Eduardo Soriano

Summary

Country: Spain

Publications

  1. ncbi The cells of cajal-retzius: still a mystery one century after
    Eduardo Soriano
    Institut de Recerca Biomedica de Barcelona, Parc Cientific de Barcelona, University of Barcelona, Barcelona 08028, Spain
    Neuron 46:389-94. 2005
  2. doi Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants
    Carmen Díaz-Ruiz
    Institute for Research in Biomedicine Barcelona IRB, Department of Cell Biology and CIBERNED ISCIII, University of Barcelona, Barcelona Science Park, Lab A1 S1, Josep Samitier 1 5, Barcelona 08028, Spain
    Mol Cell Neurosci 39:519-28. 2008
  3. doi A signaling mechanism coupling netrin-1/deleted in colorectal cancer chemoattraction to SNARE-mediated exocytosis in axonal growth cones
    Tiziana Cotrufo
    Developmental Neurobiology and Regeneration Unit, Institut de Recerca Biomedica Barcelona, Parc Cientific de Barcelona, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Instituto de Salud Carlos III, Department of Cell Biology, University of Barcelona, E 08028 Barcelona, Spain
    J Neurosci 31:14463-80. 2011
  4. ncbi Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion
    Oriol Nicolas
    Department of Cell Biology, University of Barcelona, Barcelona, Spain
    FASEB J 21:3107-17. 2007
  5. ncbi Semaphorin 6C leads to GSK-3-dependent growth cone collapse and redistributes after entorhino-hippocampal axotomy
    Ferran Burgaya
    Institute for Research in Biomedicine IRB and Cell Biology Department, Faculty of Biology, University of Barcelona, Barcelona, Spain
    Mol Cell Neurosci 33:321-34. 2006
  6. pmc Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression
    Marta Pascual
    Institut de Recerca Biomèdica, Parc Cientific de Barcelona, Universitat de Barcelona, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:5193-8. 2007
  7. ncbi Netrin1 exerts a chemorepulsive effect on migrating cerebellar interneurons in a Dcc-independent way
    Patricia Guijarro
    Institute for Research in Biomedicine IRB Barcelona Science Park PCB and Department of Cell Biology, University of Barcelona, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Mol Cell Neurosci 33:389-400. 2006
  8. ncbi Involvement of the myelin-associated inhibitor Nogo-A in early cortical development and neuronal maturation
    Ana Mingorance-Le Meur
    Department of Cell Biology, Cellular and Molecular Basis of Neurodegeneration and Neurorepair, Institute for Research in Biomedicine, University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, 08028 Barcelona, Spain
    Cereb Cortex 17:2375-86. 2007
  9. doi Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons
    Rosalina Gavin
    Cellular and Molecular Basis of Neurodegeneration and Neurorepair, Department of Cell Biology, University of Barcelona, Spain
    Neurobiol Dis 30:243-54. 2008
  10. ncbi Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain
    Jesús Mariano Ureña
    Developmental Neurobiology and Regeneration Lab, Institute of Biomedical Research of Barcelona Parc Científic de Barcelona, University of Barcelona, Josep Samitier 1 5, E08028 Barcelona, Spain
    J Comp Neurol 490:119-32. 2005

Collaborators

Detail Information

Publications60

  1. ncbi The cells of cajal-retzius: still a mystery one century after
    Eduardo Soriano
    Institut de Recerca Biomedica de Barcelona, Parc Cientific de Barcelona, University of Barcelona, Barcelona 08028, Spain
    Neuron 46:389-94. 2005
    ..Given these key and complex developmental properties, it is therefore conceivable for CR cells to be implicated in the pathogenesis of a variety of neurological disorders...
  2. doi Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants
    Carmen Díaz-Ruiz
    Institute for Research in Biomedicine Barcelona IRB, Department of Cell Biology and CIBERNED ISCIII, University of Barcelona, Barcelona Science Park, Lab A1 S1, Josep Samitier 1 5, Barcelona 08028, Spain
    Mol Cell Neurosci 39:519-28. 2008
    ....
  3. doi A signaling mechanism coupling netrin-1/deleted in colorectal cancer chemoattraction to SNARE-mediated exocytosis in axonal growth cones
    Tiziana Cotrufo
    Developmental Neurobiology and Regeneration Unit, Institut de Recerca Biomedica Barcelona, Parc Cientific de Barcelona, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Instituto de Salud Carlos III, Department of Cell Biology, University of Barcelona, E 08028 Barcelona, Spain
    J Neurosci 31:14463-80. 2011
    ..Our data provide evidence of a new signaling mechanism that couples chemotropic Netrin-1/DCC axonal guidance and Sytx1/TI-VAMP SNARE proteins regulating membrane turnover and exocytosis...
  4. ncbi Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar degeneration in prion-deficient mice that overexpress amino-terminally truncated prion
    Oriol Nicolas
    Department of Cell Biology, University of Barcelona, Barcelona, Spain
    FASEB J 21:3107-17. 2007
    ....
  5. ncbi Semaphorin 6C leads to GSK-3-dependent growth cone collapse and redistributes after entorhino-hippocampal axotomy
    Ferran Burgaya
    Institute for Research in Biomedicine IRB and Cell Biology Department, Faculty of Biology, University of Barcelona, Barcelona, Spain
    Mol Cell Neurosci 33:321-34. 2006
    ..Growth cone collapse of entorhinal and pyramidal neurons, as well as activation of glycogen synthase kinase-3 (GSK-3) through depletion of the inactive pool, induced by diffusible Sema6C1 further supports this view...
  6. pmc Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression
    Marta Pascual
    Institut de Recerca Biomèdica, Parc Cientific de Barcelona, Universitat de Barcelona, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:5193-8. 2007
    ..Moreover, our results suggest that Ptf1a is also required for the suppression of the granule cell specification program in cerebellar ventricular zone precursors...
  7. ncbi Netrin1 exerts a chemorepulsive effect on migrating cerebellar interneurons in a Dcc-independent way
    Patricia Guijarro
    Institute for Research in Biomedicine IRB Barcelona Science Park PCB and Department of Cell Biology, University of Barcelona, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Mol Cell Neurosci 33:389-400. 2006
    ..Finally, experiments using blocking antibodies allow us to conclude that Dcc, although expressed by postnatal cerebellar interneurons, is not involved in the repulsive response triggered by Netrin1 in these cells...
  8. ncbi Involvement of the myelin-associated inhibitor Nogo-A in early cortical development and neuronal maturation
    Ana Mingorance-Le Meur
    Department of Cell Biology, Cellular and Molecular Basis of Neurodegeneration and Neurorepair, Institute for Research in Biomedicine, University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, 08028 Barcelona, Spain
    Cereb Cortex 17:2375-86. 2007
    ..On the basis of these observations, we propose that Nogo proteins, particularly Nogo-A, are involved in multiple processes during cortical development...
  9. doi Fibrillar prion peptide PrP(106-126) treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons
    Rosalina Gavin
    Cellular and Molecular Basis of Neurodegeneration and Neurorepair, Department of Cell Biology, University of Barcelona, Spain
    Neurobiol Dis 30:243-54. 2008
    ..Taken together, these data indicate a link between intracellular events induced by exposure to extracellular fibrillar peptide or PrP(res), and APP processing and implicate Dab1 in this link...
  10. ncbi Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain
    Jesús Mariano Ureña
    Developmental Neurobiology and Regeneration Lab, Institute of Biomedical Research of Barcelona Parc Científic de Barcelona, University of Barcelona, Josep Samitier 1 5, E08028 Barcelona, Spain
    J Comp Neurol 490:119-32. 2005
    ..Altogether, our findings indicate that Ack1/Pyk1 tyrosine kinase may be involved both in adult synaptic function and plasticity and in brain development...
  11. doi Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation
    Lluís Pujadas
    Developmental Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine, Barcelona, Department of Cell Biology, University of Barcelona, and Centro de Investigación en Red sobre Enfermedades Neurodegenerativas CIBERNED ISCIII, 08028 Barcelona, Spain
    J Neurosci 30:4636-49. 2010
    ..These observations suggest that Reelin controls developmental processes that remain active in the adult brain...
  12. ncbi Overexpression of myelin-associated glycoprotein after axotomy of the perforant pathway
    Ana Mingorance
    Development and Regeneration of the CNS, Cellular Biology Department, Barcelona Science Park IRB, University of Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Mol Cell Neurosci 29:471-83. 2005
    ..These results demonstrate that MAG expression is regulated in response to cortical axotomy, and indicate that it may limit axonal regeneration after CNS injury...
  13. ncbi Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease
    Vanessa Gil
    Development and Regeneration of the CNS, IRB PCB, Barcelona Science Park, University of Barcelona, Spain
    J Neuropathol Exp Neurol 65:433-44. 2006
    ..These findings also indicate that Reticulon proteins could be considered as new putative drug targets in therapies of neurodegenerative disorders...
  14. doi Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip
    Tiziana Cotrufo
    Developmental Neurobiology and Regeneration Unit, Department of Cell Biology, Institute for Research in Biomedicine, Parc Cientific de Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, University of Barcelona, Barcelona, Spain
    Eur J Neurosci 36:3152-64. 2012
    ..These findings indicate that a Sytx1/DCC interaction is required for Netrin-1 guidance of migrating neurons, thereby highlighting a relationship between guidance signaling and SNARE proteins that regulate membrane turnover...
  15. ncbi Regeneration of lesioned entorhino-hippocampal axons in vitro by combined degradation of inhibitory proteoglycans and blockade of Nogo-66/NgR signaling
    Ana Mingorance
    Development and Regeneration of the CNS, Department of Cell Biology, IRB PCB, University of Barcelona, Barcelona, Spain
    FASEB J 20:491-3. 2006
    ..These results provide insight into the development of new assays and strategies to enhance axon regeneration in injured cortical connections...
  16. ncbi Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation
    Sergi Simo
    Developmental Neurobiology and Regeneration Laboratory, Barcelona Science Park IRB and Department of Cell Biology, University of Barcelona, E 08028 Barcelona, Spain
    Cereb Cortex 17:294-303. 2007
    ....
  17. pmc Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus
    Cátia M Teixeira
    Developmental Neurobiology and Regeneration Laboratory, IRB Barcelona, Parc Cientific de Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, ISCIII, Department of Cell Biology, University of Barcelona, Barcelona E 08028, Spain
    J Neurosci 32:12051-65. 2012
    ..Moreover, our data reveal a novel role of the Reelin cascade in adult brain function with potential implications for the pathogenesis of several neurological and psychiatric disorders...
  18. doi The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity
    Fernando Aguado
    Department of Cell Biology, Centro de Investigación Biomédica en Red para Enfermedades Neurodegenerativas, Institute for Research in Biomedicine, University of Barcelona, Barcelona, Spain
    J Neurosci 29:328-33. 2009
    ..Thus, the functions of CREB/CREM genes in neural activity differ in distinct periods of neural development...
  19. ncbi Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: Role of AMPA/kainate receptors
    Alejandra Rangel
    Cellular and Molecular Basis of Neurodegeneration and Neurorepair, Department of Cell Biology, University of Barcelona, Spain
    J Neurosci Res 85:2741-55. 2007
    ..These results indicate that PrPc exerts a neuroprotective role against KA-induced neurotoxicity, probably by regulating the expression of KA receptor subunits...
  20. ncbi A semaphorin 3A inhibitor blocks axonal chemorepulsion and enhances axon regeneration
    Marisol Montolio
    IRB Barcelona, Department of Cell Biology, University of Barcelona, and CIBERNED ISCIII, Barcelona Science Park, Baldiri i Reixac 10, Barcelona E 08028, Spain
    Chem Biol 16:691-701. 2009
    ..We also show that SICHI promotes neural regeneration of damaged axons. We suggest that SICHI, a selective inhibitor of semaphorin 3A, is of therapeutic interest for approaches aimed at promoting axonal regeneration and brain repair...
  21. ncbi Bcl-2 overexpression does not promote axonal regeneration of the entorhino-hippocampal connections in vitro after axotomy
    Marta Solé
    Development and Regeneration of the CNS, Department of Cell Biology, I R B B P C B, Science Park of Barcelona, University of Barcelona, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Brain Res 1020:204-9. 2004
    ..Thus, in the entorhino-hippocampal formation in vitro, bcl-2 overexpression rescues neurons from axotomy-induced cell death but fails to enhance the regeneration of the entorhino-hippocampal connection...
  22. pmc The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3
    Román Serrat
    Department of Cell Biology, University of Barcelona, Barcelona, Spain
    PLoS ONE 8:e67773. 2013
    ..Our data suggest that the Wnt pathway regulates mitochondrial distribution and dynamics through Alex3 protein degradation. ..
  23. ncbi Cell proliferation in the adult hippocampal formation of rodents and its modulation by entorhinal and fimbria-fornix afferents
    Xavier Fontana
    Development and Regeneration of the CNS, Department of Cell Biology, Barcelona Science Park IRB, University of Barcelona, E 08028 Barcelona, Spain
    Cereb Cortex 16:301-12. 2006
    ....
  24. pmc Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder
    Cátia M Teixeira
    Developmental Neurobiology and Regeneration Unit, Institute for Research in Biomedicine, Parc Cientific de Barcelona, University of Barcelona, Barcelona, Spain
    Neuropsychopharmacology 36:2395-405. 2011
    ..Together, these results point to the Reelin signaling pathway as a relevant drug target for the treatment of a range of psychiatric disorders...
  25. ncbi Coordinated functions of Netrin-1 and Class 3 secreted Semaphorins in the guidance of reciprocal septohippocampal connections
    Marta Pascual
    Department of Cell Biology, University of Barcelona, and IRBB Barcelona Science Park, Barcelona 08028, Spain
    Mol Cell Neurosci 26:24-33. 2004
    ....
  26. pmc Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation
    Nathalia Vitureira
    Institute for Research in Biomedicine, Parc Cientific de Barcelona, Barcelona, Spain
    PLoS ONE 5:e12003. 2010
    ..We also show that whereas some of the brain PC functions require PSA, others depend on PC per se. Our results show that PC, the second highly sialylated neural adhesion protein, plays multiple roles in neural development...
  27. ncbi Age-dependent spontaneous hyperexcitability and impairment of GABAergic function in the hippocampus of mice lacking trkB
    Maria A Carmona
    Department of Cell Biology and IRBB Barcelona Science Park, University of Barcelona, Barcelona E 08028, Spain
    Cereb Cortex 16:47-63. 2006
    ..Furthermore, the present study indicates that long-lasting TrkB signaling may contribute to the construction of CNS circuits by modulating patterns of spontaneous [Ca2+]i oscillations...
  28. ncbi Involvement of Cajal-Retzius cells in robust and layer-specific regeneration of the entorhino-hippocampal pathways
    Jose A Del Río
    Department of Cell Biology, Faculty of Biology, and Neuroscience Research Center CERN, University of Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Eur J Neurosci 15:1881-90. 2002
    ..These results show that the growth-promoting cells controlling the development of neural circuits will be a relevant approach to promoting the regeneration of lesioned adult CNS pathways...
  29. ncbi The Netrin family of guidance factors: emphasis on Netrin-1 signalling
    María J Barallobre
    Department of Cell Biology and IRBB Barcelona Science Park, University of Barcelona, Barcelona E 08028, Spain
    Brain Res Brain Res Rev 49:22-47. 2005
    ..Several signal transduction pathways and effector molecules have been implicated in the response to Netrin-1: small Rho-GTPases, MAP-Kinases, second messengers and the Microtubule Associated Protein 1B (MAP1B)...
  30. ncbi Mouse neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration
    María José Martínez-López
    Department of Biochemistry and Molecular Biology, Cell Signaling Group, School of Pharmacy, University of Barcelona, Spain
    Mol Cell Neurosci 28:599-612. 2005
    ..The abolition of mNAV1 causes loss of directionality in the leading processes of pontine-migrating cells, providing evidence for a role of mNAV1 in mediating Netrin-1-induced directional migration...
  31. ncbi Msx1 disruption leads to diencephalon defects and hydrocephalus
    Casto Ramos
    Department of Cell Biology, University of Barcelona, Barcelona, Spain
    Dev Dyn 230:446-60. 2004
    ....
  32. doi Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease
    Lluís Pujadas
    1 Department of Cell Biology, University of Barcelona, Barcelona 08028, Spain 2 Centro de Investigación en Red sobre Enfermedades Neurodegenerativas CIBERNED, Madrid 28031, Spain 3 Institute for Research in Biomedicine, Barcelona IRB Barcelona, Barcelona 08028, Spain 4 Vall D Hebrón Institut de Recerca VHIR, Barcelona 08035, Spain 5
    Nat Commun 5:3443. 2014
    ....
  33. ncbi The GABAergic septohippocampal pathway in control and reeler mice: target specificity and termination onto Reelin-expressing interneurons
    Marta Pascual
    Department of Cell Biology, University of Barcelona, and Barcelona Science Park, Barcelona 08028, Spain
    Mol Cell Neurosci 25:679-91. 2004
    ..Thus, whereas target layer termination of septal fibers is severely impaired in reeler mice, our data indicate that the cell-specific targeting of GABAergic septohippocampal axons is governed by Reelin-independent signals...
  34. ncbi Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions
    Ana Mingorance
    Development and Regeneration of the CNS, Barcelona Science Park IRBB, University of Barcelona, E 08028 Barcelona, Spain
    Mol Cell Neurosci 26:34-49. 2004
    ..In conclusion, our results show that Nogo and its receptor might play key roles during development of hippocampal connections and that they are implicated in neuronal plasticity in the adult...
  35. ncbi MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance
    Jose A Del Río
    Developmental Neurobiology and Regeneration Unit, Institut de Recerca Biomedica de Barcelona, Barcelona Science Park and Department of Cell Biology, University of Barcelona, Barcelona 08028, Spain
    Curr Biol 14:840-50. 2004
    ..MAP1B is a neuron-specific microtubule-associated protein implicated in the crosstalk between microtubules and actin filaments...
  36. pmc Transient downregulation of Dab1 protein levels during development leads to behavioral and structural deficits: relevance for psychiatric disorders
    Cátia M Teixeira
    1 Department of Cell Biology, University of Barcelona, Barcelona, Spain 2 Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Barcelona, Spain
    Neuropsychopharmacology 39:556-68. 2014
    ..Our results indicate a causal relation between the downregulation of Dab1 protein levels during development and the structural and behavioral deficits associated with psychiatric diseases in the adult. ..
  37. doi The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2
    Guillermo López-Doménech
    Developmental Neurobiology and Regeneration Lab, IRB Barcelona, Parc Cientific de Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, ISCIII, Department of Cell Biology, University of Barcelona, Barcelona E 08028, Spain
    Nat Commun 3:814. 2012
    ..Our data provide evidence of a new Eutherian-specific family of mitochondrial proteins that controls mitochondrial dynamics and indicate that this key process is differentially regulated in the brain of higher vertebrates...
  38. ncbi PrP(106-126) activates neuronal intracellular kinases and Egr1 synthesis through activation of NADPH-oxidase independently of PrPc
    Rosalina Gavin
    Development and Regeneration of the CNS, Department of Cell Biology, Barcelona Science Park IRB, University of Barcelona, Spain
    FEBS Lett 579:4099-106. 2005
    ..However, cells lacking PrPc are similarly affected after peptide exposure, and this questions the involvement of PrPc in these effects...
  39. ncbi A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain
    Cristina Garcia-Frigola
    IRBB PCB and Department of Cell Biology, Faculty of Biology, University of Barcelona, 08071 Barcelona, Spain
    Brain Res Mol Brain Res 122:133-50. 2004
    ..We thus cloned a collection of subtracted cDNAs coding for protein products that may be involved in the development of the cerebral cortex...
  40. ncbi Distribution of CNT2 and ENT1 transcripts in rat brain: selective decrease of CNT2 mRNA in the cerebral cortex of sleep-deprived rats
    Elena Guillen-Gomez
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    J Neurochem 90:883-93. 2004
    ..This specific decrease in CNT2 transcript suggests a new physiological role for the transporter in the modulation of extracellular adenosine levels and the sleep/wakefulness cycle...
  41. ncbi Pattern of expression of the podocalyxin gene in the mouse brain during development
    Nathalia Vitureira
    IRBB PCB, Barcelona Science Park and Department of Cell Biology, University of Barcelona, Josep Samitier 1 5, Barcelona E 08028, Spain
    Gene Expr Patterns 5:349-54. 2005
    ..The highest levels of expression were postnatal. Podocalyxin expression was particularly elevated in the cortical plate, the hippocampus and cerebellum, and in several basal forebrain nuclei...
  42. ncbi Neuronal activity regulates correlated network properties of spontaneous calcium transients in astrocytes in situ
    Fernando Aguado
    Department of Cell Biology and Barcelona Science Park, University of Barcelona, Barcelona E 08028, Spain
    J Neurosci 22:9430-44. 2002
    ..This network activity may be essential for neural development and synaptic plasticity...
  43. doi Regenerating cortical connections in a dish: the entorhino-hippocampal organotypic slice co-culture as tool for pharmacological screening of molecules promoting axon regeneration
    José Antonio del Río
    Molecular and Cellular Neurobiotechnology, Catalonian Institute of Bioengineering IBEC, Science Park of Barcelona, Barcelona, Spain
    Nat Protoc 5:217-26. 2010
    ..The well-preserved cytoarchitectonics in the co-culture facilitate the analysis of identified cells or regenerating axons. The protocol takes up to a month...
  44. ncbi Functions of ephrin/Eph interactions in the development of the nervous system: emphasis on the hippocampal system
    ALBERT MARTINEZ
    Neuronal Development and Regeneration Group S1 A1, Department of Cell Biology, University of Barcelona Barcelona Science Park, Josep Samitier 1 5, Barcelona E 08028, Spain
    Brain Res Brain Res Rev 49:211-26. 2005
    ..Therefore, ephrin/Eph interactions should be considered a crucial system in the development and maturation of the brain regions, including the hippocampus...
  45. ncbi BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2
    Fernando Aguado
    Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
    Development 130:1267-80. 2003
    ..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
  46. ncbi Ca(2+)-evoked synaptic transmission and neurotransmitter receptor levels are impaired in the forebrain of trkb (-/-) mice
    Maria A Carmona
    Department of Cell Biology and Barcelona Science Park, University of Barcelona, 08028, Barcelona, Spain
    Mol Cell Neurosci 22:210-26. 2003
    ..The present results indicate that long-lasting TrkB signaling is required for the precise adjustment of neurotransmitter release and for the correct composition of the fast glutamatergic and GABAergic receptor subunits in vivo...
  47. ncbi BDNF-modulated spatial organization of Cajal-Retzius and GABAergic neurons in the marginal zone plays a role in the development of cortical organization
    Soledad Alcantara
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Cereb Cortex 16:487-99. 2006
    ....
  48. ncbi Expression pattern of ACK1 tyrosine kinase during brain development in the mouse
    Anna La Torre
    Neurobiology of Development and Cellular Regeneration Laboratory, Institut de Recerca Biomèdica IRB, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Gene Expr Patterns 6:886-92. 2006
    ..These results demonstrate that this kinase is up-regulated during development and that it is expressed in proliferative areas and in migratory pathways in the developing brain...
  49. ncbi A role of MAP1B in Reelin-dependent neuronal migration
    Christian Gonzalez-Billault
    Centro de Biologia Molecular, Universidad Autonoma de Madrid CSIC, Madrid 28049, Spain
    Cereb Cortex 15:1134-45. 2005
    ..Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration...
  50. ncbi Role of class 3 semaphorins in the development and maturation of the septohippocampal pathway
    Marta Pascual
    Department of Cell Biology, Faculty of Biology, University of Barcelona Barcelona Science Park, Barcelona, Spain
    Hippocampus 15:184-202. 2005
    ....
  51. ncbi Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts
    Oscar Teijido
    Department of Biochemistry and Molecular Biology, Josep Samitier 1 5 Barcelona E 08028, Spain
    Hum Mol Genet 13:2581-94. 2004
    ..In summary, this study provides an explanation as to why mutations in MLC1 provoke the disease and points to a possible therapy for some patients...
  52. pmc Reelin expression and glycosylation patterns are altered in Alzheimer's disease
    Arancha Botella-Lopez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, E 03550 Sant Joan d Alacant, Spain
    Proc Natl Acad Sci U S A 103:5573-8. 2006
    ....
  53. ncbi Reelin and mDab1 regulate the development of hippocampal connections
    Victor Borrell
    Developmental Neurobiology and Regeneration Laboratory, Institute for Research in Biomedicine IRB Barcelona Science Park, Barcelona, E 08028, Spain
    Mol Cell Neurosci 36:158-73. 2007
    ..Altogether these results indicate that Reelin and mDab1 participate in the development and refinement of hippocampal connections by regulating axonal extension, targeting and branching...
  54. ncbi Lack of TrkB and TrkC signaling alters the synaptogenesis and maturation of mossy fiber terminals in the hippocampus
    Raquel Otal
    Department of Cell Biology, Faculty of Biology, University of Barcelona and Barcelona Science Park, Barcelona, 08028, Spain
    Cell Tissue Res 319:349-58. 2005
    ..Our results therefore reveal that TrkB and TrkC signaling is required for the maturation of granule cell axons...
  55. ncbi Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
    David Vilchez
    Institute for Research in Biomedicine and University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Nat Neurosci 10:1407-13. 2007
    ..Here we explain the formation of polyglucosan inclusions in Lafora disease by demonstrating a crucial role for laforin and malin in glycogen synthesis...
  56. doi Developmental analysis of Lingo-1/Lern1 protein expression in the mouse brain: interaction of its intracellular domain with Myt1l
    Franc Llorens
    Bioinformatics and Genomics Program, Center for Genomic Regulation CRG, UPF, Barcelona 08003, Spain
    Dev Neurobiol 68:521-41. 2008
    ....
  57. ncbi Expression patterns of MLC1 protein in the central and peripheral nervous systems
    Oscar Teijido
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona and Institute for Research in Biomedicine, Barcelona Science Park, Josep Samitier 1 5 Barcelona, E 08028, Spain
    Neurobiol Dis 26:532-45. 2007
    ..Our data provide a mouse MLC1 expression map that could be useful to understand the phenotype of MLC patients, and suggested that MLC disease is caused by an astrocytic and a neuronal dysfunction...
  58. ncbi Spontaneous network activity of cerebellar granule neurons: impairment by in vivo chronic cannabinoid administration
    Sandy Ghozland
    Laboratory of Neuropharmacology, University Pompeu Fabra, Barcelona 08003, Spain
    Eur J Neurosci 16:641-51. 2002
    ..These data provide physiological evidence of the involvement of cerebellar circuits in the adaptive changes occurring during chronic THC exposure and withdrawal...
  59. pmc Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice
    Vassiliki Fotaki
    Medical and Molecular Genetics Center, Institut de Recerca Oncologica, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Mol Cell Biol 22:6636-47. 2002
    ..These data provide evidence about the nonredundant, vital role of Dyrk1A and suggest a conserved mode of action that determines normal growth and brain size in both mice and flies...
  60. ncbi The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis
    Miguel F Segura
    Cell Signaling and Apoptosis Group, Departament de Ciencies Mediques Basiques, Universitat de Lleida Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain
    J Neurosci 27:11228-41. 2007
    ..In conclusion, our results indicate that FAIM(L) could be responsible for maintaining initiator caspases inactive after receptor engagement protecting neurons from the cytotoxic action of death ligands...