Cristina Sierra

Summary

Country: Spain

Publications

  1. pmc Connecting cerebral white matter lesions and hypertensive target organ damage
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Institute of Medicine and Dermatology, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Aging Res 2011:438978. 2011
  2. ncbi Essential hypertension, cerebral white matter pathology and ischemic stroke
    C Sierra
    Hypertension and Vascular Risk Unit, Department of Internal Medicine, Hospital Clinic of Barcelona, Villarroel 170 Barcelona 08036, Spain
    Curr Med Chem 21:2156-64. 2014
  3. pmc Associations between Ambulatory Blood Pressure Parameters and Cerebral White Matter Lesions
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Institute of Medicine and Dermatology, IDIBAPS, Hospital Clinic of Barcelona, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Int J Hypertens 2011:478710. 2011
  4. doi Hypertension and mild cognitive impairment
    Cristina Sierra
    Hypertension and Vascular Risk Unit, Department of Internal Medicine, Hospital Clinic of Barcelona, Spain
    Curr Hypertens Rep 14:548-55. 2012
  5. ncbi Cerebral small vessel disease, cognitive impairment and vascular dementia
    C Sierra
    Hypertension and Vascular Risk Unit, Department of Internal Medicine, Institute of Medicine and DermatologyHospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain
    Panminerva Med 54:179-88. 2012
  6. ncbi Early brain damage in essential hypertension: "to have and have not"--is it important?
    Cristina Sierra
    Department of Internal Medicine, Hypertension Unit, Institut d Investigacions Biomediques August Pi i Sunyer, IDIBAPS, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain
    Curr Hypertens Rep 8:269-70. 2006
  7. ncbi Relation of left ventricular hypertrophy to regional cerebral blood flow: single photon emission computed tomography abnormalities in essential hypertension
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital ClAnic, University of Barcelona, Spain
    J Clin Hypertens (Greenwich) 8:700-5. 2006
  8. ncbi Cerebral hemodynamics and silent cerebral white matter lesions in middle-aged essential hypertensive patients
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Blood Press 13:304-9. 2004
  9. ncbi White matter lesions and cognitive impairment as silent cerebral disease in hypertension
    Cristina Sierra
    Hypertension Unit, Hospital Clinic of Barcelona University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, 170 Villarroel, 08036 Barcelona, Spain
    ScientificWorldJournal 6:494-501. 2006
  10. ncbi Silent cerebral white matter lesions and cognitive function in middle-aged essential hypertensive patients
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Am J Hypertens 17:529-34. 2004

Collaborators

Detail Information

Publications42

  1. pmc Connecting cerebral white matter lesions and hypertensive target organ damage
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Institute of Medicine and Dermatology, Hospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Aging Res 2011:438978. 2011
    ..There is strong evidence that cerebral white matter lesions in hypertensive patients should be considered a silent early marker of brain damage...
  2. ncbi Essential hypertension, cerebral white matter pathology and ischemic stroke
    C Sierra
    Hypertension and Vascular Risk Unit, Department of Internal Medicine, Hospital Clinic of Barcelona, Villarroel 170 Barcelona 08036, Spain
    Curr Med Chem 21:2156-64. 2014
    ....
  3. pmc Associations between Ambulatory Blood Pressure Parameters and Cerebral White Matter Lesions
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Institute of Medicine and Dermatology, IDIBAPS, Hospital Clinic of Barcelona, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Int J Hypertens 2011:478710. 2011
    ..This paper focuses on the associations between blood pressure parameters obtained by 24-hour ABMP and cerebral WMLs...
  4. doi Hypertension and mild cognitive impairment
    Cristina Sierra
    Hypertension and Vascular Risk Unit, Department of Internal Medicine, Hospital Clinic of Barcelona, Spain
    Curr Hypertens Rep 14:548-55. 2012
    ..The BP levels that should be targeted to achieve optimal perfusion while preventing cognitive decline are still under debate...
  5. ncbi Cerebral small vessel disease, cognitive impairment and vascular dementia
    C Sierra
    Hypertension and Vascular Risk Unit, Department of Internal Medicine, Institute of Medicine and DermatologyHospital Clinic of Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain
    Panminerva Med 54:179-88. 2012
    ..The BP levels that should be targeted to achieve optimal perfusion while preventing cognitive decline are still under debate...
  6. ncbi Early brain damage in essential hypertension: "to have and have not"--is it important?
    Cristina Sierra
    Department of Internal Medicine, Hypertension Unit, Institut d Investigacions Biomediques August Pi i Sunyer, IDIBAPS, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain
    Curr Hypertens Rep 8:269-70. 2006
  7. ncbi Relation of left ventricular hypertrophy to regional cerebral blood flow: single photon emission computed tomography abnormalities in essential hypertension
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital ClAnic, University of Barcelona, Spain
    J Clin Hypertens (Greenwich) 8:700-5. 2006
    ..The authors conclude that the presence of LVH in middle-aged patients with essential hypertension is associated with a reduction of regional cerebral blood flow in the striatum area...
  8. ncbi Cerebral hemodynamics and silent cerebral white matter lesions in middle-aged essential hypertensive patients
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Blood Press 13:304-9. 2004
    ..This increased pulsatility is also associated with higher pulse pressure values, suggesting a pathogenetic link between pulse pressure, pulsatility and the development of WML...
  9. ncbi White matter lesions and cognitive impairment as silent cerebral disease in hypertension
    Cristina Sierra
    Hypertension Unit, Hospital Clinic of Barcelona University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, 170 Villarroel, 08036 Barcelona, Spain
    ScientificWorldJournal 6:494-501. 2006
    ..Some authors have suggested that the presence of white matter lesions in hypertensive patients could be considered an early marker of brain damage...
  10. ncbi Silent cerebral white matter lesions and cognitive function in middle-aged essential hypertensive patients
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Am J Hypertens 17:529-34. 2004
    ..The aim of the present study was to evaluate cognitive function in asymptomatic middle-aged hypertensive patients according to the presence or absence of white matter lesions...
  11. doi The ACTION study: nifedipine in patients with symptomatic stable angina and hypertension
    Cristina Sierra
    Department of Internal Medicine, Institute of Medicine and Dematology, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Expert Rev Cardiovasc Ther 6:1055-62. 2008
    ..The aim of this review is to provide an update on the status of the reported ACTION study results from different studies and subgroups...
  12. doi Vascular mechanisms in the pathogenesis of stroke
    Cristina Sierra
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Curr Hypertens Rep 13:200-7. 2011
    ..This article reviews recent data on vascular mechanisms that participate in the pathogenesis of stroke...
  13. ncbi Correlation between silent cerebral white matter lesions and left ventricular mass and geometry in essential hypertension
    Cristina Sierra
    Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Am J Hypertens 15:507-12. 2002
    ..The aim of this study was to assess the association between the presence of silent WMLs and left ventricular mass and geometry in middle-aged individuals with hypertension that had never been treated...
  14. ncbi Renin-angiotensin system genetic polymorphisms and cerebral white matter lesions in essential hypertension
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain
    Hypertension 39:343-7. 2002
    ..However, because of the small sample size, these results require confirmation in a larger study...
  15. ncbi Silent cerebral white matter lesions in middle-aged essential hypertensive patients
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    J Hypertens 20:519-24. 2002
    ..This study investigates which factors related to hypertension per se are associated with the presence of WML in asymptomatic, middle-aged, never-treated essential hypertensive patients...
  16. ncbi Cerebral white matter lesions in essential hypertension
    C Sierra
    Hypertension Unit, Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain
    Curr Hypertens Rep 3:429-33. 2001
    ..Some authors suggest that the presence of WML in hypertensive patients could be considered an early marker of brain damage...
  17. ncbi Reproducibility of the circadian blood pressure pattern in 24-h versus 48-h recordings: the Spanish Ambulatory Blood Pressure Monitoring Registry
    Raquel Hernández-del Rey
    Hypertension and Vascular Risk Unit, Department of Internal Medicine, Hospital General de L Hospitalet, University of Barcelona, Spain
    J Hypertens 25:2406-12. 2007
    ..To assess the reproducibility of the circadian blood pressure (BP) pattern over a 48-h period by comparing the first 24 h of ambulatory blood pressure monitoring (ABPM) with the following 24 h and with the mean over 48 h...
  18. ncbi Increased levels of atherosclerosis markers in salt-sensitive hypertension
    Maria Larrousse
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, Villaroel 170, 08036 Barcelona, Spain
    Am J Hypertens 19:87-93. 2006
    ..We evaluated several serum markers of atherosclerosis and endothelial function in a group of essential hypertensive patients classified on the basis of their salt sensitivity...
  19. ncbi Blood pressure variability and silent cerebral damage in essential hypertension
    Elisenda Gómez-Angelats
    Department of Internal Medicine, Hospital Clinic, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Spain
    Am J Hypertens 17:696-700. 2004
    ..The aim of this study was to analyze the association between blood pressure variability and the presence of silent cerebral white matter lesions in middle-aged asymptomatic essential hypertensives...
  20. ncbi Antihypertensive, cardiovascular, and pleiotropic effects of angiotensin-receptor blockers
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, 170 Villaroel, 08036 Barcelona, Spain
    Curr Opin Nephrol Hypertens 14:435-41. 2005
    ..To review the antihypertensive, cardiovascular and pleiotropic effects of angiotensin-receptor blockers (ARBs)...
  21. doi Folate analysis for the differential diagnosis of profound cerebrospinal fluid folate deficiency
    Aida Ormazabal
    Department of Clinical Biochemistry, Hospital Sant Joan de Deu, Barcelona, Spain
    Clin Biochem 44:719-21. 2011
    ..To evaluate the automated determination of total cerebrospinal fluid (CSF) folates for the diagnosis of cerebral folate deficiency...
  22. pmc Early detection and management of the high-risk patient with elevated blood pressure
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic University of Barcelona, Spain
    Vasc Health Risk Manag 4:289-96. 2008
    ..The objective would be to impair the progression or to induce the regression of silent vascular damage before a clinical event develops...
  23. doi Ambulatory blood pressure in stroke and cognitive dysfunction
    Antonio Coca
    Hypertension and Vascular Risk Unit, Department of Internal Medicine, Institute of Medicine and Dermatology, Hospital Clinic IDIBAPS, C Villarroel 170, 08036, Barcelona, Spain
    Curr Hypertens Rep 15:150-9. 2013
    ..Unfortunately most of these studies were cross-sectional and the associations do not establish causality...
  24. ncbi Once-daily fixed-combination irbesartan 300 mg/ hydrochlorothiazide 25 mg and circadian blood pressure profile in patients with essential hypertension
    Antonio Coca
    Hospital Clinico IDIBAPS, University of Barcelona, Barcelona, Spain
    Clin Ther 25:2849-64. 2003
    ..Tolerable combinations using higher doses of antihypertensive drugs are frequently required to control blood pressure...
  25. doi Urinary albumin excretion at follow-up predicts cardiovascular outcomes in subjects with resistant hypertension
    Anna Oliveras
    Hypertension Unit, Nephrology Department, Hospital Universitari del Mar, Barcelona, Catalonia, Spain
    Am J Hypertens 26:1148-54. 2013
    ..Renal function and albuminuria predict cardiovascular disease (CVD) in general population. However, their prognostic value in patients with resistant hypertension (RH) is somewhat unknown...
  26. ncbi [Ambulatory blood pressure monitoring (CABPM): clinical characteristics of 31,530 patients]
    Cristina Sierra
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Clinic, Barcelona, Espana
    Med Clin (Barc) 129:1-5. 2007
    ..Ambulatory blood pressure monitoring (ABPM) is a useful diagnostic and therapeutic tool in hypertensive patients. This study reports the clinical characteristics of 31,530 patients included in the Spanish Registry of ABPM...
  27. ncbi [Lack of association between blood pressure variability and left ventricular hypertrophy in essential hypertension]
    Elisenda Gómez Angelats
    Unidad de Hipertension, Servicio de Medicina Interna, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Med Clin (Barc) 123:731-4. 2004
    ..The aim of the present study was to analyze the association between BP variability, defined through different instrument measures, and LVH in a group of essential hypertensive patients...
  28. doi Analysis of cerebrospinal fluid γ-aminobutyric acid by capillary electrophoresis with laser-induced fluorescence detection
    Mercedes Casado
    Department of Clinical Biochemistry and Neuropaediatrics, Hospital Sant Joan de Déu CIBERER ISCIII, Barcelona, Spain Department of Biochemistry and Molecular Biology, UAB, Barcelona, Spain
    Electrophoresis 35:1181-7. 2014
    ..Significantly, higher GABA values were obtained in patients taking valproic acid or vigabatrin therapy, which are antiepileptic drugs that modulate GABA metabolism. ..
  29. doi [Hypertension in the elderly population]
    Cristina Sierra
    Unidad de Hipertension Arterial, Servicio de Medicina Interna, Hospital Clinic, Universidad de Barcelona, Barcelona, Espana
    Rev Esp Geriatr Gerontol 43:53-9. 2008
    ..In addition, although there is recent evidence of the benefit of antihypertensive treatment in the oldest old (> 85 years), comprehensive geriatric assessment and individualized treatment should be applied in daily clinical practice...
  30. ncbi [Impact of components and methods of measurement of blood pressure on damage of target organs and cardiovascular complications in arterial hypertension]
    Alejandro de la Sierra
    Unidad de Hipertensión Servicio de Medicina Interna Hospital Clínic IDIBAPS Universidad de Barcelona España
    Med Clin (Barc) 119:125-9. 2002
    ....
  31. ncbi Microalbuminuria in essential hypertension: clinical and biochemical profile
    A de la Sierra
    Hypertension Unit, Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Br J Biomed Sci 57:287-91. 2000
    ..Likewise, microalbuminuria is associated with the degree of renal impairment, and with increased uric acid and triglycerides and decreased HDL-cholesterol...
  32. doi Selenium concentration in cerebrospinal fluid samples from a paediatric population
    Mireia Tondo
    Clinical Biochemistry Department, Hospital Sant Joan de Deu, Instituto de Salud Carlos III MICIN, Barcelona, Spain
    Neurochem Res 35:1290-3. 2010
    ..The association observed between CSF Se and GPX activity suggests that Se quantification might be a reflection of some Se-dependent protein function. Cerebrospinal fluid Se values were independent of serum Se concentrations...
  33. ncbi Role of the selective aldosterone receptor blockers in arterial hypertension
    Cristina Sierra
    Hypertension Unit, Hospital Clinic, Barcelona, Spain
    J Renin Angiotensin Aldosterone Syst 5:23-5. 2004
    ..The fact that eplerenone is much better tolerated open the possibility of this therapy in cardiovascular, as well as in renal disease...
  34. ncbi Assessment of salt sensitivity in essential hypertension by 24-h ambulatory blood pressure monitoring
    A de la Sierra
    Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain
    Am J Hypertens 8:970-7. 1995
    ....
  35. ncbi Oral insulin-mimetic compounds that act independently of insulin
    Silvia García-Vicente
    Institute for Research in Biomedicine, Josep Samitier 1 5, Barcelona, Spain
    Diabetes 56:486-93. 2007
    ..This represents a novel therapeutic approach for diabetic patients with severe insulin resistance...
  36. doi Cerebral folate deficiency syndromes in childhood: clinical, analytical, and etiologic aspects
    Belen Perez-Duenas
    Department of Neurology, Hospital Sant Joan de Deu, Passeig Sant Joan de Déu 2, Esplugues, Barcelona, Spain
    Arch Neurol 68:615-21. 2011
    ..Diverse metabolic pathways and unrelated processes can lead to cerebrospinal fluid 5-methyltetrahydrofolate (5-MTHF) depletion, the hallmark of cerebral folate deficiency...
  37. doi Idebenone treatment in paediatric and adult patients with Friedreich ataxia: long-term follow-up
    Merce Pineda
    Neuropediatrics Department, Hospital Sant Joan de Déu and Centre for Biomedical Research on Rare Diseases CIBERER, Barcelona, Spain
    Eur J Paediatr Neurol 12:470-5. 2008
    ..Antioxidant therapy is a new therapeutical approach for patients with Friedreich ataxia...
  38. ncbi New-onset diabetes and antihypertensive therapy: comments on ALLHAT trial
    Cristina Sierra
    Hypertension Units, Hospital Clinic of Barcelona, Madrid, Spain
    J Renin Angiotensin Aldosterone Syst 4:169-70. 2003
    ..Long-term studies are required to determine the relevance of development of new-onset diabetes in treated hypertensive patients...
  39. ncbi A longitudinal study of antioxidant status in phenylketonuric patients
    Rafael Artuch
    Serveis de Bioquímica, Hospital Sant Joan de Deu, Esplugues, Barcelona, Spain
    Clin Biochem 37:198-203. 2004
    ....
  40. ncbi [Finapres and Portapres devices]
    C Sierra
    Unidad de Hipertension, IDIBAPS, Hospital Clinic, Universidad de Barcelona
    Nefrologia 22:12-5. 2002
  41. ncbi Nocturnal fall of blood pressure with antihypertensive therapy and recurrence of ischaemic stroke: 'the lower the better' revisited
    Cristina Sierra
    J Hypertens 23:1131-2. 2005
  42. ncbi Ambulatory blood pressure monitoring in hypertensive patients with high cardiovascular risk: a cross-sectional analysis of a 20,000-patient database in Spain
    Manuel Gorostidi
    Hospital San Agustin, Aviles, Asturias, Spain
    J Hypertens 25:977-84. 2007
    ..To evaluate ambulatory blood pressure monitoring (ABPM) parameters in a broad sample of high-risk hypertensive patients...