Jose Such

Summary

Country: Spain

Publications

  1. doi request reprint Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis
    Pedro Zapater
    Unidad Hepática, Hospital General Universitario de Alicante, Universidad Miguel Hernandez, Elche, Alicante, Spain
    Hepatology 48:1924-31. 2008
  2. pmc The peritoneal macrophage inflammatory profile in cirrhosis depends on the alcoholic or hepatitis C viral etiology and is related to ERK phosphorylation
    Ana Tapia-Abellán
    Departamento de Bioquimica, Biología Molecular B e Inmunología Facultad de Medicina, Universidad de Murcia, and Unidadde Trasplante Hepático, Servicio de Aparato Digestivo, Hospital Universitario Virgen de la Arrixaca, Murcia, 30100, Spain
    BMC Immunol 13:42. 2012
  3. ncbi request reprint Ultrastructural characteristics of distal duodenum mucosa in patients with cirrhosis
    Jose Such
    Liver Unit, University General Hospital of Alicante, Miguel Hernandez University, 03010 Alicante, Spain
    Eur J Gastroenterol Hepatol 14:371-6. 2002
  4. ncbi request reprint Nitric oxide in ascitic fluid is an independent predictor of the development of renal impairment in patients with cirrhosis and spontaneous bacterial peritonitis
    Jose Such
    Liver Unit and Department of Immunology, Hospital General Universitario, Alicante, Spain
    Eur J Gastroenterol Hepatol 16:571-7. 2004
  5. ncbi request reprint Nitric oxide in patients with cirrhosis and bacterial infections
    Jose Such
    Liver Unit, Hospital General Universitario, Alicante, Spain
    Metab Brain Dis 17:303-9. 2002
  6. ncbi request reprint Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites
    Jose Such
    Unidad Hepática, Hospital General Universitario, Universidad Miguel Hernandez, Campus de San Juan, San Juan de Alicante, c Pintor Baeza s n, 03010 Alicante, Spain
    Hepatology 36:135-41. 2002
  7. ncbi request reprint The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation
    Carlos Guarner
    Liver Section, Escuela de Patologia Digestiva, Hospital de la Sta Creu i St Pau, Barcelona, and Liver Unit, Hospital General Universitario, Alicante, Spain
    Hepatology 44:633-9. 2006
  8. doi request reprint Norfloxacin modulates the inflammatory response and directly affects neutrophils in patients with decompensated cirrhosis
    Pedro Zapater
    Sección de Farmacología Clínica, Hospital General Universitario, Alicante, and Universidad Miguel Hernandez, Elche, Spain
    Gastroenterology 137:1669-79.e1. 2009
  9. ncbi request reprint A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites
    Rubén Francés
    Unidad Hepática Sección de Inmunología, Alicante, Spain
    Hepatology 39:484-91. 2004
  10. doi request reprint Proteomic evidence of bacterial peptide translocation in afebrile patients with cirrhosis and ascites
    Rocío Caño
    Unidad Hepática, Hospital General Universitario, Avda Pintor Baeza 12, 03010, Alicante, Spain
    J Mol Med (Berl) 88:487-95. 2010

Collaborators

Detail Information

Publications37

  1. doi request reprint Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis
    Pedro Zapater
    Unidad Hepática, Hospital General Universitario de Alicante, Universidad Miguel Hernandez, Elche, Alicante, Spain
    Hepatology 48:1924-31. 2008
    ..This fact may be related to the development of acute-on-chronic liver failure at short term and does not predict the development of spontaneous bacterial peritonitis...
  2. pmc The peritoneal macrophage inflammatory profile in cirrhosis depends on the alcoholic or hepatitis C viral etiology and is related to ERK phosphorylation
    Ana Tapia-Abellán
    Departamento de Bioquimica, Biología Molecular B e Inmunología Facultad de Medicina, Universidad de Murcia, and Unidadde Trasplante Hepático, Servicio de Aparato Digestivo, Hospital Universitario Virgen de la Arrixaca, Murcia, 30100, Spain
    BMC Immunol 13:42. 2012
    ..Cytokines and the cell content in ascites were assessed by ELISA and flow cytometry, respectively. Cytokines and ERK phosphorylation in peritoneal monocyte-derived macrophages isolated and stimulated in vitro were also determined...
  3. ncbi request reprint Ultrastructural characteristics of distal duodenum mucosa in patients with cirrhosis
    Jose Such
    Liver Unit, University General Hospital of Alicante, Miguel Hernandez University, 03010 Alicante, Spain
    Eur J Gastroenterol Hepatol 14:371-6. 2002
    ..The aim of this observational study was to investigate the ultrastructural characteristics of the intestinal epithelial layer of duodenum mucosa in patients with cirrhosis...
  4. ncbi request reprint Nitric oxide in ascitic fluid is an independent predictor of the development of renal impairment in patients with cirrhosis and spontaneous bacterial peritonitis
    Jose Such
    Liver Unit and Department of Immunology, Hospital General Universitario, Alicante, Spain
    Eur J Gastroenterol Hepatol 16:571-7. 2004
    ..Our aim was to assess whether patients with ascitic fluid infection show increased levels of nitric oxide, and whether this is related to the development of renal impairment...
  5. ncbi request reprint Nitric oxide in patients with cirrhosis and bacterial infections
    Jose Such
    Liver Unit, Hospital General Universitario, Alicante, Spain
    Metab Brain Dis 17:303-9. 2002
    ....
  6. ncbi request reprint Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites
    Jose Such
    Unidad Hepática, Hospital General Universitario, Universidad Miguel Hernandez, Campus de San Juan, San Juan de Alicante, c Pintor Baeza s n, 03010 Alicante, Spain
    Hepatology 36:135-41. 2002
    ..In conclusion, we have detected bactDNA in serum and AF in 32% of all patients studied, and this likely represents single clone episodes of translocation and systemic seeding. E. coli is the most frequently identified bacteria...
  7. ncbi request reprint The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation
    Carlos Guarner
    Liver Section, Escuela de Patologia Digestiva, Hospital de la Sta Creu i St Pau, Barcelona, and Liver Unit, Hospital General Universitario, Alicante, Spain
    Hepatology 44:633-9. 2006
    ..In conclusion, the presence of bactDNA in biological fluids in rats with cirrhosis constitutes a marker of BT, and it is associated with a marked inflammatory response, independent of the result of the culture...
  8. doi request reprint Norfloxacin modulates the inflammatory response and directly affects neutrophils in patients with decompensated cirrhosis
    Pedro Zapater
    Sección de Farmacología Clínica, Hospital General Universitario, Alicante, and Universidad Miguel Hernandez, Elche, Spain
    Gastroenterology 137:1669-79.e1. 2009
    ..Patients with cirrhosis undergoing selective intestinal decontamination with norfloxacin show a reduction in serum cytokine levels, probably because of a combined effect of norfloxacin on bowel flora and neutrophils...
  9. ncbi request reprint A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites
    Rubén Francés
    Unidad Hepática Sección de Inmunología, Alicante, Spain
    Hepatology 39:484-91. 2004
    ..In conclusion, bacterial translocation is a single-species, dynamic process that appears to develop in a subgroup of patients with advanced cirrhosis...
  10. doi request reprint Proteomic evidence of bacterial peptide translocation in afebrile patients with cirrhosis and ascites
    Rocío Caño
    Unidad Hepática, Hospital General Universitario, Avda Pintor Baeza 12, 03010, Alicante, Spain
    J Mol Med (Berl) 88:487-95. 2010
    ..Bacterial peptide translocation is present in the ascitic fluid of a subgroup of patients with advanced cirrhosis and is associated with an increased immune response...
  11. doi request reprint Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications
    Pablo Bellot
    Liver Unit, Hospital General Universitario de Alicante and Miguel Hernández University, Elche, Alicante, Spain
    Liver Int 33:31-9. 2013
    ....
  12. doi request reprint Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease
    Ana Gutierrez
    Servicio de Medicina Digestiva, Hospital General Universitario de Alicante, Alicante, Spain
    Gut 63:272-80. 2014
    ....
  13. ncbi request reprint Intracellular cytokine expression in peritoneal monocyte/macrophages obtained from patients with cirrhosis and presence of bacterial DNA
    Rubén Francés
    Seccion de Inmunologia, Hospital General Universitario, Alicante, Spain
    Eur J Gastroenterol Hepatol 17:45-51. 2005
    ..Since different cell types give rise to cytokines, flow cytometry becomes a powerful tool to discriminate between populations involved in a bacterial challenge...
  14. ncbi request reprint A study of intestinal permeability in relation to the inflammatory response and plasma endocab IgM levels in patients with acute pancreatitis
    Juan C Penalva
    Department of Internal Medicine, Hospital General Universitario Alicante, Hospital General Elche, Alicante, Spain
    J Clin Gastroenterol 38:512-7. 2004
    ..There is scarce information regarding intestinal permeability (IP) in patients with acute pancreatitis (AP) and its relationship with systemic inflammatory response and bacterial translocation (BT)...
  15. doi request reprint Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study
    Enrique de-Madaria
    Unidad Hepática, Hospital General Universitario de Alicante, Alicante, Spain
    Eur J Gastroenterol Hepatol 22:507-12. 2010
    ..Our aim was to determine whether the response of the hepatic venous pressure gradient (HVPG) to the intravenous administration of propranolol predicts the response after chronic oral propranolol treatment...
  16. doi request reprint Usefulness of surveillance programmes for early diagnosis of hepatocellular carcinoma in clinical practice
    Sonia Pascual
    Liver Unit, Hospital General Universitario de Alicante, Alicante, Spain
    Liver Int 28:682-9. 2008
    ..The aims of this study have been to compare the survival of patients with HCC being diagnosed or not in SPs, and to establish a more accurate profile of the best target population...
  17. ncbi request reprint Randomized trial comparing albumin and saline in the prevention of paracentesis-induced circulatory dysfunction in cirrhotic patients with ascites
    Javier Sola-Vera
    Liver Unit, Internal Medicine Department, Hospital General Universitario de Alicante, Spain
    Hepatology 37:1147-53. 2003
    ..01] without significant variations after albumin). In conclusion, albumin is more effective than saline in the prevention of PICD. Saline is a valid alternative to albumin when less than 6 L of ascitic fluid is evacuated...
  18. ncbi request reprint [Treatment of refractory hepatic encephalopathy associated with insertion of a transjugular intrahepatic portosystemic shunt through new endovascular techniques: a case report]
    Belén Martínez Moreno
    Unidad Hepática, Hospital General y Universitario de Alicante, Alicante, Espana
    Gastroenterol Hepatol 34:468-73. 2011
    ..We report the case of a patient who underwent TIPS insertion to control bleeding due to esophageal varices. The patient subsequently developed refractory hepatic encephalopathy, requiring reduction of the caliber of the shunt...
  19. doi request reprint Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis
    Isabel Gómez-Hurtado
    Hepatic Unit and Clinical Pharmacology Service, Hospital General Universitario de Alicante, Universidad Miguel Hernandez, Elche, Alicante, Spain
    Hepatology 53:935-44. 2011
    ..Unblocking IL-10 restored proinflammatory mediator and HO-1 expression to previously observed levels in response to LPS stimulation...
  20. doi request reprint Causality assessment of liver injury after chronic oral amiodarone intake
    Lucía Llanos
    Clinical Pharmacology Section, University General Hospital, Alicante, Spain
    Pharmacoepidemiol Drug Saf 18:291-300. 2009
    ..As clinically significant hepatotoxicity associated with oral amiodarone is infrequent and difficult to predict, a new Bayesian-developed model is proposed to help in the causality assessment of amiodarone-induced liver injury...
  21. ncbi request reprint Intestinal permeability is increased in patients with advanced cirrhosis
    Sonia Pascual
    Liver Unit, Department of Internal Medicine, University General Hospital of Alicante C Pintor Baeza s n, Alicante 03010, Spain
    Hepatogastroenterology 50:1482-6. 2003
    ..The aim of this study was to investigate if the alterations of the intestinal barrier in cirrhosis are related with the degree of liver failure and associated with other clinical complications...
  22. doi request reprint Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis
    Pablo Bellot
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hepatology 52:2044-52. 2010
    ..Conclusion: Presence of bacterial DNA, a marker of bacterial translocation, is associated with aggravation of peripheral vasodilation and with worsening of intrahepatic endothelial dysfunction...
  23. doi request reprint Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype
    Ana Gutierrez
    Servicio de Medicina Digestiva, Hospital General Universitario de Alicante, Alicante, Spain
    Inflamm Bowel Dis 17:1641-50. 2011
    ..The aim was to test whether defensins and cathelicidin (LL-37) expression and NOD2/CARD15 mutations in blood neutrophils are related to molecular bacterial translocation events in CD patients...
  24. ncbi request reprint Understanding the mechanisms of paracentesis-induced crculatory dysfunction
    Javier Sola-Vera
    Department of Gastroenterology, Hospital Universitario de Elche, Hospital General Universitario, Alicante, Spain
    Eur J Gastroenterol Hepatol 16:295-8. 2004
    ..Preliminary evidence suggests that other approaches, such as the use of splanchnic vasoconstrictors or modulating the rate of ascitic fluid extraction, could be also effective, although more studies are needed...
  25. ncbi request reprint Development of an experimental model of induced bacterial peritonitis in cirrhotic rats with or without ascites
    Elisabet Sánchez
    Liver Unit, Hospital de la Santa Creu i Sant Pau, Autonomous University, Barcelona, Spain
    Am J Gastroenterol 102:1230-6. 2007
    ..Spontaneous bacterial peritonitis (SBP) is a severe complication of cirrhotic patients associated with a high mortality...
  26. doi request reprint Automated low flow pump system for the treatment of refractory ascites: a multi-center safety and efficacy study
    Pablo Bellot
    Liver Unit, Hospital General Universitario de Alicante and Universidad Miguel Hernández, Elche, Alicante, Spain
    J Hepatol 58:922-7. 2013
    ..We present the results of a multicenter, non-randomized trial to assess the safety and efficacy of a new automated pump system for treatment of RA...
  27. doi request reprint Low-level HIV viremia is associated with microbial translocation and inflammation
    Sergio Reus
    Infectious Disease Unit, Hospital General Universitario de Alicante, Alicante, Spain
    J Acquir Immune Defic Syndr 62:129-34. 2013
    ..The aim of this study was to determine whether strict control of HIV-VL is associated with MT and chronic inflammation...
  28. ncbi request reprint [Bacterial translocation in cirrhosis]
    Pablo Bellot
    Unidad de Hepatologia, Hospital General Universitario, Alicante, Espana
    Gastroenterol Hepatol 31:508-14. 2008
    ..This article provides a detailed description of the abnormalities present in patients with cirrhosis that allow the existence of TB and the immune and clinical repercussions of this phenomenon...
  29. ncbi request reprint Comparison of staging systems to predict survival in hepatocellular carcinoma
    Sonia Pascual
    Liver Unit, Hospital General Universitario de Alicante, Alicante, Spain
    Liver Int 26:673-9. 2006
    ..Some new staging systems in hepatocellular carcinoma (HCC) have been described in the last years. The aim of this study was to compare the survival-predicting capacity of some variables and the prognostic classifications...
  30. ncbi request reprint Hepatotoxicity related to paraquat and diquat absorption through intact skin
    Ana M Peiró
    Clinical Pharmacology Unit, Hospital General de Alicante, Pintor Baeza, S N, 03010, Alicante, Spain
    Dig Dis Sci 52:3282-4. 2007
  31. ncbi request reprint Clinical significance of extrapyramidal signs in patients with cirrhosis
    Rodrigo Jover
    Department of Gastroenterology Liver Unit, Hospital General Universitario de Alicante, C Pintor Baeza, sn, E 03010 Alicante, Spain
    J Hepatol 42:659-65. 2005
    ..The aims of this study have been to investigate the relationship between extrapyramidal signs and cognitive impairment, and what is their influence on quality of life...
  32. doi request reprint Cytokine association with bacterial DNA in serum of patients with inflammatory bowel disease
    Ana Gutierrez
    Servicio de Medicina Digestiva, Hospital General Universitario de Alicante, Spain
    Inflamm Bowel Dis 15:508-14. 2009
    ..Blood microbiological cultures, however, are frequently negative. The aim was to evaluate the presence of bacterial DNA (bactDNA) and the associated cytokine response in patients with IBD...
  33. ncbi request reprint Comparison of stool immunoassay with standard methods for detection of Helicobacter pylori infection in patients with upper-gastrointestinal bleeding of peptic origin
    Pilar Griñó
    Gastroenterology Unit, Department of Internal Medicine, University General Hospital, Miguel Hernandez University, Alicante, Spain
    Eur J Gastroenterol Hepatol 15:525-9. 2003
    ....
  34. ncbi request reprint Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis
    Javier Fernandez
    Liver Unit, Hospital Clinic Barcelona, Barcelona, Spain
    Gastroenterology 133:818-24. 2007
    ..Norfloxacin is highly effective in preventing spontaneous bacterial peritonitis recurrence in cirrhosis, but its role in the primary prevention of this complication is uncertain...
  35. ncbi request reprint Bacterial DNA translocation holds increased insulin resistance and systemic inflammatory levels in morbid obese patients
    Sergio Ortiz
    Servicio de Cirugía General y Digestiva S O, J L E, P E, M R, F L, Servicio de Farmacología Clínica P Z, and Servicio de Endocrinología A A, Hospital General Universitario de Alicante, 03010 Alicante, Spain CIBERehd P Z, J S, R F, Instituto de Salud Carlos III, 28029 Madrid, Spain and Departamento de Medicina Clínica P Z, J S, R F, Universidad Miguel Hernandez, 03550 San Juan de Alicante, Spain
    J Clin Endocrinol Metab 99:2575-83. 2014
    ..Conclusion: Bacterial DNA translocation holds increased insulin resistance and systemic inflammatory levels in morbidly obese patients despite significant weight loss. ..
  36. ncbi request reprint A new Poisson and Bayesian-based method to assign risk and causality in patients with suspected hepatic adverse drug reactions: a report of two new cases of ticlopidine-induced hepatotoxicity
    Pedro Zapater
    Clinical Pharmacology Unit, University General Hospital of Alicante and Department of Pharmacology and Therapeutics, Faculty of Medicine, University Miguel Hernandez, San Juan de Alicante, Spain
    Drug Saf 25:735-50. 2002
    ..The diagnosis of drug-induced hepatotoxicity is based on circumstantial evidence and is often inaccurate. We have designed a method based on published data to assign causality to suspected cases of drug-induced hepatotoxicity...
  37. doi request reprint Phenotypic differences during the osteogenic differentiation of single cell-derived clones isolated from human lipoaspirates
    Beatriz Paredes
    Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, Alicante, Spain
    J Tissue Eng Regen Med 5:589-99. 2011
    ..Copyright © 2010 John Wiley & Sons, Ltd...