B Soria

Summary

Country: Spain

Publications

  1. ncbi request reprint Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
    B Soria
    Institute of Bioengineering, Universidad Miguel Hernandez, San Juan, Alicante, Spain
    Diabetes 49:157-62. 2000
  2. ncbi request reprint In-vitro differentiation of pancreatic beta-cells
    B Soria
    Institute of Bioengineering and Department of Physiology, School of Medicine, Miguel Hernandez University, Alicante, Spain
    Differentiation 68:205-19. 2001
  3. ncbi request reprint Gastrointestinal stem cells. I. Pancreatic stem cells
    Bernat Soria
    Institute of Bioengineering, Ctra Alicante Valencia N332, S N, Campus de San Juan, University Miguel Hernandez, E 03550 San Juan de Alicante, Spain
    Am J Physiol Gastrointest Liver Physiol 289:G177-80. 2005
  4. ncbi request reprint Engineering pancreatic islets
    B Soria
    Instituto de Bioingenieria, Universidad Miguel Hernandez, Alicante, Spain
    Pflugers Arch 440:1-18. 2000
  5. ncbi request reprint Novel players in pancreatic islet signaling: from membrane receptors to nuclear channels
    Bernat Soria
    Institute of Bioengineering, Miguel Hernandez University, Alicante, Spain
    Diabetes 53:S86-91. 2004
  6. ncbi request reprint Cytosolic calcium oscillations and insulin release in pancreatic islets of Langerhans
    B Soria
    Dept of Physiology, Miguel Hernandez University, San Juan, Alicante, Spain
    Diabetes Metab 24:37-40. 1998
  7. ncbi request reprint Diminished fraction of blockable ATP-sensitive K+ channels in islets transplanted into diabetic mice
    B Soria
    Department of Physiology, School of Medicine, University of Alicante, Spain
    Diabetes 45:1755-60. 1996
  8. ncbi request reprint Stem cells and diabetes
    G Berna
    Institute of Bioengineering, University Miguel Hernandez, Alicante, Spain
    Biomed Pharmacother 55:206-12. 2001
  9. ncbi request reprint Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor
    A Nadal
    Institute of Bioengineering and Department of Physiology, Miguel Hernandez University, San Juan Campus, Alicante, Spain
    FASEB J 12:1341-8. 1998
  10. ncbi request reprint A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas
    Ana B Ropero
    Institute of Bioengineering, Miguel Hernandez University, Campus of San Juan, Alicante 03550, Spain
    Mol Endocrinol 16:497-505. 2002

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
    B Soria
    Institute of Bioengineering, Universidad Miguel Hernandez, San Juan, Alicante, Spain
    Diabetes 49:157-62. 2000
    ..This approach opens new possibilities for tissue transplantation in the treatment of type 1 and type 2 diabetes and offers an alternative to gene therapy...
  2. ncbi request reprint In-vitro differentiation of pancreatic beta-cells
    B Soria
    Institute of Bioengineering and Department of Physiology, School of Medicine, Miguel Hernandez University, Alicante, Spain
    Differentiation 68:205-19. 2001
    ..The aim of this review is to discuss the different strategies that may be followed to in-vitro differentiate pancreatic beta-cells from stem cells...
  3. ncbi request reprint Gastrointestinal stem cells. I. Pancreatic stem cells
    Bernat Soria
    Institute of Bioengineering, Ctra Alicante Valencia N332, S N, Campus de San Juan, University Miguel Hernandez, E 03550 San Juan de Alicante, Spain
    Am J Physiol Gastrointest Liver Physiol 289:G177-80. 2005
    ..Finally, although much work remains to be done, there is sufficient evidence to warrant continued efforts on stem cell research to cure diabetes...
  4. ncbi request reprint Engineering pancreatic islets
    B Soria
    Instituto de Bioingenieria, Universidad Miguel Hernandez, Alicante, Spain
    Pflugers Arch 440:1-18. 2000
    ..Gaining deep physiological understanding of the basis governing these processes is instrumental for engineering new pancreatic islets...
  5. ncbi request reprint Novel players in pancreatic islet signaling: from membrane receptors to nuclear channels
    Bernat Soria
    Institute of Bioengineering, Miguel Hernandez University, Alicante, Spain
    Diabetes 53:S86-91. 2004
    ..An integrated view of these pathways should improve the present description of the beta-cell biology and provide new targets for novel drugs...
  6. ncbi request reprint Cytosolic calcium oscillations and insulin release in pancreatic islets of Langerhans
    B Soria
    Dept of Physiology, Miguel Hernandez University, San Juan, Alicante, Spain
    Diabetes Metab 24:37-40. 1998
    ..Slow [Ca2+]i oscillations may constitute the framework for pulsatile insulin release observed in vivo...
  7. ncbi request reprint Diminished fraction of blockable ATP-sensitive K+ channels in islets transplanted into diabetic mice
    B Soria
    Department of Physiology, School of Medicine, University of Alicante, Spain
    Diabetes 45:1755-60. 1996
    ..01). Glucose supersensitivity was attributed to a resting decrease in the fraction of blockable ATP-sensitive K+ (K+(ATP)) channels in transplanted islets that maintained normoglycemia with a limited beta-cell mass...
  8. ncbi request reprint Stem cells and diabetes
    G Berna
    Institute of Bioengineering, University Miguel Hernandez, Alicante, Spain
    Biomed Pharmacother 55:206-12. 2001
    ..These investigations have increased the expectations that cell therapy could be one of the solutions to diabetes...
  9. ncbi request reprint Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor
    A Nadal
    Institute of Bioengineering and Department of Physiology, Miguel Hernandez University, San Juan Campus, Alicante, Spain
    FASEB J 12:1341-8. 1998
    ..Gaining deeper knowledge of the effect induced by 17beta-estradiol may be important in order to better understand the hormonal regulation of insulin secretion and for the treatment of NIDDM. receptor...
  10. ncbi request reprint A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas
    Ana B Ropero
    Institute of Bioengineering, Miguel Hernandez University, Campus of San Juan, Alicante 03550, Spain
    Mol Endocrinol 16:497-505. 2002
    ..Therefore, rapid estrogen actions in islet cells are initiated by a nonclassical estrogen membrane receptor...
  11. ncbi request reprint From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus
    B Soria
    Institute of Bioengineering, , Alicante, Spain
    Diabetologia 44:407-15. 2001
    ..These results show that diabetes could be among the first applications of stem cell therapy...
  12. ncbi request reprint Bio-engineering inslulin-secreting cells from embryonic stem cells: a review of progress
    E Roche
    Institute of Bioengineering, University Miguel Hernandez, San Juan, Alicante, Spain
    Med Biol Eng Comput 41:384-91. 2003
    ....
  13. ncbi request reprint Induction of differentiation of embryonic stem cells into insulin-secreting cells by fetal soluble factors
    Pilar Vaca
    Institute of Bioengineering, Miguel Hernandez University, San Juan de Alicante, Spain
    Stem Cells 24:258-65. 2006
    ..Moreover, identification of factors released by the developing pancreas may be instrumental in engineering beta cells from stem cells...
  14. ncbi request reprint In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells
    T Leon-quinto
    Institute of Bioengineering, School of Medicine, Miguel Hernandez University, San Juan Campus, Alicante, Spain
    Diabetologia 47:1442-51. 2004
    ..Thus, to improve its effectiveness, new strategies have been developed, which increase the number of islet cells or islet progenitors...
  15. pmc Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse
    A Nadal
    Institute of Bioengineering and Department of Physiology, Miguel Hernandez University, Campus of San Juan, Alicante 03550, Spain
    J Physiol 517:85-93. 1999
    ....
  16. pmc Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta
    A Nadal
    Institute of Bioengineering, Department of Physiology, and Department of Applied Biology, Miguel Hernandez University, San Juan Campus, Alicante 03550, Spain
    Proc Natl Acad Sci U S A 97:11603-8. 2000
    ..This binding site is shared by dopamine, epinephrine, and norepinephrine and has the pharmacological profile of the gammaadrenergic receptor. This study provides an outline of the membrane receptor involved in rapid xenoestrogen actions...
  17. pmc Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans
    Paloma Alonso-Magdalena
    Institute of Bioengineering, Miguel Hernandez University, Sant Joan d Alacant, Alicante, Spain
    Environ Health Perspect 113:969-77. 2005
    ..The action of E2, BPA, and DES in pancreatic alpha-cells may explain some of the effects elicited by endocrine disruptors in the metabolism of glucose and lipid...
  18. pmc Nuclear KATP channels trigger nuclear Ca(2+) transients that modulate nuclear function
    Ivan Quesada
    Institute of Bioengineering, Miguel Hernandez University, San Juan Campus, 03550 Alicante, Spain
    Proc Natl Acad Sci U S A 99:9544-9. 2002
    ..These results demonstrate a functional K(ATP) channel in nuclei linking glucose metabolism, nuclear Ca(2+) signals, and nuclear function...
  19. ncbi request reprint Nicotinamide induces both proliferation and differentiation of embryonic stem cells into insulin-producing cells
    P Vaca
    Institute of Bioengineering, University Miguel Hernandez, San Juan de Alicante, Alicante, Spain
    Transplant Proc 35:2021-3. 2003
    ..We herein describe an strategy in which the combination of nutrient restriction and nicotinamide supplementation results in a consistent increase in the mass of insulin-producing cells...
  20. ncbi request reprint Generation of insulin-producing cells from stem cells
    Bernat Soria
    Institute of Bioengineering, University Miguel Hernandez, San Juan, 03550 Alicante, Spain
    Novartis Found Symp 265:158-67; discussion 167-73, 204-11. 2005
    ..This approach opens new possibilities for tissue transplantation in the treatment of type 1 and 2 diabetes...
  21. ncbi request reprint Glucose induces opposite intracellular Ca2+ concentration oscillatory patterns in identified alpha- and beta-cells within intact human islets of Langerhans
    Ivan Quesada
    Institute of Bioengineering, Miguel Hernandez University, Ctra N 332, Km 87, 03550 Sant Joan d Alacant, Spain
    Diabetes 55:2463-9. 2006
    ..A deeper knowledge of alpha- and beta-cell behavior within intact human islets is important to better understand the physiology of the human endocrine pancreas and may be useful to select high-quality islets for transplantation...
  22. pmc Different metabolic responses in alpha-, beta-, and delta-cells of the islet of Langerhans monitored by redox confocal microscopy
    Ivan Quesada
    Institute of Bioengineering, Miguel Hernandez University, Sant Joan d Alacant, Spain
    Biophys J 90:2641-50. 2006
    ..Our findings indicate metabolic differences in glucose utilization among the alpha-, beta-, and delta-cell populations, which might be important in the signal transduction events that lead to hormone release...
  23. ncbi request reprint Role of small bioorganic molecules in stem cell differentiation to insulin-producing cells
    Enrique Roche
    Institute of Bioengineering, University Miguel Hernandez, San Juan, Alicante, Spain
    Bioorg Med Chem 14:6466-74. 2006
    ..In addition, the study of such molecules will help to understand the mechanisms involved in stem cell biology as well as contribute to the design of specific drugs for islet repair and regeneration in diabetes...
  24. doi request reprint Developing biological resource banks as a supporting tool for wildlife reproduction and conservation The Iberian lynx bank as a model for other endangered species
    Trinidad Leon-Quinto
    Institute of Bioengineering, University Miguel Hernandez, Av Universidad s n, E03202 Elche, Spain
    Anim Reprod Sci 112:347-61. 2009
    ..This work describes the main aspects involved in the practical implementation of the Iberian lynx Biological Resource Bank, as a model that could be useful for the development of similar banks for other endangered species...
  25. ncbi request reprint Ectodermal commitment of insulin-producing cells derived from mouse embryonic stem cells
    Enrique Roche
    Institute of Bioengineering, University Miguel Hernandez, San Juan, Alicante, Spain
    FASEB J 19:1341-3. 2005
    ..These results have implications for insulin gene regulation and hormone secretion in order to generate insulin-producing cells for replacement protocols in the treatment of diabetes...
  26. ncbi request reprint Estrogen and xenoestrogen actions on endocrine pancreas: from ion channel modulation to activation of nuclear function
    Angel Nadal
    Institute of Bioengineering, Miguel Hernandez University, San Juan Campus, Carretera Alicante Valencia Km 87, Alicante 03550, Spain
    Steroids 69:531-6. 2004
    ..Although the physiological roles of this receptor are still unknown, it may be implicated in the responses of the endocrine pancreas to the physiological and pathological changes of 17beta-estradiol...
  27. doi request reprint Cryobanking the genetic diversity in the critically endangered Iberian lynx (Lynx pardinus) from skin biopsies. Investigating the cryopreservation and culture ability of highly valuable explants and cells
    Trinidad Leon-Quinto
    Institute of Bioengineering, University Miguel Hernandez, Av Universidad s n, Elche, Spain
    Cryobiology 62:145-51. 2011
    ..These results, focussed on the most endangered felid in the world, could be also useful for other threatened/endangered species...
  28. ncbi request reprint Low doses of the endocrine disruptor bisphenol-A and the native hormone 17beta-estradiol rapidly activate transcription factor CREB
    Ivan Quesada
    Institute of Bioengineering, Miguel Hernandez University, Campus of San Juan, Alicante 03550, Spain
    FASEB J 16:1671-3. 2002
    ..Because these effects are elicited at concentrations as low as 10(-9) M, this observation is of environmental and public health relevance...
  29. doi request reprint Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells
    Pilar Vaca
    Institute of Bioengineering, University Miguel Hernandez, Alicante, Spain
    Exp Cell Res 314:969-74. 2008
    ..Both aspects are very important when thinking about cell therapy for the treatment of diabetes based on ES cells...
  30. ncbi request reprint Isolation and characterization of residual undifferentiated mouse embryonic stem cells from embryoid body cultures by fluorescence tracking
    Roberto Ensenat-Waser
    Instituto de Bioingenieria, Unidad de Bioquímica y Terapia Celular, Universidad Miguel Hernandez, Elche, Alicante, Spain
    In Vitro Cell Dev Biol Anim 42:115-23. 2006
    ....
  31. ncbi request reprint Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1
    Isabel Maestre
    Instituto de Bioingeniería Division of Nutrition, University Miguel Hernandez, San Juan, 03550 Alicante, Spain
    Endocrinology 144:335-45. 2003
    ....
  32. ncbi request reprint Direct visualization by confocal fluorescent microscopy of the permeation of myristoylated peptides through the cell membrane
    Roberto Ensenat-Waser
    Instituto de Bioingenieria, Universidad Miguel Hernandez, Alicante, Spain
    IUBMB Life 54:33-6. 2002
    ..Our results demonstrate that myristoylated peptides diffuse into intact cells, showing an heterogeneous distribution, but they do not reach the cellular nucleous, at least during the time range used...
  33. ncbi request reprint Gap junctional intercellular communication is required to maintain embryonic stem cells in a non-differentiated and proliferative state
    Mariana G Todorova
    Institute of Bioengineering, Miguel Hernandez University, Elche, Alicante, Spain
    J Cell Physiol 214:354-62. 2008
    ..Our findings define a major function of GJIC in the regulation of self-renewal and maintenance of pluripotency in ES cells...
  34. doi request reprint Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway
    Mariana G Todorova
    Instituto de Bioingenieria, Universidad Miguel Hernandez de Elche, 03202 Elche, Alicante, Spain
    Cell Signal 21:523-8. 2009
    ..Additionally, LPA increased the proliferation rate of mESC. Our findings therefore outline the physiological role of LPA in mESC...
  35. ncbi request reprint On-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells
    Ivan Quesada
    Institute of Bioengineering, Miguel Hernandez University, San Juan Campus, 03550 San Juan de Alicante, Spain
    Am J Physiol Endocrinol Metab 284:E980-7. 2003
    ..The results indicate that the electrical coupling of native islet cells is more extensive than dye communication. Dye-coupling domains in islet cells appear more restricted than previously inferred with other methods...
  36. doi request reprint Toward cell-based therapy of type I diabetes
    Dieter Kabelitz
    Institute of Immunology, University Hospital Schleswig Holstein, Kiel, Germany
    Trends Immunol 29:68-74. 2008
    ..A combination of both approaches will be required to turn cell-based therapy of T1D into clinical success...
  37. ncbi request reprint Nutrients induce different Ca(2+) signals in cytosol and nucleus in pancreatic beta-cells
    Ivan Quesada
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Diabetes 53:S92-5. 2004
    ..These amplitude-modulated Ca(2+) signals transmitted to the nucleus might play an important role in the control of gene expression in the pancreatic beta-cell...
  38. ncbi request reprint Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells
    Maren Ruhnke
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    Gastroenterology 128:1774-86. 2005
    ..We evaluated the differentiation potential of human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells...
  39. pmc Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells
    Anouchka Skoudy
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, 08003 Barcelona, Spain
    Biochem J 379:749-56. 2004
    ....
  40. ncbi request reprint Software for simulating calcium-triggered exocytotic processes
    Germán Carrera
    Departamento de Matematicas, Estadistica y Computacion, Universidad de Cantabria, 39005 Santander, Spain
    Am J Physiol Cell Physiol 292:C749-55. 2007
    ..The software package also provides a descriptive statistical data analysis of the different output data...
  41. ncbi request reprint Bovine subcommissural organ displays spontaneous and synchronous intracellular calcium oscillations
    F Javier Bermúdez-Silva
    Departamento de Biologia Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Malaga, Campus de Teatinos s n, 29071 Malaga, Spain
    Brain Res 977:90-6. 2003
    ....
  42. ncbi request reprint Nitric oxide mediates the survival action of IGF-1 and insulin in pancreatic beta cells
    Gladys M Cahuana
    Andalusian Center for Molecular Biology and Regenerative Medicine CABIMER University Pablo de Olavide, Sevilla, Spain
    Cell Signal 20:301-10. 2008
    ..We then conclude that generation of NO participates in the activation of survival pathways by IGF-1 and insulin in beta cells...