimonides de Investigación Biomedica de Cordoba IMIBIC Hospital Universitario Reina Sofia M A S G, F R P, M M L, S L, D G G, J P C, R M L, A R R, J M C, L P, M T S, University of Cordoba, 14004 Cordoba, Spain and Department of Physiology C D, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Endocrinology 155:1067-79. 2014
    ..Our study demonstrates that nutritional stress, especially HFD, has a profound deleterious impact on metabolic and gonadotropic function as well as on the Kiss1 system and precipitates neuroendocrine reproductive senescence in the male. ..
  29. ncbi request reprint Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats
    Juan M Castellano
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Diabetes 55:2602-10. 2006
    ....
  30. doi request reprint Characterization of the reproductive effects of the anorexigenic VGF-derived peptide TLQP-21: in vivo and in vitro studies in male rats
    Leonor Pinilla
    Physiology Section, Dept of Cell Biology, Physiology, and Immunology, Faculty of Medicine, Univ of Cordoba, Avda Menendez Pidal s n, Cordoba, Spain
    Am J Physiol Endocrinol Metab 300:E837-47. 2011
    ....
  31. doi request reprint The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis
    Mayte Alvarez-Crespo
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain and CIBER Fisiopatología de la Obesidad y Nutrición CIBERobn, 15706, Spain
    Endocrinology 154:3589-98. 2013
    ..Overall, this evidence suggests that the orexigenic action of OX-A depends on an intact GH axis and that this neuroendocrine feedback loop may be of interest in the understanding of orexins action on energy balance and GH deficiency. ..
  32. ncbi request reprint Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies
    Rafael Fernandez-Fernandez
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 82:245-55. 2005
    ..Overall, our results further document the reproductive role of ghrelin, which might be relevant for the integrated control of energy balance and reproduction...
  33. doi request reprint Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system
    Juan M Castellano
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Avda Menendez Pidal s n 14004 Cordoba, Spain
    Endocrinology 152:3396-408. 2011
    ....
  34. doi request reprint Characterization of the reproductive effects of the Vgf-derived peptide TLQP-21 in female rats: in vivo and in vitro studies
    Enrique Aguilar
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, CIBER Fisiopatologia de la Obesidad y Nutricion, and Instituto Maimónides de Investigaciones Biomédicas IMIBIC Hospital Reina Sofía, Cordoba, Spain
    Neuroendocrinology 98:38-50. 2013
    ..Previous studies of our group reported that this molecule participates also in the regulation of reproductive function in male rats, with predominant stimulatory effects...
  35. ncbi request reprint The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat
    David García-Galiano
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    J Neurosci 30:7783-92. 2010
    ..In sum, our data are the first to disclose the indispensable role of NUCB2/nesfatin-1 in the central networks driving puberty onset, a function that may contribute to its functional coupling to energy homeostasis...
  36. doi request reprint Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission
    David García-Galiano
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Cordoba, Spain
    Am J Physiol Endocrinol Metab 303:E1252-63. 2012
    ..Our pharmacological data will help to characterize the central interactions and putative hierarchy of key neuroendocrine pathways involved in the control of the gonadotropic axis...
  37. doi request reprint The ovary-mediated FSH attenuation of the LH surge in the rat involves a decreased gonadotroph progesterone receptor (PR) action but not PR expression
    Ana Gordon
    Departments of Cell Biology, Physiology and Immunology and Comparative Pathology, University of Cordoba, 14004 Cordoba, Spain IVI Madrid, Madrid, Spain
    J Endocrinol 196:583-92. 2008
    ..The action of such a factor seemed to be due to a blockade of gonadotroph PR action rather than to an inhibition of PR expression...
  38. ncbi request reprint Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, C San Francisco s n, 15705, Spain
    J Cell Sci 117:3247-57. 2004
    ..These data underscore a reproductive facet of this recently cloned molecule, which may operate as a novel endocrine integrator linking energy homeostasis and reproduction...
  39. ncbi request reprint Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism
    Francisco Gaytan
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 154:1321-36. 2013
    ..Our findings suggest distinct functional roles of these two related, but not overlapping, miRNA-binding proteins in the male gonad...
  40. ncbi request reprint Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen
    Rafael Fernandez-Fernandez
    Physiology Section, Faculty of Medicine, University of Cordoba, 14004 Cordoba, Spain
    Reproduction 133:1223-32. 2007
    ..Overall, our present data reinforce the concept that ghrelin participates in the control of LH secretion, with potential stimulatory actions at the pituitary level that require the presence of NO and are modulated by ovarian signals...
  41. doi request reprint Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction
    Rafael Pineda
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Prog Brain Res 181:55-77. 2010
    ....
  42. doi request reprint Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice
    David García-Galiano
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Endocrinology 153:316-28. 2012
    ....
  43. pmc Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin
    Luis Martins
    Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela, Spain
    PLoS ONE 7:e46923. 2012
    ..Taken together, these data indicate that, in addition to previous reported mechanisms, ghrelin also promotes feeding through modulation of hypothalamic mTOR pathway...
  44. ncbi request reprint Perturbation of hypothalamic microRNA expression patterns in male rats after metabolic distress: impact of obesity and conditions of negative energy balance
    Susana Sangiao-Alvarellos
    Department of Medicine S S A, L P B, F C, School of Health Science, University of A Coruna, Campus de Oza, 15006 A Coruna, Spain Instituto de Investigación Biomédica de A Coruña S S A, L P B, F C, Xubias de Arriba, 84, 15006 A Coruna, Spain Division of Endocrinology L P B, F C, Complexo Hospitalario Universitario de A Coruña CHUAC, 15006 A Coruna, Spain and Department of Cell Biology M M L, M T S, Physiology and Immunology, University of Cordoba, Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, and Instituto Maimónides de Investigación Biomédica Hospital Universitario Reina Sofía, 14004 Cordoba, Spain
    Endocrinology 155:1838-50. 2014
    ....
  45. ncbi request reprint Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod
    Eva Vigo
    Physiology Section, Department of Cell Biology, Physiology and Immunology Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004, Cordoba, Spain
    Am J Physiol Endocrinol Metab 293:E1265-73. 2007
    ....
  46. pmc Role of neurokinin B in the control of female puberty and its modulation by metabolic status
    Victor M Navarro
    Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Spain
    J Neurosci 32:2388-97. 2012
    ..Altogether, our observations suggest that NKB-NK3R signaling plays a role in pubertal maturation and that its alterations may contribute to pubertal disorders linked to metabolic stress and negative energy balance...
  47. ncbi request reprint Ghrelin inhibits prolactin secretion in prepubertal rats
    Manuel Tena-Sempere
    Department of Cell Biology, Physiology and Immunology, Physiology Section, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 79:133-41. 2004
    ..In conclusion, our data indicate that ghrelin is able to inhibit PRL secretion in male and female rats, likely through an extrapituitary primary site of action that is independent of nitric oxide, dopamine, and serotonin systems...
  48. ncbi request reprint Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids
    Leonor Pinilla
    Section of Physiology, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Neuroendocrinology 77:83-90. 2003
    ..The data also demonstrate for the first time the existence of a cross-talk between ghrelin and other neurotransmitter systems, such as EAAs and serotonin, in precise control of GH secretion...
  49. ncbi request reprint New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function
    Juan Roa
    Physiology Section, Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Front Neuroendocrinol 29:48-69. 2008
    ..In addition, the 'comparative endocrinology' of this system has begun to be explored recently. These facets of kisspeptin/GPR54 function, as fundamental gatekeepers of reproduction, will be comprehensively reviewed herein...
  50. doi request reprint Kisspeptins and reproduction: physiological roles and regulatory mechanisms
    Leonor Pinilla
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Spain
    Physiol Rev 92:1235-316. 2012
    ..By doing so, we aim to endow the reader with a critical and updated view of the physiological roles and potential translational relevance of kisspeptins in the integral control of reproductive function...
  51. doi request reprint Kisspeptins in reproductive biology: consensus knowledge and recent developments
    Juan Roa
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Biol Reprod 85:650-60. 2011
    ....
  52. doi request reprint Metabolic control of puberty onset: new players, new mechanisms
    Juan Roa
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Mol Cell Endocrinol 324:87-94. 2010
    ..Elucidation of these novel players and regulatory mechanisms will help for a better understanding of the determinants of the timing of puberty, and its eventual alterations in adverse metabolic conditions...
  53. ncbi request reprint Regulation of pituitary cell function by adiponectin
    Francisca Rodriguez-Pacheco
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, E 14014 Cordoba, Spain
    Endocrinology 148:401-10. 2007
    ..In sum, our data indicate that adiponectin, either locally produced or from other sources, may play a neuroendocrine role in the control of both somatotrophs and gonadotrophs...
  54. pmc Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms
    Raul M Luque
    Department of Cell Biology, Physiology, and Immunology, Campus Universitario de Rabanales, Edificio Severo Ochoa, Planta 3, University of Cordoba, E 14014 Cordoba, Spain
    Endocrinology 152:957-66. 2011
    ....
  55. ncbi request reprint KiSS-1 system and reproduction: comparative aspects and roles in the control of female gonadotropic axis in mammals
    Juan Roa
    Physiology Section, Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain
    Gen Comp Endocrinol 153:132-40. 2007
    ....
  56. doi request reprint Expanding roles of NUCB2/nesfatin-1 in neuroendocrine regulation
    David García-Galiano
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    J Mol Endocrinol 45:281-90. 2010
    ....
  57. doi request reprint Metabolic regulation of kisspeptin
    Juan Manuel Castellano
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Adv Exp Med Biol 784:363-83. 2013
    ....
  58. ncbi request reprint Ghrelin effects on gonadotropin secretion in male and female rats
    Rafael Fernandez-Fernandez
    Department of Physiology, Faculty of Medicine, University of Cordoba, 14004 Cordoba, Spain
    Neurosci Lett 362:103-7. 2004
    ....
  59. doi request reprint Kisspeptins: bridging energy homeostasis and reproduction
    Juan M Castellano
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Spain
    Brain Res 1364:129-38. 2010
    ....
  60. doi request reprint Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain
    Front Neuroendocrinol 31:113-27. 2010
    ..Understanding this aspect of orexin/hypocretin physiology could open new therapeutic possibilities in the treatment of sleep, energy homeostasis and endocrine pathologies...
  61. doi request reprint Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner
    Carmen Ruth González
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain
    Physiol Behav 99:91-9. 2010
    ....
  62. ncbi request reprint Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice
    Raul M Luque
    Department of Cell Biology, Physiology, and Immunology R M L, J C C, A I C, F G N, M T S, M D G, J P C, University of Cordoba, Instituto Maimonides de Investigacion Biomedica de Cordoba, Hospital Universitario Reina Sofia, and Centros de Investigación Biomédica en Red CIBER Fisiopatología de la Obesidad y Nutrición, E 14014 Cordoba, Spain Department of Medicine J C C, R D K, University of Illinois at Chicago, and Jesse Brown Veterans Affairs Medical Center J C C, R D K, Research and Development Division, Chicago, Illinois 60612 and Department of Medical Sciences I G, C G, E G, R G, University of Torino, 10126 Torino, Italy
    Endocrinology 155:1407-17. 2014
    ..Taken together, our results provide evidence that obestatin can act directly at the pituitary to control somatotrope and corticotrope function, and these effects are conserved across species. ..
  63. ncbi request reprint Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation?
    Maria Gaytan
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Cordoba, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Cell Tissue Res 329:571-9. 2007
    ..This knowledge of the regional- and cycle-specific pattern of expression of KiSS-1 in rat oviduct should open up the possibility of a physiological role of kisspeptins in the prevention of ectopic (tubal) implantation...
  64. doi request reprint Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility
    Victor M Navarro
    Department of Cell Biology, Physiology and Immunology and CIBERobn, Faculty of Medicine, University of Cordoba, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Nat Rev Endocrinol 8:40-53. 2012
    ..In this Review, we present the major reproductive features of kisspeptins, especially their interplay with neurokinin B and potential roles in the metabolic control of puberty and fertility, and suggest new avenues for research...
  65. ncbi request reprint Role of ghrelin in reproduction
    Maria C Garcia
    Department of Physiology, School of Medicine, University of Santiago de Compostela, R San Francisco s n, 15782 Santiago de Compostela A Coruña, Spain
    Reproduction 133:531-40. 2007
    ..We propose that ghrelin either acting as an endocrine and/or paracrine signal may play a major role in the endocrine network that integrates energy balance and reproduction...
  66. ncbi request reprint Ghrelin is produced by and directly activates corticotrope cells from adrenocorticotropin-secreting adenomas
    Antonio J Martinez-Fuentes
    Department of Cell Biology, Physiology, and Immunology, Edificio Severo Ochoa, Planta 3, Campus de Rabanales, University of Cordoba, E 14014 Cordoba, Spain
    J Clin Endocrinol Metab 91:2225-31. 2006
    ....
  67. doi request reprint Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism
    Luis Varela
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
    J Pathol 227:209-22. 2012
    ....
  68. doi request reprint Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance
    Pablo Blanco Martínez de Morentin
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Rev Endocr Metab Disord 12:127-40. 2011
    ..Understanding this key molecule and especially its functions at central level may provide new therapeutic targets for the treatment of metabolic alterations and obesity...
  69. ncbi request reprint Tamoxifen induces gonadotropin-releasing hormone self-priming through an estrogen-dependent progesterone receptor expression in the gonadotrope of the rat
    Carmina Bellido
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Spain
    Neuroendocrinology 77:425-35. 2003
    ..In conclusion, tamoxifen induced PR expression (mRNA and nuclear IR) in the gonadotrope in an E-dependent manner, while activation of these PR through intracellular signaling of GnRH induced GnRH self-priming...
  70. ncbi request reprint Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line
    Raul M Luque
    Physiology Section, Department of Cell Biology, Physiology, and Immunology, University of Cordoba, Avenida Menendez Pidal, 14004 Cordoba, Spain
    Endocrinology 148:4601-11. 2007
    ..In sum, our present data further characterize the functional relevance and putative key mediators (such as leptin and NPY) of the metabolic regulation of the hypothalamic KiSS-1 system in the mouse...
  71. ncbi request reprint Role of excitatory amino acids in the control of growth hormone secretion
    Enrique Aguilar
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Av da Menéndez Pidal s n, 14004 Cordoba, Spain
    Endocrine 28:295-302. 2005
    ..In conclusion, our data using the rat as animal model provide evidence for a pivotal role of glutamate pathways in the regulation of GH secretion throughout the life-span...
  72. doi request reprint Energy balance and puberty onset: emerging role of central mTOR signaling
    Juan Roa
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    Trends Endocrinol Metab 21:519-28. 2010
    ....
  73. doi request reprint Intracellular signaling pathways activated by kisspeptins through GPR54: do multiple signals underlie function diversity?
    Justo P Castaño
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, and CIBER Fisiopatología de la Obesidad y Nutrición CB06 03, Instituto de Salud Carlos III, Cordoba, Spain
    Peptides 30:10-5. 2009
    ..In this scenario, it will be important to decipher kisspeptin/GPR54 signaling mechanisms in reproductive and non-reproductive tissues by studying additional models, especially on natural kisspeptin targets expressing endogenous GPR54...
  74. ncbi request reprint 5-HT1 and 5-HT2 receptor activation reduces N-methyl-D-aspartate (NMDA)-stimulated LH secretion in prepubertal male and female rats
    Leonor Pinilla
    Department of Physiology, Faculty of Medicine, Cordoba University, Avda Menendez Pidal s n, Cordoba 14004, Spain
    Eur J Endocrinol 148:121-7. 2003
    ..The present experiments were carried out to analyze the effects of activation of different 5-hydroxytryptamine (5-HT) receptor subtypes on gonadotropin secretion and their role in the N-methyl-d-aspartate (NMDA)-stimulated LH release...
  75. ncbi request reprint In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides
    Ester Gutiérrez-Pascual
    Department of Cell Biology, Physiology and Immunology, Campus de Rabanales, University of Cordoba, Cordoba, Spain
    Mol Pharmacol 76:58-67. 2009
    ..Furthermore, they emphasize the importance of using combined, multidisciplinary approaches, including in vivo studies, to reliably evaluate structure function properties of novel kisspeptin analogs...
  76. ncbi request reprint Sex differences, developmental changes, response to injury and cAMP regulation of the mRNA levels of steroidogenic acute regulatory protein, cytochrome p450scc, and aromatase in the olivocerebellar system
    Esteban Lavaque
    Instituto Cajal, C S I C, E 28002 Madrid, Spain
    J Neurobiol 66:308-18. 2006
    ....
  77. ncbi request reprint Hypothalamic KiSS-1: the missing link in gonadotropin feedback control?
    Manuel Tena-Sempere
    Endocrinology 146:3683-5. 2005
  78. ncbi request reprint Expression of leptin and adiponectin in the rat oviduct
    Marta Archanco
    Department of Histology and Pathology, University of Navarra, C Irunlarrea 1, 31008 Pamplona, Spain
    J Histochem Cytochem 55:1027-37. 2007
    ....
  79. ncbi request reprint Sexual differentiation of Kiss1 gene expression in the brain of the rat
    Alexander S Kauffman
    Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Endocrinology 148:1774-83. 2007
    ..Our findings suggest that sex differences in kisspeptin signaling from the AVPV subserve the cellular mechanisms controlling the sexually differentiated GnRH/LH surge...