M Serrano

Summary

Country: Spain

Publications

  1. ncbi Putting the stress on senescence
    M Serrano
    Department of Immunology and Oncology, National Center of Biotechnology CSIC, Campus de Cantoblanco, Madrid E 28049, Spain
    Curr Opin Cell Biol 13:748-53. 2001
  2. ncbi The INK4a/ARF locus in murine tumorigenesis
    M Serrano
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Campus de Cantoblanco, Madrid E 28049, Spain
    Carcinogenesis 21:865-9. 2000
  3. ncbi The tumor suppressor protein p16INK4a
    M Serrano
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Exp Cell Res 237:7-13. 1997
  4. pmc The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
    M Barradas
    , , , Canto Blanco, Madrid, Spain
    EMBO J 18:6362-9. 1999
  5. ncbi Normal cellular senescence and cancer susceptibility in mice genetically deficient in Ras-induced senescence-1 (Ris1)
    M Nieto
    Tumor Suppression Group, Spanish National Cancer Center CNIO, Madrid, Spain
    Oncogene 26:1673-80. 2007
  6. pmc SIRT1 stabilizes PML promoting its sumoylation
    M Campagna
    Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma, Madrid 28049, Spain
    Cell Death Differ 18:72-9. 2011
  7. pmc Regulation of the tumor suppressor PTEN by SUMO
    J González-Santamaría
    Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Cell Death Dis 3:e393. 2012
  8. doi SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
    D Herranz
    Tumor Suppression Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Oncogene 32:4052-6. 2013
  9. ncbi Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression
    A Efeyan
    Molecular Oncology Program, Spanish National Cancer Centre CNIO, Madrid, Spain
    Oncogene 26:1645-9. 2007
  10. doi Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
    E Lara
    Cancer Epigenetics Laboratory, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Oncogene 28:781-91. 2009

Collaborators

  • D Gonzalez
  • Lucia Altucci
  • J H Calvo
  • J Moscat
  • M Esteller
  • A M Goldstein
  • L Chin
  • Charles J Sherr
  • C Walker
  • Joachim Schneider
  • Jesus M Paramio
  • K Ranade
  • D Herranz
  • J González-Santamaría
  • M Campagna
  • L Marcos-Villar
  • M Esteban
  • C Rivas
  • P Gallego
  • M Collado
  • E Lara
  • M Barradas
  • M Herranz
  • A Efeyan
  • M Nieto
  • J M Flores
  • L Gonzalez
  • E de la Cueva
  • J Fernandez-Piqueras
  • I Palmero
  • X Matias-Guiu
  • E Castelblanco
  • L Inglada-Pérez
  • A Maraver
  • G Gomez-Lopez
  • M Robledo
  • M Canamero
  • C Pantoja
  • C F de la Cruz-Herrera
  • A Ortega-Molina
  • F Lopitz-Otsoa
  • M S Rodriguez
  • M A Garcia
  • S Gutierrez
  • G Montoya
  • A Inhof
  • M Witt
  • A Nebbioso
  • J M Mato
  • A Mai
  • S Ropero
  • P Lopez-Nieva
  • M Varela-Rey
  • D Rotili
  • J Oyarzabal
  • A Imhof
  • S Velasco
  • M L Martinez-Chantar
  • V Calvanese
  • M F Fraga
  • A Villar-Garea
  • L M Criado
  • S Velasco-Miguel
  • E Llano
  • P Lopez
  • J M P Freije
  • P Garcia-Palencia
  • I Garcia-Cao
  • C Lopez-Otin
  • J Santos
  • S Cal
  • D H Brotherton
  • J Martin-Caballero
  • D Beach
  • M Malumbres
  • D F Knapek
  • D E Quelle
  • D Trono
  • T Wolfel
  • A Monjas
  • E Salido
  • M T Diaz-Meco
  • E D Laue
  • V Dhanaraj
  • E Volyanik
  • A Okamoto
  • S J Archer
  • S L Brenner
  • T L Blundell
  • X Xu

Detail Information

Publications28

  1. ncbi Putting the stress on senescence
    M Serrano
    Department of Immunology and Oncology, National Center of Biotechnology CSIC, Campus de Cantoblanco, Madrid E 28049, Spain
    Curr Opin Cell Biol 13:748-53. 2001
    ..Importantly, the analysis of the various aspects and types of senescence has turned out to be very informative about numerous in vivo processes, and particularly about carcinogenesis...
  2. ncbi The INK4a/ARF locus in murine tumorigenesis
    M Serrano
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Campus de Cantoblanco, Madrid E 28049, Spain
    Carcinogenesis 21:865-9. 2000
    ..Here, I review the evidence accumulated on the involvement of the INK4a/ARF locus in murine tumorigenesis. Also, I summarize the phenotype of the different transgenic mouse models based on the inactivation of the INK4a/ARF locus...
  3. ncbi The tumor suppressor protein p16INK4a
    M Serrano
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Exp Cell Res 237:7-13. 1997
    ..p16INK4a is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4a are starting to be characterized...
  4. pmc The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
    M Barradas
    , , , Canto Blanco, Madrid, Spain
    EMBO J 18:6362-9. 1999
    ..This indicates that the downregulation of Par-4 by oncogenic Ras is a critical event in tumor progression...
  5. ncbi Normal cellular senescence and cancer susceptibility in mice genetically deficient in Ras-induced senescence-1 (Ris1)
    M Nieto
    Tumor Suppression Group, Spanish National Cancer Center CNIO, Madrid, Spain
    Oncogene 26:1673-80. 2007
    ..These findings do not support a role of Ris1 in tumor suppression or in OIS...
  6. pmc SIRT1 stabilizes PML promoting its sumoylation
    M Campagna
    Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma, Madrid 28049, Spain
    Cell Death Differ 18:72-9. 2011
    ..These results show a novel function of SIRT1 in the control of PML and PML-NBs...
  7. pmc Regulation of the tumor suppressor PTEN by SUMO
    J González-Santamaría
    Centro Nacional de Biotecnologia, CSIC, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Cell Death Dis 3:e393. 2012
    ..Moreover, we found that virus infection induces PTEN SUMOylation and favors PTEN localization at the cell membrane. Finally, we demonstrated that SUMOylation contributes to the control of virus infection by PTEN...
  8. doi SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
    D Herranz
    Tumor Suppression Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Oncogene 32:4052-6. 2013
    ..Finally, we show in cultured thyroid cancer cells that SIRT1 stabilizes c-MYC protein. These results implicate SIRT1 as a new candidate target for the treatment of thyroid carcinomas...
  9. ncbi Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression
    A Efeyan
    Molecular Oncology Program, Spanish National Cancer Centre CNIO, Madrid, Spain
    Oncogene 26:1645-9. 2007
    ..We conclude that cell-cycle arrest through p21 plays a significant role in mediating p53-dependent cancer protection...
  10. doi Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
    E Lara
    Cancer Epigenetics Laboratory, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Oncogene 28:781-91. 2009
    ..Taken together, our results underline Salermide's promise as an anticancer drug and provide evidence for the molecular mechanism through which Sirt1 is involved in human tumorigenesis...
  11. ncbi Linkage mapping of ovine cysteine and histidine-rich protein gene (CYHR1) to chromosome 9
    J H Calvo
    Departamento de Mejora Genética Animal, INIA, Madrid, Spain
    Anim Genet 35:263-4. 2004
  12. ncbi Identification of the gene immediately downstream of the murine INK4a/ARF locus
    C Pantoja
    Department of Immunology and Oncology, National Center of Biotechnology, Campus de Cantoblanco, Madrid E 28049, Spain
    Exp Gerontol 36:1289-302. 2001
    ..Finally, these data identify the gene immediately downstream of the INK4a/ARF locus, a region that has been previously proposed to contain another tumor suppressor different from the INK4a/ARF genes...
  13. ncbi A functional link between the tumour suppressors ARF and p33ING1
    L Gonzalez
    Institute of Biomedical Research, CSIC UAM, Arturo Duperier 4, Madrid, Spain
    Oncogene 25:5173-9. 2006
    ..Based on these observations, we propose that the interaction with p33ING1 represents a novel mechanism for the tumour suppression function of ARF...
  14. ncbi Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma
    E de la Cueva
    Unit of Animal Experimentation, Spanish National Cancer Center CNIO, Madrid, Spain
    Oncogene 25:4128-32. 2006
    ..Together, our results indicate that p21 plays an oncogenic role restricted to thymic lymphomas that is mechanistically independent of p53 and associated to a lower tumor apoptotic rate...
  15. ncbi Role of the INK4a locus in tumor suppression and cell mortality
    M Serrano
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York, 11724 USA
    Cell 85:27-37. 1996
    ..These findings directly demonstrate that the INK4a locus functions to suppress neoplastic growth...
  16. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
    ..Negation of ras-induced senescence may be relevant during multistep tumorigenesis...
  17. ncbi Association of the heart fatty acid-binding protein (FABP3) gene with milk traits in Manchega breed sheep
    J H Calvo
    Departamento de Mejora Genética Animal, INIA, 28040 Madrid, Spain
    Anim Genet 35:347-9. 2004
    ..These results could indicate linkage disequilibrium between the FABP3 gene and a quantitative trait loci (QTL) for FC, with the heterozygous genotype associated with a positive effect in this trait...
  18. ncbi Characterization, genetic variation and chromosomal assignment to sheep chromosome 2 of the ovine heart fatty acid-binding protein gene (FABP3)
    J H Calvo
    Departamento de Mejora Genética Animal, INIA, 28040 Madrid, Spain
    Cytogenet Genome Res 98:270-3. 2002
    ..This poly A tract was found in association with a SINE/artiodactyls repeat. In addition, two SNPs were screened in different sheep breeds...
  19. ncbi The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis
    J M Paramio
    Cell, Molecular Biology, and Gene Therapy Project, CIEMAT, Avenida Complutense 22, E 28040 Madrid, Spain
    J Biol Chem 276:44203-11. 2001
    ..These results indicate that ink4a/arf and cip1/waf genes cooperate to allow normal keratinocyte differentiation and that the absence of both favors malignant transformation...
  20. ncbi Cloning and characterization of murine p16INK4a and p15INK4b genes
    D E Quelle
    Howard Hughes Medical Institute, Memphis, Tennessee, USA
    Oncogene 11:635-45. 1995
    ..Expression vectors encoding human or mouse p16INK4a caused G1 phase arrest in NIH3T3 fibroblasts, and cyclin D1- and cdk4-dependent pRb kinase activities were inhibited in the p16INK4a-arrested cells...
  21. ncbi A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
    T Wolfel
    Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat, Mainz, Germany
    Science 269:1281-4. 1995
    ..These results suggest that mutation of CDK4 can create a tumor-specific antigen and can disrupt the cell-cycle regulation exerted by the tumor suppressor p16INK4a...
  22. ncbi Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors
    D F Knapek
    University of Texas M D Anderson Cancer Center, Smithville 78957, USA
    Cancer Res 55:1607-12. 1995
    ....
  23. pmc Mutations and altered expression of p16INK4 in human cancer
    A Okamoto
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:11045-9. 1994
    ....
  24. ncbi A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    M Serrano
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Nature 366:704-7. 1993
    ..p16 seems to act in a regulatory feedback circuit with CDK4, D-type cyclins and retinoblastoma protein...
  25. ncbi Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas
    M Malumbres
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York 10016, USA
    Oncogene 14:1361-70. 1997
    ..Moreover, they show the importance of allelic losses and CpG island methylation of p15INK4b gene inactivation and support a tumor suppressor role for p15INK4b in T-cell lymphomas independent of p16INK4a...
  26. ncbi Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d
    D H Brotherton
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, UK
    Nature 395:244-50. 1998
    ..Identification of the critical residues involved in the interaction explains how mutations in Cdk4 and p16INK4a result in loss of kinase inhibition and cancer...
  27. ncbi Mouse p73 gene maps to the distal part of chromosome 4 and might be involved in the progression of gamma-radiation-induced T-cell lymphomas
    M Herranz
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Cancer Res 59:2068-71. 1999
    ..6% (16 of 49) of the tumors analyzed. Interestingly, allelic losses occur concurrently at both p73 and D4Mit205b, thus suggesting that p73 could be specifically inactivated in radiation-induced T-cell lymphomas...
  28. ncbi Mutations associated with familial melanoma impair p16INK4 function
    K Ranade
    Nat Genet 10:114-6. 1995
    ..Our data provide a biochemical rationale for the hypothesis that carriers of certain p16INK4 mutations are at increased risk of developing melanoma...